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Protein

Cleft lip and palate transmembrane protein 1 homolog

Gene

Clptm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in T-cell development.1 Publication

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. regulation of T cell differentiation in thymus Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1 homolog
Alternative name(s):
Thymic epithelial cell surface antigen
Gene namesi
Name:Clptm1
Synonyms:N14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1927155. Clptm1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 354353ExtracellularSequence AnalysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence AnalysisAdd
BLAST
Topological domaini376 – 39015CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence AnalysisAdd
BLAST
Topological domaini412 – 4165ExtracellularSequence Analysis
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Topological domaini438 – 47740CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence AnalysisAdd
BLAST
Topological domaini499 – 5024ExtracellularSequence Analysis
Transmembranei503 – 52321HelicalSequence AnalysisAdd
BLAST
Topological domaini524 – 664141CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 664663Cleft lip and palate transmembrane protein 1 homologPRO_0000245097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis
Modified residuei601 – 6011PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8VBZ3.
PaxDbiQ8VBZ3.
PRIDEiQ8VBZ3.

PTM databases

PhosphoSiteiQ8VBZ3.

Expressioni

Tissue specificityi

Widely expressed. Expressed by subcapsular and outer cortical thymic cells.1 Publication

Developmental stagei

Ubiquitously expressed in mouse embryo.1 Publication

Gene expression databases

BgeeiQ8VBZ3.
GenevestigatoriQ8VBZ3.

Interactioni

Protein-protein interaction databases

MINTiMINT-1858736.
STRINGi10090.ENSMUSP00000051293.

Structurei

3D structure databases

ProteinModelPortaliQ8VBZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287859.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ8VBZ3.
OMAiDNTSWMI.
OrthoDBiEOG74N5GH.
PhylomeDBiQ8VBZ3.
TreeFamiTF318501.

Family and domain databases

InterProiIPR008429. CLPTM1.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAQEADGA GSAVVAAGGG SSGQVTSNGS IGRDTPAETQ PQNPPPQPAP
60 70 80 90 100
NAWQVIKGVL FRIFIIWAIS SWFRRGPSPQ DQSGPGGAPR VASRNLFPKD
110 120 130 140 150
TLMNLHVYIS EHEHFTDFNA TSALFWEQHD LVYGDWTSGE NSDGCYEHFA
160 170 180 190 200
ELDIPQSVQQ NGSIYIHVYF TKSGFHPDPR QKALYRRLAT VHMSRMINKY
210 220 230 240 250
KRRRFQKTKN LLTGETEADP EMIKRAEDYG PVEVISHWHP NITINIVDDH
260 270 280 290 300
TPWVKGSVPP PLDQYVKFDA VSGDYYPIIY FNDYWNLQKD YYPINESLAS
310 320 330 340 350
LPLRVSFCPL SLWRWQLYAA QSTKSPWNFL GDELYEQSDE EQDSVKVALL
360 370 380 390 400
ETSPYLLALT IIVSIVHSVF EFLAFKNDIQ FWNSRQSLEG LSVRSVFFGV
410 420 430 440 450
FQSFVVLLYI LDNETNFVVQ VSVFIGVLID LWKITKVMDV RLDREHRVAG
460 470 480 490 500
IFPCPTFKDK STYIESSTKV YDDMAFRYLS WILFPLLGCY AVYSLLYLEH
510 520 530 540 550
KGWYSWVLSM LYGFLLTFGF ITMTPQLFIN YKLKSVAHLP WRMLTYKALN
560 570 580 590 600
TFIDDLFAFV IKMPVMYRIG CLRDDVVFFI YLYQRWIYRV DPTRVNEFGM
610 620 630 640 650
SGEDVSAAAS RAQASTAAGA LTPAPSTAVS GEDASTVPKA TSGACTASQP
660
QEAPPKPAED KKKD
Length:664
Mass (Da):75,291
Last modified:March 1, 2002 - v1
Checksum:i6F78F58549CC7EE1
GO

Sequence cautioni

The sequence BAA19836.1 differs from that shown. Reason: Frameshift at position 484. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611N → Y in BAE28332 (PubMed:16141072).Curated
Sequence conflicti470 – 4701V → A in BAE31514 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67067 mRNA. Translation: BAA19836.1. Frameshift.
AK148080 mRNA. Translation: BAE28332.1.
AK152410 mRNA. Translation: BAE31196.1.
AK152809 mRNA. Translation: BAE31514.1.
BC018389 mRNA. Translation: AAH18389.1.
BC022172 mRNA. Translation: AAH22172.1.
CCDSiCCDS39800.1.
RefSeqiNP_062623.2. NM_019649.2.
UniGeneiMm.290960.

Genome annotation databases

EnsembliENSMUST00000055242; ENSMUSP00000051293; ENSMUSG00000002981.
GeneIDi56457.
KEGGimmu:56457.
UCSCiuc009fmq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67067 mRNA. Translation: BAA19836.1. Frameshift.
AK148080 mRNA. Translation: BAE28332.1.
AK152410 mRNA. Translation: BAE31196.1.
AK152809 mRNA. Translation: BAE31514.1.
BC018389 mRNA. Translation: AAH18389.1.
BC022172 mRNA. Translation: AAH22172.1.
CCDSiCCDS39800.1.
RefSeqiNP_062623.2. NM_019649.2.
UniGeneiMm.290960.

3D structure databases

ProteinModelPortaliQ8VBZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1858736.
STRINGi10090.ENSMUSP00000051293.

PTM databases

PhosphoSiteiQ8VBZ3.

Proteomic databases

MaxQBiQ8VBZ3.
PaxDbiQ8VBZ3.
PRIDEiQ8VBZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055242; ENSMUSP00000051293; ENSMUSG00000002981.
GeneIDi56457.
KEGGimmu:56457.
UCSCiuc009fmq.1. mouse.

Organism-specific databases

CTDi1209.
MGIiMGI:1927155. Clptm1.

Phylogenomic databases

eggNOGiNOG287859.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ8VBZ3.
OMAiDNTSWMI.
OrthoDBiEOG74N5GH.
PhylomeDBiQ8VBZ3.
TreeFamiTF318501.

Miscellaneous databases

NextBioi312694.
PROiQ8VBZ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VBZ3.
GenevestigatoriQ8VBZ3.

Family and domain databases

InterProiIPR008429. CLPTM1.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transgenic expression of a novel thymic epithelial cell antigen stimulates aberrant development of thymocytes."
    Takeuchi T., Kuro-o M., Miyazawa H., Ohtsuki Y., Yamamoto H.
    J. Immunol. 159:726-733(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Thymus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor and Salivary gland.
  4. "Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate."
    Yoshiura K., Machida J., Daack-Hirsch S., Patil S.R., Ashworth L.K., Hecht J.T., Murray J.C.
    Genomics 54:231-240(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCLPT1_MOUSE
AccessioniPrimary (citable) accession number: Q8VBZ3
Secondary accession number(s): O08708
, Q3U758, Q3U823, Q3UG77, Q8VEJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2002
Last modified: March 4, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice overexpressing Clptm1 exhibit an aberrant development of thymocytes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.