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Protein

Phospholipase B-like 1

Gene

Plbd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. However, in view of the small size of the putative binding pocket, it has been proposed that it may act rather as an amidase or a peptidase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase B-like 1 (EC:3.1.1.-)
Alternative name(s):
LAMA-like protein 1
Lamina ancestor homolog 1
Phospholipase B domain-containing protein 1
Cleaved into the following 3 chains:
Gene namesi
Name:Plbd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914107. Plbd1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39By similarityAdd BLAST39
ChainiPRO_000028610740 – 550Phospholipase B-like 1Add BLAST511
ChainiPRO_000042542540 – 209Phospholipase B-like 1 chain AAdd BLAST170
ChainiPRO_000042542694 – 209Phospholipase B-like 1 chain CAdd BLAST116
PropeptideiPRO_0000425427210 – 228Removed in mature formBy similarityAdd BLAST19
ChainiPRO_0000425428229 – 550Phospholipase B-like 1 chain BAdd BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi309N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi309N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1
Glycosylationi367N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi367N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1
Glycosylationi412N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi412N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1
Disulfide bondi471 ↔ 476By similarity
Disulfide bondi475 ↔ 490By similarity
Glycosylationi527N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi527N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1

Post-translational modificationi

The maturation cleavages that produces chains A and B are required to open the putative substrate binding pocket. Both chains A and B remain associated in the mature protein (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8VCI0.
PaxDbiQ8VCI0.
PeptideAtlasiQ8VCI0.
PRIDEiQ8VCI0.

PTM databases

iPTMnetiQ8VCI0.
PhosphoSitePlusiQ8VCI0.
UniCarbKBiQ8VCI0.

Expressioni

Gene expression databases

CleanExiMM_1100001H23RIK.

Interactioni

Subunit structurei

May form a homodimer, each monomer is composed of a chain A and a chain B.By similarity

Protein-protein interaction databases

IntActiQ8VCI0. 1 interactor.
MINTiMINT-4126656.

Structurei

3D structure databases

ProteinModelPortaliQ8VCI0.
SMRiQ8VCI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase B-like family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3774. Eukaryota.
ENOG410XQRV. LUCA.
HOGENOMiHOG000006903.
HOVERGENiHBG108264.
InParanoidiQ8VCI0.
PhylomeDBiQ8VCI0.
TreeFamiTF315042.

Family and domain databases

InterProiView protein in InterPro
IPR007000. PLipase_B-like.
PANTHERiPTHR12370. PTHR12370. 1 hit.
PfamiView protein in Pfam
PF04916. Phospholip_B. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHRSPGRSL RPPSPLLLLL PLLLQPPWAA GAASQSDPTG VHCATAYWSP
60 70 80 90 100
ESKKVEIKTV LDKNGDAYGY YNDSIKTTGW GILEIRAGYG SQVLSNEIIM
110 120 130 140 150
FLAGYLEGYL TALHMYDHFT NLYPQLIKNP SIVKKVQDFM EKQEMWTRQN
160 170 180 190 200
IKAQKDDPFW RHTGYVVTQL DGLYLGAQKR ASEEKIKPMT MFQIQFLNAV
210 220 230 240 250
GDLLDLIPSL SPTKSSSMMK FKIWEMGHCS ALIKVLPGFE NIYFAHSSWY
260 270 280 290 300
TYAAMLRIYK HWDFNIKDKY TLSKRLSFSS YPGFLESLDD FYILSSGLIL
310 320 330 340 350
LQTTNSVYNK TLLKQVVPKT LLAWQRVRVA NMMAEGGKEW AQIFSKHNSG
360 370 380 390 400
TYNNQYMVLD LKKVTINRSL DKGTLYIVEQ IPTYVEYSDQ TNVLRKGYWA
410 420 430 440 450
SYNIPFHKTI YNWSGYPLLV HKLGLDYSYD LAPRAKIFRR DQGNVTDMAS
460 470 480 490 500
MKYIMRYNNY KEDPYSKGDP CSTICCREDL NGASPSPGGC YDTKVADIFL
510 520 530 540 550
ASQYKAYAIS GPTVQDGLPP FNWNRFNETL HRGMPEVFDF NFVTMKPILS
Length:550
Mass (Da):62,998
Last modified:March 1, 2002 - v1
Checksum:iC89FC31C0D14B5F6
GO

Sequence cautioni

The sequence BAE42780 differs from that shown. Reason: Frameshift at position 51.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127I → F in BAB22618 (PubMed:16141072).Curated1
Sequence conflicti528E → D in BAB22618 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003169 mRNA. Translation: BAB22618.1.
AK172021 mRNA. Translation: BAE42780.1. Frameshift.
BC019793 mRNA. Translation: AAH19793.1.
CCDSiCCDS20652.1.
RefSeqiNP_080082.1. NM_025806.2.
UniGeneiMm.3311.

Genome annotation databases

GeneIDi66857.
KEGGimmu:66857.
UCSCiuc009elz.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiPLBL1_MOUSE
AccessioniPrimary (citable) accession number: Q8VCI0
Secondary accession number(s): Q3TA89, Q9D1S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2002
Last modified: August 30, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families