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Protein

Rab9 effector protein with kelch motifs

Gene

Rabepk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rab9 effector required for endosome to trans-Golgi network (TGN) transport.By similarity

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Rab9 effector protein with kelch motifs
Gene namesi
Name:Rabepk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139530 Rabepk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002806171 – 380Rab9 effector protein with kelch motifsAdd BLAST380

Post-translational modificationi

Phosphorylated on Ser residues most probably by PIP5K3.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VCH5
MaxQBiQ8VCH5
PaxDbiQ8VCH5
PRIDEiQ8VCH5

PTM databases

iPTMnetiQ8VCH5
PhosphoSitePlusiQ8VCH5

Expressioni

Gene expression databases

BgeeiENSMUSG00000070953
CleanExiMM_RABEPK
ExpressionAtlasiQ8VCH5 baseline and differential
GenevisibleiQ8VCH5 MM

Interactioni

Subunit structurei

Interacts with PIP5K3. Interacts with RAB9 in its GTP-bound conformation (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8VCH5, 1 interactor
MINTiQ8VCH5
STRINGi10090.ENSMUSP00000122360

Structurei

3D structure databases

ProteinModelPortaliQ8VCH5
SMRiQ8VCH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 103Kelch 1Add BLAST47
Repeati108 – 154Kelch 2Add BLAST47
Repeati159 – 211Kelch 3Add BLAST53
Repeati212 – 258Kelch 4Add BLAST47
Repeati262 – 311Kelch 5Add BLAST50
Repeati357 – 380Kelch 6Add BLAST24

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00760000119086
HOVERGENiHBG080504
InParanoidiQ8VCH5
KOiK20285
OMAiIIPWPVT
OrthoDBiEOG091G0IS4
PhylomeDBiQ8VCH5
TreeFamiTF329153

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011498 Kelch_2
PfamiView protein in Pfam
PF01344 Kelch_1, 1 hit
PF07646 Kelch_2, 1 hit
SUPFAMiSSF117281 SSF117281, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VCH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLRQGIMK QLPILEPGDK PRKATWYTLT CPGDRPCPRV GHSCSYFPPV
60 70 80 90 100
GDAESGKIFI VGGANPNQSF SDVHTMDLGT HQWDTATREG LLPRYEHASF
110 120 130 140 150
LPSCSPHSIW VFGGADQSGN RNCLQVMSPE DRTWSTPEVT GSPPSPRTFH
160 170 180 190 200
TSSAAIGNQL YVFGGGERGA QPVEDVKLHV FDANTLTWSQ PETHGSPPSP
210 220 230 240 250
RHGHVMVAAG TKLFIHGGLA GDKFFDDLHC IDIGDMSWQK LGPTGAVPVG
260 270 280 290 300
CAAHAAVAVG HHVYMFGGMT ATGALNMMYK YHTEKQHWTV LQFDTSLPAG
310 320 330 340 350
RLDHSMCVIP WPVMSTSENK DSDSVILTLQ DEKGDAAEKA ETQSGGPHEE
360 370 380
SPTTVLLCFV FGGMNTEGEV YDDCLVTVVD
Length:380
Mass (Da):41,119
Last modified:December 7, 2004 - v2
Checksum:iFC7FD5CC44BAD21A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035343 mRNA Translation: BAC29041.1
AL929106 Genomic DNA No translation available.
BC019800 mRNA Translation: AAH19800.2
CCDSiCCDS15951.1
RefSeqiNP_663497.2, NM_145522.4
UniGeneiMm.158705

Genome annotation databases

EnsembliENSMUST00000145903; ENSMUSP00000122360; ENSMUSG00000070953
GeneIDi227746
KEGGimmu:227746
UCSCiuc008jiu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRABEK_MOUSE
AccessioniPrimary (citable) accession number: Q8VCH5
Secondary accession number(s): Q8BZG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 7, 2004
Last modified: February 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health