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Protein

3-ketoacyl-CoA thiolase B, peroxisomal

Gene

Acaa1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei123Acyl-thioester intermediateBy similarity1
Active sitei377Proton acceptorPROSITE-ProRule annotation1
Active sitei408Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.16 3474
ReactomeiR-MMU-2046106 alpha-linolenic acid (ALA) metabolism
R-MMU-390247 Beta-oxidation of very long chain fatty acids
R-MMU-6798695 Neutrophil degranulation
R-MMU-9033241 Peroxisomal protein import
UniPathwayiUPA00199

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolase B, peroxisomal (EC:2.3.1.16)
Alternative name(s):
Acetyl-CoA acyltransferase B
Beta-ketothiolase B
Peroxisomal 3-oxoacyl-CoA thiolase B
Gene namesi
Name:Acaa1b
Synonyms:Acaa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3605455 Acaa1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26PeroxisomeBy similarityAdd BLAST26
ChainiPRO_000003406927 – 4243-ketoacyl-CoA thiolase B, peroxisomalAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173N6-acetyllysineCombined sources1
Modified residuei234N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8VCH0
PaxDbiQ8VCH0
PeptideAtlasiQ8VCH0
PRIDEiQ8VCH0

PTM databases

CarbonylDBiQ8VCH0
iPTMnetiQ8VCH0
PhosphoSitePlusiQ8VCH0
SwissPalmiQ8VCH0

Expressioni

Tissue specificityi

Mainly expressed in liver; weaker levels in kidney, intestine and white adipose tissue.1 Publication

Gene expression databases

BgeeiENSMUSG00000010651
ExpressionAtlasiQ8VCH0 baseline and differential
GenevisibleiQ8VCH0 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8VCH0, 5 interactors
MINTiQ8VCH0
STRINGi10090.ENSMUSP00000010795

Structurei

3D structure databases

ProteinModelPortaliQ8VCH0
SMRiQ8VCH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1389 Eukaryota
COG0183 LUCA
GeneTreeiENSGT00910000144143
HOGENOMiHOG000012239
HOVERGENiHBG003112
InParanoidiQ8VCH0
KOiK07513
OMAiRYGLTTM
OrthoDBiEOG091G09C6
PhylomeDBiQ8VCH0
TreeFamiTF332308

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRLQVVLGH LAGRPESSSA LQAAPCSAGF LQASASDVVV VHGRRTPIGR
60 70 80 90 100
ASRGCFKDTT PDELLSAVLT AVLQDVKLKP EQLGDISVGN VLQPGAGAIM
110 120 130 140 150
ARIAQFLSGI PETVPLSTVN RQCSSGLQAV ANIAGGIRNG SYDIGMACGV
160 170 180 190 200
ESMTLSQRGN HGNISSRLLE NEKARDCLIP MGITSENVAE RFGVSRQKQD
210 220 230 240 250
AFALASQQKA ASAQSRGCFH AEIVPVTTTV LNDKGDKKTI TVSQDEGVRP
260 270 280 290 300
STTMQGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI
310 320 330 340 350
LGVLRSYAVV GVPPDVMGIG PAYAIPAALQ KAGLTVNDID IFEINEAFAS
360 370 380 390 400
QAVYCVEKLG IPAEKVNPLG GAIALGHPLG CTGARQVVTL LNELKRRGRR
410 420
AYGVVSMCIG TGMGAAAVFE YPGN
Length:424
Mass (Da):43,995
Last modified:March 1, 2002 - v1
Checksum:i29BFFFF02DD43BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273812 mRNA Translation: AAP31669.1
BC019882 mRNA Translation: AAH19882.1
CCDSiCCDS23608.1
RefSeqiNP_666342.1, NM_146230.3
UniGeneiMm.379402

Genome annotation databases

EnsembliENSMUST00000010795; ENSMUSP00000010795; ENSMUSG00000010651
GeneIDi235674
KEGGimmu:235674
UCSCiuc009saj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTHIKB_MOUSE
AccessioniPrimary (citable) accession number: Q8VCH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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