Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8VBZ3

- CLPT1_MOUSE

UniProt

Q8VBZ3 - CLPT1_MOUSE

Protein

Cleft lip and palate transmembrane protein 1 homolog

Gene

Clptm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play a role in T-cell development.1 Publication

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. regulation of T cell differentiation in thymus Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cleft lip and palate transmembrane protein 1 homolog
    Alternative name(s):
    Thymic epithelial cell surface antigen
    Gene namesi
    Name:Clptm1
    Synonyms:N14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1927155. Clptm1.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: BHF-UCL
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 664663Cleft lip and palate transmembrane protein 1 homologPRO_0000245097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    MaxQBiQ8VBZ3.
    PaxDbiQ8VBZ3.
    PRIDEiQ8VBZ3.

    PTM databases

    PhosphoSiteiQ8VBZ3.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed by subcapsular and outer cortical thymic cells.1 Publication

    Developmental stagei

    Ubiquitously expressed in mouse embryo.1 Publication

    Gene expression databases

    BgeeiQ8VBZ3.
    GenevestigatoriQ8VBZ3.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1858736.
    STRINGi10090.ENSMUSP00000051293.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VBZ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 354353ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini376 – 39015CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini412 – 4165ExtracellularSequence Analysis
    Topological domaini438 – 47740CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini499 – 5024ExtracellularSequence Analysis
    Topological domaini524 – 664141CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei355 – 37521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei503 – 52321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CLPTM1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287859.
    GeneTreeiENSGT00530000063461.
    HOGENOMiHOG000201405.
    HOVERGENiHBG057146.
    InParanoidiQ8VBZ3.
    OMAiTRMESFF.
    OrthoDBiEOG74N5GH.
    PhylomeDBiQ8VBZ3.
    TreeFamiTF318501.

    Family and domain databases

    InterProiIPR008429. CLPTM1.
    [Graphical view]
    PANTHERiPTHR21347. PTHR21347. 1 hit.
    PfamiPF05602. CLPTM1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VBZ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAQEADGA GSAVVAAGGG SSGQVTSNGS IGRDTPAETQ PQNPPPQPAP    50
    NAWQVIKGVL FRIFIIWAIS SWFRRGPSPQ DQSGPGGAPR VASRNLFPKD 100
    TLMNLHVYIS EHEHFTDFNA TSALFWEQHD LVYGDWTSGE NSDGCYEHFA 150
    ELDIPQSVQQ NGSIYIHVYF TKSGFHPDPR QKALYRRLAT VHMSRMINKY 200
    KRRRFQKTKN LLTGETEADP EMIKRAEDYG PVEVISHWHP NITINIVDDH 250
    TPWVKGSVPP PLDQYVKFDA VSGDYYPIIY FNDYWNLQKD YYPINESLAS 300
    LPLRVSFCPL SLWRWQLYAA QSTKSPWNFL GDELYEQSDE EQDSVKVALL 350
    ETSPYLLALT IIVSIVHSVF EFLAFKNDIQ FWNSRQSLEG LSVRSVFFGV 400
    FQSFVVLLYI LDNETNFVVQ VSVFIGVLID LWKITKVMDV RLDREHRVAG 450
    IFPCPTFKDK STYIESSTKV YDDMAFRYLS WILFPLLGCY AVYSLLYLEH 500
    KGWYSWVLSM LYGFLLTFGF ITMTPQLFIN YKLKSVAHLP WRMLTYKALN 550
    TFIDDLFAFV IKMPVMYRIG CLRDDVVFFI YLYQRWIYRV DPTRVNEFGM 600
    SGEDVSAAAS RAQASTAAGA LTPAPSTAVS GEDASTVPKA TSGACTASQP 650
    QEAPPKPAED KKKD 664
    Length:664
    Mass (Da):75,291
    Last modified:March 1, 2002 - v1
    Checksum:i6F78F58549CC7EE1
    GO

    Sequence cautioni

    The sequence BAA19836.1 differs from that shown. Reason: Frameshift at position 484.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti161 – 1611N → Y in BAE28332. (PubMed:16141072)Curated
    Sequence conflicti470 – 4701V → A in BAE31514. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D67067 mRNA. Translation: BAA19836.1. Frameshift.
    AK148080 mRNA. Translation: BAE28332.1.
    AK152410 mRNA. Translation: BAE31196.1.
    AK152809 mRNA. Translation: BAE31514.1.
    BC018389 mRNA. Translation: AAH18389.1.
    BC022172 mRNA. Translation: AAH22172.1.
    CCDSiCCDS39800.1.
    RefSeqiNP_062623.2. NM_019649.2.
    UniGeneiMm.290960.

    Genome annotation databases

    EnsembliENSMUST00000055242; ENSMUSP00000051293; ENSMUSG00000002981.
    GeneIDi56457.
    KEGGimmu:56457.
    UCSCiuc009fmq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D67067 mRNA. Translation: BAA19836.1 . Frameshift.
    AK148080 mRNA. Translation: BAE28332.1 .
    AK152410 mRNA. Translation: BAE31196.1 .
    AK152809 mRNA. Translation: BAE31514.1 .
    BC018389 mRNA. Translation: AAH18389.1 .
    BC022172 mRNA. Translation: AAH22172.1 .
    CCDSi CCDS39800.1.
    RefSeqi NP_062623.2. NM_019649.2.
    UniGenei Mm.290960.

    3D structure databases

    ProteinModelPortali Q8VBZ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1858736.
    STRINGi 10090.ENSMUSP00000051293.

    PTM databases

    PhosphoSitei Q8VBZ3.

    Proteomic databases

    MaxQBi Q8VBZ3.
    PaxDbi Q8VBZ3.
    PRIDEi Q8VBZ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055242 ; ENSMUSP00000051293 ; ENSMUSG00000002981 .
    GeneIDi 56457.
    KEGGi mmu:56457.
    UCSCi uc009fmq.1. mouse.

    Organism-specific databases

    CTDi 1209.
    MGIi MGI:1927155. Clptm1.

    Phylogenomic databases

    eggNOGi NOG287859.
    GeneTreei ENSGT00530000063461.
    HOGENOMi HOG000201405.
    HOVERGENi HBG057146.
    InParanoidi Q8VBZ3.
    OMAi TRMESFF.
    OrthoDBi EOG74N5GH.
    PhylomeDBi Q8VBZ3.
    TreeFami TF318501.

    Miscellaneous databases

    NextBioi 312694.
    PROi Q8VBZ3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VBZ3.
    Genevestigatori Q8VBZ3.

    Family and domain databases

    InterProi IPR008429. CLPTM1.
    [Graphical view ]
    PANTHERi PTHR21347. PTHR21347. 1 hit.
    Pfami PF05602. CLPTM1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transgenic expression of a novel thymic epithelial cell antigen stimulates aberrant development of thymocytes."
      Takeuchi T., Kuro-o M., Miyazawa H., Ohtsuki Y., Yamamoto H.
      J. Immunol. 159:726-733(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Thymus.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor and Salivary gland.
    4. "Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate."
      Yoshiura K., Machida J., Daack-Hirsch S., Patil S.R., Ashworth L.K., Hecht J.T., Murray J.C.
      Genomics 54:231-240(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCLPT1_MOUSE
    AccessioniPrimary (citable) accession number: Q8VBZ3
    Secondary accession number(s): O08708
    , Q3U758, Q3U823, Q3UG77, Q8VEJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mice overexpressing Clptm1 exhibit an aberrant development of thymocytes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3