Acaa1b

Functionⁱ

Catalytic activityⁱ

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Pathwayⁱ: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	123	Acyl-thioester intermediateBy similarity	1
Active siteⁱ	377	Proton acceptorPROSITE-ProRule annotation	1
Active siteⁱ	408	Proton acceptorPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

acetyl-CoA C-acyltransferase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid metabolic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BRENDAⁱ	2.3.1.16 3474
Reactomeⁱ	R-MMU-2046106 alpha-linolenic acid (ALA) metabolism R-MMU-390247 Beta-oxidation of very long chain fatty acids R-MMU-6798695 Neutrophil degranulation R-MMU-9033241 Peroxisomal protein import
UniPathwayⁱ	UPA00199

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 3-ketoacyl-CoA thiolase B, peroxisomal (EC:2.3.1.16) Alternative name(s): Acetyl-CoA acyltransferase B Beta-ketothiolase B Peroxisomal 3-oxoacyl-CoA thiolase B
Gene namesⁱ	Name:Acaa1b Synonyms:Acaa1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:3605455 Acaa1b

Keywords - Cellular componentⁱ

Peroxisome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 26	PeroxisomeBy similarityAdd BLAST		26
ChainⁱPRO_0000034069	27 – 424	3-ketoacyl-CoA thiolase B, peroxisomalAdd BLAST		398

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	173	N6-acetyllysineCombined sources		1
Modified residueⁱ	234	N6-acetyllysineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8VCH0
PaxDbⁱ	Q8VCH0
PeptideAtlas More...PeptideAtlasⁱ	Q8VCH0
PRIDEⁱ	Q8VCH0

PTM databases

CarbonylDBⁱ	Q8VCH0
iPTMnetⁱ	Q8VCH0
PhosphoSitePlusⁱ	Q8VCH0
SwissPalmⁱ	Q8VCH0

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in liver; weaker levels in kidney, intestine and white adipose tissue.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000010651
ExpressionAtlasⁱ	Q8VCH0 baseline and differential
Genevisibleⁱ	Q8VCH0 MM

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

IntActⁱ	Q8VCH0, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q8VCH0
STRINGⁱ	10090.ENSMUSP00000010795

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8VCH0
SMRⁱ	Q8VCH0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the thiolase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1389 Eukaryota COG0183 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144143
HOGENOMⁱ	HOG000012239
HOVERGENⁱ	HBG003112
InParanoidⁱ	Q8VCH0
KEGG Orthology (KO) More...KOⁱ	K07513
OMAⁱ	RYGLTTM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09C6
PhylomeDBⁱ	Q8VCH0
TreeFamⁱ	TF332308

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00751 thiolase, 1 hit
Gene3Dⁱ	3.40.47.10, 4 hits
InterProⁱ	View protein in InterPro IPR002155 Thiolase IPR016039 Thiolase-like IPR020615 Thiolase_acyl_enz_int_AS IPR020610 Thiolase_AS IPR020617 Thiolase_C IPR020613 Thiolase_CS IPR020616 Thiolase_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02803 Thiolase_C, 1 hit PF00108 Thiolase_N, 1 hit
PIRSFⁱ	PIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMⁱ	SSF53901 SSF53901, 2 hits
TIGRFAMsⁱ	TIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEⁱ	View protein in PROSITE PS00098 THIOLASE_1, 1 hit PS00737 THIOLASE_2, 1 hit PS00099 THIOLASE_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8VCH0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHRLQVVLGH LAGRPESSSA LQAAPCSAGF LQASASDVVV VHGRRTPIGR 
        60         70         80         90        100
ASRGCFKDTT PDELLSAVLT AVLQDVKLKP EQLGDISVGN VLQPGAGAIM 
       110        120        130        140        150
ARIAQFLSGI PETVPLSTVN RQCSSGLQAV ANIAGGIRNG SYDIGMACGV 
       160        170        180        190        200
ESMTLSQRGN HGNISSRLLE NEKARDCLIP MGITSENVAE RFGVSRQKQD 
       210        220        230        240        250
AFALASQQKA ASAQSRGCFH AEIVPVTTTV LNDKGDKKTI TVSQDEGVRP 
       260        270        280        290        300
STTMQGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI 
       310        320        330        340        350
LGVLRSYAVV GVPPDVMGIG PAYAIPAALQ KAGLTVNDID IFEINEAFAS 
       360        370        380        390        400
QAVYCVEKLG IPAEKVNPLG GAIALGHPLG CTGARQVVTL LNELKRRGRR 
       410        420 
AYGVVSMCIG TGMGAAAVFE YPGN

