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Protein

Regulatory factor X-associated protein

Gene

Rfxap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the RFX complex that binds to the X-box of MHC II promoters.By similarity

GO - Molecular functioni

  • DNA binding Source: MGI

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory factor X-associated protein
Short name:
RFX-associated protein
Gene namesi
Name:Rfxap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2180854. Rfxap.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Regulatory factor X-associated proteinPRO_0000300252Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VCG9.
MaxQBiQ8VCG9.
PaxDbiQ8VCG9.
PRIDEiQ8VCG9.

PTM databases

PhosphoSiteiQ8VCG9.

Expressioni

Gene expression databases

CleanExiMM_RFXAP.

Interactioni

Subunit structurei

RFX consists of at least 3 different subunits; RFXAP, RFX5 and RFX-B/RFXANK; with each subunit representing a separate complementation group. RFX forms cooperative DNA binding complexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi228427. 1 interaction.
STRINGi10090.ENSMUSP00000040917.

Structurei

3D structure databases

ProteinModelPortaliQ8VCG9.
SMRiQ8VCG9. Positions 173-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi123 – 13816Nuclear localization signalSequence analysisAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IYNY. Eukaryota.
ENOG4111S79. LUCA.
HOGENOMiHOG000154106.
HOVERGENiHBG073517.
InParanoidiQ8VCG9.
KOiK08063.
PhylomeDBiQ8VCG9.

Family and domain databases

InterProiIPR029316. RFXAP_RFXANK-bd.
[Graphical view]
PfamiPF15289. RFXA_RFXANK_bdg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAQAVPEGS GPSTASPRTA PPVTVLVMRQ DEAEADGALR PGLAGSEAAA
60 70 80 90 100
DAEDEAGDDD ADLLDTSDPA GGGESAASPE ELEDEDAEGG GAARRRGSKT
110 120 130 140 150
CTYEGCRETT SQVAKQRKPW MCKKHRNKMY KDKYKKKKSD QALGSGGPSA
160 170 180 190 200
ASTGNVKLEE STDNILSIVK QRTGSFGDRP ARPTLLEQVL NQKRLSLLRS
210 220 230
PEVVQFLQKQ QQLLNQQVLE QRQQHFPGAP V
Length:231
Mass (Da):24,787
Last modified:September 5, 2006 - v2
Checksum:i4BB22676F5A4FA55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335512 mRNA. Translation: AAK38586.1.
BC019935 mRNA. Translation: AAH19935.2.
CCDSiCCDS50907.1.
RefSeqiNP_573494.1. NM_133231.2.
UniGeneiMm.185735.

Genome annotation databases

GeneIDi170767.
KEGGimmu:170767.
UCSCiuc008pfw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335512 mRNA. Translation: AAK38586.1.
BC019935 mRNA. Translation: AAH19935.2.
CCDSiCCDS50907.1.
RefSeqiNP_573494.1. NM_133231.2.
UniGeneiMm.185735.

3D structure databases

ProteinModelPortaliQ8VCG9.
SMRiQ8VCG9. Positions 173-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228427. 1 interaction.
STRINGi10090.ENSMUSP00000040917.

PTM databases

PhosphoSiteiQ8VCG9.

Proteomic databases

EPDiQ8VCG9.
MaxQBiQ8VCG9.
PaxDbiQ8VCG9.
PRIDEiQ8VCG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170767.
KEGGimmu:170767.
UCSCiuc008pfw.1. mouse.

Organism-specific databases

CTDi5994.
MGIiMGI:2180854. Rfxap.

Phylogenomic databases

eggNOGiENOG410IYNY. Eukaryota.
ENOG4111S79. LUCA.
HOGENOMiHOG000154106.
HOVERGENiHBG073517.
InParanoidiQ8VCG9.
KOiK08063.
PhylomeDBiQ8VCG9.

Miscellaneous databases

PROiQ8VCG9.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RFXAP.

Family and domain databases

InterProiIPR029316. RFXAP_RFXANK-bd.
[Graphical view]
PfamiPF15289. RFXA_RFXANK_bdg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRFXAP_MOUSE
AccessioniPrimary (citable) accession number: Q8VCG9
Secondary accession number(s): Q91Y54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.