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Protein

Protein ERGIC-53-like

Gene

Lman1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ERGIC-53-like
Alternative name(s):
ERGIC53-like protein
Lectin mannose-binding 1-like
Short name:
LMAN1-like protein
Sublingual acinar membrane protein
Short name:
Slamp
Gene namesi
Name:Lman1l
Synonyms:Ergl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2667537. Lman1l.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 438LumenalSequence analysisAdd BLAST413
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Topological domaini460 – 505CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001766426 – 505Protein ERGIC-53-likeAdd BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi177 ↔ 216PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VCD3.
PRIDEiQ8VCD3.

PTM databases

PhosphoSitePlusiQ8VCD3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056271.
CleanExiMM_LMAN1L.
GenevisibleiQ8VCD3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091352.

Structurei

3D structure databases

ProteinModelPortaliQ8VCD3.
SMRiQ8VCD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 254L-type lectin-likePROSITE-ProRule annotationAdd BLAST223

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3838. Eukaryota.
ENOG410ZFRX. LUCA.
GeneTreeiENSGT00530000062977.
HOGENOMiHOG000017354.
HOVERGENiHBG099863.
InParanoidiQ8VCD3.
KOiK10081.
OMAiPFWSHHG.
OrthoDBiEOG091G08WZ.
PhylomeDBiQ8VCD3.
TreeFamiTF313311.

Family and domain databases

InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR005052. Lectin_leg.
PfamiView protein in Pfam
PF03388. Lectin_leg-like. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51328. L_LECTIN_LIKE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VCD3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEIRGLSPS LCLLSLLLVL HGAERSQPPP RRRFEYKLSF KGPRLAVPGA
60 70 80 90 100
GIPFWSHHGD AILGLEEVRL VPSMKNRSGA VWSNISVSFP SWEVEMQMRV
110 120 130 140 150
TGPGRRGAQG VAMWYTKDRA QVGSVVEELA SWDGIGIYFD SSTSDVQDSP
160 170 180 190 200
VIRVLASDGH DLQEQSGDGN VRELGSCHRD FRNRPFPFRA RVTYWRQRLR
210 220 230 240 250
VSLSGGLTPK DPEEVCVDVE PLFLAPGGFF GVSAATGTLA ADDHDVLSFL
260 270 280 290 300
TFSLREPGPE ETPQPFMEKD QLLLARKLEE LKARLALGTR EASIPPLNPK
310 320 330 340 350
AQEEGERFFN LEDTLGRQSQ ILQALQALSR QMAQAEKHWK QQLGSTVQVR
360 370 380 390 400
PEGGWNTAKV STLLYGQRTL IQALQEMREA AARMASGAHV FYLPVGTKHH
410 420 430 440 450
FFELDHILSL LQKDLRGLVK KTAKAPRPSG WLLGSSTCLH TSIFLFFLLL
460 470 480 490 500
QTVGFFCYVN FSRQELDKRL QEYLSTGSLS LEPALPITRT IGVLRRQPIS

PSMQA
Length:505
Mass (Da):56,312
Last modified:October 5, 2010 - v2
Checksum:iF56B1A83DCBCA16F
GO
Isoform 2 (identifier: Q8VCD3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-374: NTAKVSTLLYGQRTLIQAL → GSSCPDGFRSTRLLPACGH
     375-505: Missing.

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):41,424
Checksum:i2555520A36DAC425
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039811356 – 374NTAKV…LIQAL → GSSCPDGFRSTRLLPACGH in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_039812375 – 505Missing in isoform 2. 1 PublicationAdd BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211986 mRNA. Translation: BAE16262.1.
CH466522 Genomic DNA. Translation: EDL25917.1.
BC020188 mRNA. Translation: AAH20188.1.
CCDSiCCDS52810.1. [Q8VCD3-1]
RefSeqiNP_954692.2. NM_199222.3. [Q8VCD3-1]
UniGeneiMm.295630.

Genome annotation databases

EnsembliENSMUST00000044937; ENSMUSP00000041631; ENSMUSG00000056271. [Q8VCD3-2]
ENSMUST00000093832; ENSMUSP00000091352; ENSMUSG00000056271. [Q8VCD3-1]
GeneIDi235416.
KEGGimmu:235416.
UCSCiuc009pvi.2. mouse. [Q8VCD3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLMA1L_MOUSE
AccessioniPrimary (citable) accession number: Q8VCD3
Secondary accession number(s): Q4H2F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 5, 2010
Last modified: February 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome