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Protein

U6 snRNA-associated Sm-like protein LSm1

Gene

Lsm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • deadenylation-dependent decapping of nuclear-transcribed mRNA Source: GO_Central
  • histone mRNA catabolic process Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • negative regulation of neuron differentiation Source: MGI
  • RNA splicing Source: UniProtKB-KW
  • stem cell population maintenance Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm1
Gene namesi
Name:Lsm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914457. Lsm1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytoplasm Source: MGI
  • cytoplasmic mRNA processing body Source: MGI
  • dendrite Source: Ensembl
  • messenger ribonucleoprotein complex Source: Ensembl
  • neuronal cell body Source: Ensembl
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133U6 snRNA-associated Sm-like protein LSm1PRO_0000125555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231PhosphoserineBy similarity
Modified residuei129 – 1291PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VC85.
MaxQBiQ8VC85.
PaxDbiQ8VC85.
PRIDEiQ8VC85.

2D gel databases

REPRODUCTION-2DPAGEQ8VC85.

PTM databases

iPTMnetiQ8VC85.
PhosphoSiteiQ8VC85.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037296.
ExpressionAtlasiQ8VC85. baseline and differential.
GenevisibleiQ8VC85. MM.

Interactioni

Subunit structurei

Interacts with SLBP. Interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a doughnut shape (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-60113N.
STRINGi10090.ENSMUSP00000041022.

Structurei

3D structure databases

ProteinModelPortaliQ8VC85.
SMRiQ8VC85. Positions 7-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1782. Eukaryota.
ENOG411224Q. LUCA.
GeneTreeiENSGT00730000111133.
HOGENOMiHOG000223544.
HOVERGENiHBG027238.
InParanoidiQ8VC85.
KOiK12620.
OMAiFHQTVER.
OrthoDBiEOG091G0UEO.
PhylomeDBiQ8VC85.
TreeFamiTF105846.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VC85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYMPGTASL IEDIDKKHLV LLRDGRTLIG FLRSIDQFAN LVLHQTVERI
60 70 80 90 100
HVGKKYGDIP RGIFVVRGEN VVLLGEIDLE KESDTPLQQV SIEEILEEQR
110 120 130
VQQQTRLEAE KLKVQTLKDR GLSIPRADTL DEY
Length:133
Mass (Da):15,236
Last modified:March 1, 2002 - v1
Checksum:i92A34D7205CE036F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021460 mRNA. Translation: AAH21460.1.
CCDSiCCDS22202.1.
RefSeqiNP_080308.1. NM_026032.1.
UniGeneiMm.30198.

Genome annotation databases

EnsembliENSMUST00000038421; ENSMUSP00000041022; ENSMUSG00000037296.
GeneIDi67207.
KEGGimmu:67207.
UCSCiuc009lgz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021460 mRNA. Translation: AAH21460.1.
CCDSiCCDS22202.1.
RefSeqiNP_080308.1. NM_026032.1.
UniGeneiMm.30198.

3D structure databases

ProteinModelPortaliQ8VC85.
SMRiQ8VC85. Positions 7-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60113N.
STRINGi10090.ENSMUSP00000041022.

PTM databases

iPTMnetiQ8VC85.
PhosphoSiteiQ8VC85.

2D gel databases

REPRODUCTION-2DPAGEQ8VC85.

Proteomic databases

EPDiQ8VC85.
MaxQBiQ8VC85.
PaxDbiQ8VC85.
PRIDEiQ8VC85.

Protocols and materials databases

DNASUi67207.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038421; ENSMUSP00000041022; ENSMUSG00000037296.
GeneIDi67207.
KEGGimmu:67207.
UCSCiuc009lgz.1. mouse.

Organism-specific databases

CTDi27257.
MGIiMGI:1914457. Lsm1.

Phylogenomic databases

eggNOGiKOG1782. Eukaryota.
ENOG411224Q. LUCA.
GeneTreeiENSGT00730000111133.
HOGENOMiHOG000223544.
HOVERGENiHBG027238.
InParanoidiQ8VC85.
KOiK12620.
OMAiFHQTVER.
OrthoDBiEOG091G0UEO.
PhylomeDBiQ8VC85.
TreeFamiTF105846.

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.

Miscellaneous databases

PROiQ8VC85.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037296.
ExpressionAtlasiQ8VC85. baseline and differential.
GenevisibleiQ8VC85. MM.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSM1_MOUSE
AccessioniPrimary (citable) accession number: Q8VC85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.