Acaa1b

Functionⁱ

Catalytic activityⁱ

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Pathwayⁱ: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	123	Acyl-thioester intermediateBy similarity	1
Active siteⁱ	377	Proton acceptorPROSITE-ProRule annotation	1
Active siteⁱ	408	Proton acceptorPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

acetyl-CoA C-acyltransferase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid metabolic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BRENDAⁱ	2.3.1.16. 3474.
Reactomeⁱ	R-MMU-2046106. alpha-linolenic acid (ALA) metabolism. R-MMU-390247. Beta-oxidation of very long chain fatty acids. R-MMU-6798695. Neutrophil degranulation.
UniPathwayⁱ	UPA00199.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 3-ketoacyl-CoA thiolase B, peroxisomal (EC:2.3.1.16) Alternative name(s): Acetyl-CoA acyltransferase B Beta-ketothiolase B Peroxisomal 3-oxoacyl-CoA thiolase B
Gene namesⁱ	Name:Acaa1b Synonyms:Acaa1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:3605455. Acaa1b.

Keywords - Cellular componentⁱ

Peroxisome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 26	PeroxisomeBy similarityAdd BLAST		26
ChainⁱPRO_0000034069	27 – 424	3-ketoacyl-CoA thiolase B, peroxisomalAdd BLAST		398

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	173	N6-acetyllysineCombined sources		1
Modified residueⁱ	234	N6-acetyllysineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8VCH0.
PaxDbⁱ	Q8VCH0.
PeptideAtlas More...PeptideAtlasⁱ	Q8VCH0.
PRIDEⁱ	Q8VCH0.

PTM databases

CarbonylDBⁱ	Q8VCH0.
iPTMnetⁱ	Q8VCH0.
PhosphoSitePlusⁱ	Q8VCH0.
SwissPalmⁱ	Q8VCH0.

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in liver; weaker levels in kidney, intestine and white adipose tissue.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000010651.
ExpressionAtlasⁱ	Q8VCH0. baseline and differential.
Genevisibleⁱ	Q8VCH0. MM.

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

IntActⁱ	Q8VCH0. 5 interactors.
Molecular INTeraction database More...MINTⁱ	Q8VCH0.
STRINGⁱ	10090.ENSMUSP00000010795.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8VCH0.
SMRⁱ	Q8VCH0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the thiolase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1389. Eukaryota. COG0183. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144143.
HOGENOMⁱ	HOG000012239.
HOVERGENⁱ	HBG003112.
InParanoidⁱ	Q8VCH0.
KEGG Orthology (KO) More...KOⁱ	K07513.
OMAⁱ	RYGLTTM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09C6.
PhylomeDBⁱ	Q8VCH0.
TreeFamⁱ	TF332308.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00751. thiolase. 1 hit.
Gene3Dⁱ	3.40.47.10. 4 hits.
InterProⁱ	View protein in InterPro IPR002155. Thiolase. IPR016039. Thiolase-like. IPR020615. Thiolase_acyl_enz_int_AS. IPR020610. Thiolase_AS. IPR020617. Thiolase_C. IPR020613. Thiolase_CS. IPR020616. Thiolase_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02803. Thiolase_C. 1 hit. PF00108. Thiolase_N. 1 hit.
PIRSFⁱ	PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMⁱ	SSF53901. SSF53901. 2 hits.
TIGRFAMsⁱ	TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00098. THIOLASE_1. 1 hit. PS00737. THIOLASE_2. 1 hit. PS00099. THIOLASE_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8VCH0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHRLQVVLGH LAGRPESSSA LQAAPCSAGF LQASASDVVV VHGRRTPIGR 
        60         70         80         90        100
ASRGCFKDTT PDELLSAVLT AVLQDVKLKP EQLGDISVGN VLQPGAGAIM 
       110        120        130        140        150
ARIAQFLSGI PETVPLSTVN RQCSSGLQAV ANIAGGIRNG SYDIGMACGV 
       160        170        180        190        200
ESMTLSQRGN HGNISSRLLE NEKARDCLIP MGITSENVAE RFGVSRQKQD 
       210        220        230        240        250
AFALASQQKA ASAQSRGCFH AEIVPVTTTV LNDKGDKKTI TVSQDEGVRP 
       260        270        280        290        300
STTMQGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI 
       310        320        330        340        350
LGVLRSYAVV GVPPDVMGIG PAYAIPAALQ KAGLTVNDID IFEINEAFAS 
       360        370        380        390        400
QAVYCVEKLG IPAEKVNPLG GAIALGHPLG CTGARQVVTL LNELKRRGRR 
       410        420 
AYGVVSMCIG TGMGAAAVFE YPGN

Length:424

Mass (Da):43,995

Last modified:March 1, 2002 - v1

Checksum:ⁱ29BFFFF02DD43BAC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY273812 mRNA. Translation: AAP31669.1. BC019882 mRNA. Translation: AAH19882.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23608.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_666342.1. NM_146230.3.
UniGeneⁱ	Mm.379402.

