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Protein

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Gene

Hpgd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).By similarity1 Publication

Catalytic activityi

(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91NAD; via carbonyl oxygenBy similarity1
Binding sitei138SubstrateBy similarity1
Binding sitei148SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20NADBy similarity9
Nucleotide bindingi36 – 37NADBy similarity2
Nucleotide bindingi63 – 65NADBy similarity3
Nucleotide bindingi151 – 155NADBy similarity5
Nucleotide bindingi186 – 188NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Prostaglandin metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-MMU-2142700. Synthesis of Lipoxins (LX).

Names & Taxonomyi

Protein namesi
Recommended name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)] (EC:1.1.1.141)
Short name:
15-PGDH
Alternative name(s):
Prostaglandin dehydrogenase 1
Gene namesi
Name:Hpgd
Synonyms:Pgdh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:108085. Hpgd.

Subcellular locationi

GO - Cellular componenti

  • basolateral plasma membrane Source: MGI
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002536261 – 26915-hydroxyprostaglandin dehydrogenase [NAD(+)]Add BLAST269

Proteomic databases

MaxQBiQ8VCC1.
PaxDbiQ8VCC1.
PeptideAtlasiQ8VCC1.
PRIDEiQ8VCC1.

PTM databases

iPTMnetiQ8VCC1.
PhosphoSitePlusiQ8VCC1.

Expressioni

Tissue specificityi

Expressed in lung, intestine, stomach and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000031613.
CleanExiMM_HPGD.
GenevisibleiQ8VCC1. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8VCC1. 1 interactor.
MINTiMINT-1855369.
STRINGi10090.ENSMUSP00000034026.

Structurei

3D structure databases

ProteinModelPortaliQ8VCC1.
SMRiQ8VCC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG107379.
InParanoidiQ8VCC1.
KOiK00069.
OMAiQDYDATP.
OrthoDBiEOG091G0OC9.
PhylomeDBiQ8VCC1.
TreeFamiTF324093.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVNGKVALV TGAAQGIGKA FAEALLLHGA KVALVDWNLE AGVKCKAALD
60 70 80 90 100
EQFEPQKTLF VQCDVADQKQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW
110 120 130 140 150
EQTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV
160 170 180 190 200
YCASKHGIIG FTRSAAMAAN LMKSGVRLNV ICPGFVDTPI LESIEKEENM
210 220 230 240 250
GQYIEYKDQI KAMMKFYGVL HPSTIANGLI NLIEDDALNG AIMKITASKG
260
IHFQDYDISP LLVKAPLTS
Length:269
Mass (Da):29,181
Last modified:March 1, 2002 - v1
Checksum:i10E879A7E31A8E34
GO

Sequence cautioni

The sequence AAB41825 differs from that shown. Reason: Frameshift at position 267.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113S → G in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti153A → S in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti205E → G in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti224T → A in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti231N → D in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti241A → P in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti246T → S in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti249K → E in AAB41825 (PubMed:8950170).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44389 mRNA. Translation: AAB41825.1. Frameshift.
AK146038 mRNA. Translation: BAE26850.1.
BC021157 mRNA. Translation: AAH21157.1.
CCDSiCCDS40341.1.
RefSeqiNP_032304.2. NM_008278.2.
UniGeneiMm.18832.

Genome annotation databases

EnsembliENSMUST00000034026; ENSMUSP00000034026; ENSMUSG00000031613.
GeneIDi15446.
KEGGimmu:15446.
UCSCiuc009lso.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44389 mRNA. Translation: AAB41825.1. Frameshift.
AK146038 mRNA. Translation: BAE26850.1.
BC021157 mRNA. Translation: AAH21157.1.
CCDSiCCDS40341.1.
RefSeqiNP_032304.2. NM_008278.2.
UniGeneiMm.18832.

3D structure databases

ProteinModelPortaliQ8VCC1.
SMRiQ8VCC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCC1. 1 interactor.
MINTiMINT-1855369.
STRINGi10090.ENSMUSP00000034026.

PTM databases

iPTMnetiQ8VCC1.
PhosphoSitePlusiQ8VCC1.

Proteomic databases

MaxQBiQ8VCC1.
PaxDbiQ8VCC1.
PeptideAtlasiQ8VCC1.
PRIDEiQ8VCC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034026; ENSMUSP00000034026; ENSMUSG00000031613.
GeneIDi15446.
KEGGimmu:15446.
UCSCiuc009lso.1. mouse.

Organism-specific databases

CTDi3248.
MGIiMGI:108085. Hpgd.

Phylogenomic databases

eggNOGiKOG4169. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG107379.
InParanoidiQ8VCC1.
KOiK00069.
OMAiQDYDATP.
OrthoDBiEOG091G0OC9.
PhylomeDBiQ8VCC1.
TreeFamiTF324093.

Enzyme and pathway databases

ReactomeiR-MMU-2142700. Synthesis of Lipoxins (LX).

Miscellaneous databases

ChiTaRSiHpgd. mouse.
PROiQ8VCC1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031613.
CleanExiMM_HPGD.
GenevisibleiQ8VCC1. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGDH_MOUSE
AccessioniPrimary (citable) accession number: Q8VCC1
Secondary accession number(s): Q61106
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.