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Q8VCD0

- Q8VCD0_MOUSE

UniProt

Q8VCD0 - Q8VCD0_MOUSE

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Protein
Submitted name:

Kinase insert domain protein receptor

Gene
Kdr, mCG_7209
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. growth factor binding Source: MGI
  3. protein binding Source: MGI
  4. vascular endothelial growth factor-activated receptor activity Source: MGI

GO - Biological processi

  1. branching morphogenesis of an epithelial tube Source: MGI
  2. calcium ion homeostasis Source: MGI
  3. calcium-mediated signaling using intracellular calcium source Source: Ensembl
  4. cell fate commitment Source: MGI
  5. cell maturation Source: MGI
  6. cell migration Source: MGI
  7. endothelial cell differentiation Source: MGI
  8. hemopoiesis Source: MGI
  9. lung alveolus development Source: MGI
  10. lung development Source: MGI
  11. lymph vessel development Source: MGI
  12. negative regulation of endothelial cell apoptotic process Source: Ensembl
  13. ovarian follicle development Source: MGI
  14. positive regulation of angiogenesis Source: Ensembl
  15. positive regulation of endothelial cell migration Source: Ensembl
  16. positive regulation of endothelial cell proliferation Source: Ensembl
  17. positive regulation of epithelial cell proliferation Source: MGI
  18. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  19. positive regulation of focal adhesion assembly Source: Ensembl
  20. positive regulation of mesenchymal cell proliferation Source: MGI
  21. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  22. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  23. positive regulation of positive chemotaxis Source: Ensembl
  24. positive regulation of protein phosphorylation Source: Ensembl
  25. protein autophosphorylation Source: Ensembl
  26. regulation of cell shape Source: Ensembl
  27. surfactant homeostasis Source: MGI
  28. vascular endothelial growth factor receptor signaling pathway Source: MGI
  29. vascular endothelial growth factor signaling pathway Source: GOC
  30. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotationsImported, Transferase, Tyrosine-protein kinaseSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
REACT_216309. Integrin cell surface interactions.
REACT_227870. Neurophilin interactions with VEGF and VEGFR.

Names & Taxonomyi

Protein namesi
Submitted name:
Kinase insert domain protein receptorImported
Submitted name:
Vascular endothelial growth factor receptor 2Imported
Gene namesi
Name:KdrImported
ORF Names:mCG_7209Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:96683. Kdr.

Subcellular locationi

GO - Cellular componenti

  1. cell periphery Source: MGI
  2. endosome Source: Ensembl
  3. external side of plasma membrane Source: MGI
  4. Golgi apparatus Source: Ensembl
  5. integral component of plasma membrane Source: Ensembl
  6. membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations, PhosphoproteinUniRule annotationSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ8VCD0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075443.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotations

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotations, RepeatSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00720000108679.
HOGENOMiHOG000037949.
HOVERGENiHBG053432.
KOiK05098.
OMAiISYAGMV.
OrthoDBiEOG75F4CC.
TreeFamiTF325768.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
IPR009136. VEGFR2_rcpt.
[Graphical view]
PANTHERiPTHR24416:SF45. PTHR24416:SF45. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01834. VEGFRECEPTR2.
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCD0-1 [UniParc]FASTAAdd to Basket

