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Protein

Spondin-1

Gene

Spon1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi325 – 3251CalciumBy similarity
Metal bindingi354 – 3541CalciumBy similarity
Metal bindingi358 – 3581Calcium; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Spondin-1
Alternative name(s):
F-spondin
Gene namesi
Name:Spon1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2385287. Spon1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 807779Spondin-1PRO_0000035866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 128PROSITE-ProRule annotation
Disulfide bondi156 ↔ 182PROSITE-ProRule annotation
Disulfide bondi199 ↔ 336By similarity
Disulfide bondi200 ↔ 340By similarity
Disulfide bondi202 ↔ 415By similarity
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi443 ↔ 480PROSITE-ProRule annotation
Disulfide bondi454 ↔ 489PROSITE-ProRule annotation
Disulfide bondi459 ↔ 494PROSITE-ProRule annotation
Disulfide bondi502 ↔ 538PROSITE-ProRule annotation
Disulfide bondi513 ↔ 517PROSITE-ProRule annotation
Disulfide bondi548 ↔ 554PROSITE-ProRule annotation
Disulfide bondi559 ↔ 595PROSITE-ProRule annotation
Disulfide bondi570 ↔ 574PROSITE-ProRule annotation
Disulfide bondi605 ↔ 610PROSITE-ProRule annotation
Disulfide bondi615 ↔ 650PROSITE-ProRule annotation
Disulfide bondi626 ↔ 630PROSITE-ProRule annotation
Disulfide bondi660 ↔ 665PROSITE-ProRule annotation
Glycosylationi681 – 6811N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8VCC9.
PaxDbiQ8VCC9.
PRIDEiQ8VCC9.

PTM databases

iPTMnetiQ8VCC9.
PhosphoSiteiQ8VCC9.

Expressioni

Gene expression databases

BgeeiQ8VCC9.
ExpressionAtlasiQ8VCC9. baseline and differential.
GenevisibleiQ8VCC9. MM.

Interactioni

Subunit structurei

Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.By similarity

Protein-protein interaction databases

IntActiQ8VCC9. 2 interactions.
MINTiMINT-4135381.
STRINGi10090.ENSMUSP00000041157.

Structurei

3D structure databases

ProteinModelPortaliQ8VCC9.
SMRiQ8VCC9. Positions 44-183, 192-427, 441-499, 559-610, 618-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 194166ReelinPROSITE-ProRule annotationAdd
BLAST
Domaini195 – 388194SpondinPROSITE-ProRule annotationAdd
BLAST
Domaini442 – 49554TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini501 – 55555TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini558 – 61154TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini614 – 66653TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini668 – 72154TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini754 – 80653TSP type-1 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reelin domain.PROSITE-ProRule annotation
Contains 1 spondin domain.PROSITE-ProRule annotation
Contains 6 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3539. Eukaryota.
ENOG410XQHP. LUCA.
GeneTreeiENSGT00810000125397.
HOGENOMiHOG000124667.
HOVERGENiHBG052920.
InParanoidiQ8VCC9.
OMAiKQFPDDG.
OrthoDBiEOG71CFK9.
PhylomeDBiQ8VCC9.
TreeFamiTF313353.

