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Protein

Uncharacterized protein C18orf8 homolog

Gene

Mic1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C18orf8 homolog
Alternative name(s):
Colon cancer-associated protein Mic1
Short name:
Mic-1
Gene namesi
Name:Mic1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1916528. 3110002H16Rik.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Uncharacterized protein C18orf8 homologPRO_0000096482Add
BLAST

Proteomic databases

EPDiQ8VC42.
MaxQBiQ8VC42.
PaxDbiQ8VC42.
PRIDEiQ8VC42.

PTM databases

iPTMnetiQ8VC42.

Expressioni

Tissue specificityi

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.1 Publication

Gene expression databases

BgeeiQ8VC42.
CleanExiMM_3110002H16RIK.
ExpressionAtlasiQ8VC42. baseline and differential.
GenevisibleiQ8VC42. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8VC42. 1 interaction.
STRINGi10090.ENSMUSP00000025276.

Structurei

3D structure databases

ProteinModelPortaliQ8VC42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini471 – 637167Mic1Add
BLAST

Sequence similaritiesi

Belongs to the Mic1 family.Curated
Contains 1 Mic1 domain.Curated

Phylogenomic databases

eggNOGiKOG2377. Eukaryota.
ENOG410YC1K. LUCA.
GeneTreeiENSGT00390000009127.
HOGENOMiHOG000006772.
HOVERGENiHBG052473.
InParanoidiQ8VC42.
OMAiTREVERH.
OrthoDBiEOG7VB2FB.
PhylomeDBiQ8VC42.
TreeFamiTF105850.

Family and domain databases

InterProiIPR009755. Mic1.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07035. Mic1. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VC42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG
60 70 80 90 100
PDDRNPISFR MDDRGEVKCI KFSLENKILA VQRTAKAVDF CNFIPDNSQL
110 120 130 140 150
EYTQECKTKN ANILGFCWTS STEIVFITDQ GIEFYQVMPE KRSLKLLKSH
160 170 180 190 200
NINVNWYTYC PESAVILLST TVLENVLQPF HFRAGTMSKL PKFEIELPAA
210 220 230 240 250
PKSTKLSLSE RDIAMATIYG QLYILFLRHH SRTSNSTGAE VVLYHLPREG
260 270 280 290 300
ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI RLRGEFDGTV
310 320 330 340 350
TFHHPVLPAR SIQPYEIPLA GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS
360 370 380 390 400
ASQGYLWNLQ VKLQPIVNLL PDKGRLMDFL LQRKECKAVV LSVCSQMLSE
410 420 430 440 450
SDRATLPVIA TVFDKLNHEY KKYLDADQSY TMAVEAGQSR SNPPLKRPVR
460 470 480 490 500
TQAVVDQSDV YTQVLSPFVE NKEMPHKFVI AVLMEYIRSL NQFQIPVQHY
510 520 530 540 550
LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL ESFYPPAHQL
560 570 580 590 600
SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA
610 620 630 640 650
RQTDDVMLFY TIFRFFEQRN QRLRGNPNFT PGEHCEEHVA FFKQVFGEQA

LMRPTTF
Length:657
Mass (Da):74,922
Last modified:March 1, 2002 - v1
Checksum:i2F37B8288BD8E1FA
GO

Sequence cautioni

The sequence AAB63375.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021846 mRNA. Translation: AAH21846.1.
AF003352 mRNA. Translation: AAB63375.1. Different initiation.
CCDSiCCDS29063.1.
RefSeqiNP_083899.1. NM_029623.2.
UniGeneiMm.196596.

Genome annotation databases

EnsembliENSMUST00000025276; ENSMUSP00000025276; ENSMUSG00000024410.
GeneIDi76482.
KEGGimmu:76482.
UCSCiuc008eca.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021846 mRNA. Translation: AAH21846.1.
AF003352 mRNA. Translation: AAB63375.1. Different initiation.
CCDSiCCDS29063.1.
RefSeqiNP_083899.1. NM_029623.2.
UniGeneiMm.196596.

3D structure databases

ProteinModelPortaliQ8VC42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VC42. 1 interaction.
STRINGi10090.ENSMUSP00000025276.

PTM databases

iPTMnetiQ8VC42.

Proteomic databases

EPDiQ8VC42.
MaxQBiQ8VC42.
PaxDbiQ8VC42.
PRIDEiQ8VC42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025276; ENSMUSP00000025276; ENSMUSG00000024410.
GeneIDi76482.
KEGGimmu:76482.
UCSCiuc008eca.1. mouse.

Organism-specific databases

MGIiMGI:1916528. 3110002H16Rik.

Phylogenomic databases

eggNOGiKOG2377. Eukaryota.
ENOG410YC1K. LUCA.
GeneTreeiENSGT00390000009127.
HOGENOMiHOG000006772.
HOVERGENiHBG052473.
InParanoidiQ8VC42.
OMAiTREVERH.
OrthoDBiEOG7VB2FB.
PhylomeDBiQ8VC42.
TreeFamiTF105850.

Miscellaneous databases

PROiQ8VC42.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VC42.
CleanExiMM_3110002H16RIK.
ExpressionAtlasiQ8VC42. baseline and differential.
GenevisibleiQ8VC42. MM.

Family and domain databases

InterProiIPR009755. Mic1.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07035. Mic1. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  2. "Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene."
    Loftus S.K., Morris J.A., Carstea E.D., Gu J.Z., Cummings C., Brown A., Ellison J., Ohno K., Rosenfeld M.A., Tagle D.A., Pentchev P.G., Pavan W.J.
    Science 277:232-235(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 353-657, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiMIC1_MOUSE
AccessioniPrimary (citable) accession number: Q8VC42
Secondary accession number(s): O35606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.