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Protein

Leucine-rich repeat-containing protein 14

Gene

Lrrc14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14By similarity
Gene namesi
Name:Lrrc14Imported
Synonyms:Kiaa00141 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2445060. Lrrc14.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003436811 – 493Leucine-rich repeat-containing protein 14Add BLAST493

Proteomic databases

MaxQBiQ8VC16.
PaxDbiQ8VC16.
PeptideAtlasiQ8VC16.
PRIDEiQ8VC16.

PTM databases

iPTMnetiQ8VC16.
PhosphoSitePlusiQ8VC16.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033728.
ExpressionAtlasiQ8VC16. baseline and differential.
GenevisibleiQ8VC16. MM.

Interactioni

Subunit structurei

Interacts with IKBKB; disrupts IKBKB-IKBKG interaction preventing I-kappa-B-kinase (IKK) core complex formation and leading to a decrease of IKBKB phosphorylation and NF-kappaB activation. Interacts with CHUK.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049466.

Structurei

3D structure databases

ProteinModelPortaliQ8VC16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 146LRR 1; degenerateBy similarityAdd BLAST36
Repeati194 – 218LRR 2; degenerateBy similarityAdd BLAST25
Repeati219 – 246LRR 3; degenerateBy similarityAdd BLAST28
Repeati247 – 282LRR 4; degenerateBy similarityAdd BLAST36
Repeati283 – 307LRR 5By similarityAdd BLAST25
Repeati308 – 339LRR 6By similarityAdd BLAST32
Repeati340 – 360LRR 7By similarityAdd BLAST21
Repeati364 – 391LRR 8By similarityAdd BLAST28
Repeati392 – 416LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIBA. Eukaryota.
ENOG4111FCX. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiQ8VC16.
OMAiPILTRCT.
OrthoDBiEOG091G05TB.
PhylomeDBiQ8VC16.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
IPR026292. LRRC14.
PANTHERiPTHR14224:SF9. PTHR14224:SF9. 1 hit.
PfamiView protein in Pfam
PF13516. LRR_6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VC16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTLVLREL
60 70 80 90 100
VHTWPFPLLS FQQLLQECAH CSRALLQERL STESMQAVIL GLTARIHTQE
110 120 130 140 150
TEAGTQPLCR KHALRVLDMT GLLDDGVEQD PETMSMWDCT AAVARTCIAQ
160 170 180 190 200
QQGGTAEPGL SPVPVEIRVD LRVNRASYTF LREALQSSVA SPLRLCCRDL
210 220 230 240 250
RAEDLPMRNT VALLQLLDAG CLRRIDLRFN NLGLRGLSVI IPHVARFQHL
260 270 280 290 300
ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFMCLRELS MGSSLLSGRL
310 320 330 340 350
DQLLSTLQRP LESLELAFCA LLPEDLRFLA QSSHAAHLKK LDLSGNDLSG
360 370 380 390 400
NQLTPFQGLL QAVATTLLHL ELTECQLADA QLLATLPTLT RCASLRYLGL
410 420 430 440 450
YGNPLSMAGL KELLRDSVVQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA
460 470 480 490
SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL
Length:493
Mass (Da):54,969
Last modified:March 1, 2002 - v1
Checksum:iDD516098BA9DBE89
GO

Sequence cautioni

The sequence BAD32149 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 50EL → DV in AAP23937 (Ref. 1) Curated2
Sequence conflicti155T → TA in AAP23937 (Ref. 1) Curated1
Sequence conflicti160 – 161LS → CP in AAP23937 (Ref. 1) Curated2
Sequence conflicti255L → V in AAP23937 (Ref. 1) Curated1
Sequence conflicti327R → C in BAD32149 (PubMed:15368895).Curated1
Sequence conflicti363 – 364VA → SS in AAP23937 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY239226 mRNA. Translation: AAP23937.1.
AK172871 Transcribed RNA. Translation: BAD32149.1. Frameshift.
AK036278 mRNA. Translation: BAC29370.1.
AK159836 mRNA. Translation: BAE35414.1.
CH466545 Genomic DNA. Translation: EDL29611.1.
CH466545 Genomic DNA. Translation: EDL29614.1.
BC022126 mRNA. Translation: AAH22126.1.
BC138217 mRNA. Translation: AAI38218.1.
CCDSiCCDS27589.1.
RefSeqiNP_663446.1. NM_145471.2.
XP_006520848.1. XM_006520785.3.
XP_006520849.1. XM_006520786.3.
XP_006520850.1. XM_006520787.2.
XP_006520852.1. XM_006520789.3.
XP_011243881.1. XM_011245579.2.
XP_017172047.1. XM_017316558.1.
XP_017172048.1. XM_017316559.1.
UniGeneiMm.277582.

Genome annotation databases

EnsembliENSMUST00000036423; ENSMUSP00000049466; ENSMUSG00000033728.
ENSMUST00000127208; ENSMUSP00000114921; ENSMUSG00000033728.
ENSMUST00000137649; ENSMUSP00000121982; ENSMUSG00000033728.
ENSMUST00000155735; ENSMUSP00000115446; ENSMUSG00000033728.
GeneIDi223664.
KEGGimmu:223664.
UCSCiuc007wlx.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiLRC14_MOUSE
AccessioniPrimary (citable) accession number: Q8VC16
Secondary accession number(s): Q6A0E7, Q80WK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families