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Protein

Rhomboid-related protein 1

Gene

Rhbdl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.By similarity

Catalytic activityi

Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei247 – 2471NucleophileBy similarity
Active sitei312 – 3121By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS54.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhomboid-related protein 1 (EC:3.4.21.105)
Short name:
RRP
Alternative name(s):
Rhomboid-like protein 1
Gene namesi
Name:Rhbdl1
Synonyms:Rhbdl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2384891. Rhbdl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST
Transmembranei275 – 29420HelicalSequence analysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence analysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Rhomboid-related protein 1PRO_0000206174Add
BLAST

Proteomic databases

PaxDbiQ8VC82.
PRIDEiQ8VC82.

PTM databases

iPTMnetiQ8VC82.
PhosphoSiteiQ8VC82.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025735.
CleanExiMM_RHBDL1.
ExpressionAtlasiQ8VC82. baseline and differential.
GenevisibleiQ8VC82. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997817.
STRINGi10090.ENSMUSP00000026831.

Chemistry

BindingDBiQ8VC82.

Structurei

3D structure databases

ProteinModelPortaliQ8VC82.
SMRiQ8VC82. Positions 44-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2289. Eukaryota.
COG0705. LUCA.
GeneTreeiENSGT00390000005726.
HOGENOMiHOG000231407.
HOVERGENiHBG059476.
InParanoidiQ8VC82.
KOiK02857.
OMAiERLQDQC.
OrthoDBiEOG091G12OK.
PhylomeDBiQ8VC82.
TreeFamiTF313540.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.1540.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR017213. Peptidase_S54_rhomboid_met.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
[Graphical view]
PIRSFiPIRSF037470. Rhomboid. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VC82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSSLLQLI QEQQLDPENT GFIGADTFAG LVHSHELPLD PTKLDMLVAL
60 70 80 90 100
AQSNERGQVC YQELVDLISS KRSSSFKRAI ANGQRALPRD GLLDEPGLSV
110 120 130 140 150
YKRFVRYVAY EILPCEVDRR WYFYRHRTCP PPVFMASVTL AQIIVFLCYG
160 170 180 190 200
ARLNKWVLQT YHPEYMKSPL VYHPGHRARA WRFLTYMFMH VGLEQLGFNA
210 220 230 240 250
LLQLMIGVPL EMVHGVLRIS LLYLAGVLAG SLTVSITDMR APVVGGSGGV
260 270 280 290 300
YALCSAHLAN VVMNWAGMRC PYKLLRMVLA LVCMSSEVGR AVWLRFSPPL
310 320 330 340 350
PASGPQPSFM AHLAGAVVGV SMGLTILRSY EERLRDQCGW WVVLLAYGTF
360 370
LLFAIFWNVF AYDLLGADIP PPP
Length:373
Mass (Da):41,786
Last modified:March 1, 2002 - v1
Checksum:i1F4E538B3A363D2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021549 mRNA. Translation: AAH21549.1.
CCDSiCCDS28534.1.
RefSeqiNP_659065.1. NM_144816.1.
UniGeneiMm.490018.

Genome annotation databases

EnsembliENSMUST00000026831; ENSMUSP00000026831; ENSMUSG00000025735.
GeneIDi214951.
KEGGimmu:214951.
UCSCiuc008bcg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021549 mRNA. Translation: AAH21549.1.
CCDSiCCDS28534.1.
RefSeqiNP_659065.1. NM_144816.1.
UniGeneiMm.490018.

3D structure databases

ProteinModelPortaliQ8VC82.
SMRiQ8VC82. Positions 44-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997817.
STRINGi10090.ENSMUSP00000026831.

Chemistry

BindingDBiQ8VC82.

Protein family/group databases

MEROPSiS54.005.

PTM databases

iPTMnetiQ8VC82.
PhosphoSiteiQ8VC82.

Proteomic databases

PaxDbiQ8VC82.
PRIDEiQ8VC82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026831; ENSMUSP00000026831; ENSMUSG00000025735.
GeneIDi214951.
KEGGimmu:214951.
UCSCiuc008bcg.1. mouse.

Organism-specific databases

CTDi9028.
MGIiMGI:2384891. Rhbdl1.

Phylogenomic databases

eggNOGiKOG2289. Eukaryota.
COG0705. LUCA.
GeneTreeiENSGT00390000005726.
HOGENOMiHOG000231407.
HOVERGENiHBG059476.
InParanoidiQ8VC82.
KOiK02857.
OMAiERLQDQC.
OrthoDBiEOG091G12OK.
PhylomeDBiQ8VC82.
TreeFamiTF313540.

Miscellaneous databases

PROiQ8VC82.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025735.
CleanExiMM_RHBDL1.
ExpressionAtlasiQ8VC82. baseline and differential.
GenevisibleiQ8VC82. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.1540.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR017213. Peptidase_S54_rhomboid_met.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
[Graphical view]
PIRSFiPIRSF037470. Rhomboid. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHBL1_MOUSE
AccessioniPrimary (citable) accession number: Q8VC82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.