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Protein

BTB/POZ domain-containing protein KCTD5

Gene

Kctd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD5
Gene namesi
Name:Kctd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916509. Kctd5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912922 – 234BTB/POZ domain-containing protein KCTD5Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VC57.
MaxQBiQ8VC57.
PaxDbiQ8VC57.
PRIDEiQ8VC57.

PTM databases

iPTMnetiQ8VC57.
PhosphoSitePlusiQ8VC57.

Interactioni

Subunit structurei

Homopentamer (By similarity). Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213321. 87 interactors.
IntActiQ8VC57. 87 interactors.
STRINGi10090.ENSMUSP00000017090.

Structurei

3D structure databases

ProteinModelPortaliQ8VC57.
SMRiQ8VC57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 146BTBAdd BLAST103

Domaini

The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118 (By similarity).By similarity

Phylogenomic databases

eggNOGiKOG2715. Eukaryota.
ENOG410XT4J. LUCA.
HOVERGENiHBG053302.
InParanoidiQ8VC57.
KOiK21914.
PhylomeDBiQ8VC57.
TreeFamiTF313754.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VC57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENHCELLP PAPSGLGAGL GGGLCRRCSA GMGALAQRPG GVSKWVRLNV
60 70 80 90 100
GGTYFLTTRQ TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG
110 120 130 140 150
PVLNYLRHGK LVINKDLAEE GVLEEAEFYN ITSLIKLVKD KIRERDSRIS
160 170 180 190 200
QMPVKHVYRV LQCQEEELTQ MVSTMSDGWK FEQLVSIGSS YNYGNEDQAE
210 220 230
FLCVVSKELH NTPYGTTSEP SEKAKILQER GSRM
Length:234
Mass (Da):26,164
Last modified:March 1, 2002 - v1
Checksum:i915F4796A139755E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148R → K in BAE25476 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162410 Genomic DNA. Translation: AAO17163.1.
AK143644 mRNA. Translation: BAE25476.1.
BC021777 mRNA. Translation: AAH21777.1.
CCDSiCCDS28473.1.
RefSeqiNP_081284.2. NM_027008.2.
UniGeneiMm.28171.
Mm.395963.

Genome annotation databases

GeneIDi69259.
KEGGimmu:69259.
UCSCiuc008auh.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiKCTD5_MOUSE
AccessioniPrimary (citable) accession number: Q8VC57
Secondary accession number(s): Q3UPC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot