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Q8VBZ3 (CLPT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cleft lip and palate transmembrane protein 1 homolog
Alternative name(s):
Thymic epithelial cell surface antigen
Gene names
Name:Clptm1
Synonyms:N14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length664 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in T-cell development. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Widely expressed. Expressed by subcapsular and outer cortical thymic cells. Ref.1

Developmental stage

Ubiquitously expressed in mouse embryo. Ref.4

Miscellaneous

Mice overexpressing Clptm1 exhibit an aberrant development of thymocytes.

Sequence similarities

Belongs to the CLPTM1 family.

Sequence caution

The sequence BAA19836.1 differs from that shown. Reason: Frameshift at position 484.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 664663Cleft lip and palate transmembrane protein 1 homolog
PRO_0000245097

Regions

Topological domain2 – 354353Extracellular Potential
Transmembrane355 – 37521Helical; Potential
Topological domain376 – 39015Cytoplasmic Potential
Transmembrane391 – 41121Helical; Potential
Topological domain412 – 4165Extracellular Potential
Transmembrane417 – 43721Helical; Potential
Topological domain438 – 47740Cytoplasmic Potential
Transmembrane478 – 49821Helical; Potential
Topological domain499 – 5024Extracellular Potential
Transmembrane503 – 52321Helical; Potential
Topological domain524 – 664141Cytoplasmic Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation4131N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1611N → Y in BAE28332. Ref.2
Sequence conflict4701V → A in BAE31514. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8VBZ3 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 6F78F58549CC7EE1

FASTA66475,291
        10         20         30         40         50         60 
MAAAQEADGA GSAVVAAGGG SSGQVTSNGS IGRDTPAETQ PQNPPPQPAP NAWQVIKGVL 

        70         80         90        100        110        120 
FRIFIIWAIS SWFRRGPSPQ DQSGPGGAPR VASRNLFPKD TLMNLHVYIS EHEHFTDFNA 

       130        140        150        160        170        180 
TSALFWEQHD LVYGDWTSGE NSDGCYEHFA ELDIPQSVQQ NGSIYIHVYF TKSGFHPDPR 

       190        200        210        220        230        240 
QKALYRRLAT VHMSRMINKY KRRRFQKTKN LLTGETEADP EMIKRAEDYG PVEVISHWHP 

       250        260        270        280        290        300 
NITINIVDDH TPWVKGSVPP PLDQYVKFDA VSGDYYPIIY FNDYWNLQKD YYPINESLAS 

       310        320        330        340        350        360 
LPLRVSFCPL SLWRWQLYAA QSTKSPWNFL GDELYEQSDE EQDSVKVALL ETSPYLLALT 

       370        380        390        400        410        420 
IIVSIVHSVF EFLAFKNDIQ FWNSRQSLEG LSVRSVFFGV FQSFVVLLYI LDNETNFVVQ 

       430        440        450        460        470        480 
VSVFIGVLID LWKITKVMDV RLDREHRVAG IFPCPTFKDK STYIESSTKV YDDMAFRYLS 

       490        500        510        520        530        540 
WILFPLLGCY AVYSLLYLEH KGWYSWVLSM LYGFLLTFGF ITMTPQLFIN YKLKSVAHLP 

       550        560        570        580        590        600 
WRMLTYKALN TFIDDLFAFV IKMPVMYRIG CLRDDVVFFI YLYQRWIYRV DPTRVNEFGM 

       610        620        630        640        650        660 
SGEDVSAAAS RAQASTAAGA LTPAPSTAVS GEDASTVPKA TSGACTASQP QEAPPKPAED 


KKKD 

« Hide

References

« Hide 'large scale' references
[1]"Transgenic expression of a novel thymic epithelial cell antigen stimulates aberrant development of thymocytes."
Takeuchi T., Kuro-o M., Miyazawa H., Ohtsuki Y., Yamamoto H.
J. Immunol. 159:726-733(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Thymus.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor and Salivary gland.
[4]"Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate."
Yoshiura K., Machida J., Daack-Hirsch S., Patil S.R., Ashworth L.K., Hecht J.T., Murray J.C.
Genomics 54:231-240(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D67067 mRNA. Translation: BAA19836.1. Frameshift.
AK148080 mRNA. