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Q8VCB3

- GYS2_MOUSE

UniProt

Q8VCB3 - GYS2_MOUSE

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Protein

Glycogen [starch] synthase, liver

Gene
Gys2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

Catalytic activityi

UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

Enzyme regulationi

Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401UDP-glucose By similarity

GO - Molecular functioni

  1. glycogen (starch) synthase activity Source: UniProtKB

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB
  2. response to glucose Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Glycogen biosynthesis

Enzyme and pathway databases

ReactomeiREACT_188939. Glycogen synthesis.
REACT_203841. Myoclonic epilepsy of Lafora.
UniPathwayiUPA00164.

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen [starch] synthase, liver (EC:2.4.1.11)
Gene namesi
Name:Gys2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2385254. Gys2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: UniProtKB
  2. cortical actin cytoskeleton Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. cytoskeleton Source: UniProtKB
  5. cytosol Source: UniProtKB
  6. ectoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 704704Glycogen [starch] synthase, liverPRO_0000274489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei641 – 6411Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei645 – 6451Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei649 – 6491Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei653 – 6531Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei657 – 6571Phosphoserine; by CK2 By similarity
Modified residuei684 – 6841Phosphoserine1 Publication

Post-translational modificationi

Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VCB3.
PaxDbiQ8VCB3.
PRIDEiQ8VCB3.

PTM databases

PhosphoSiteiQ8VCB3.

Expressioni

Inductioni

Expression in the liver oscillates in a circadian manner with peak levels during the night.1 Publication

Gene expression databases

BgeeiQ8VCB3.
CleanExiMM_GYS2.
GenevestigatoriQ8VCB3.

Interactioni

Protein-protein interaction databases

IntActiQ8VCB3. 2 interactions.
MINTiMINT-4119490.
STRINGi10090.ENSMUSP00000032371.

Structurei

3D structure databases

ProteinModelPortaliQ8VCB3.
SMRiQ8VCB3. Positions 25-621.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0438.
GeneTreeiENSGT00390000018612.
HOGENOMiHOG000160890.
HOVERGENiHBG001960.
InParanoidiQ3UTY0.
KOiK00693.
OMAiEVSWEVT.
OrthoDBiEOG741Z1N.
TreeFamiTF300306.

Family and domain databases

InterProiIPR008631. Glycogen_synth.
[Graphical view]
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiPF05693. Glycogen_syn. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCB3-1 [UniParc]FASTAAdd to Basket

« Hide

MLRGRSLSVT SLGGLPVWEA ERLPVEDLLL FEVSWEVTNK VGGICTVIQT    50
KAKTTADEWG ENYFLIGPYF EHNMKTQVEQ CEPTNDAVRK AVDAMNKHGC 100
QVHFGRWLIE GSPYVVLFDI SSSAWNLDRW KGDFWEACGV GIPHHDREAN 150
DMLIFGSLTA WFLKEVTDHA DGKHVIAQFH EWQAGTGLIL SRARKLPIAT 200
VFTTHATLLG RYLCAANIDF YNQLDKFDID KEAGERQIYH RYCMERASVH 250
CAHVFTTVSE ITAIEAEHML KRKPDVVTPN GLNVKKFSAV HEFQNLHAMY 300
KARIQDFVRG HFYGHLDFDL EKTLFLFIAG RYEFSNKGAD IFLESLSRLN 350
FLLRMHKSNV TVVVFFIMPA KTNNFNVETL KGQAVRKQLW DTVHCLKEKF 400
GKKLYDGLLR GEIPDMNSIL DRDDLTIMKR AIFSTQRQSL PPVTTHNMID 450
DSTDPILSTI RRIGLFNNRA DRVKVILHPE FLSSTSPLLP MDYEEFVRGC 500
HLGVFPSYYE PWGYTPAECT VMGIPSVTTN LSGFGCFVQE HVADPTAYGI 550
YIVDRRFRSP DDSCNQLTQF LYGFCKQSRR QRIIQRNRTE RLSDLLDWRY 600
LGRYYQHARH LTLSRAFPDK FHLEPTSPPT TDGFKYPRPS SVPPSPSGSQ 650
ASSPQCSDAE DEEDEDERYD EEEEAERDRL NIKSPFSLNH FPKGKKKLHG 700
EYKN 704
Length:704
Mass (Da):80,871
Last modified:July 27, 2011 - v2
Checksum:iC4B87195B5FC41FE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti630 – 6301T → M in AAH21322. 1 Publication
Sequence conflicti656 – 6561C → S in AAH21322. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK138992 mRNA. Translation: BAE23850.1.
BC021322 mRNA. Translation: AAH21322.1.
BC158081 mRNA. Translation: AAI58082.1.
CCDSiCCDS20683.1.
RefSeqiNP_663547.2. NM_145572.2.
UniGeneiMm.275975.

Genome annotation databases

EnsembliENSMUST00000032371; ENSMUSP00000032371; ENSMUSG00000030244.
GeneIDi232493.
KEGGimmu:232493.
UCSCiuc009epi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK138992 mRNA. Translation: BAE23850.1 .
BC021322 mRNA. Translation: AAH21322.1 .
BC158081 mRNA. Translation: AAI58082.1 .
CCDSi CCDS20683.1.
RefSeqi NP_663547.2. NM_145572.2.
UniGenei Mm.275975.

3D structure databases

ProteinModelPortali Q8VCB3.
SMRi Q8VCB3. Positions 25-621.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8VCB3. 2 interactions.
MINTi MINT-4119490.
STRINGi 10090.ENSMUSP00000032371.

Protein family/group databases

CAZyi GT3. Glycosyltransferase Family 3.

PTM databases

PhosphoSitei Q8VCB3.

Proteomic databases

MaxQBi Q8VCB3.
PaxDbi Q8VCB3.
PRIDEi Q8VCB3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032371 ; ENSMUSP00000032371 ; ENSMUSG00000030244 .
GeneIDi 232493.
KEGGi mmu:232493.
UCSCi uc009epi.2. mouse.

Organism-specific databases

CTDi 2998.
MGIi MGI:2385254. Gys2.

Phylogenomic databases

eggNOGi COG0438.
GeneTreei ENSGT00390000018612.
HOGENOMi HOG000160890.
HOVERGENi HBG001960.
InParanoidi Q3UTY0.
KOi K00693.
OMAi EVSWEVT.
OrthoDBi EOG741Z1N.
TreeFami TF300306.

Enzyme and pathway databases

UniPathwayi UPA00164 .
Reactomei REACT_188939. Glycogen synthesis.
REACT_203841. Myoclonic epilepsy of Lafora.

Miscellaneous databases

NextBioi 381135.
PROi Q8VCB3.
SOURCEi Search...

Gene expression databases

Bgeei Q8VCB3.
CleanExi MM_GYS2.
Genevestigatori Q8VCB3.

Family and domain databases

InterProi IPR008631. Glycogen_synth.
[Graphical view ]
PANTHERi PTHR10176. PTHR10176. 1 hit.
Pfami PF05693. Glycogen_syn. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta and Vein.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2."
    Doi R., Oishi K., Ishida N.
    J. Biol. Chem. 285:22114-22121(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiGYS2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCB3
Secondary accession number(s): Q3UTY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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