Skip Header

 
Contribute Send feedback
Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8VC97 (BUP1_MOUSE)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Beta-ureidopropionase
    EC=3.5.1.6
Alternative name(s):
    Beta-alanine synthase
    N-carbamoyl-beta-alanine amidohydrolase
Gene names
Name: Upb1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Converts N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide.

Catalytic activity

N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Enzyme regulation

Allosteric enzyme with positive cooperativity toward the substrate N-carbamoyl-beta-alanine By similarity.

Pathway

Amino-acid biosynthesis; beta-alanine biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the CN hydrolase family. BUP subfamily.

Contains 1 CN hydrolase domain.

Hide | Top

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termAllosteric enzyme
Gene Ontology (GO)
   Biological processnitrogen compound metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionbeta-ureidopropionase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Beta-ureidopropionase
PRO_0000204052

Regions

Domain72 – 366295CN hydrolase

Sites

Metal binding971Zinc Potential
Metal binding1581Zinc Potential
Metal binding2801Zinc Potential
Metal binding2931Zinc Potential
Metal binding3071Zinc Potential

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q8VC97-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 442A33470A54BEBA

FASTA39343,937
        10         20         30         40         50         60 
MAGPEWQSLE QCLEKHLPPD DLAQVKRILY GKQTRNLDLP REALKAASER NFELKGYAFG 

        70         80         90        100        110        120 
AAKEQQRCPQ IVRVGLVQNR IPLPTSAPVA EQVSALHKSI EEIAEVAAMC GVNIICFQEA 

       130        140        150        160        170        180 
WNMPFAFCTR EKLPWTEFAE SAEDGLTTRF CQKLAKKHNM VVVSPILERD REHGGVLWNT 

       190        200        210        220        230        240 
AVVISNSGLV MGKTRKNHIP RVGDFNESTY YMEGNLGHPV FQTQFGRIAV NICYGRHHPL 

       250        260        270        280        290        300 
NWLMYSINGA EIIFNPSATI GELSESLWPI EARNAAIANH CFTCALNRVG QEHFPNEFTS 

       310        320        330        340        350        360 
GDGKKAHHDL GYFYGSSYVA APDGSRTPGL SRNQDGLLVT ELNLNLCQQI NDFWTFKMTG 

       370        380        390 
RLEMYARELA EAVKPNYSPN IVKEDLVLAP SSG

« Hide

Hide | Top

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney and Liver.

Hide | Top

Cross-references

Sequence databases

BC021388 mRNA. Translation: AAH21388.1.
BC024447 mRNA. Translation: AAH24447.1.
IPIIPI00121639.
RefSeqNP_598756.1.
UniGeneMm.441195

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000033427. Mus musculus. [Contig view]
GeneID103149.
KEGGmmu:103149.
NMPDRfig|10090.3.peg.13860.

Organism-specific databases

MGIMGI:2143535. Upb1.

Phylogenomic databases

HOGENOMQ8VC97.
HOVERGENQ8VC97.
OMAQ8VC97. AIANSYF.

Enzyme and pathway databases

BRENDA3.5.1.6. 244.

Gene expression databases

ArrayExpressQ8VC97.
BgeeQ8VC97.
CleanExMM_UPB1.
GermOnlineENSMUSG00000033427. Mus musculus.

Family and domain databases

InterProIPR003010. Ntlse/CNhydtse.
[Graphical view]
Gene3DG3DSA:3.60.110.10. Ntlse/CNhydtse. 1 hit.
PfamPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PROSITEPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio355819.
SOURCESearch...

Hide | Top

Entry information

Entry nameBUP1_MOUSE
AccessionPrimary (citable) accession number: Q8VC97
Secondary accession number(s): Q8R1K8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2002
Last modified: June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents