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Protein

Liver carboxylesterase 1

Gene

Ces1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.1 Publication

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei221Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei353Charge relay systemBy similarity1
Active sitei466Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • chylomicron assembly Source: MGI
  • regulation of chylomicron remnant clearance Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of triglyceride metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERimouse-Ces1g. Carb_B_Chordata.
MEROPSiS09.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Liver carboxylesterase 1 (EC:3.1.1.1)
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase
Carboxylesterase 1G
ES-x
Gene namesi
Name:Ces1
Synonyms:Ces1g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:88378. Ces1g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000857119 – 565Liver carboxylesterase 1Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi87 ↔ 116By similarity
Disulfide bondi273 ↔ 284By similarity
Modified residuei378PhosphoserineBy similarity1
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1
Glycosylationi489N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8VCC2.
PaxDbiQ8VCC2.
PeptideAtlasiQ8VCC2.
PRIDEiQ8VCC2.

PTM databases

iPTMnetiQ8VCC2.
PhosphoSitePlusiQ8VCC2.
SwissPalmiQ8VCC2.

Expressioni

Tissue specificityi

Detected in kidney, liver and lung.1 Publication

Inductioni

Up-regulated in liver upon feeding a diet enriched in cholestyramine or cholate.1 Publication

Gene expression databases

BgeeiENSMUSG00000057074.
CleanExiMM_CES1.
ExpressionAtlasiQ8VCC2. baseline and differential.
GenevisibleiQ8VCC2. MM.

Interactioni

Subunit structurei

Homotrimer and homohexamer. Binds to beta-glucuronidase (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8VCC2. 2 interactors.
MINTiMINT-4094716.

Structurei

3D structure databases

ProteinModelPortaliQ8VCC2.
SMRiQ8VCC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
InParanoidiQ8VCC2.
OMAiVITEKSH.
OrthoDBiEOG091G03ZC.
PhylomeDBiQ8VCC2.
TreeFamiTF315470.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLCALSLIS LTACLSLGHP SLPPVVHTVH GKVLGKYVTL EGFSQPVAVF
60 70 80 90 100
LGVPFAKPPL GSLRFAPPEP AEPWSFVKHT TSYPPLCYQN PEAALRLAEL
110 120 130 140 150
FTNQRKIIPH KFSEDCLYLN IYTPADLTQN SRLPVMVWIH GGGLVIDGAS
160 170 180 190 200
TYDGVPLAVH ENVVVVVIQY RLGIWGFFST EDEHSRGNWG HLDQVAALHW
210 220 230 240 250
VQDNIANFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAIAQSSVI
260 270 280 290 300
FNPCLFGRAA RPLAKKIAAL AGCKTTTSAA MVHCLRQKTE DELLEVSLKM
310 320 330 340 350
KFGTVDFLGD PRESYPFLPT VIDGVLLPKA PEEILAEKSF NTVPYMVGIN
360 370 380 390 400
KHEFGWIIPM FLDFPLSERK LDQKTAASIL WQAYPILNIS EKLIPAAIEK
410 420 430 440 450
YLGGTEDPAT MTDLFLDLIG DIMFGVPSVI VSRSHRDAGA PTYMYEYQYR
460 470 480 490 500
PSFVSDDRPQ ELLGDHADEL FSVWGAPFLK EGASEEEINL SKMVMKFWAN
510 520 530 540 550
FARNGNPNGE GLPHWPEYDQ KEGYLQIGVP AQAAHRLKDK EVDFWTELRA
560
KETAERSSHR EHVEL
Length:565
Mass (Da):62,680
Last modified:March 1, 2002 - v1
Checksum:i21F3BE0184C2EB81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100L → R in CAA73388 (PubMed:9565681).Curated1
Sequence conflicti372D → E in CAA73388 (PubMed:9565681).Curated1
Sequence conflicti492K → N in CAA73388 (PubMed:9565681).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12887 mRNA. Translation: CAA73388.1.
BC021150 mRNA. Translation: AAH21150.1.
BC026897 mRNA. Translation: AAH26897.1.
CCDSiCCDS22531.1.
RefSeqiNP_067431.2. NM_021456.4.
UniGeneiMm.22720.

Genome annotation databases

EnsembliENSMUST00000044602; ENSMUSP00000037555; ENSMUSG00000057074.
GeneIDi12623.
KEGGimmu:12623.
UCSCiuc009muq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12887 mRNA. Translation: CAA73388.1.
BC021150 mRNA. Translation: AAH21150.1.
BC026897 mRNA. Translation: AAH26897.1.
CCDSiCCDS22531.1.
RefSeqiNP_067431.2. NM_021456.4.
UniGeneiMm.22720.

3D structure databases

ProteinModelPortaliQ8VCC2.
SMRiQ8VCC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCC2. 2 interactors.
MINTiMINT-4094716.

Protein family/group databases

ESTHERimouse-Ces1g. Carb_B_Chordata.
MEROPSiS09.972.

PTM databases

iPTMnetiQ8VCC2.
PhosphoSitePlusiQ8VCC2.
SwissPalmiQ8VCC2.

Proteomic databases

MaxQBiQ8VCC2.
PaxDbiQ8VCC2.
PeptideAtlasiQ8VCC2.
PRIDEiQ8VCC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044602; ENSMUSP00000037555; ENSMUSG00000057074.
GeneIDi12623.
KEGGimmu:12623.
UCSCiuc009muq.2. mouse.

Organism-specific databases

CTDi12623.
MGIiMGI:88378. Ces1g.

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
InParanoidiQ8VCC2.
OMAiVITEKSH.
OrthoDBiEOG091G03ZC.
PhylomeDBiQ8VCC2.
TreeFamiTF315470.

Miscellaneous databases

PROiQ8VCC2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057074.
CleanExiMM_CES1.
ExpressionAtlasiQ8VCC2. baseline and differential.
GenevisibleiQ8VCC2. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEST1_MOUSE
AccessioniPrimary (citable) accession number: Q8VCC2
Secondary accession number(s): O55136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.