UniProtKB - Q8VCH0 (THIKB_MOUSE)
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Protein
3-ketoacyl-CoA thiolase B, peroxisomal
Gene
Acaa1b
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
: fatty acid metabolism Pathwayi
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 123 | Acyl-thioester intermediateBy similarity | 1 | |
Active sitei | 377 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 408 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- acetyl-CoA C-acyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- fatty acid metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 2.3.1.16. 3474. |
Reactomei | R-MMU-2046106. alpha-linolenic acid (ALA) metabolism. R-MMU-390247. Beta-oxidation of very long chain fatty acids. R-MMU-6798695. Neutrophil degranulation. |
UniPathwayi | UPA00199. |
Names & Taxonomyi
Protein namesi | Recommended name: 3-ketoacyl-CoA thiolase B, peroxisomal (EC:2.3.1.16)Alternative name(s): Acetyl-CoA acyltransferase B Beta-ketothiolase B Peroxisomal 3-oxoacyl-CoA thiolase B |
Gene namesi | Name:Acaa1b Synonyms:Acaa1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3605455. Acaa1b. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 26 | PeroxisomeBy similarityAdd BLAST | 26 | |
ChainiPRO_0000034069 | 27 – 424 | 3-ketoacyl-CoA thiolase B, peroxisomalAdd BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 173 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 234 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
MaxQBi | Q8VCH0. |
PaxDbi | Q8VCH0. |
PeptideAtlasi | Q8VCH0. |
PRIDEi | Q8VCH0. |
PTM databases
CarbonylDBi | Q8VCH0. |
iPTMneti | Q8VCH0. |
PhosphoSitePlusi | Q8VCH0. |
SwissPalmi | Q8VCH0. |
Expressioni
Tissue specificityi
Mainly expressed in liver; weaker levels in kidney, intestine and white adipose tissue.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000010651. |
ExpressionAtlasi | Q8VCH0. baseline and differential. |
Genevisiblei | Q8VCH0. MM. |
Interactioni
Subunit structurei
Homodimer.By similarity
Protein-protein interaction databases
IntActi | Q8VCH0. 5 interactors. |
MINTi | Q8VCH0. |
STRINGi | 10090.ENSMUSP00000010795. |
Structurei
3D structure databases
ProteinModelPortali | Q8VCH0. |
SMRi | Q8VCH0. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the thiolase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1389. Eukaryota. COG0183. LUCA. |
GeneTreei | ENSGT00910000144143. |
HOGENOMi | HOG000012239. |
HOVERGENi | HBG003112. |
InParanoidi | Q8VCH0. |
KOi | K07513. |
OMAi | RYGLTTM. |
OrthoDBi | EOG091G09C6. |
PhylomeDBi | Q8VCH0. |
TreeFami | TF332308. |
Family and domain databases
CDDi | cd00751. thiolase. 1 hit. |
Gene3Di | 3.40.47.10. 4 hits. |
InterProi | View protein in InterPro IPR002155. Thiolase. IPR016039. Thiolase-like. IPR020615. Thiolase_acyl_enz_int_AS. IPR020610. Thiolase_AS. IPR020617. Thiolase_C. IPR020613. Thiolase_CS. IPR020616. Thiolase_N. |
Pfami | View protein in Pfam PF02803. Thiolase_C. 1 hit. PF00108. Thiolase_N. 1 hit. |
PIRSFi | PIRSF000429. Ac-CoA_Ac_transf. 1 hit. |
SUPFAMi | SSF53901. SSF53901. 2 hits. |
TIGRFAMsi | TIGR01930. AcCoA-C-Actrans. 1 hit. |
PROSITEi | View protein in PROSITE PS00098. THIOLASE_1. 1 hit. PS00737. THIOLASE_2. 1 hit. PS00099. THIOLASE_3. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8VCH0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRLQVVLGH LAGRPESSSA LQAAPCSAGF LQASASDVVV VHGRRTPIGR
60 70 80 90 100
ASRGCFKDTT PDELLSAVLT AVLQDVKLKP EQLGDISVGN VLQPGAGAIM
110 120 130 140 150
ARIAQFLSGI PETVPLSTVN RQCSSGLQAV ANIAGGIRNG SYDIGMACGV
160 170 180 190 200
ESMTLSQRGN HGNISSRLLE NEKARDCLIP MGITSENVAE RFGVSRQKQD
210 220 230 240 250
AFALASQQKA ASAQSRGCFH AEIVPVTTTV LNDKGDKKTI TVSQDEGVRP
260 270 280 290 300
STTMQGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI
310 320 330 340 350
LGVLRSYAVV GVPPDVMGIG PAYAIPAALQ KAGLTVNDID IFEINEAFAS
360 370 380 390 400
QAVYCVEKLG IPAEKVNPLG GAIALGHPLG CTGARQVVTL LNELKRRGRR
410 420
AYGVVSMCIG TGMGAAAVFE YPGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY273812 mRNA. Translation: AAP31669.1. BC019882 mRNA. Translation: AAH19882.1. |
CCDSi | CCDS23608.1. |
RefSeqi | NP_666342.1. NM_146230.3. |
UniGenei | Mm.379402. |
Genome annotation databases
Ensembli | ENSMUST00000010795; ENSMUSP00000010795; ENSMUSG00000010651. |
GeneIDi | 235674. |
KEGGi | mmu:235674. |
UCSCi | uc009saj.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | THIKB_MOUSE | |
Accessioni | Q8VCH0Primary (citable) accession number: Q8VCH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | March 1, 2002 | |
Last modified: | March 28, 2018 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |