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Protein

Liver carboxylesterase 1

Gene

Ces1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.1 Publication

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei221Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei353Charge relay systemBy similarity1
Active sitei466Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • chylomicron assembly Source: MGI
  • regulation of chylomicron remnant clearance Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of triglyceride metabolic process Source: MGI

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Protein family/group databases

ESTHERimouse-Ces1g Carb_B_Chordata
MEROPSiS09.972

Names & Taxonomyi

Protein namesi
Recommended name:
Liver carboxylesterase 1 (EC:3.1.1.1)
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase
Carboxylesterase 1G
ES-x
Gene namesi
Name:Ces1
Synonyms:Ces1g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:88378 Ces1g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000857119 – 565Liver carboxylesterase 1Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi87 ↔ 116By similarity
Disulfide bondi273 ↔ 284By similarity
Modified residuei378PhosphoserineBy similarity1
Glycosylationi388N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi489N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8VCC2
PaxDbiQ8VCC2
PeptideAtlasiQ8VCC2
PRIDEiQ8VCC2

PTM databases

iPTMnetiQ8VCC2
PhosphoSitePlusiQ8VCC2
SwissPalmiQ8VCC2

Expressioni

Tissue specificityi

Detected in kidney, liver and lung.1 Publication

Inductioni

Up-regulated in liver upon feeding a diet enriched in cholestyramine or cholate.1 Publication

Gene expression databases

BgeeiENSMUSG00000057074
CleanExiMM_CES1
ExpressionAtlasiQ8VCC2 baseline and differential
GenevisibleiQ8VCC2 MM

Interactioni

Subunit structurei

Homotrimer and homohexamer. Binds to beta-glucuronidase (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8VCC2, 2 interactors
MINTiQ8VCC2

Structurei

3D structure databases

ProteinModelPortaliQ8VCC2
SMRiQ8VCC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000091866
HOVERGENiHBG008839
InParanoidiQ8VCC2
OMAiDGMDYIN
OrthoDBiEOG091G03ZC
PhylomeDBiQ8VCC2
TreeFamiTF315470

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLCALSLIS LTACLSLGHP SLPPVVHTVH GKVLGKYVTL EGFSQPVAVF
60 70 80 90 100
LGVPFAKPPL GSLRFAPPEP AEPWSFVKHT TSYPPLCYQN PEAALRLAEL
110 120 130 140 150
FTNQRKIIPH KFSEDCLYLN IYTPADLTQN SRLPVMVWIH GGGLVIDGAS
160 170 180 190 200
TYDGVPLAVH ENVVVVVIQY RLGIWGFFST EDEHSRGNWG HLDQVAALHW
210 220 230 240 250
VQDNIANFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAIAQSSVI
260 270 280 290 300
FNPCLFGRAA RPLAKKIAAL AGCKTTTSAA MVHCLRQKTE DELLEVSLKM
310 320 330 340 350
KFGTVDFLGD PRESYPFLPT VIDGVLLPKA PEEILAEKSF NTVPYMVGIN
360 370 380 390 400
KHEFGWIIPM FLDFPLSERK LDQKTAASIL WQAYPILNIS EKLIPAAIEK
410 420 430 440 450
YLGGTEDPAT MTDLFLDLIG DIMFGVPSVI VSRSHRDAGA PTYMYEYQYR
460 470 480 490 500
PSFVSDDRPQ ELLGDHADEL FSVWGAPFLK EGASEEEINL SKMVMKFWAN
510 520 530 540 550
FARNGNPNGE GLPHWPEYDQ KEGYLQIGVP AQAAHRLKDK EVDFWTELRA
560
KETAERSSHR EHVEL
Length:565
Mass (Da):62,680
Last modified:March 1, 2002 - v1
Checksum:i21F3BE0184C2EB81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100L → R in CAA73388 (PubMed:9565681).Curated1
Sequence conflicti372D → E in CAA73388 (PubMed:9565681).Curated1
Sequence conflicti492K → N in CAA73388 (PubMed:9565681).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12887 mRNA Translation: CAA73388.1
BC021150 mRNA Translation: AAH21150.1
BC026897 mRNA Translation: AAH26897.1
CCDSiCCDS22531.1
RefSeqiNP_067431.2, NM_021456.4
UniGeneiMm.22720

Genome annotation databases

EnsembliENSMUST00000044602; ENSMUSP00000037555; ENSMUSG00000057074
GeneIDi12623
KEGGimmu:12623
UCSCiuc009muq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiEST1_MOUSE
AccessioniPrimary (citable) accession number: Q8VCC2
Secondary accession number(s): O55136
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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