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Protein

Nucleoporin NDC1

Gene

Ndc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nuclear pore complex assembly Source: MGI
  • nuclear pore distribution Source: MGI
  • nuclear pore organization Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • spermatogenesis Source: MGI
  • synapsis Source: MGI

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-MMU-191859 snRNP Assembly
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NDC1
Alternative name(s):
Transmembrane protein 48
Gene namesi
Name:Ndc1
Synonyms:Tmem48
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920037 Ndc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 71Perinuclear spaceSequence analysisAdd BLAST25
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 115CytoplasmicSequence analysisAdd BLAST23
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 166Perinuclear spaceSequence analysisAdd BLAST30
Transmembranei167 – 187Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini188 – 226CytoplasmicSequence analysisAdd BLAST39
Transmembranei227 – 247Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini248 – 261Perinuclear spaceSequence analysisAdd BLAST14
Transmembranei262 – 282Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini283 – 673CytoplasmicSequence analysisAdd BLAST391

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352411 – 673Nucleoporin NDC1Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407PhosphoserineBy similarity1
Modified residuei415PhosphothreonineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei439PhosphothreonineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei448PhosphothreonineCombined sources1
Modified residuei470PhosphoserineBy similarity1
Modified residuei473PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VCB1
MaxQBiQ8VCB1
PaxDbiQ8VCB1
PeptideAtlasiQ8VCB1
PRIDEiQ8VCB1

PTM databases

iPTMnetiQ8VCB1
PhosphoSitePlusiQ8VCB1

Expressioni

Gene expression databases

BgeeiENSMUSG00000028614
CleanExiMM_TMEM48
ExpressionAtlasiQ8VCB1 baseline and differential
GenevisibleiQ8VCB1 MM

Interactioni

Subunit structurei

Interacts with the NUP35/NUP53.By similarity

Protein-protein interaction databases

BioGridi215568, 2 interactors
IntActiQ8VCB1, 1 interactor
STRINGi10090.ENSMUSP00000120365

Family & Domainsi

Sequence similaritiesi

Belongs to the NDC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4358 Eukaryota
ENOG4110XEC LUCA
GeneTreeiENSGT00390000014590
HOGENOMiHOG000231135
HOVERGENiHBG080133
InParanoidiQ8VCB1
KOiK14315
OMAiYVVQCLA
OrthoDBiEOG091G0MME
PhylomeDBiQ8VCB1
TreeFamiTF324843

Family and domain databases

InterProiView protein in InterPro
IPR019049 Nucleoporin_prot_Ndc1/Nup
PANTHERiPTHR13269 PTHR13269, 1 hit
PfamiView protein in Pfam
PF09531 Ndc1_Nup, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VCB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAASGPCA GGSPRDILWR VLGWRIVTSI VWSVVLLPVC ITAFIVLSSI
60 70 80 90 100
NLFHPIQWLS DSCNDFYSSQ VIFHLLLLAV VIIIISIFNV EFYTVVPSIS
110 120 130 140 150
GSRLALIARI LHPQQLTHSF IHAAMGMAVA WCAAIMTKGQ YSSLVVPCTG
160 170 180 190 200
TESLDSPAAQ TCLNEYHLFF LLSGAFMGYS YSLLYFINNM NYLPFPIIQQ
210 220 230 240 250
YKFLRFRRSL LLLVKHSCVE SLFMVRNFCI VYYFFGHIPK AWISTALDLH
260 270 280 290 300
TDEQAHRPLD TIGGLLNVSL LYHVWLCGVF LLVTWYSSWI LFKIYATEAH
310 320 330 340 350
VFPVQPPFAE ASDECLPKVL NSNPPRIVKY LALQDLMLLS QYSPSRRQEV
360 370 380 390 400
FSLSQPGGHP HNWTAISREC LNLLNDMTQK LVLYQEAAAT NGRMYSSYSV
410 420 430 440 450
EPKKLSSAEE TAFQTPKPSQ TPSVPPLVKT SLFSPKLSTP NVSSPFGTPF
460 470 480 490 500
GSSVVNRMAG ILDVNPFSGS PQSPQLIRRG PRLWTHTSDQ QVSAISNPSP
510 520 530 540 550
CASVTAEGKT VRQPSVIYSW IQNKREQIKN FLSKRVLIMY FFSKHPEASI
560 570 580 590 600
QAVFSDAQMH IWALEGLSHL VAASFTEDRF GVVQTTLPAI LHTLLTLQEA
610 620 630 640 650
VDKYFKLPHA SSKPPRASGS LVDTSYKTLR FAFRASLKTA IYRITTTFGE
660 670
HLNAVQASAE HQKRLQQFLE FKE
Length:673
Mass (Da):75,409
Last modified:March 1, 2002 - v1
Checksum:i0957ED1C3C4DB6B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141695 mRNA Translation: AAZ73086.1
AK144734 mRNA Translation: BAE26039.1
BC021337 mRNA Translation: AAH21337.1
CCDSiCCDS18438.1
RefSeqiNP_082631.1, NM_028355.3
UniGeneiMm.28478

Genome annotation databases

EnsembliENSMUST00000139560; ENSMUSP00000120365; ENSMUSG00000028614
GeneIDi72787
KEGGimmu:72787
UCSCiuc008tzt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDC1_MOUSE
AccessioniPrimary (citable) accession number: Q8VCB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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