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Protein

RNA-binding motif, single-stranded-interacting protein 2

Gene

Rbms2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif, single-stranded-interacting protein 2
Gene namesi
Name:Rbms2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1861776. Rbms2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383RNA-binding motif, single-stranded-interacting protein 2PRO_0000081801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei108 – 1081PhosphoserineBy similarity
Modified residuei287 – 2871PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8VC70.
MaxQBiQ8VC70.
PaxDbiQ8VC70.
PeptideAtlasiQ8VC70.
PRIDEiQ8VC70.

PTM databases

iPTMnetiQ8VC70.
PhosphoSiteiQ8VC70.

Expressioni

Gene expression databases

BgeeiQ8VC70.
ExpressionAtlasiQ8VC70. baseline and differential.
GenevisibleiQ8VC70. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089664.

Structurei

3D structure databases

ProteinModelPortaliQ8VC70.
SMRiQ8VC70. Positions 56-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 13174RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 22286RRM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4733. Eukaryota.
ENOG410XRB5. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000008467.
HOVERGENiHBG053108.
InParanoidiQ8VC70.
OMAiPGMDHPL.
OrthoDBiEOG71G9V3.
PhylomeDBiQ8VC70.
TreeFamiTF314644.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VC70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSVTSRPG ISTFGYNKNN KKLYVAQQMA PPSPRNSTPN SSGGGGGGSG
60 70 80 90 100
GNDQLSKTNL YIRGLQPGTT DQDLVKLCQP YGKIVSTKAI LDKTTNKCKG
110 120 130 140 150
YGFVDFDSPS SAQKAVTALK ASGVQAQMAK QQEQDPTNLY ISNLPLSMDE
160 170 180 190 200
QELEGMLKPF GQVISTRILR DTSGASRGVG FARMESTEKC EAIITHFNGK
210 220 230 240 250
YIKTPPGVAA PSDPLLCKFA DGGPKKRQSQ GRYVQNGRAW PRNGDMGGMA
260 270 280 290 300
LTYDPTAALQ NGFYAAPYSI AHSRMLAQSA LAPYLPSPVS SYQGSVLTPG
310 320 330 340 350
MDHPLSLQPA SMMGPLTQQL GHLSLNSLGT FMPAAAAMHG AYISQYPAVP
360 370 380
SSSVSAEESN GQQNQLAVEP PSDHGVYPFQ FSK
Length:383
Mass (Da):40,724
Last modified:March 1, 2002 - v1
Checksum:i2CD11874A92CEBEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021627 mRNA. Translation: AAH21627.1.
AK054482 mRNA. Translation: BAC35797.1.
CCDSiCCDS24261.1.
RefSeqiNP_001034169.1. NM_001039080.1.
NP_062685.2. NM_019711.2.
XP_006513962.1. XM_006513899.1.
XP_006513963.1. XM_006513900.1.
UniGeneiMm.42247.

Genome annotation databases

EnsembliENSMUST00000092033; ENSMUSP00000089664; ENSMUSG00000040043.
GeneIDi56516.
KEGGimmu:56516.
UCSCiuc007hlm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021627 mRNA. Translation: AAH21627.1.
AK054482 mRNA. Translation: BAC35797.1.
CCDSiCCDS24261.1.
RefSeqiNP_001034169.1. NM_001039080.1.
NP_062685.2. NM_019711.2.
XP_006513962.1. XM_006513899.1.
XP_006513963.1. XM_006513900.1.
UniGeneiMm.42247.

3D structure databases

ProteinModelPortaliQ8VC70.
SMRiQ8VC70. Positions 56-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089664.

PTM databases

iPTMnetiQ8VC70.
PhosphoSiteiQ8VC70.

Proteomic databases

EPDiQ8VC70.
MaxQBiQ8VC70.
PaxDbiQ8VC70.
PeptideAtlasiQ8VC70.
PRIDEiQ8VC70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092033; ENSMUSP00000089664; ENSMUSG00000040043.
GeneIDi56516.
KEGGimmu:56516.
UCSCiuc007hlm.1. mouse.

Organism-specific databases

CTDi5939.
MGIiMGI:1861776. Rbms2.

Phylogenomic databases

eggNOGiKOG4733. Eukaryota.
ENOG410XRB5. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000008467.
HOVERGENiHBG053108.
InParanoidiQ8VC70.
OMAiPGMDHPL.
OrthoDBiEOG71G9V3.
PhylomeDBiQ8VC70.
TreeFamiTF314644.

Miscellaneous databases

ChiTaRSiRbms2. mouse.
PROiQ8VC70.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VC70.
ExpressionAtlasiQ8VC70. baseline and differential.
GenevisibleiQ8VC70. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Ovary.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart and Lung.

Entry informationi

Entry nameiRBMS2_MOUSE
AccessioniPrimary (citable) accession number: Q8VC70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.