Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8VC88

- GRAN_MOUSE

UniProt

Q8VC88 - GRAN_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Grancalcin

Gene

Gca

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi105 – 116121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi135 – 146122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
  2. calcium ion binding Source: UniProtKB

GO - Biological processi

  1. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Grancalcin
Gene namesi
Name:Gca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1918521. Gca.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmic granule membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. cytosol Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Not essential for normal resistance to microbial infections. Grancalcin-deficient neutrophils exhibit decreased adhesion to fibronectin, and a strongly reduced number of focal adhesion complexes.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220GrancalcinPRO_0000073722Add
BLAST

Proteomic databases

MaxQBiQ8VC88.
PaxDbiQ8VC88.
PRIDEiQ8VC88.

2D gel databases

REPRODUCTION-2DPAGEIPI00308789.

PTM databases

PhosphoSiteiQ8VC88.

Expressioni

Gene expression databases

BgeeiQ8VC88.
CleanExiMM_GCA.
GenevestigatoriQ8VC88.

Interactioni

Subunit structurei

Homodimer. Interacts with SRI and LCP1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8VC88.
SMRiQ8VC88. Positions 56-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 8636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini92 – 12736EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini122 – 15736EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini158 – 19336EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG298587.
GeneTreeiENSGT00620000087734.
HOGENOMiHOG000231982.
HOVERGENiHBG004492.
InParanoidiQ8VC88.
OMAiSAGDPMW.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ8VC88.
TreeFamiTF314682.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VC88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYPGYGGAF GNFSGQIPGM QMQMGQPMPG AGPNMFSGGY PGYLGYSDSY
60 70 80 90 100
SPADDSMWTY FTAVAGQDGE VDAEELQRCL TQSGISGTYA PFSLETCRIM
110 120 130 140 150
IAMLDRDYTG KMGFNEFKEL WAALNAWKQN FMTIDQDQSG TVEHHELSQA
160 170 180 190 200
IALMGYRLSP QTLAAIVRRY SKNGRIFFDD YVACCVKLRA LTDFFRRRDH
210 220
LQQGIVNFMY EDFLQGTMTI
Length:220
Mass (Da):24,663
Last modified:March 1, 2002 - v1
Checksum:i694DCA7D6ADF8279
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1882KL → NV in AAM66720. (PubMed:12529388)Curated
Sequence conflicti217 – 2171T → P in BAC32686. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518325 mRNA. Translation: AAM66720.1.
AB088388 mRNA. Translation: BAC07231.1.
AK033740 mRNA. Translation: BAC28458.1.
AK046347 mRNA. Translation: BAC32686.1.
AK049317 mRNA. Translation: BAC33679.1.
AK050540 mRNA. Translation: BAC34315.1.
AK078915 mRNA. Translation: BAC37457.1.
BC021450 mRNA. Translation: AAH21450.1.
CCDSiCCDS16069.1.
RefSeqiNP_663498.1. NM_145523.3.
UniGeneiMm.219877.

Genome annotation databases

EnsembliENSMUST00000028257; ENSMUSP00000028257; ENSMUSG00000026893.
GeneIDi227960.
KEGGimmu:227960.
UCSCiuc008jvp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518325 mRNA. Translation: AAM66720.1 .
AB088388 mRNA. Translation: BAC07231.1 .
AK033740 mRNA. Translation: BAC28458.1 .
AK046347 mRNA. Translation: BAC32686.1 .
AK049317 mRNA. Translation: BAC33679.1 .
AK050540 mRNA. Translation: BAC34315.1 .
AK078915 mRNA. Translation: BAC37457.1 .
BC021450 mRNA. Translation: AAH21450.1 .
CCDSi CCDS16069.1.
RefSeqi NP_663498.1. NM_145523.3.
UniGenei Mm.219877.

3D structure databases

ProteinModelPortali Q8VC88.
SMRi Q8VC88. Positions 56-220.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8VC88.

2D gel databases

REPRODUCTION-2DPAGE IPI00308789.

Proteomic databases

MaxQBi Q8VC88.
PaxDbi Q8VC88.
PRIDEi Q8VC88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028257 ; ENSMUSP00000028257 ; ENSMUSG00000026893 .
GeneIDi 227960.
KEGGi mmu:227960.
UCSCi uc008jvp.1. mouse.

Organism-specific databases

CTDi 25801.
MGIi MGI:1918521. Gca.

Phylogenomic databases

eggNOGi NOG298587.
GeneTreei ENSGT00620000087734.
HOGENOMi HOG000231982.
HOVERGENi HBG004492.
InParanoidi Q8VC88.
OMAi SAGDPMW.
OrthoDBi EOG7RV9FM.
PhylomeDBi Q8VC88.
TreeFami TF314682.

Miscellaneous databases

NextBioi 378876.
PROi Q8VC88.
SOURCEi Search...

Gene expression databases

Bgeei Q8VC88.
CleanExi MM_GCA.
Genevestigatori Q8VC88.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Granulocyte function in grancalcin-deficient mice."
    Roes J., Choi B.K., Power D., Xu P., Segal A.W.
    Mol. Cell. Biol. 23:826-830(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE.
  2. "Characterization of murine grancalcin specifically expressed in leukocytes and its possible role in host defense against bacterial infection."
    Liu F., Shinomiya H., Kirikae T., Hirata H., Asano Y.
    Biosci. Biotechnol. Biochem. 68:894-902(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum, Corpora quadrigemina and Pancreas.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. "The role of grancalcin in adhesion of neutrophils."
    Xu P., Roes J., Segal A.W., Radulovic M.
    Cell. Immunol. 240:116-121(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.

Entry informationi

Entry nameiGRAN_MOUSE
AccessioniPrimary (citable) accession number: Q8VC88
Secondary accession number(s): Q8BL53, Q8K3Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has been shown to bind calcium with high affinity.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3