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Protein

UBX domain-containing protein 4

Gene

Ubxn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 4
Alternative name(s):
Erasin
UBX domain-containing protein 2
Gene namesi
Name:Ubxn4
Synonyms:Ubxd2, Ubxdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915062. Ubxn4.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity
  • Nucleus envelope By similarity

  • Note: Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 411CytoplasmicSequence analysisAdd BLAST411
Intramembranei412 – 432Sequence analysisAdd BLAST21
Topological domaini433 – 506CytoplasmicSequence analysisAdd BLAST74

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110281 – 506UBX domain-containing protein 4Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei487PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VCH8.
MaxQBiQ8VCH8.
PaxDbiQ8VCH8.
PeptideAtlasiQ8VCH8.
PRIDEiQ8VCH8.

PTM databases

iPTMnetiQ8VCH8.
PhosphoSitePlusiQ8VCH8.
SwissPalmiQ8VCH8.

Expressioni

Tissue specificityi

Expressed in many tissues, including brain, heart, kidney, liver, muscle and spleen (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000026353.

Interactioni

Subunit structurei

Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.By similarity

Protein-protein interaction databases

MINTiMINT-1863647.
STRINGi10090.ENSMUSP00000027592.

Structurei

Secondary structure

1506
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi318 – 323Combined sources6
Beta strandi325 – 327Combined sources3
Beta strandi329 – 334Combined sources6
Helixi340 – 351Combined sources12
Beta strandi359 – 361Combined sources3
Beta strandi363 – 365Combined sources3
Turni371 – 375Combined sources5
Helixi379 – 381Combined sources3
Beta strandi384 – 392Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DZKNMR-A312-409[»]
ProteinModelPortaliQ8VCH8.
SMRiQ8VCH8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VCH8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 391UBXPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 199Interaction with UBQLN1By similarityAdd BLAST199

Domaini

The UBX domain is required for interaction with VCP.By similarity
The intramembrane domain also contains the signal for ER targeting.By similarity

Sequence similaritiesi

Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2507. Eukaryota.
ENOG410ZR21. LUCA.
HOGENOMiHOG000007283.
HOVERGENiHBG056020.
InParanoidiQ8VCH8.
PhylomeDBiQ8VCH8.
TreeFamiTF317466.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWFQGAIPA AIASAKRSGA VFVVFVAGDD EQSIQMAASW EDEKVTQASS
60 70 80 90 100
NNFVAIKIDT KSEACLQFSQ IYPVVCVPSS FFIGDSGIPL EVIAGSVSAD
110 120 130 140 150
ELVTRIHKVQ QMHSSKGEAS VTNDNQSESS VSTPSASFEP DVCENPESKN
160 170 180 190 200
TELCETPATS DIKSDTATGG ECTGHDSHSQ EPHGCSNQRP AEDLTVRVER
210 220 230 240 250
LTKKLEERRE EKRKEEAQRE IKKEIERRKT GKEMLDYKRK QEEELTKRML
260 270 280 290 300
EERSREKAED RAARERIKQQ IALDRAERAA RFAKTKEAEA AKAAALLTKQ
310 320 330 340 350
AGTEVKREST ARDRSTIARI QFRLPDGSSF TNQFPSDAPL EEARQFAAQT
360 370 380 390 400
VGNTYGNFSL ATMFPRREFT REDYKRRLLD LELAPSASVV LLPAGRPATS
410 420 430 440 450
IVHSSSGDIW TLLGTVLYPF LAIWRLISNF LFSNPPPAQT SARATSTEPS
460 470 480 490 500
NSASSSKSEK REPVRKRMLE KRGEDFKKEG KIYRLRTQDD GEDENNTWNG

NSTQQM
Length:506
Mass (Da):56,472
Last modified:March 1, 2002 - v1
Checksum:iDD9CCC380F29C80F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65C → R in BAC35906 (PubMed:16141072).Curated1
Sequence conflicti162I → T in BAE28143 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075716 mRNA. Translation: BAC35906.1.
AK147795 mRNA. Translation: BAE28143.1.
BC019795 mRNA. Translation: AAH19795.1.
CCDSiCCDS15251.1.
RefSeqiNP_080666.2. NM_026390.2.
UniGeneiMm.293321.

Genome annotation databases

GeneIDi67812.
KEGGimmu:67812.
UCSCiuc007cll.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075716 mRNA. Translation: BAC35906.1.
AK147795 mRNA. Translation: BAE28143.1.
BC019795 mRNA. Translation: AAH19795.1.
CCDSiCCDS15251.1.
RefSeqiNP_080666.2. NM_026390.2.
UniGeneiMm.293321.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DZKNMR-A312-409[»]
ProteinModelPortaliQ8VCH8.
SMRiQ8VCH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1863647.
STRINGi10090.ENSMUSP00000027592.

PTM databases

iPTMnetiQ8VCH8.
PhosphoSitePlusiQ8VCH8.
SwissPalmiQ8VCH8.

Proteomic databases

EPDiQ8VCH8.
MaxQBiQ8VCH8.
PaxDbiQ8VCH8.
PeptideAtlasiQ8VCH8.
PRIDEiQ8VCH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67812.
KEGGimmu:67812.
UCSCiuc007cll.1. mouse.

Organism-specific databases

CTDi23190.
MGIiMGI:1915062. Ubxn4.

Phylogenomic databases

eggNOGiKOG2507. Eukaryota.
ENOG410ZR21. LUCA.
HOGENOMiHOG000007283.
HOVERGENiHBG056020.
InParanoidiQ8VCH8.
PhylomeDBiQ8VCH8.
TreeFamiTF317466.

Miscellaneous databases

ChiTaRSiUbxn4. mouse.
EvolutionaryTraceiQ8VCH8.
PROiQ8VCH8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026353.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBXN4_MOUSE
AccessioniPrimary (citable) accession number: Q8VCH8
Secondary accession number(s): Q3UGR4, Q8BW17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.