Length:424

Mass (Da):43,995

Last modified:March 1, 2002 - v1

Checksum:ⁱ29BFFFF02DD43BAC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY273812 mRNA Translation: AAP31669.1 BC019882 mRNA Translation: AAH19882.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23608.1
NCBI Reference Sequences More...RefSeqⁱ	NP_666342.1, NM_146230.3
UniGeneⁱ	Mm.379402

Genome annotation databases

Ensemblⁱ	ENSMUST00000010795; ENSMUSP00000010795; ENSMUSG00000010651
GeneIDⁱ	235674
KEGGⁱ	mmu:235674
UCSC genome browser More...UCSCⁱ	uc009saj.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8VCH0	MCG21883, isoform CRA_e		MOUSE		424
UPI000154C849		MOUSE		272
Uncharacterized protein (Fragment)		MOUSE		406

Protein	Similar proteins		Species	Score	Length
Q8VCH0	3-ketoacyl-CoA thiolase A, peroxisomal		RAT		424
Uncharacterized protein		NEOLE		425
UPI000A30D37F		MUSPA		424
Uncharacterized protein		MOUSE		424
UPI00038BF42C		MICOH		424
+18

Protein	Similar proteins		Species	Score	Length
Q8VCH0	3-ketoacyl-CoA thiolase A, peroxisomal		RAT		424
Uncharacterized protein		NEOLE		425
UPI000A318C68		MUSCR		424
UPI000A30D37F		MUSPA		424
3-ketoacyl-CoA thiolase A, peroxisomal		MOUSE		424
+68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY273812 mRNA Translation: AAP31669.1 BC019882 mRNA Translation: AAH19882.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23608.1
NCBI Reference Sequences More...RefSeqⁱ	NP_666342.1, NM_146230.3
UniGeneⁱ	Mm.379402

3D structure databases

ProteinModelPortalⁱ	Q8VCH0
SMRⁱ	Q8VCH0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8VCH0, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q8VCH0
STRINGⁱ	10090.ENSMUSP00000010795

PTM databases

CarbonylDBⁱ	Q8VCH0
iPTMnetⁱ	Q8VCH0
PhosphoSitePlusⁱ	Q8VCH0
SwissPalmⁱ	Q8VCH0

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8VCH0
PaxDbⁱ	Q8VCH0
PeptideAtlas More...PeptideAtlasⁱ	Q8VCH0
PRIDEⁱ	Q8VCH0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000010795; ENSMUSP00000010795; ENSMUSG00000010651
GeneIDⁱ	235674
KEGGⁱ	mmu:235674
UCSC genome browser More...UCSCⁱ	uc009saj.1 mouse

Organism-specific databases

CTDⁱ	235674
MGIⁱ	MGI:3605455 Acaa1b

Phylogenomic databases

eggNOGⁱ	KOG1389 Eukaryota COG0183 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144143
HOGENOMⁱ	HOG000012239
HOVERGENⁱ	HBG003112
InParanoidⁱ	Q8VCH0
KEGG Orthology (KO) More...KOⁱ	K07513
OMAⁱ	RYGLTTM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09C6
PhylomeDBⁱ	Q8VCH0
TreeFamⁱ	TF332308

Enzyme and pathway databases

UniPathwayⁱ	UPA00199
BRENDAⁱ	2.3.1.16 3474
Reactomeⁱ	R-MMU-2046106 alpha-linolenic acid (ALA) metabolism R-MMU-390247 Beta-oxidation of very long chain fatty acids R-MMU-6798695 Neutrophil degranulation R-MMU-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSⁱ	Acaa1b mouse
Protein Ontology More...PROⁱ	PR:Q8VCH0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000010651
ExpressionAtlasⁱ	Q8VCH0 baseline and differential
Genevisibleⁱ	Q8VCH0 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00751 thiolase, 1 hit
Gene3Dⁱ	3.40.47.10, 4 hits
InterProⁱ	View protein in InterPro IPR002155 Thiolase IPR016039 Thiolase-like IPR020615 Thiolase_acyl_enz_int_AS IPR020610 Thiolase_AS IPR020617 Thiolase_C IPR020613 Thiolase_CS IPR020616 Thiolase_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02803 Thiolase_C, 1 hit PF00108 Thiolase_N, 1 hit
PIRSFⁱ	PIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMⁱ	SSF53901 SSF53901, 2 hits
TIGRFAMsⁱ	TIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEⁱ	View protein in PROSITE PS00098 THIOLASE_1, 1 hit PS00737 THIOLASE_2, 1 hit PS00099 THIOLASE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THIKB_MOUSE
Accessionⁱ	Q8VCH0Primary (citable) accession number: Q8VCH0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	March 1, 2002
	Last modified:	May 23, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8VCH0 (THIKB_MOUSE)

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3-ketoacyl-CoA thiolase B, peroxisomal

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Mitochondrion

Peroxisome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: fatty acid metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