Q8VC97 (BUP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-ureidopropionase
EC=3.5.1.6

Alternative name(s):
Beta-alanine synthase
N-carbamoyl-beta-alanine amidohydrolase

Gene names

Name:

Upb1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide.
Catalytic activity	N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Enzyme regulation	Allosteric enzyme with positive cooperativity toward the substrate N-carbamoyl-beta-alanine By similarity.
Pathway	Amino-acid biosynthesis; beta-alanine biosynthesis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the CN hydrolase family. BUP subfamily. Contains 1 CN hydrolase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Allosteric enzyme Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-ureidopropionase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Beta-ureidopropionase		PRO_0000204052
Regions
	Domain	72 – 366	295	CN hydrolase
Sites
	Metal binding	97	1	Zinc Potential
	Metal binding	158	1	Zinc Potential
	Metal binding	280	1	Zinc Potential
	Metal binding	293	1	Zinc Potential
	Metal binding	307	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8VC97 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 442A33470A54BEBA	FASTA	393	43,937
	10 20 30 40 50 60 MAGPEWQSLE QCLEKHLPPD DLAQVKRILY GKQTRNLDLP REALKAASER NFELKGYAFG 70 80 90 100 110 120 AAKEQQRCPQ IVRVGLVQNR IPLPTSAPVA EQVSALHKSI EEIAEVAAMC GVNIICFQEA 130 140 150 160 170 180 WNMPFAFCTR EKLPWTEFAE SAEDGLTTRF CQKLAKKHNM VVVSPILERD REHGGVLWNT 190 200 210 220 230 240 AVVISNSGLV MGKTRKNHIP RVGDFNESTY YMEGNLGHPV FQTQFGRIAV NICYGRHHPL 250 260 270 280 290 300 NWLMYSINGA EIIFNPSATI GELSESLWPI EARNAAIANH CFTCALNRVG QEHFPNEFTS 310 320 330 340 350 360 GDGKKAHHDL GYFYGSSYVA APDGSRTPGL SRNQDGLLVT ELNLNLCQQI NDFWTFKMTG 370 380 390 RLEMYARELA EAVKPNYSPN IVKEDLVLAP SSG

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney and Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC021388 mRNA. Translation: AAH21388.1. BC024447 mRNA. Translation: AAH24447.1.
IPI	IPI00121639.
RefSeq	NP_598756.1. NM_133995.3.
UniGene	Mm.441195.
3D structure databases
ProteinModelPortal	Q8VC97.
SMR	Q8VC97. Positions 7-384.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VC97.
PTM databases
PhosphoSite	Q8VC97.
Proteomic databases
PRIDE	Q8VC97.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000039925; ENSMUSP00000049342; ENSMUSG00000033427.
GeneID	103149.
KEGG	mmu:103149.
NMPDR	fig|10090.3.peg.13860.
Organism-specific databases
CTD	51733.
MGI	MGI:2143535. Upb1.
Phylogenomic databases
GeneTree	ENSGT00390000004906.
HOGENOM	HBG742418.
HOVERGEN	HBG018848.
InParanoid	Q8VC97.
OMA	VGTEVFP.
OrthoDB	EOG43R3MV.
PhylomeDB	Q8VC97.
Gene expression databases
ArrayExpress	Q8VC97.
Bgee	Q8VC97.
CleanEx	MM_UPB1.
Genevestigator	Q8VC97.
GermOnline	ENSMUSG00000033427. Mus musculus.
Family and domain databases
InterPro	IPR003010. Ntlse/CNhydtse. [Graphical view]
Gene3D	G3DSA:3.60.110.10. Ntlse/CNhydtse. 1 hit.
KO	K01431.
Pfam	PF00795. CN_hydrolase. 1 hit. [Graphical view]
SUPFAM	SSF56317. Ntlse/CNhydtse. 1 hit.
PROSITE	PS50263. CN_HYDROLASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	355819.
SOURCE	Search...

Entry information

Entry name

BUP1_MOUSE

Accession

Primary (citable) accession number: Q8VC97
Secondary accession number(s): Q8R1K8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	March 1, 2002
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program