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Protein

Peroxisome assembly protein 12

Gene

Pex12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for protein import into peroxisomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Gene namesi
Name:Pex12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144177 Pex12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 158CytoplasmicSequence analysisAdd BLAST158
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 239Peroxisomal matrixSequence analysisAdd BLAST60
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 359CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186111 – 359Peroxisome assembly protein 12Add BLAST359

Proteomic databases

MaxQBiQ8VC48
PaxDbiQ8VC48
PRIDEiQ8VC48

PTM databases

PhosphoSitePlusiQ8VC48

Expressioni

Gene expression databases

BgeeiENSMUSG00000018733
CleanExiMM_PEX12
ExpressionAtlasiQ8VC48 baseline and differential
GenevisibleiQ8VC48 MM

Interactioni

Subunit structurei

Interacts with PEX5 and PEX10. Interacts with PEX19 via its cytoplasmic domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018877

Structurei

3D structure databases

ProteinModelPortaliQ8VC48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 285Poly-Pro6

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 343RING-type; degenerateAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0826 Eukaryota
ENOG410Y4Q2 LUCA
GeneTreeiENSGT00390000016209
HOGENOMiHOG000038427
HOVERGENiHBG053569
InParanoidiQ8VC48
KOiK13345
OMAiYPTEVQH
OrthoDBiEOG091G0BN4
PhylomeDBiQ8VC48
TreeFamiTF314511

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017375 PEX12
IPR006845 Pex_N
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12888 PTHR12888, 1 hit
PfamiView protein in Pfam
PF04757 Pex2_Pex12, 1 hit
PIRSFiPIRSF038074 Peroxisome_assembly_p12, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VC48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEYGAHITT ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPA
60 70 80 90 100
HYGFLWRWFD EIFTLLDFLL QQHYLSRTSA SFSEHFYGLK RIVAGSSPHL
110 120 130 140 150
QRPASAGLPK EHLWKSAMFL VLLPYLKVKL EKLASSLREE DEYSIHPPSS
160 170 180 190 200
RWKRFYRAFL AAYPFVNMAW EGWFLTQQLR YILGKAEHHS PLLKLAGVRL
210 220 230 240 250
ARLTAQDMQA IKQRLVEASA MQEPVRSVGE KIKSALKKAV GGVALSLSTG
260 270 280 290 300
LSVGVFFLQF LDWWYSSENQ EAIKSLTALP TPPPPVHLDY NSDSPLLPKM
310 320 330 340 350
KTVCPLCRKT RVNDTVLATS GYVFCYRCVF NYVRSHQACP ITGYPTEVQH

LIKLYSPEN
Length:359
Mass (Da):40,633
Last modified:March 1, 2002 - v1
Checksum:i20FABDFC806E9315
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021800 mRNA Translation: AAH21800.1
CCDSiCCDS25160.1
RefSeqiNP_598786.1, NM_134025.3
XP_006531976.1, XM_006531913.1
XP_006531977.1, XM_006531914.2
XP_006531978.1, XM_006531915.2
UniGeneiMm.102205

Genome annotation databases

EnsembliENSMUST00000018877; ENSMUSP00000018877; ENSMUSG00000018733
ENSMUST00000108146; ENSMUSP00000103781; ENSMUSG00000018733
ENSMUST00000175741; ENSMUSP00000135145; ENSMUSG00000018733
ENSMUST00000176518; ENSMUSP00000135632; ENSMUSG00000018733
GeneIDi103737
KEGGimmu:103737
UCSCiuc007kon.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPEX12_MOUSE
AccessioniPrimary (citable) accession number: Q8VC48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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