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Protein

Peroxisome assembly protein 12

Gene

Pex12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for protein import into peroxisomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Gene namesi
Name:Pex12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144177. Pex12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 158CytoplasmicSequence analysisAdd BLAST158
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 239Peroxisomal matrixSequence analysisAdd BLAST60
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 359CytoplasmicSequence analysisAdd BLAST99

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186111 – 359Peroxisome assembly protein 12Add BLAST359

Proteomic databases

MaxQBiQ8VC48.
PaxDbiQ8VC48.
PRIDEiQ8VC48.

PTM databases

PhosphoSitePlusiQ8VC48.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018733.
CleanExiMM_PEX12.
ExpressionAtlasiQ8VC48. baseline and differential.
GenevisibleiQ8VC48. MM.

Interactioni

Subunit structurei

Interacts with PEX5 and PEX10. Interacts with PEX19 via its cytoplasmic domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018877.

Structurei

3D structure databases

ProteinModelPortaliQ8VC48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 285Poly-Pro6

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0826. Eukaryota.
ENOG410Y4Q2. LUCA.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
HOVERGENiHBG053569.
InParanoidiQ8VC48.
KOiK13345.
OMAiFHYVRSH.
OrthoDBiEOG091G0BN4.
PhylomeDBiQ8VC48.
TreeFamiTF314511.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
PIRSFiPIRSF038074. Peroxisome_assembly_p12. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VC48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEYGAHITT ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPA
60 70 80 90 100
HYGFLWRWFD EIFTLLDFLL QQHYLSRTSA SFSEHFYGLK RIVAGSSPHL
110 120 130 140 150
QRPASAGLPK EHLWKSAMFL VLLPYLKVKL EKLASSLREE DEYSIHPPSS
160 170 180 190 200
RWKRFYRAFL AAYPFVNMAW EGWFLTQQLR YILGKAEHHS PLLKLAGVRL
210 220 230 240 250
ARLTAQDMQA IKQRLVEASA MQEPVRSVGE KIKSALKKAV GGVALSLSTG
260 270 280 290 300
LSVGVFFLQF LDWWYSSENQ EAIKSLTALP TPPPPVHLDY NSDSPLLPKM
310 320 330 340 350
KTVCPLCRKT RVNDTVLATS GYVFCYRCVF NYVRSHQACP ITGYPTEVQH

LIKLYSPEN
Length:359
Mass (Da):40,633
Last modified:March 1, 2002 - v1
Checksum:i20FABDFC806E9315
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021800 mRNA. Translation: AAH21800.1.
CCDSiCCDS25160.1.
RefSeqiNP_598786.1. NM_134025.3.
XP_006531976.1. XM_006531913.1.
XP_006531977.1. XM_006531914.2.
XP_006531978.1. XM_006531915.2.
UniGeneiMm.102205.

Genome annotation databases

EnsembliENSMUST00000018877; ENSMUSP00000018877; ENSMUSG00000018733.
ENSMUST00000108146; ENSMUSP00000103781; ENSMUSG00000018733.
ENSMUST00000175741; ENSMUSP00000135145; ENSMUSG00000018733.
ENSMUST00000176518; ENSMUSP00000135632; ENSMUSG00000018733.
GeneIDi103737.
KEGGimmu:103737.
UCSCiuc007kon.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021800 mRNA. Translation: AAH21800.1.
CCDSiCCDS25160.1.
RefSeqiNP_598786.1. NM_134025.3.
XP_006531976.1. XM_006531913.1.
XP_006531977.1. XM_006531914.2.
XP_006531978.1. XM_006531915.2.
UniGeneiMm.102205.

3D structure databases

ProteinModelPortaliQ8VC48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018877.

PTM databases

PhosphoSitePlusiQ8VC48.

Proteomic databases

MaxQBiQ8VC48.
PaxDbiQ8VC48.
PRIDEiQ8VC48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018877; ENSMUSP00000018877; ENSMUSG00000018733.
ENSMUST00000108146; ENSMUSP00000103781; ENSMUSG00000018733.
ENSMUST00000175741; ENSMUSP00000135145; ENSMUSG00000018733.
ENSMUST00000176518; ENSMUSP00000135632; ENSMUSG00000018733.
GeneIDi103737.
KEGGimmu:103737.
UCSCiuc007kon.1. mouse.

Organism-specific databases

CTDi5193.
MGIiMGI:2144177. Pex12.

Phylogenomic databases

eggNOGiKOG0826. Eukaryota.
ENOG410Y4Q2. LUCA.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
HOVERGENiHBG053569.
InParanoidiQ8VC48.
KOiK13345.
OMAiFHYVRSH.
OrthoDBiEOG091G0BN4.
PhylomeDBiQ8VC48.
TreeFamiTF314511.

Miscellaneous databases

PROiQ8VC48.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018733.
CleanExiMM_PEX12.
ExpressionAtlasiQ8VC48. baseline and differential.
GenevisibleiQ8VC48. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
PIRSFiPIRSF038074. Peroxisome_assembly_p12. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPEX12_MOUSE
AccessioniPrimary (citable) accession number: Q8VC48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.