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Protein

Cleft lip and palate transmembrane protein 1 homolog

Gene

Clptm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in T-cell development.1 Publication

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • regulation of T cell differentiation in thymus Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1 homolog
Alternative name(s):
Thymic epithelial cell surface antigen
Gene namesi
Name:Clptm1
Synonyms:N14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1927155. Clptm1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 354ExtracellularSequence analysisAdd BLAST353
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 390CytoplasmicSequence analysisAdd BLAST15
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 416ExtracellularSequence analysis5
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 477CytoplasmicSequence analysisAdd BLAST40
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 502ExtracellularSequence analysis4
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Topological domaini524 – 664CytoplasmicSequence analysisAdd BLAST141

GO - Cellular componenti

  • external side of plasma membrane Source: BHF-UCL
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002450972 – 664Cleft lip and palate transmembrane protein 1 homologAdd BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1
Modified residuei601PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8VBZ3.
MaxQBiQ8VBZ3.
PaxDbiQ8VBZ3.
PeptideAtlasiQ8VBZ3.
PRIDEiQ8VBZ3.

PTM databases

iPTMnetiQ8VBZ3.
PhosphoSitePlusiQ8VBZ3.
SwissPalmiQ8VBZ3.

Expressioni

Tissue specificityi

Widely expressed. Expressed by subcapsular and outer cortical thymic cells.1 Publication

Developmental stagei

Ubiquitously expressed in mouse embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000002981.
GenevisibleiQ8VBZ3. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1858736.
STRINGi10090.ENSMUSP00000051293.

Structurei

3D structure databases

ProteinModelPortaliQ8VBZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2489. Eukaryota.
ENOG410XPEV. LUCA.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ8VBZ3.
OMAiRIFIIWV.
OrthoDBiEOG091G05EF.
PhylomeDBiQ8VBZ3.
TreeFamiTF318501.

Family and domain databases

InterProiIPR008429. CLPTM1.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAQEADGA GSAVVAAGGG SSGQVTSNGS IGRDTPAETQ PQNPPPQPAP
60 70 80 90 100
NAWQVIKGVL FRIFIIWAIS SWFRRGPSPQ DQSGPGGAPR VASRNLFPKD
110 120 130 140 150
TLMNLHVYIS EHEHFTDFNA TSALFWEQHD LVYGDWTSGE NSDGCYEHFA
160 170 180 190 200
ELDIPQSVQQ NGSIYIHVYF TKSGFHPDPR QKALYRRLAT VHMSRMINKY
210 220 230 240 250
KRRRFQKTKN LLTGETEADP EMIKRAEDYG PVEVISHWHP NITINIVDDH
260 270 280 290 300
TPWVKGSVPP PLDQYVKFDA VSGDYYPIIY FNDYWNLQKD YYPINESLAS
310 320 330 340 350
LPLRVSFCPL SLWRWQLYAA QSTKSPWNFL GDELYEQSDE EQDSVKVALL
360 370 380 390 400
ETSPYLLALT IIVSIVHSVF EFLAFKNDIQ FWNSRQSLEG LSVRSVFFGV
410 420 430 440 450
FQSFVVLLYI LDNETNFVVQ VSVFIGVLID LWKITKVMDV RLDREHRVAG
460 470 480 490 500
IFPCPTFKDK STYIESSTKV YDDMAFRYLS WILFPLLGCY AVYSLLYLEH
510 520 530 540 550
KGWYSWVLSM LYGFLLTFGF ITMTPQLFIN YKLKSVAHLP WRMLTYKALN
560 570 580 590 600
TFIDDLFAFV IKMPVMYRIG CLRDDVVFFI YLYQRWIYRV DPTRVNEFGM
610 620 630 640 650
SGEDVSAAAS RAQASTAAGA LTPAPSTAVS GEDASTVPKA TSGACTASQP
660
QEAPPKPAED KKKD
Length:664
Mass (Da):75,291
Last modified:March 1, 2002 - v1
Checksum:i6F78F58549CC7EE1
GO

Sequence cautioni

The sequence BAA19836 differs from that shown. Reason: Frameshift at position 484.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161N → Y in BAE28332 (PubMed:16141072).Curated1
Sequence conflicti470V → A in BAE31514 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67067 mRNA. Translation: BAA19836.1. Frameshift.
AK148080 mRNA. Translation: BAE28332.1.
AK152410 mRNA. Translation: BAE31196.1.
AK152809 mRNA. Translation: BAE31514.1.
BC018389 mRNA. Translation: AAH18389.1.
BC022172 mRNA. Translation: AAH22172.1.
CCDSiCCDS39800.1.
RefSeqiNP_062623.2. NM_019649.2.
UniGeneiMm.290960.

Genome annotation databases

EnsembliENSMUST00000055242; ENSMUSP00000051293; ENSMUSG00000002981.
GeneIDi56457.
KEGGimmu:56457.
UCSCiuc009fmq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67067 mRNA. Translation: BAA19836.1. Frameshift.
AK148080 mRNA. Translation: BAE28332.1.
AK152410 mRNA. Translation: BAE31196.1.
AK152809 mRNA. Translation: BAE31514.1.
BC018389 mRNA. Translation: AAH18389.1.
BC022172 mRNA. Translation: AAH22172.1.
CCDSiCCDS39800.1.
RefSeqiNP_062623.2. NM_019649.2.
UniGeneiMm.290960.

3D structure databases

ProteinModelPortaliQ8VBZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1858736.
STRINGi10090.ENSMUSP00000051293.

PTM databases

iPTMnetiQ8VBZ3.
PhosphoSitePlusiQ8VBZ3.
SwissPalmiQ8VBZ3.

Proteomic databases

EPDiQ8VBZ3.
MaxQBiQ8VBZ3.
PaxDbiQ8VBZ3.
PeptideAtlasiQ8VBZ3.
PRIDEiQ8VBZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055242; ENSMUSP00000051293; ENSMUSG00000002981.
GeneIDi56457.
KEGGimmu:56457.
UCSCiuc009fmq.1. mouse.

Organism-specific databases

CTDi1209.
MGIiMGI:1927155. Clptm1.

Phylogenomic databases

eggNOGiKOG2489. Eukaryota.
ENOG410XPEV. LUCA.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ8VBZ3.
OMAiRIFIIWV.
OrthoDBiEOG091G05EF.
PhylomeDBiQ8VBZ3.
TreeFamiTF318501.

Miscellaneous databases

PROiQ8VBZ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002981.
GenevisibleiQ8VBZ3. MM.

Family and domain databases

InterProiIPR008429. CLPTM1.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLPT1_MOUSE
AccessioniPrimary (citable) accession number: Q8VBZ3
Secondary accession number(s): O08708
, Q3U758, Q3U823, Q3UG77, Q8VEJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice overexpressing Clptm1 exhibit an aberrant development of thymocytes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.