Reviewed, UniProtKB/Swiss-Prot Q8VC28 (AK1CD_MOUSE)

Names and origin

Protein names

Recommended name:
    Aldo-keto reductase family 1 member C13
    EC=1.1.1.-

Gene names

Name:

Akr1c13

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW xenobiotic metabolic process Ref.1 Traceable author statement. Source: MGI
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Aldo-keto reductase family 1 member C13		PRO_0000124644
Regions
	Nucleotide binding	13 – 22	10	NADP Potential
	Nucleotide binding	217 – 280	64	NADP By similarity
Sites
	Active site	55	1	Proton donor By similarity
	Binding site	117	1	Substrate By similarity
	Site	84	1	Lowers pKa of active site Tyr By similarity
Experimental info
	Sequence conflict	47	1	R → L in BAA86850. Ref.1
	Sequence conflict	81	1	I → V in AAH21937. Ref.3
	Sequence conflict	183	1	K → N in BAB25986. Ref.2
	Sequence conflict	226	1	E → K in BAA86850. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8VC28-1 [UniParc]. Last modified January 17, 2003. Version 2. Checksum: 8B51A5820402AE5A	FASTA	323	37,058
	10 20 30 40 50 60 MSSKQHCVKL NDGHLIPALG FGTYKPKEVP KSKSLEAACL ALDVGYRHVD TAYAYQVEEE 70 80 90 100 110 120 IGQAIQSKIK AGVVKREDLF ITTKLWCTCF RPELVKPALE KSLKKLQLDY VDLYIMHYPV 130 140 150 160 170 180 PMKSGDNDFP VNEQGKSLLD TVDFCDTWER LEECKDAGLV KSIGVSNFNH RQLERILNKP 190 200 210 220 230 240 GLKYKPVCNQ VECHLYLNQR KLLDYCESKD IVLVAYGALG TQRYKEWVDQ NSPVLLNDPV 250 260 270 280 290 300 LCDVAKKNKR SPALIALRYL IQRGIVPLAQ SFKENEMREN LQVFGFQLSP EDMKTLDGLN 310 320 KNFRYLPAEF LVDHPEYPFV EEY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach." Ikeda S., Okuda-Ashitaka E., Masu Y., Suzuki T., Watanabe K., Nakao M., Shingu K., Ito S. FEBS Lett. 459:433-437(1999) [PubMed: 10526179] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Stomach.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Stomach.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[4]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 201-209, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB027125 mRNA. Translation: BAA86850.1. AK008949 mRNA. Translation: BAB25986.1. BC021937 mRNA. Translation: AAH21937.1.
IPI	IPI00310658.
RefSeq	NP_038806.2.
UniGene	Mm.27447
3D structure databases
HSSP	HSSP built from PDB template 1J96 based on UniProtKB P52895.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000021213. Mus musculus. [Contig view]
GeneID	27384.
KEGG	mmu:27384.
Organism-specific databases
MGI	MGI:1351662. Akr1c13.
Phylogenomic databases
HOVERGEN	Q8VC28.
OMA	Q8VC28. MHYPVPM.
Gene expression databases
ArrayExpress	Q8VC28.
Bgee	Q8VC28.
CleanEx	MM_AKR1C13.
GermOnline	ENSMUSG00000021213. Mus musculus.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
ProDom	PD000288. Aldo/ket_red. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	305324.
SOURCE	Search...

Entry information

Entry name

AK1CD_MOUSE

Accession

Primary (citable) accession number: Q8VC28
Secondary accession number(s): Q9D7R9, Q9R0M9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	January 17, 2003
Last modified:	June 16, 2009
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)