Genome annotation databases

Ensemblⁱ	ENSMUST00000010795; ENSMUSP00000010795; ENSMUSG00000010651.
GeneIDⁱ	235674.
KEGGⁱ	mmu:235674.
UCSC genome browser More...UCSCⁱ	uc009saj.1. mouse.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8VCH0	Q3UKM0 Q3TUU3 UPI000154C849	Mus musculus (Mouse)	424	UniRef100_Q8VCH0	Cluster: 3-ketoacyl-CoA thiolase B, peroxisomal	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8VCH0	P21775 UPI000016852C F1LPD6 A0A1A6HB35 UPI000A30D37F Q3UPU8 UPI0004ED0A78 UPI000A318C68 UPI00038BF42C UPI000A3189B7 +13	Rattus norvegicus (Rat) Neotoma lepida (Desert woodrat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mus musculus (Mouse) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Mus caroli (Ryukyu mouse) (Ricefield mouse) Microtus ochrogaster (Prairie vole) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	424	UniRef90_P21775	Cluster: 3-ketoacyl-CoA thiolase A, peroxisomal	24

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8VCH0	P21775 UPI000016852C F1LPD6 A0A1A6HB35 UPI000A3189B7 UPI000A318C68 P07871 UPI000A30D37F UPI0004ED0A78 Q921H8 +58	Rattus norvegicus (Rat) Neotoma lepida (Desert woodrat) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Mus musculus (Mouse) Microtus ochrogaster (Prairie vole) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Thecamonas trahens ATCC 50062 Heterocephalus glaber (Naked mole rat) And more	424	UniRef50_P21775	Cluster: 3-ketoacyl-CoA thiolase A, peroxisomal	69

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY273812 mRNA. Translation: AAP31669.1. BC019882 mRNA. Translation: AAH19882.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23608.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_666342.1. NM_146230.3.
UniGeneⁱ	Mm.379402.

3D structure databases

ProteinModelPortalⁱ	Q8VCH0.
SMRⁱ	Q8VCH0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8VCH0. 5 interactors.
Molecular INTeraction database More...MINTⁱ	Q8VCH0.
STRINGⁱ	10090.ENSMUSP00000010795.

PTM databases

CarbonylDBⁱ	Q8VCH0.
iPTMnetⁱ	Q8VCH0.
PhosphoSitePlusⁱ	Q8VCH0.
SwissPalmⁱ	Q8VCH0.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8VCH0.
PaxDbⁱ	Q8VCH0.
PeptideAtlas More...PeptideAtlasⁱ	Q8VCH0.
PRIDEⁱ	Q8VCH0.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000010795; ENSMUSP00000010795; ENSMUSG00000010651.
GeneIDⁱ	235674.
KEGGⁱ	mmu:235674.
UCSC genome browser More...UCSCⁱ	uc009saj.1. mouse.

Organism-specific databases

CTDⁱ	235674.
MGIⁱ	MGI:3605455. Acaa1b.

Phylogenomic databases

eggNOGⁱ	KOG1389. Eukaryota. COG0183. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144143.
HOGENOMⁱ	HOG000012239.
HOVERGENⁱ	HBG003112.
InParanoidⁱ	Q8VCH0.
KEGG Orthology (KO) More...KOⁱ	K07513.
OMAⁱ	RYGLTTM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09C6.
PhylomeDBⁱ	Q8VCH0.
TreeFamⁱ	TF332308.

Enzyme and pathway databases

UniPathwayⁱ	UPA00199.
BRENDAⁱ	2.3.1.16. 3474.
Reactomeⁱ	R-MMU-2046106. alpha-linolenic acid (ALA) metabolism. R-MMU-390247. Beta-oxidation of very long chain fatty acids. R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSⁱ	Acaa1b. mouse.
Protein Ontology More...PROⁱ	PR:Q8VCH0.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000010651.
ExpressionAtlasⁱ	Q8VCH0. baseline and differential.
Genevisibleⁱ	Q8VCH0. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00751. thiolase. 1 hit.
Gene3Dⁱ	3.40.47.10. 4 hits.
InterProⁱ	View protein in InterPro IPR002155. Thiolase. IPR016039. Thiolase-like. IPR020615. Thiolase_acyl_enz_int_AS. IPR020610. Thiolase_AS. IPR020617. Thiolase_C. IPR020613. Thiolase_CS. IPR020616. Thiolase_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02803. Thiolase_C. 1 hit. PF00108. Thiolase_N. 1 hit.
PIRSFⁱ	PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMⁱ	SSF53901. SSF53901. 2 hits.
TIGRFAMsⁱ	TIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00098. THIOLASE_1. 1 hit. PS00737. THIOLASE_2. 1 hit. PS00099. THIOLASE_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THIKB_MOUSE
Accessionⁱ	Q8VCH0Primary (citable) accession number: Q8VCH0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	March 1, 2002
	Last modified:	March 28, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8VCH0 (THIKB_MOUSE)

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3-ketoacyl-CoA thiolase B, peroxisomal

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Mitochondrion

Peroxisome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: fatty acid metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