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Protein

Peroxisomal biogenesis factor 19

Gene

Pex19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 19
Alternative name(s):
Peroxin-19
Peroxisomal farnesylated protein
Short name:
PxF
Gene namesi
Name:Pex19
Synonyms:Pxf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1334458. Pex19.

Subcellular locationi

  • Cytoplasm By similarity
  • Peroxisome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

  • Note: Mainly cytoplasmic, some fraction membrane-associated to the outer surface of peroxisomes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002187602 – 296Peroxisomal biogenesis factor 19Add BLAST295
PropeptideiPRO_0000396701297 – 299Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei66PhosphoserineBy similarity1
Modified residuei236PhosphothreonineCombined sources1
Modified residuei296Cysteine methyl esterBy similarity1
Lipidationi296S-farnesyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ8VCI5.
PaxDbiQ8VCI5.
PeptideAtlasiQ8VCI5.
PRIDEiQ8VCI5.

PTM databases

iPTMnetiQ8VCI5.
PhosphoSitePlusiQ8VCI5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003464.
CleanExiMM_PEX19.
GenevisibleiQ8VCI5. MM.

Interactioni

Subunit structurei

Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Cdkn2aQ64364-14EBI-1810767,EBI-1202306

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202520. 2 interactors.
IntActiQ8VCI5. 4 interactors.
MINTiMINT-4107226.
STRINGi10090.ENSMUSP00000075289.

Structurei

3D structure databases

ProteinModelPortaliQ8VCI5.
SMRiQ8VCI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 91Necessary for PEX19 function on peroxisome biogenesisBy similarityAdd BLAST90
Regioni2 – 56Docking to the peroxisome membrane and binding to PEX3By similarityAdd BLAST55

Sequence similaritiesi

Belongs to the peroxin-19 family.Curated

Phylogenomic databases

eggNOGiKOG3133. Eukaryota.
ENOG4111QGU. LUCA.
GeneTreeiENSGT00390000010993.
HOGENOMiHOG000038537.
HOVERGENiHBG053573.
InParanoidiQ8VCI5.
KOiK13337.
OMAiILMGMME.
OrthoDBiEOG091G0IMB.
PhylomeDBiQ8VCI5.
TreeFamiTF315082.

Family and domain databases

InterProiIPR006708. Pex19.
[Graphical view]
PANTHERiPTHR12774. PTHR12774. 1 hit.
PfamiPF04614. Pex19. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VCI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAEEGCGV GVEDDRELEE LLESALDDFD KAKPSPEHAP TISAPDASGP
60 70 80 90 100
QKRAPGDTAK DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH
110 120 130 140 150
LVEQFQKLSE AAGRVGSDAS SQQEFTSCLK ETLSGLAKNA TELQNSGMSE
160 170 180 190 200
EELMKAMEGL GMDEGDGEAS ILPIMQSIMQ NLLSKDVLYP SLKEITEKYP
210 220 230 240 250
EWLQSHQDST PPEQFEKYQQ QHSVMVKICE QFEAETPTDS EATQRARFEA
260 270 280 290
MLDLMQQLQA LGHPPKELAG EMPPGLNFDL DALNLSGPPG ANGEQCLIM
Length:299
Mass (Da):32,733
Last modified:March 1, 2002 - v1
Checksum:i530A3A0C29370E51
GO
Isoform 2 (identifier: Q8VCI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-116: Missing.