« Hide

MESKALLAVA LWFCVETRAA SVGLPGDFLH PPKLSTQKDI LTILANTTLQ     50
ITCRGQRDLD WLWPNAQRDS EERVLVTECG GGDSIFCKTL TIPRVVGNDT 100
GAYKCSYRDV DIASTVYVYV RDYRSPFIAS VSDQHGIVYI TENKNKTVVI 150
PCRGSISNLN VSLCARYPEK RFVPDGNRIS WDSEIGFTLP SYMISYAGMV 200
FCEAKINDET YQSIMYIVVV VGYRIYDVIL SPPHEIELSA GEKLVLNCTA 250
RTELNVGLDF TWHSPPSKSH HKKIVNRDVK PFPGTVAKMF LSTLTIESVT 300
KSDQGEYTCV ASSGRMIKRN RTFVRVHTKP FIAFGSGMKS LVEATVGSQV 350
RIPVKYLSYP APDIKWYRNG RPIESNYTMI VGDELTIMEV TERDAGNYTV 400
ILTNPISMEK QSHMVSLVVN VPPQIGEKAL ISPMDSYQYG TMQTLTCTVY 450
ANPPLHHIQW YWQLEEACSY RPGQTSPYAC KEWRHVEDFQ GGNKIEVTKN 500
QYALIEGKNK TVSTLVIQAA NVSALYKCEA INKAGRGERV ISFHVIRGPE 550
ITVQPAAQPT EQESVSLLCT ADRNTFENLT WYKLGSQATS VHMGESLTPV 600
CKNLDALWKL NGTMFSNSTN DILIVAFQNA SLQDQGDYVC SAQDKKTKKR 650
HCLVKQLIIL ERMAPMITGN LENQTTTIGE TIEVTCPASG NPTPHITWFK 700
DNETLVEDSG IVLRDGNRNL TIRRVRKEDG GLYTCQACNV LGCARAETLF 750
IIEGAQEKTN LEVIILVGTA VIAMFFWLLL VIVLRTVKRA NEGELKTGYL 800
SIVMDPDELP LDERCERLPY DASKWEFPRD RLKLGKPLGR GAFGQVIEAD 850
AFGIDKTATC KTVAVKMLKE GATHSEHRAL MSELKILIHI GHHLNVVNLL 900
GACTKPGGPL MVIVEFCKFG NLSTYLRGKR NEFVPYKSKG ARFRQGKDYV 950
GELSVDLKRR LDSITSSQSS ASSGFVEEKS LSDVEEEEAS EELYKDFLTL 1000
EHLICYSFQV AKGMEFLASR KCIHRDLAAR NILLSEKNVV KICDFGLARD 1050
IYKDPDYVRK GDARLPLKWM APETIFDRVY TIQSDVWSFG VLLWEIFSLG 1100
ASPYPGVKID EEFCRRLKEG TRMRAPDYTT PEMYQTMLDC WHEDPNQRPS 1150
FSELVEHLGN LLQANAQQDG KDYIVLPMSE TLSMEEDSGL SLPTSPVSCM 1200
EEEEVCDPKF HYDNTAGISH YLQNSKRKSR PVSVKTFEDI PLEEPEVKVI 1250
PDDSQTDSGM VLASEELKTL EDRNKLSPSF GGMMPSKSRE SVASEGSNQT 1300
SGYQSGYHSD DTDTTVYSSD EAGLLKMVDA AVHADSGTTL RSPPV 1345
Length:1,345
Mass (Da):150,462
Last modified:March 1, 2002 - v1
Checksum:i11859F8A58A33A39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC124615 Genomic DNA. No translation available.
AC134903 Genomic DNA. No translation available.
AC160723 Genomic DNA. No translation available.
BC020530 mRNA. Translation: AAH20530.1.
CH466524 Genomic DNA. Translation: EDL37891.1.
RefSeqiNP_034742.2. NM_010612.2.
UniGeneiMm.285.

Genome annotation databases

EnsembliENSMUST00000113516; ENSMUSP00000109144; ENSMUSG00000062960.
GeneIDi16542.
KEGGimmu:16542.
UCSCiuc008xul.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC124615 Genomic DNA. No translation available.
AC134903 Genomic DNA. No translation available.
AC160723 Genomic DNA. No translation available.
BC020530 mRNA. Translation: AAH20530.1 .
CH466524 Genomic DNA. Translation: EDL37891.1 .
RefSeqi NP_034742.2. NM_010612.2.
UniGenei Mm.285.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000075443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113516 ; ENSMUSP00000109144 ; ENSMUSG00000062960 .
GeneIDi 16542.
KEGGi mmu:16542.
UCSCi uc008xul.2. mouse.

Organism-specific databases

CTDi 3791.
MGIi MGI:96683. Kdr.

Phylogenomic databases

GeneTreei ENSGT00720000108679.
HOGENOMi HOG000037949.
HOVERGENi HBG053432.
KOi K05098.
OMAi ISYAGMV.
OrthoDBi EOG75F4CC.
TreeFami TF325768.

Enzyme and pathway databases

Reactomei REACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
REACT_216309. Integrin cell surface interactions.
REACT_227870. Neurophilin interactions with VEGF and VEGFR.

Miscellaneous databases

ChiTaRSi KDR. mouse.
NextBioi 290003.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8VCD0.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
IPR009136. VEGFR2_rcpt.
[Graphical view ]
PANTHERi PTHR24416:SF45. PTHR24416:SF45. 1 hit.
Pfami PF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
PRINTSi PR01834. VEGFRECEPTR2.
SMARTi SM00409. IG. 5 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50835. IG_LIKE. 5 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: KidneyImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8VCD0_MOUSE
AccessioniPrimary (citable) accession number: Q8VCD0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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