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Protein

Beta-ureidopropionase

Gene

Upb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts N-carbamoyl-beta-aminoisobutyrate and N-carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide.By similarity

Catalytic activityi

3-ureidopropanoate + H2O = beta-alanine + CO2 + NH3.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Enzyme regulationi

Allosteric enzyme with positive cooperativity toward the substrate N-carbamoyl-beta-alanine.By similarity

Pathwayi: beta-alanine biosynthesis

This protein is involved in the pathway beta-alanine biosynthesis, which is part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971ZincSequence analysis
Active sitei119 – 1191Proton acceptorPROSITE-ProRule annotation
Metal bindingi158 – 1581ZincSequence analysis
Active sitei196 – 1961Proton donorPROSITE-ProRule annotation
Active sitei233 – 2331NucleophilePROSITE-ProRule annotation
Metal bindingi280 – 2801ZincSequence analysis
Metal bindingi293 – 2931ZincSequence analysis
Metal bindingi307 – 3071ZincSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-73621. Pyrimidine catabolism.
UniPathwayiUPA00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-ureidopropionase (EC:3.5.1.6)
Alternative name(s):
Beta-alanine synthase
N-carbamoyl-beta-alanine amidohydrolase
Gene namesi
Name:Upb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2143535. Upb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Beta-ureidopropionasePRO_0000204052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei378 – 3781PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VC97.
MaxQBiQ8VC97.
PaxDbiQ8VC97.
PRIDEiQ8VC97.

PTM databases

iPTMnetiQ8VC97.
PhosphoSiteiQ8VC97.

Expressioni

Gene expression databases

BgeeiQ8VC97.
CleanExiMM_UPB1.
ExpressionAtlasiQ8VC97. baseline and differential.
GenevisibleiQ8VC97. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8VC97. 2 interactions.
MINTiMINT-1855432.
STRINGi10090.ENSMUSP00000049342.

Structurei

3D structure databases

ProteinModelPortaliQ8VC97.
SMRiQ8VC97. Positions 7-384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 366295CN hydrolasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0808. Eukaryota.
COG0388. LUCA.
GeneTreeiENSGT00390000004906.
HOGENOMiHOG000222701.
HOVERGENiHBG018848.
InParanoidiQ8VC97.
KOiK01431.
OMAiRILYGVE.
OrthoDBiEOG7CCBR4.
PhylomeDBiQ8VC97.
TreeFamiTF313402.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR003010. C-N_Hydrolase.
[Graphical view]
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VC97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPEWQSLE QCLEKHLPPD DLAQVKRILY GKQTRNLDLP REALKAASER
60 70 80 90 100
NFELKGYAFG AAKEQQRCPQ IVRVGLVQNR IPLPTSAPVA EQVSALHKSI
110 120 130 140 150
EEIAEVAAMC GVNIICFQEA WNMPFAFCTR EKLPWTEFAE SAEDGLTTRF
160 170 180 190 200
CQKLAKKHNM VVVSPILERD REHGGVLWNT AVVISNSGLV MGKTRKNHIP
210 220 230 240 250
RVGDFNESTY YMEGNLGHPV FQTQFGRIAV NICYGRHHPL NWLMYSINGA
260 270 280 290 300
EIIFNPSATI GELSESLWPI EARNAAIANH CFTCALNRVG QEHFPNEFTS
310 320 330 340 350
GDGKKAHHDL GYFYGSSYVA APDGSRTPGL SRNQDGLLVT ELNLNLCQQI
360 370 380 390
NDFWTFKMTG RLEMYARELA EAVKPNYSPN IVKEDLVLAP SSG
Length:393
Mass (Da):43,937
Last modified:March 1, 2002 - v1
Checksum:i442A33470A54BEBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021388 mRNA. Translation: AAH21388.1.
BC024447 mRNA. Translation: AAH24447.1.
CCDSiCCDS23925.1.
RefSeqiNP_598756.1. NM_133995.4.
UniGeneiMm.441195.

Genome annotation databases

EnsembliENSMUST00000039925; ENSMUSP00000049342; ENSMUSG00000033427.
GeneIDi103149.
KEGGimmu:103149.
UCSCiuc007fqj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021388 mRNA. Translation: AAH21388.1.
BC024447 mRNA. Translation: AAH24447.1.
CCDSiCCDS23925.1.
RefSeqiNP_598756.1. NM_133995.4.
UniGeneiMm.441195.

3D structure databases

ProteinModelPortaliQ8VC97.
SMRiQ8VC97. Positions 7-384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VC97. 2 interactions.
MINTiMINT-1855432.
STRINGi10090.ENSMUSP00000049342.

PTM databases

iPTMnetiQ8VC97.
PhosphoSiteiQ8VC97.

Proteomic databases

EPDiQ8VC97.
MaxQBiQ8VC97.
PaxDbiQ8VC97.
PRIDEiQ8VC97.

Protocols and materials databases

DNASUi103149.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039925; ENSMUSP00000049342; ENSMUSG00000033427.
GeneIDi103149.
KEGGimmu:103149.
UCSCiuc007fqj.2. mouse.

Organism-specific databases

CTDi51733.
MGIiMGI:2143535. Upb1.

Phylogenomic databases

eggNOGiKOG0808. Eukaryota.
COG0388. LUCA.
GeneTreeiENSGT00390000004906.
HOGENOMiHOG000222701.
HOVERGENiHBG018848.
InParanoidiQ8VC97.
KOiK01431.
OMAiRILYGVE.
OrthoDBiEOG7CCBR4.
PhylomeDBiQ8VC97.
TreeFamiTF313402.

Enzyme and pathway databases

UniPathwayiUPA00131.
ReactomeiR-MMU-73621. Pyrimidine catabolism.

Miscellaneous databases

NextBioi355819.
PROiQ8VC97.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VC97.
CleanExiMM_UPB1.
ExpressionAtlasiQ8VC97. baseline and differential.
GenevisibleiQ8VC97. MM.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR003010. C-N_Hydrolase.
[Graphical view]
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Liver.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Liver.

Entry informationi

Entry nameiBUP1_MOUSE
AccessioniPrimary (citable) accession number: Q8VC97
Secondary accession number(s): Q8R1K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2002
Last modified: March 16, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.