Show »
Length:207
Mass (Da):22,774
Checksum:iFDC78A79C614113D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31K → E in BAB28468 (PubMed:16141072).Curated1
Sequence conflicti55P → S in CAA70255 (Ref. 1) Curated1
Sequence conflicti55P → S in CAA70256 (Ref. 1) Curated1
Sequence conflicti55P → S in AAH12517 (Ref. 3) Curated1
Sequence conflicti110E → K in BAB28468 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01265225 – 116Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09046 mRNA. Translation: CAA70255.1.
Y09047 Genomic DNA. Translation: CAA70256.1.
AK012785 mRNA. Translation: BAB28468.1.
AK028449 mRNA. Translation: BAC25957.1.
AK029368 mRNA. Translation: BAC26421.1.
CT010305 mRNA. Translation: CAJ18513.1.
BC012517 mRNA. Translation: AAH12517.1.
BC019767 mRNA. Translation: AAH19767.1.
CCDSiCCDS15508.1. [Q8VCI5-1]
CCDS48445.1. [Q8VCI5-2]
RefSeqiNP_001152997.1. NM_001159525.1. [Q8VCI5-2]
NP_075528.3. NM_023041.3. [Q8VCI5-1]
UniGeneiMm.247764.

Genome annotation databases

EnsembliENSMUST00000075895; ENSMUSP00000075289; ENSMUSG00000003464. [Q8VCI5-1]
ENSMUST00000111252; ENSMUSP00000106883; ENSMUSG00000003464. [Q8VCI5-2]
GeneIDi19298.
KEGGimmu:19298.
UCSCiuc007dpq.2. mouse. [Q8VCI5-1]
uc011wwj.1. mouse. [Q8VCI5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09046 mRNA. Translation: CAA70255.1.
Y09047 Genomic DNA. Translation: CAA70256.1.
AK012785 mRNA. Translation: BAB28468.1.
AK028449 mRNA. Translation: BAC25957.1.
AK029368 mRNA. Translation: BAC26421.1.
CT010305 mRNA. Translation: CAJ18513.1.
BC012517 mRNA. Translation: AAH12517.1.
BC019767 mRNA. Translation: AAH19767.1.
CCDSiCCDS15508.1. [Q8VCI5-1]
CCDS48445.1. [Q8VCI5-2]
RefSeqiNP_001152997.1. NM_001159525.1. [Q8VCI5-2]
NP_075528.3. NM_023041.3. [Q8VCI5-1]
UniGeneiMm.247764.

3D structure databases

ProteinModelPortaliQ8VCI5.
SMRiQ8VCI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202520. 2 interactors.
IntActiQ8VCI5. 4 interactors.
MINTiMINT-4107226.
STRINGi10090.ENSMUSP00000075289.

PTM databases

iPTMnetiQ8VCI5.
PhosphoSitePlusiQ8VCI5.

Proteomic databases

EPDiQ8VCI5.
PaxDbiQ8VCI5.
PeptideAtlasiQ8VCI5.
PRIDEiQ8VCI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075895; ENSMUSP00000075289; ENSMUSG00000003464. [Q8VCI5-1]
ENSMUST00000111252; ENSMUSP00000106883; ENSMUSG00000003464. [Q8VCI5-2]
GeneIDi19298.
KEGGimmu:19298.
UCSCiuc007dpq.2. mouse. [Q8VCI5-1]
uc011wwj.1. mouse. [Q8VCI5-2]

Organism-specific databases

CTDi5824.
MGIiMGI:1334458. Pex19.

Phylogenomic databases

eggNOGiKOG3133. Eukaryota.
ENOG4111QGU. LUCA.
GeneTreeiENSGT00390000010993.
HOGENOMiHOG000038537.
HOVERGENiHBG053573.
InParanoidiQ8VCI5.
KOiK13337.
OMAiILMGMME.
OrthoDBiEOG091G0IMB.
PhylomeDBiQ8VCI5.
TreeFamiTF315082.

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.

Miscellaneous databases

PROiQ8VCI5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003464.
CleanExiMM_PEX19.
GenevisibleiQ8VCI5. MM.

Family and domain databases

InterProiIPR006708. Pex19.
[Graphical view]
PANTHERiPTHR12774. PTHR12774. 1 hit.
PfamiPF04614. Pex19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX19_MOUSE
AccessioniPrimary (citable) accession number: Q8VCI5
Secondary accession number(s): Q4FJU7
, Q8CEE1, Q921H0, Q9CZC1, Q9QUQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.