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Protein

Leucine-rich repeat-containing protein 14

Gene

Lrrc14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14
Gene namesi
Name:Lrrc14
Synonyms:Kiaa0014
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2445060. Lrrc14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003436811 – 493Leucine-rich repeat-containing protein 14Add BLAST493

Proteomic databases

MaxQBiQ8VC16.
PaxDbiQ8VC16.
PeptideAtlasiQ8VC16.
PRIDEiQ8VC16.

PTM databases

PhosphoSitePlusiQ8VC16.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033728.
ExpressionAtlasiQ8VC16. baseline and differential.
GenevisibleiQ8VC16. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049466.

Structurei

3D structure databases

ProteinModelPortaliQ8VC16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati285 – 307LRR 1Add BLAST23
Repeati310 – 330LRR 2Add BLAST21
Repeati337 – 360LRR 3Add BLAST24
Repeati366 – 387LRR 4Add BLAST22
Repeati394 – 414LRR 5Add BLAST21

Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIBA. Eukaryota.
ENOG4111FCX. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiQ8VC16.
OMAiPILTRCT.
OrthoDBiEOG091G05TB.
PhylomeDBiQ8VC16.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR026292. LRRC14.
[Graphical view]
PANTHERiPTHR14224:SF9. PTHR14224:SF9. 1 hit.
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VC16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTLVLREL
60 70 80 90 100
VHTWPFPLLS FQQLLQECAH CSRALLQERL STESMQAVIL GLTARIHTQE
110 120 130 140 150
TEAGTQPLCR KHALRVLDMT GLLDDGVEQD PETMSMWDCT AAVARTCIAQ
160 170 180 190 200
QQGGTAEPGL SPVPVEIRVD LRVNRASYTF LREALQSSVA SPLRLCCRDL
210 220 230 240 250
RAEDLPMRNT VALLQLLDAG CLRRIDLRFN NLGLRGLSVI IPHVARFQHL
260 270 280 290 300
ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFMCLRELS MGSSLLSGRL
310 320 330 340 350
DQLLSTLQRP LESLELAFCA LLPEDLRFLA QSSHAAHLKK LDLSGNDLSG
360 370 380 390 400
NQLTPFQGLL QAVATTLLHL ELTECQLADA QLLATLPTLT RCASLRYLGL
410 420 430 440 450
YGNPLSMAGL KELLRDSVVQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA
460 470 480 490
SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL
Length:493
Mass (Da):54,969
Last modified:March 1, 2002 - v1
Checksum:iDD516098BA9DBE89
GO

Sequence cautioni

The sequence BAD32149 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 50EL → DV in AAP23937 (Ref. 1) Curated2
Sequence conflicti155T → TA in AAP23937 (Ref. 1) Curated1
Sequence conflicti160 – 161LS → CP in AAP23937 (Ref. 1) Curated2
Sequence conflicti255L → V in AAP23937 (Ref. 1) Curated1
Sequence conflicti327R → C in BAD32149 (PubMed:15368895).Curated1
Sequence conflicti363 – 364VA → SS in AAP23937 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY239226 mRNA. Translation: AAP23937.1.
AK172871 Transcribed RNA. Translation: BAD32149.1. Frameshift.
AK036278 mRNA. Translation: BAC29370.1.
AK159836 mRNA. Translation: BAE35414.1.
CH466545 Genomic DNA. Translation: EDL29611.1.
CH466545 Genomic DNA. Translation: EDL29614.1.
BC022126 mRNA. Translation: AAH22126.1.
BC138217 mRNA. Translation: AAI38218.1.
CCDSiCCDS27589.1.
RefSeqiNP_663446.1. NM_145471.2.
XP_006520848.1. XM_006520785.3.
XP_006520849.1. XM_006520786.3.
XP_006520850.1. XM_006520787.2.
XP_006520852.1. XM_006520789.3.
XP_011243881.1. XM_011245579.2.
XP_017172047.1. XM_017316558.1.
XP_017172048.1. XM_017316559.1.
UniGeneiMm.277582.

Genome annotation databases

EnsembliENSMUST00000036423; ENSMUSP00000049466; ENSMUSG00000033728.
ENSMUST00000127208; ENSMUSP00000114921; ENSMUSG00000033728.
ENSMUST00000137649; ENSMUSP00000121982; ENSMUSG00000033728.
ENSMUST00000155735; ENSMUSP00000115446; ENSMUSG00000033728.
GeneIDi223664.
KEGGimmu:223664.
UCSCiuc007wlx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY239226 mRNA. Translation: AAP23937.1.
AK172871 Transcribed RNA. Translation: BAD32149.1. Frameshift.
AK036278 mRNA. Translation: BAC29370.1.
AK159836 mRNA. Translation: BAE35414.1.
CH466545 Genomic DNA. Translation: EDL29611.1.
CH466545 Genomic DNA. Translation: EDL29614.1.
BC022126 mRNA. Translation: AAH22126.1.
BC138217 mRNA. Translation: AAI38218.1.
CCDSiCCDS27589.1.
RefSeqiNP_663446.1. NM_145471.2.
XP_006520848.1. XM_006520785.3.
XP_006520849.1. XM_006520786.3.
XP_006520850.1. XM_006520787.2.
XP_006520852.1. XM_006520789.3.
XP_011243881.1. XM_011245579.2.
XP_017172047.1. XM_017316558.1.
XP_017172048.1. XM_017316559.1.
UniGeneiMm.277582.

3D structure databases

ProteinModelPortaliQ8VC16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049466.

PTM databases

PhosphoSitePlusiQ8VC16.

Proteomic databases

MaxQBiQ8VC16.
PaxDbiQ8VC16.
PeptideAtlasiQ8VC16.
PRIDEiQ8VC16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036423; ENSMUSP00000049466; ENSMUSG00000033728.
ENSMUST00000127208; ENSMUSP00000114921; ENSMUSG00000033728.
ENSMUST00000137649; ENSMUSP00000121982; ENSMUSG00000033728.
ENSMUST00000155735; ENSMUSP00000115446; ENSMUSG00000033728.
GeneIDi223664.
KEGGimmu:223664.
UCSCiuc007wlx.2. mouse.

Organism-specific databases

CTDi9684.
MGIiMGI:2445060. Lrrc14.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IIBA. Eukaryota.
ENOG4111FCX. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiQ8VC16.
OMAiPILTRCT.
OrthoDBiEOG091G05TB.
PhylomeDBiQ8VC16.
TreeFamiTF332708.

Miscellaneous databases

PROiQ8VC16.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033728.
ExpressionAtlasiQ8VC16. baseline and differential.
GenevisibleiQ8VC16. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR026292. LRRC14.
[Graphical view]
PANTHERiPTHR14224:SF9. PTHR14224:SF9. 1 hit.
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC14_MOUSE
AccessioniPrimary (citable) accession number: Q8VC16
Secondary accession number(s): Q6A0E7, Q80WK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.