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Protein

Nucleoporin NDC1

Gene

Ndc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nuclear pore complex assembly Source: MGI
  • nuclear pore distribution Source: MGI
  • nuclear pore organization Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • spermatogenesis Source: MGI
  • synapsis Source: MGI
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NDC1
Alternative name(s):
Transmembrane protein 48
Gene namesi
Name:Ndc1
Synonyms:Tmem48
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920037. Ndc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 7125Perinuclear spaceSequence analysisAdd
BLAST
Transmembranei72 – 9221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini93 – 11523CytoplasmicSequence analysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 16630Perinuclear spaceSequence analysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini188 – 22639CytoplasmicSequence analysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini248 – 26114Perinuclear spaceSequence analysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini283 – 673391CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • nuclear membrane Source: MGI
  • nuclear pore Source: MGI
  • nuclear pore transmembrane ring Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673Nucleoporin NDC1PRO_0000235241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei407 – 4071PhosphoserineBy similarity
Modified residuei415 – 4151PhosphothreonineBy similarity
Modified residuei438 – 4381PhosphoserineBy similarity
Modified residuei439 – 4391PhosphothreonineBy similarity
Modified residuei444 – 4441PhosphoserineBy similarity
Modified residuei448 – 4481PhosphothreonineCombined sources
Modified residuei470 – 4701PhosphoserineBy similarity
Modified residuei473 – 4731PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VCB1.
MaxQBiQ8VCB1.
PaxDbiQ8VCB1.
PeptideAtlasiQ8VCB1.
PRIDEiQ8VCB1.

PTM databases

iPTMnetiQ8VCB1.
PhosphoSiteiQ8VCB1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028614.
CleanExiMM_TMEM48.
ExpressionAtlasiQ8VCB1. baseline and differential.
GenevisibleiQ8VCB1. MM.

Interactioni

Subunit structurei

Interacts with the NUP35/NUP53.By similarity

Protein-protein interaction databases

BioGridi215568. 2 interactions.
IntActiQ8VCB1. 1 interaction.
STRINGi10090.ENSMUSP00000120365.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4358. Eukaryota.
ENOG4110XEC. LUCA.
GeneTreeiENSGT00390000014590.
HOGENOMiHOG000231135.
HOVERGENiHBG080133.
InParanoidiQ8VCB1.
KOiK14315.
OMAiRHFKLPH.
OrthoDBiEOG091G0MME.
PhylomeDBiQ8VCB1.
TreeFamiTF324843.

Family and domain databases

InterProiIPR019049. Nucleoporin_prot_Ndc1/Nup.
[Graphical view]
PfamiPF09531. Ndc1_Nup. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAASGPCA GGSPRDILWR VLGWRIVTSI VWSVVLLPVC ITAFIVLSSI
60 70 80 90 100
NLFHPIQWLS DSCNDFYSSQ VIFHLLLLAV VIIIISIFNV EFYTVVPSIS
110 120 130 140 150
GSRLALIARI LHPQQLTHSF IHAAMGMAVA WCAAIMTKGQ YSSLVVPCTG
160 170 180 190 200
TESLDSPAAQ TCLNEYHLFF LLSGAFMGYS YSLLYFINNM NYLPFPIIQQ
210 220 230 240 250
YKFLRFRRSL LLLVKHSCVE SLFMVRNFCI VYYFFGHIPK AWISTALDLH
260 270 280 290 300
TDEQAHRPLD TIGGLLNVSL LYHVWLCGVF LLVTWYSSWI LFKIYATEAH
310 320 330 340 350
VFPVQPPFAE ASDECLPKVL NSNPPRIVKY LALQDLMLLS QYSPSRRQEV
360 370 380 390 400
FSLSQPGGHP HNWTAISREC LNLLNDMTQK LVLYQEAAAT NGRMYSSYSV
410 420 430 440 450
EPKKLSSAEE TAFQTPKPSQ TPSVPPLVKT SLFSPKLSTP NVSSPFGTPF
460 470 480 490 500
GSSVVNRMAG ILDVNPFSGS PQSPQLIRRG PRLWTHTSDQ QVSAISNPSP
510 520 530 540 550
CASVTAEGKT VRQPSVIYSW IQNKREQIKN FLSKRVLIMY FFSKHPEASI
560 570 580 590 600
QAVFSDAQMH IWALEGLSHL VAASFTEDRF GVVQTTLPAI LHTLLTLQEA
610 620 630 640 650
VDKYFKLPHA SSKPPRASGS LVDTSYKTLR FAFRASLKTA IYRITTTFGE
660 670
HLNAVQASAE HQKRLQQFLE FKE
Length:673
Mass (Da):75,409
Last modified:March 1, 2002 - v1
Checksum:i0957ED1C3C4DB6B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141695 mRNA. Translation: AAZ73086.1.
AK144734 mRNA. Translation: BAE26039.1.
BC021337 mRNA. Translation: AAH21337.1.
CCDSiCCDS18438.1.
RefSeqiNP_082631.1. NM_028355.3.
UniGeneiMm.28478.

Genome annotation databases

EnsembliENSMUST00000139560; ENSMUSP00000120365; ENSMUSG00000028614.
GeneIDi72787.
KEGGimmu:72787.
UCSCiuc008tzt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141695 mRNA. Translation: AAZ73086.1.
AK144734 mRNA. Translation: BAE26039.1.
BC021337 mRNA. Translation: AAH21337.1.
CCDSiCCDS18438.1.
RefSeqiNP_082631.1. NM_028355.3.
UniGeneiMm.28478.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215568. 2 interactions.
IntActiQ8VCB1. 1 interaction.
STRINGi10090.ENSMUSP00000120365.

PTM databases

iPTMnetiQ8VCB1.
PhosphoSiteiQ8VCB1.

Proteomic databases

EPDiQ8VCB1.
MaxQBiQ8VCB1.
PaxDbiQ8VCB1.
PeptideAtlasiQ8VCB1.
PRIDEiQ8VCB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000139560; ENSMUSP00000120365; ENSMUSG00000028614.
GeneIDi72787.
KEGGimmu:72787.
UCSCiuc008tzt.1. mouse.

Organism-specific databases

CTDi55706.
MGIiMGI:1920037. Ndc1.

Phylogenomic databases

eggNOGiKOG4358. Eukaryota.
ENOG4110XEC. LUCA.
GeneTreeiENSGT00390000014590.
HOGENOMiHOG000231135.
HOVERGENiHBG080133.
InParanoidiQ8VCB1.
KOiK14315.
OMAiRHFKLPH.
OrthoDBiEOG091G0MME.
PhylomeDBiQ8VCB1.
TreeFamiTF324843.

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiQ8VCB1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028614.
CleanExiMM_TMEM48.
ExpressionAtlasiQ8VCB1. baseline and differential.
GenevisibleiQ8VCB1. MM.

Family and domain databases

InterProiIPR019049. Nucleoporin_prot_Ndc1/Nup.
[Graphical view]
PfamiPF09531. Ndc1_Nup. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDC1_MOUSE
AccessioniPrimary (citable) accession number: Q8VCB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.