Reviewed,
UniProtKB/Swiss-Prot Q8VCB3 (GYS2_MOUSE)
Last modified
April 14, 2009.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (3) |
 Third-party data |
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Names and origin
| Protein names | Recommended name: Glycogen [starch] synthase, liver EC=2.4.1.11 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 704 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. |
| Catalytic activity | UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1). |
| Enzyme regulation | Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the glycosyltransferase 3 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycogen biosynthesis |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Phosphoprotein |
| Technical term | Allosteric enzyme |
| Gene Ontology (GO) | |
| Biological process | glycogen biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB response to glucose stimulusInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | cortical actin cytoskeleton Inferred from sequence or structural similarity. Source: UniProtKB cytosolInferred from sequence or structural similarity. Source: UniProtKB ectoplasmInferred from sequence or structural similarity. Source: UniProtKB insoluble fractionInferred from sequence or structural similarity. Source: UniProtKB soluble fractionInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | glycogen (starch) synthase activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 704 | 704 | Glycogen [starch] synthase, liver | PRO_0000274489 | |||||
Sites | |||||||||
| Binding site | 40 | 1 | UDP-glucose By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 6 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 8 | 1 | Phosphoserine Ref.2 | ||||||
| Modified residue | 11 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 626 | 1 | Phosphothreonine Ref.2 | ||||||
| Modified residue | 641 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 645 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 649 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 653 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 657 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver. |
| [2] | "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8 AND THR-626, MASS SPECTROMETRY. Tissue: Liver. |
| [3] | "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis." Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H. J. Proteome Res. 7:3957-3967(2008) [PubMed: 18630941] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-11, MASS SPECTROMETRY. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| BC021322 mRNA. Translation: AAH21322.1. | |
| IPI | IPI00121962. |
| UniGene | Mm.275975 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT3. Glycosyltransferase Family 3. |
PTM databases | |
| PhosphoSite | Q8VCB3. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000030244. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:2385254. Gys2. |
Phylogenomic databases | |
| HOVERGEN | Q8VCB3. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.11. 244. |
Gene expression databases | |
| ArrayExpress | Q8VCB3. |
| Bgee | Q8VCB3. |
| CleanEx | MM_GYS2. |
Family and domain databases | |
| InterPro | IPR008631. Glycogen_synth. [Graphical view] |
| PANTHER | PTHR10176. Glycogen_synth. 1 hit. |
| Pfam | PF05693. Glycogen_syn. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | GYS2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8VCB3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
