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Protein

Probable palmitoyltransferase ZDHHC12

Gene

Zdhhc12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC12 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 12
Short name:
DHHC-12
Gene namesi
Name:Zdhhc12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913470. Zdhhc12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128851 – 267Probable palmitoyltransferase ZDHHC12Add BLAST267

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PeptideAtlasiQ8VC90.
PRIDEiQ8VC90.

PTM databases

PhosphoSitePlusiQ8VC90.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015335.
CleanExiMM_ZDHHC12.
GenevisibleiQ8VC90. MM.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 147DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063074.
HOGENOMiHOG000232097.
HOVERGENiHBG058239.
InParanoidiQ8VC90.
KOiK18932.
OMAiWPSGSWE.
OrthoDBiEOG091G0SSK.
PhylomeDBiQ8VC90.
TreeFamiTF329809.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VC90-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALWPPLNSG MLVRTGHTVL TWGITLVLFL HDTELRQWEE QGELLLPLTF
60 70 80 90 100
LLLVLSSLLL YLAVSLMDPG YVTTQPQPQG EPKEEQAAMV PQAVPLRRCR
110 120 130 140 150
HCLVLQPLRA RHCRDCRRCV RRYDHHCPWM ENCVGERNHP LFVAYLALQL
160 170 180 190 200
VVLLWGLCLA WSGLQFFQPW GLWLRSTGLL FTTFLLLSFF ALVVALLLAS
210 220 230 240 250
HLYLVARNTT TWEFISSHRI AYLRQRTSNP FDRGPTRNLA HFFCGWPSGP
260
WETLSAEEEE EGSSQVV
Length:267
Mass (Da):30,708
Last modified:March 1, 2002 - v1
Checksum:iBFBE43C83061FA44
GO
Isoform 2 (identifier: Q8VC90-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-34: E → GEPDTAPPRAHPITQ

Note: No experimental confirmation available.
Show »
Length:281
Mass (Da):32,147
Checksum:iCF51854B19021474
GO

Sequence cautioni

The sequence AK013074 differs from that shown. Reason: Frameshift at position 247.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20L → P in AK013074 (PubMed:16141072).Curated1
Sequence conflicti179L → F in BAC39965 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00694634E → GEPDTAPPRAHPITQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087676 mRNA. Translation: BAC39965.1.
AK013074 mRNA. No translation available.
BC021432 mRNA. Translation: AAH21432.1.
CCDSiCCDS15868.1. [Q8VC90-1]
CCDS15869.1. [Q8VC90-2]
RefSeqiNP_001032851.1. NM_001037762.1. [Q8VC90-1]
NP_079704.2. NM_025428.2. [Q8VC90-2]
UniGeneiMm.22538.

Genome annotation databases

EnsembliENSMUST00000081838; ENSMUSP00000080521; ENSMUSG00000015335. [Q8VC90-2]
ENSMUST00000102865; ENSMUSP00000099929; ENSMUSG00000015335. [Q8VC90-1]
GeneIDi66220.
KEGGimmu:66220.
UCSCiuc008jbd.1. mouse. [Q8VC90-2]
uc008jbe.1. mouse. [Q8VC90-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDH12_MOUSE
AccessioniPrimary (citable) accession number: Q8VC90
Secondary accession number(s): Q9CZ24, Q9D0T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families