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Protein

Solute carrier family 22 member 19

Gene

Slc22a19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent organic anion transporter which shows high specificity for estrone sulfate, dehydroepiandrosterone sulfate, and the mycotoxin ochratoxin A (OTA) (PubMed:15068970, PubMed:16150593). Transport of OTA is strongly inhibited by estrone sulfate and probenecid, and to a lesser extent by 2,4-dichlorophenoxyacetic acid (2,4-D) and salicylate (PubMed:15068970). Transport of estrone sulfate is inhibited by various steroid sulfate conjugates including dehydroepiandrosterone sulfate, alpha-naphthyl sulfate, beta-estradiol sulfate, 4-methylumbelliferyl sulfate and p-nitrophenyl sulfate (but not minoxidil sulfate) (PubMed:16150593).2 Publications

Kineticsi

  1. KM=2.0 µM for ochratoxin A1 Publication
  2. KM=2.2 µM for estrone sulfate1 Publication
  3. KM=3.8 µM for dehydroepiandrosterone sulfate1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Biological processIon transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 191 Publication
    Alternative name(s):
    Organic anion transporter 5Imported
    Gene namesi
    Name:Slc22a191 Publication
    Synonyms:Oat5Imported, Slc22a9Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    Proteomesi
    • UP000000589 Componenti: Chromosome 19

    Organism-specific databases

    MGIiMGI:2442751. Slc22a19.

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 5CytoplasmicCurated5
    Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
    Topological domaini27 – 145ExtracellularCuratedAdd BLAST119
    Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
    Topological domaini167 – 188CytoplasmicCuratedAdd BLAST22
    Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
    Topological domaini210 – 234ExtracellularCuratedAdd BLAST25
    Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
    Topological domaini256 – 259CytoplasmicCurated4
    Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
    Topological domaini281 – 349ExtracellularCuratedAdd BLAST69
    Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
    Topological domaini371 – 377CytoplasmicCurated7
    Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
    Topological domaini399 – 406ExtracellularCurated8
    Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
    Topological domaini428 – 434CytoplasmicCurated7
    Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
    Topological domaini456 – 468ExtracellularCuratedAdd BLAST13
    Transmembranei469 – 489HelicalSequence analysisAdd BLAST21
    Topological domaini490 – 495CytoplasmicCurated6
    Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
    Topological domaini517 – 551ExtracellularCuratedAdd BLAST35

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Chemistry databases

    ChEMBLiCHEMBL2073675.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00004410941 – 551Solute carrier family 22 member 19Add BLAST551

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8VCA0.
    PaxDbiQ6A4K9.

    PTM databases

    iPTMnetiQ8VCA0.
    PhosphoSitePlusiQ8VCA0.

    Expressioni

    Tissue specificityi

    Specifically expressed in kidney, where it localizes to proximal tubules of the outer medulla (at protein level) (PubMed:15068970, PubMed:16150593). Not detected in other tissues tested (PubMed:15068970).2 Publications

    Gene expression databases

    BgeeiENSMUSG00000024757.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8VCA0. 1 interactor.
    MINTiMINT-4119470.
    STRINGi10090.ENSMUSP00000025666.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0255. Eukaryota.
    COG0477. LUCA.
    GeneTreeiENSGT00760000118852.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    KOiK08206.
    OMAiCKRISLL.
    OrthoDBiEOG091G04GS.
    TreeFamiTF315847.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiView protein in InterPro
    IPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR036259. MFS_trans_sf.
    PfamiView protein in Pfam
    PF00083. Sugar_tr. 1 hit.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiView protein in PROSITE
    PS50850. MFS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8VCA0-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAFQDLIIQI GSLGRFQILH MIFVLICHAL SAPHTLLENF TAAIPSHRCW
    60 70 80 90 100
    VPILDNDTAS DNGSRILSQD DLLRISIPLD SNLRPDKCRR YIQPQWHLLH
    110 120 130 140 150
    LNGTFPTVTE PDTEPCVDGW VYDQSTFLST TVTQWDLVCG SQALNSVAKF
    160 170 180 190 200
    IYMTGIFIGY IMGGHLSDKF GRKLIFTCSL LKMAITETCV AFAPSFLIYC
    210 220 230 240 250
    SLRFLSGIFS STLRTNSALL ILEWTSPKFQ ALVMALIFIA SGVGQTLLGG
    260 270 280 290 300
    LAFAFRNWHH LQLALSVPMF LLLIPTRWLS ESARWLIMAN KPQKSLKELK
    310 320 330 340 350
    KAACVNRIKN SGDALTLEVV KTIMKEELEA AQTKPSPLDL FRTPNLRKRI
    360 370 380 390 400
    CLLSFVRFVS VMSLLGLLIN IQYLSNNVFL LQCLYGVVCI PANVLGNFSM
    410 420 430 440 450
    NYMGRRMTQL IFMSVLGISI LAVVFLPQEM QILRVFLSTL GGAISSASIT
    460 470 480 490 500
    STLVHANELV PTIIRATALG VVGIAGSAGG ALSPLLMILT TYSASLPWII
    510 520 530 540 550
    YGILPFLGGL VALLLPETKN QPLPDSIQDI ENKRKSSKEA KKDVVAKVTP

    L
    Length:551
    Mass (Da):60,864
    Last modified:March 1, 2002 - v1
    Checksum:i018589BC68C4DC20
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti538 – 540KEA → EET in AAQ09529 (Ref. 1) Curated3

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF529221 mRNA. Translation: AAQ09529.1.
    AC109225 Genomic DNA. No translation available.
    AC130693 Genomic DNA. No translation available.
    BC021384 mRNA. Translation: AAH21384.1.
    CH466612 Genomic DNA. Translation: EDL33322.1.
    CCDSiCCDS29532.1.
    RefSeqiNP_659034.1. NM_144785.2.
    UniGeneiMm.21365.

    Genome annotation databases

    EnsembliENSMUST00000025666; ENSMUSP00000025666; ENSMUSG00000024757.
    GeneIDi207151.
    KEGGimmu:207151.
    UCSCiuc008glo.2. mouse.

    Similar proteinsi

    Entry informationi

    Entry nameiS22AJ_MOUSE
    AccessioniPrimary (citable) accession number: Q8VCA0
    Secondary accession number(s): Q6A4K9
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
    Last sequence update: March 1, 2002
    Last modified: October 25, 2017
    This is version 118 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families