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Protein

Rhomboid-related protein 1

Gene

Rhbdl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.By similarity

Catalytic activityi

Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei247NucleophileBy similarity1
Active sitei312By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS54.005

Names & Taxonomyi

Protein namesi
Recommended name:
Rhomboid-related protein 1 (EC:3.4.21.105)
Short name:
RRP
Alternative name(s):
Rhomboid-like protein 1
Gene namesi
Name:Rhbdl1
Synonyms:Rhbdl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2384891 Rhbdl1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei275 – 294HelicalSequence analysisAdd BLAST20
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061741 – 373Rhomboid-related protein 1Add BLAST373

Proteomic databases

PaxDbiQ8VC82
PRIDEiQ8VC82

PTM databases

iPTMnetiQ8VC82
PhosphoSitePlusiQ8VC82

Expressioni

Gene expression databases

BgeeiENSMUSG00000025735
CleanExiMM_RHBDL1
ExpressionAtlasiQ8VC82 baseline and differential
GenevisibleiQ8VC82 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026831

Chemistry databases

BindingDBiQ8VC82

Structurei

3D structure databases

ProteinModelPortaliQ8VC82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2289 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00390000005726
HOGENOMiHOG000231407
HOVERGENiHBG059476
InParanoidiQ8VC82
KOiK02857
OMAiWNIFAYE
OrthoDBiEOG091G12OK
PhylomeDBiQ8VC82
TreeFamiTF313540

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR017213 Peptidase_S54_rhomboid_met
IPR035952 Rhomboid-like_sf
PANTHERiPTHR22936 PTHR22936, 1 hit
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
PIRSFiPIRSF037470 Rhomboid, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VC82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSSLLQLI QEQQLDPENT GFIGADTFAG LVHSHELPLD PTKLDMLVAL
60 70 80 90 100
AQSNERGQVC YQELVDLISS KRSSSFKRAI ANGQRALPRD GLLDEPGLSV
110 120 130 140 150
YKRFVRYVAY EILPCEVDRR WYFYRHRTCP PPVFMASVTL AQIIVFLCYG
160 170 180 190 200
ARLNKWVLQT YHPEYMKSPL VYHPGHRARA WRFLTYMFMH VGLEQLGFNA
210 220 230 240 250
LLQLMIGVPL EMVHGVLRIS LLYLAGVLAG SLTVSITDMR APVVGGSGGV
260 270 280 290 300
YALCSAHLAN VVMNWAGMRC PYKLLRMVLA LVCMSSEVGR AVWLRFSPPL
310 320 330 340 350
PASGPQPSFM AHLAGAVVGV SMGLTILRSY EERLRDQCGW WVVLLAYGTF
360 370
LLFAIFWNVF AYDLLGADIP PPP
Length:373
Mass (Da):41,786
Last modified:March 1, 2002 - v1
Checksum:i1F4E538B3A363D2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021549 mRNA Translation: AAH21549.1
CCDSiCCDS28534.1
RefSeqiNP_659065.1, NM_144816.1
UniGeneiMm.490018

Genome annotation databases

EnsembliENSMUST00000026831; ENSMUSP00000026831; ENSMUSG00000025735
GeneIDi214951
KEGGimmu:214951
UCSCiuc008bcg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRHBL1_MOUSE
AccessioniPrimary (citable) accession number: Q8VC82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health