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Q8VCC1

- PGDH_MOUSE

UniProt

Q8VCC1 - PGDH_MOUSE

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Protein

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Gene

Hpgd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).By similarity

Catalytic activityi

(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911NAD; via carbonyl oxygenBy similarity
Binding sitei138 – 1381SubstrateBy similarity
Binding sitei148 – 1481SubstrateBy similarity
Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209NADBy similarity
Nucleotide bindingi36 – 372NADBy similarity
Nucleotide bindingi63 – 653NADBy similarity
Nucleotide bindingi151 – 1555NADBy similarity
Nucleotide bindingi186 – 1883NADBy similarity

GO - Molecular functioni

  1. 15-hydroxyprostaglandin dehydrogenase (NAD+) activity Source: UniProtKB
  2. catalytic activity Source: UniProtKB
  3. NAD+ binding Source: UniProtKB
  4. NAD binding Source: UniProtKB
  5. prostaglandin E receptor activity Source: UniProtKB

GO - Biological processi

  1. ductus arteriosus closure Source: UniProtKB
  2. female pregnancy Source: UniProtKB
  3. negative regulation of cell cycle Source: UniProtKB
  4. ovulation Source: UniProtKB
  5. parturition Source: UniProtKB
  6. prostaglandin metabolic process Source: UniProtKB
  7. thrombin receptor signaling pathway Source: UniProtKB
  8. transforming growth factor beta receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Prostaglandin metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_188623. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_196544. Synthesis of Lipoxins (LX).

Names & Taxonomyi

Protein namesi
Recommended name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)] (EC:1.1.1.141)
Short name:
15-PGDH
Alternative name(s):
Prostaglandin dehydrogenase 1
Gene namesi
Name:Hpgd
Synonyms:Pgdh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:108085. Hpgd.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. cytoplasm Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26926915-hydroxyprostaglandin dehydrogenase [NAD(+)]PRO_0000253626Add
BLAST

Proteomic databases

MaxQBiQ8VCC1.
PaxDbiQ8VCC1.
PRIDEiQ8VCC1.

PTM databases

PhosphoSiteiQ8VCC1.

Expressioni

Tissue specificityi

Expressed in lung, intestine, stomach and liver.1 Publication

Gene expression databases

BgeeiQ8VCC1.
CleanExiMM_HPGD.
GenevestigatoriQ8VCC1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8VCC1. 1 interaction.
MINTiMINT-1855369.

Structurei

3D structure databases

ProteinModelPortaliQ8VCC1.
SMRiQ8VCC1. Positions 3-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG107379.
InParanoidiQ8VCC1.
KOiK00069.
OMAiIHFQNYD.
OrthoDBiEOG7966HT.
PhylomeDBiQ8VCC1.
TreeFamiTF324093.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHVNGKVALV TGAAQGIGKA FAEALLLHGA KVALVDWNLE AGVKCKAALD
60 70 80 90 100
EQFEPQKTLF VQCDVADQKQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW
110 120 130 140 150
EQTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV
160 170 180 190 200
YCASKHGIIG FTRSAAMAAN LMKSGVRLNV ICPGFVDTPI LESIEKEENM
210 220 230 240 250
GQYIEYKDQI KAMMKFYGVL HPSTIANGLI NLIEDDALNG AIMKITASKG
260
IHFQDYDISP LLVKAPLTS
Length:269
Mass (Da):29,181
Last modified:March 1, 2002 - v1
Checksum:i10E879A7E31A8E34
GO

Sequence cautioni

The sequence AAB41825.1 differs from that shown. Reason: Frameshift at position 267. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131S → G in AAB41825. (PubMed:8950170)Curated
Sequence conflicti153 – 1531A → S in AAB41825. (PubMed:8950170)Curated
Sequence conflicti205 – 2051E → G in AAB41825. (PubMed:8950170)Curated
Sequence conflicti224 – 2241T → A in AAB41825. (PubMed:8950170)Curated
Sequence conflicti231 – 2311N → D in AAB41825. (PubMed:8950170)Curated
Sequence conflicti241 – 2411A → P in AAB41825. (PubMed:8950170)Curated
Sequence conflicti246 – 2461T → S in AAB41825. (PubMed:8950170)Curated
Sequence conflicti249 – 2491K → E in AAB41825. (PubMed:8950170)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44389 mRNA. Translation: AAB41825.1. Frameshift.
AK146038 mRNA. Translation: BAE26850.1.
BC021157 mRNA. Translation: AAH21157.1.
CCDSiCCDS40341.1.
RefSeqiNP_032304.2. NM_008278.2.
UniGeneiMm.18832.

Genome annotation databases

EnsembliENSMUST00000034026; ENSMUSP00000034026; ENSMUSG00000031613.
GeneIDi15446.
KEGGimmu:15446.
UCSCiuc009lso.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44389 mRNA. Translation: AAB41825.1 . Frameshift.
AK146038 mRNA. Translation: BAE26850.1 .
BC021157 mRNA. Translation: AAH21157.1 .
CCDSi CCDS40341.1.
RefSeqi NP_032304.2. NM_008278.2.
UniGenei Mm.18832.

3D structure databases

ProteinModelPortali Q8VCC1.
SMRi Q8VCC1. Positions 3-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8VCC1. 1 interaction.
MINTi MINT-1855369.

PTM databases

PhosphoSitei Q8VCC1.

Proteomic databases

MaxQBi Q8VCC1.
PaxDbi Q8VCC1.
PRIDEi Q8VCC1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034026 ; ENSMUSP00000034026 ; ENSMUSG00000031613 .
GeneIDi 15446.
KEGGi mmu:15446.
UCSCi uc009lso.1. mouse.

Organism-specific databases

CTDi 3248.
MGIi MGI:108085. Hpgd.

Phylogenomic databases

eggNOGi COG1028.
GeneTreei ENSGT00760000118868.
HOVERGENi HBG107379.
InParanoidi Q8VCC1.
KOi K00069.
OMAi IHFQNYD.
OrthoDBi EOG7966HT.
PhylomeDBi Q8VCC1.
TreeFami TF324093.

Enzyme and pathway databases

Reactomei REACT_188623. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_196544. Synthesis of Lipoxins (LX).

Miscellaneous databases

ChiTaRSi Hpgd. mouse.
NextBioi 288244.
PROi Q8VCC1.
SOURCEi Search...

Gene expression databases

Bgeei Q8VCC1.
CleanExi MM_HPGD.
Genevestigatori Q8VCC1.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the cDNA for mouse NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase."
    Matsuo M., Ensor C.M., Tai H.H.
    Biochim. Biophys. Acta 1309:21-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiPGDH_MOUSE
AccessioniPrimary (citable) accession number: Q8VCC1
Secondary accession number(s): Q61106
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3