Family and domain databases

InterProiIPR002861. Reeler_dom.
IPR009465. Spondin_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF02014. Reeler. 1 hit.
PF06468. Spond_N. 1 hit.
PF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS51019. REELIN. 1 hit.
PS51020. SPONDIN. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSPVSLRL SRGPALLALA LPLAAALAFS DETLDKVTKS EGYCSRILRA
60 70 80 90 100
QGTRREGYTE FSLRVEGDPD FYKPGSSYRV TLSAAPPSYF RGFTLIALKE
110 120 130 140 150
NQEGDKEEDH AGTFQIIDEE ETQFMSNCPV AVTESTPRRR TRIQVFWIAP
160 170 180 190 200
PTGTGCVILK ASIVQKRIIY FQDEGSLTKK LCEQDPTLDG VTDRPILDCC
210 220 230 240 250
ACGTAKYRLT FYGNWSEKTH PKDYPRRANH WSAIIGGSHS KNYVLWEYGG
260 270 280 290 300
YASEGVKQVA ELGSPVKMEE EIRQQSDEVL TVIKAKAQWP AWQPVNVRAA
310 320 330 340 350
PSAEFSVDRT RHLMSFLTMM GPSPDWNVGL SAEDLCTKEC GWVQKVVQDL
360 370 380 390 400
IPWDAGTDSG VTYESPNKPT IPQEKIRPLT SLDHPQSPFY DPEGGSITQV
410 420 430 440 450
ARVVIERIAR KGEQCNIVPD NVDDIVADLA PEEKDEDDTP ETCIYSNWSP
460 470 480 490 500
WSACSSSTCE KGKRMRQRML KAQLDLSVPC PDTQDFQPCM GPGCSDEDGS
510 520 530 540 550
TCTMSEWITW SPCSVSCGMG MRSRERYVKQ FPEDGSVCML PTEETEKCTV
560 570 580 590 600
NEECSPSSCL VTEWGEWDDC SATCGMGMKK RHRMVKMSPA DGSMCKAETS
610 620 630 640 650
QAEKCMMPEC HTIPCLLSPW SEWSDCSVTC GKGMRTRQRM LKSLAELGDC
660 670 680 690 700
NEDLEQAEKC MLPECPIDCE LSEWSQWSEC NKSCGKGHMI RTRTIQMEPQ
710 720 730 740 750
FGGVPCPETV QRKKCRTRKC LRSPSVQKLR WREARESRRS EQLREESDGE
760 770 780 790 800
QFPGCRMRPW TAWSECTKLC GGGIQERYMT VKKRFKSSQF TSCKDKKEIR

ACNVHPC
Length:807
Mass (Da):90,821
Last modified:March 1, 2002 - v1
Checksum:i3116DF867F4AE563
GO

Sequence cautioni

The sequence AAH30339.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020531 mRNA. Translation: AAH20531.1.
BC030339 mRNA. Translation: AAH30339.1. Different initiation.
CCDSiCCDS21757.1.
RefSeqiNP_663559.1. NM_145584.2.
UniGeneiMm.334160.

Genome annotation databases

EnsembliENSMUST00000046687; ENSMUSP00000041157; ENSMUSG00000038156.
GeneIDi233744.
KEGGimmu:233744.
UCSCiuc009jhv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020531 mRNA. Translation: AAH20531.1.
BC030339 mRNA. Translation: AAH30339.1. Different initiation.
CCDSiCCDS21757.1.
RefSeqiNP_663559.1. NM_145584.2.
UniGeneiMm.334160.

3D structure databases

ProteinModelPortaliQ8VCC9.
SMRiQ8VCC9. Positions 44-183, 192-427, 441-499, 559-610, 618-720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCC9. 2 interactions.
MINTiMINT-4135381.
STRINGi10090.ENSMUSP00000041157.

PTM databases

iPTMnetiQ8VCC9.
PhosphoSiteiQ8VCC9.

Proteomic databases

MaxQBiQ8VCC9.
PaxDbiQ8VCC9.
PRIDEiQ8VCC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046687; ENSMUSP00000041157; ENSMUSG00000038156.
GeneIDi233744.
KEGGimmu:233744.
UCSCiuc009jhv.2. mouse.

Organism-specific databases

CTDi10418.
MGIiMGI:2385287. Spon1.

Phylogenomic databases

eggNOGiKOG3539. Eukaryota.
ENOG410XQHP. LUCA.
GeneTreeiENSGT00810000125397.
HOGENOMiHOG000124667.
HOVERGENiHBG052920.
InParanoidiQ8VCC9.
OMAiKQFPDDG.
OrthoDBiEOG71CFK9.
PhylomeDBiQ8VCC9.
TreeFamiTF313353.

Enzyme and pathway databases

ReactomeiR-MMU-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

ChiTaRSiSpon1. mouse.
PROiQ8VCC9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VCC9.
ExpressionAtlasiQ8VCC9. baseline and differential.
GenevisibleiQ8VCC9. MM.

Family and domain databases

InterProiIPR002861. Reeler_dom.
IPR009465. Spondin_N.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF02014. Reeler. 1 hit.
PF06468. Spond_N. 1 hit.
PF00090. TSP_1. 6 hits.
[Graphical view]
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS51019. REELIN. 1 hit.
PS51020. SPONDIN. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129 and FVB/N.
    Tissue: Kidney and Mammary tumor.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Lung.

Entry informationi

Entry nameiSPON1_MOUSE
AccessioniPrimary (citable) accession number: Q8VCC9
Secondary accession number(s): Q8K2Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.