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Protein

Leucine-rich repeat-containing protein 14

Gene

Lrrc14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14
Gene namesi
Name:Lrrc14
Synonyms:Kiaa0014
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2445060. Lrrc14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Leucine-rich repeat-containing protein 14PRO_0000343681Add
BLAST

Proteomic databases

EPDiQ8VC16.
MaxQBiQ8VC16.
PaxDbiQ8VC16.
PeptideAtlasiQ8VC16.
PRIDEiQ8VC16.

PTM databases

PhosphoSiteiQ8VC16.

Expressioni

Gene expression databases

BgeeiQ8VC16.
ExpressionAtlasiQ8VC16. baseline and differential.
GenevisibleiQ8VC16. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049466.

Structurei

3D structure databases

ProteinModelPortaliQ8VC16.
SMRiQ8VC16. Positions 215-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati285 – 30723LRR 1Add
BLAST
Repeati310 – 33021LRR 2Add
BLAST
Repeati337 – 36024LRR 3Add
BLAST
Repeati366 – 38722LRR 4Add
BLAST
Repeati394 – 41421LRR 5Add
BLAST

Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIBA. Eukaryota.
ENOG4111FCX. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiQ8VC16.
OMAiPILTRCT.
PhylomeDBiQ8VC16.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR026292. LRRC14.
[Graphical view]
PANTHERiPTHR14224:SF9. PTHR14224:SF9. 1 hit.
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VC16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTLVLREL
60 70 80 90 100
VHTWPFPLLS FQQLLQECAH CSRALLQERL STESMQAVIL GLTARIHTQE
110 120 130 140 150
TEAGTQPLCR KHALRVLDMT GLLDDGVEQD PETMSMWDCT AAVARTCIAQ
160 170 180 190 200
QQGGTAEPGL SPVPVEIRVD LRVNRASYTF LREALQSSVA SPLRLCCRDL
210 220 230 240 250
RAEDLPMRNT VALLQLLDAG CLRRIDLRFN NLGLRGLSVI IPHVARFQHL
260 270 280 290 300
ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFMCLRELS MGSSLLSGRL
310 320 330 340 350
DQLLSTLQRP LESLELAFCA LLPEDLRFLA QSSHAAHLKK LDLSGNDLSG
360 370 380 390 400
NQLTPFQGLL QAVATTLLHL ELTECQLADA QLLATLPTLT RCASLRYLGL
410 420 430 440 450
YGNPLSMAGL KELLRDSVVQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA
460 470 480 490
SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL
Length:493
Mass (Da):54,969
Last modified:March 1, 2002 - v1
Checksum:iDD516098BA9DBE89
GO

Sequence cautioni

The sequence BAD32149.1 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 502EL → DV in AAP23937 (Ref. 1) Curated
Sequence conflicti155 – 1551T → TA in AAP23937 (Ref. 1) Curated
Sequence conflicti160 – 1612LS → CP in AAP23937 (Ref. 1) Curated
Sequence conflicti255 – 2551L → V in AAP23937 (Ref. 1) Curated
Sequence conflicti327 – 3271R → C in BAD32149 (PubMed:15368895).Curated
Sequence conflicti363 – 3642VA → SS in AAP23937 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY239226 mRNA. Translation: AAP23937.1.
AK172871 Transcribed RNA. Translation: BAD32149.1. Frameshift.
AK036278 mRNA. Translation: BAC29370.1.
AK159836 mRNA. Translation: BAE35414.1.
CH466545 Genomic DNA. Translation: EDL29611.1.
CH466545 Genomic DNA. Translation: EDL29614.1.
BC022126 mRNA. Translation: AAH22126.1.
BC138217 mRNA. Translation: AAI38218.1.
CCDSiCCDS27589.1.
RefSeqiNP_663446.1. NM_145471.2.
XP_006520848.1. XM_006520785.2.
XP_006520849.1. XM_006520786.2.
XP_006520850.1. XM_006520787.1.
XP_006520852.1. XM_006520789.2.
XP_011243881.1. XM_011245579.1.
XP_011243882.1. XM_011245580.1.
UniGeneiMm.277582.

Genome annotation databases

EnsembliENSMUST00000036423; ENSMUSP00000049466; ENSMUSG00000033728.
ENSMUST00000127208; ENSMUSP00000114921; ENSMUSG00000033728.
ENSMUST00000137649; ENSMUSP00000121982; ENSMUSG00000033728.
ENSMUST00000155735; ENSMUSP00000115446; ENSMUSG00000033728.
GeneIDi223664.
KEGGimmu:223664.
UCSCiuc007wlx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY239226 mRNA. Translation: AAP23937.1.
AK172871 Transcribed RNA. Translation: BAD32149.1. Frameshift.
AK036278 mRNA. Translation: BAC29370.1.
AK159836 mRNA. Translation: BAE35414.1.
CH466545 Genomic DNA. Translation: EDL29611.1.
CH466545 Genomic DNA. Translation: EDL29614.1.
BC022126 mRNA. Translation: AAH22126.1.
BC138217 mRNA. Translation: AAI38218.1.
CCDSiCCDS27589.1.
RefSeqiNP_663446.1. NM_145471.2.
XP_006520848.1. XM_006520785.2.
XP_006520849.1. XM_006520786.2.
XP_006520850.1. XM_006520787.1.
XP_006520852.1. XM_006520789.2.
XP_011243881.1. XM_011245579.1.
XP_011243882.1. XM_011245580.1.
UniGeneiMm.277582.

3D structure databases

ProteinModelPortaliQ8VC16.
SMRiQ8VC16. Positions 215-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049466.

PTM databases

PhosphoSiteiQ8VC16.

Proteomic databases

EPDiQ8VC16.
MaxQBiQ8VC16.
PaxDbiQ8VC16.
PeptideAtlasiQ8VC16.
PRIDEiQ8VC16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036423; ENSMUSP00000049466; ENSMUSG00000033728.
ENSMUST00000127208; ENSMUSP00000114921; ENSMUSG00000033728.
ENSMUST00000137649; ENSMUSP00000121982; ENSMUSG00000033728.
ENSMUST00000155735; ENSMUSP00000115446; ENSMUSG00000033728.
GeneIDi223664.
KEGGimmu:223664.
UCSCiuc007wlx.2. mouse.

Organism-specific databases

CTDi9684.
MGIiMGI:2445060. Lrrc14.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IIBA. Eukaryota.
ENOG4111FCX. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiQ8VC16.
OMAiPILTRCT.
PhylomeDBiQ8VC16.
TreeFamiTF332708.

Miscellaneous databases

PROiQ8VC16.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VC16.
ExpressionAtlasiQ8VC16. baseline and differential.
GenevisibleiQ8VC16. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR026292. LRRC14.
[Graphical view]
PANTHERiPTHR14224:SF9. PTHR14224:SF9. 1 hit.
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel program of gene expression driven by Notch, is associated with commitment in neural stem cell lines."
    Uwanogho D.A., Mellodew K., Molloy G., Galloway D., Starling B.B., Crossland N., Price J.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Liver.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiLRC14_MOUSE
AccessioniPrimary (citable) accession number: Q8VC16
Secondary accession number(s): Q6A0E7, Q80WK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.