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Protein

Beta-ureidopropionase

Gene

Upb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts N-carbamoyl-beta-aminoisobutyrate and N-carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide.By similarity

Catalytic activityi

3-ureidopropanoate + H2O = beta-alanine + CO2 + NH3.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Enzyme regulationi

Allosteric enzyme with positive cooperativity toward the substrate N-carbamoyl-beta-alanine.By similarity

Pathwayi: beta-alanine biosynthesis

This protein is involved in the pathway beta-alanine biosynthesis, which is part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97ZincSequence analysis1
Active sitei119Proton acceptorPROSITE-ProRule annotation1
Metal bindingi158ZincSequence analysis1
Active sitei196Proton donorPROSITE-ProRule annotation1
Active sitei233NucleophilePROSITE-ProRule annotation1
Metal bindingi280ZincSequence analysis1
Metal bindingi293ZincSequence analysis1
Metal bindingi307ZincSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Hydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-73621 Pyrimidine catabolism
UniPathwayiUPA00131

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-ureidopropionase (EC:3.5.1.6)
Alternative name(s):
Beta-alanine synthase
N-carbamoyl-beta-alanine amidohydrolase
Gene namesi
Name:Upb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2143535 Upb1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040521 – 393Beta-ureidopropionaseAdd BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei378PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VC97
PaxDbiQ8VC97
PRIDEiQ8VC97

PTM databases

iPTMnetiQ8VC97
PhosphoSitePlusiQ8VC97
SwissPalmiQ8VC97

Expressioni

Gene expression databases

BgeeiENSMUSG00000033427
CleanExiMM_UPB1
ExpressionAtlasiQ8VC97 baseline and differential
GenevisibleiQ8VC97 MM

Interactioni

Protein-protein interaction databases

IntActiQ8VC97, 2 interactors
MINTiQ8VC97
STRINGi10090.ENSMUSP00000049342

Structurei

3D structure databases

ProteinModelPortaliQ8VC97
SMRiQ8VC97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 344CN hydrolasePROSITE-ProRule annotationAdd BLAST273

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0808 Eukaryota
COG0388 LUCA
GeneTreeiENSGT00390000004906
HOGENOMiHOG000222701
HOVERGENiHBG018848
InParanoidiQ8VC97
KOiK01431
OMAiVQNRTPL
OrthoDBiEOG091G087Q
PhylomeDBiQ8VC97
TreeFamiTF313402

Family and domain databases

Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VC97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPEWQSLE QCLEKHLPPD DLAQVKRILY GKQTRNLDLP REALKAASER
60 70 80 90 100
NFELKGYAFG AAKEQQRCPQ IVRVGLVQNR IPLPTSAPVA EQVSALHKSI
110 120 130 140 150
EEIAEVAAMC GVNIICFQEA WNMPFAFCTR EKLPWTEFAE SAEDGLTTRF
160 170 180 190 200
CQKLAKKHNM VVVSPILERD REHGGVLWNT AVVISNSGLV MGKTRKNHIP
210 220 230 240 250
RVGDFNESTY YMEGNLGHPV FQTQFGRIAV NICYGRHHPL NWLMYSINGA
260 270 280 290 300
EIIFNPSATI GELSESLWPI EARNAAIANH CFTCALNRVG QEHFPNEFTS
310 320 330 340 350
GDGKKAHHDL GYFYGSSYVA APDGSRTPGL SRNQDGLLVT ELNLNLCQQI
360 370 380 390
NDFWTFKMTG RLEMYARELA EAVKPNYSPN IVKEDLVLAP SSG
Length:393
Mass (Da):43,937
Last modified:March 1, 2002 - v1
Checksum:i442A33470A54BEBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021388 mRNA Translation: AAH21388.1
BC024447 mRNA Translation: AAH24447.1
CCDSiCCDS23925.1
RefSeqiNP_598756.1, NM_133995.4
UniGeneiMm.441195

Genome annotation databases

EnsembliENSMUST00000039925; ENSMUSP00000049342; ENSMUSG00000033427
GeneIDi103149
KEGGimmu:103149
UCSCiuc007fqj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBUP1_MOUSE
AccessioniPrimary (citable) accession number: Q8VC97
Secondary accession number(s): Q8R1K8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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