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Protein

BTB/POZ domain-containing protein KCTD5

Gene

Kctd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD5
Gene namesi
Name:Kctd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916509. Kctd5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912922 – 234BTB/POZ domain-containing protein KCTD5Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VC57.
MaxQBiQ8VC57.
PaxDbiQ8VC57.
PRIDEiQ8VC57.

PTM databases

iPTMnetiQ8VC57.
PhosphoSitePlusiQ8VC57.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016946.

Interactioni

Subunit structurei

Homopentamer (By similarity). Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213321. 87 interactors.
IntActiQ8VC57. 87 interactors.
STRINGi10090.ENSMUSP00000017090.

Structurei

3D structure databases

ProteinModelPortaliQ8VC57.
SMRiQ8VC57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 146BTBAdd BLAST103

Domaini

The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118 (By similarity).By similarity

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2715. Eukaryota.
ENOG410XT4J. LUCA.
HOVERGENiHBG053302.
InParanoidiQ8VC57.
PhylomeDBiQ8VC57.
TreeFamiTF313754.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VC57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENHCELLP PAPSGLGAGL GGGLCRRCSA GMGALAQRPG GVSKWVRLNV
60 70 80 90 100
GGTYFLTTRQ TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG
110 120 130 140 150
PVLNYLRHGK LVINKDLAEE GVLEEAEFYN ITSLIKLVKD KIRERDSRIS
160 170 180 190 200
QMPVKHVYRV LQCQEEELTQ MVSTMSDGWK FEQLVSIGSS YNYGNEDQAE
210 220 230
FLCVVSKELH NTPYGTTSEP SEKAKILQER GSRM
Length:234
Mass (Da):26,164
Last modified:March 1, 2002 - v1
Checksum:i915F4796A139755E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148R → K in BAE25476 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162410 Genomic DNA. Translation: AAO17163.1.
AK143644 mRNA. Translation: BAE25476.1.
BC021777 mRNA. Translation: AAH21777.1.
CCDSiCCDS28473.1.
RefSeqiNP_081284.2. NM_027008.2.
UniGeneiMm.28171.
Mm.395963.

Genome annotation databases

GeneIDi69259.
KEGGimmu:69259.
UCSCiuc008auh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162410 Genomic DNA. Translation: AAO17163.1.
AK143644 mRNA. Translation: BAE25476.1.
BC021777 mRNA. Translation: AAH21777.1.
CCDSiCCDS28473.1.
RefSeqiNP_081284.2. NM_027008.2.
UniGeneiMm.28171.
Mm.395963.

3D structure databases

ProteinModelPortaliQ8VC57.
SMRiQ8VC57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213321. 87 interactors.
IntActiQ8VC57. 87 interactors.
STRINGi10090.ENSMUSP00000017090.

PTM databases

iPTMnetiQ8VC57.
PhosphoSitePlusiQ8VC57.

Proteomic databases

EPDiQ8VC57.
MaxQBiQ8VC57.
PaxDbiQ8VC57.
PRIDEiQ8VC57.

Protocols and materials databases

DNASUi69259.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69259.
KEGGimmu:69259.
UCSCiuc008auh.2. mouse.

Organism-specific databases

CTDi54442.
MGIiMGI:1916509. Kctd5.

Phylogenomic databases

eggNOGiKOG2715. Eukaryota.
ENOG410XT4J. LUCA.
HOVERGENiHBG053302.
InParanoidiQ8VC57.
PhylomeDBiQ8VC57.
TreeFamiTF313754.

Miscellaneous databases

PROiQ8VC57.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016946.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCTD5_MOUSE
AccessioniPrimary (citable) accession number: Q8VC57
Secondary accession number(s): Q3UPC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.