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Protein

Transmembrane protease serine 4

Gene

Tmprss4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable protease. Seems to be capable of activating ENaC.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei243Charge relay systemBy similarity1
Active sitei288Charge relay systemBy similarity1
Active sitei385Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.034.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 4 (EC:3.4.21.-)
Alternative name(s):
Channel-activating protease 2
Short name:
mCAP2
Gene namesi
Name:Tmprss4
Synonyms:Cap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2384877. Tmprss4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini52 – 435ExtracellularSequence analysisAdd BLAST384

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000886931 – 435Transmembrane protease serine 4Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 81By similarity
Disulfide bondi75 ↔ 90By similarity
Disulfide bondi125 ↔ 181By similarity
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi138 ↔ 191By similarity
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi194 ↔ 308By similarity
Disulfide bondi228 ↔ 244By similarity
Disulfide bondi354 ↔ 370By similarity
Disulfide bondi381 ↔ 408By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei202 – 203CleavageSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8VCA5.
PaxDbiQ8VCA5.
PRIDEiQ8VCA5.

PTM databases

iPTMnetiQ8VCA5.
PhosphoSitePlusiQ8VCA5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032091.
CleanExiMM_TMPRSS4.
ExpressionAtlasiQ8VCA5. baseline and differential.
GenevisibleiQ8VCA5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034599.

Structurei

3D structure databases

ProteinModelPortaliQ8VCA5.
SMRiQ8VCA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 101LDL-receptor class AAdd BLAST43
Domaini102 – 202SRCRPROSITE-ProRule annotationAdd BLAST101
Domaini203 – 432Peptidase S1PROSITE-ProRule annotationAdd BLAST230

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.Curated
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251822.
HOVERGENiHBG013304.
InParanoidiQ8VCA5.
KOiK09635.
OMAiHCLACGE.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ8VCA5.
TreeFamiTF351678.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.10.250.10. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR002172. LDrepeatLR_classA_rpt.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF15494. SRCR_2. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESDSGQPLN NRDIVPFRKP RRPQETFKKV GIPIIAVLLS LIALVIVALL
60 70 80 90 100
IKVILDKYYF ICGSPLTFIQ RGQLCDGHLD CASGEDEEHC VKDFPEKPGV
110 120 130 140 150
AVRLSKDRST LQVLDAATGT WASVCFDNFT EALAKTACRQ MGYDSQPAFR
160 170 180 190 200
AVEIRPDQNL PVAQVTGNSQ ELQVQNGSRS CLSGSLVSLR CLDCGKSLKT
210 220 230 240 250
PRVVGGVEAP VDSWPWQVSI QYNKQHVCGG SILDPHWILT AAHCFRKYLD
260 270 280 290 300
VSSWKVRAGS NILGNSPSLP VAKIFIAEPN PLYPKEKDIA LVKLQMPLTF
310 320 330 340 350
SGSVRPICLP FSDEVLVPAT PVWVIGWGFT EENGGKMSDM LLQASVQVID
360 370 380 390 400
STRCNAEDAY EGEVTAEMLC AGTPQGGKDT CQGDSGGPLM YHSDKWQVVG
410 420 430
IVSWGHGCGG PSTPGVYTKV TAYLNWIYNV RKSEM
Length:435
Mass (Da):47,496
Last modified:March 1, 2002 - v1
Checksum:iDC52E45A43E01369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043240 mRNA. Translation: AAK85307.1.
BC021368 mRNA. Translation: AAH21368.1.
CCDSiCCDS40607.1.
RefSeqiNP_663378.1. NM_145403.2.
UniGeneiMm.436756.

Genome annotation databases

EnsembliENSMUST00000034599; ENSMUSP00000034599; ENSMUSG00000032091.
GeneIDi214523.
KEGGimmu:214523.
UCSCiuc009pfi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043240 mRNA. Translation: AAK85307.1.
BC021368 mRNA. Translation: AAH21368.1.
CCDSiCCDS40607.1.
RefSeqiNP_663378.1. NM_145403.2.
UniGeneiMm.436756.

3D structure databases

ProteinModelPortaliQ8VCA5.
SMRiQ8VCA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034599.

Protein family/group databases

MEROPSiS01.034.

PTM databases

iPTMnetiQ8VCA5.
PhosphoSitePlusiQ8VCA5.

Proteomic databases

MaxQBiQ8VCA5.
PaxDbiQ8VCA5.
PRIDEiQ8VCA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034599; ENSMUSP00000034599; ENSMUSG00000032091.
GeneIDi214523.
KEGGimmu:214523.
UCSCiuc009pfi.1. mouse.

Organism-specific databases

CTDi56649.
MGIiMGI:2384877. Tmprss4.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251822.
HOVERGENiHBG013304.
InParanoidiQ8VCA5.
KOiK09635.
OMAiHCLACGE.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ8VCA5.
TreeFamiTF351678.

Miscellaneous databases

ChiTaRSiTmprss4. mouse.
PROiQ8VCA5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032091.
CleanExiMM_TMPRSS4.
ExpressionAtlasiQ8VCA5. baseline and differential.
GenevisibleiQ8VCA5. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.10.250.10. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR002172. LDrepeatLR_classA_rpt.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF15494. SRCR_2. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMPS4_MOUSE
AccessioniPrimary (citable) accession number: Q8VCA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.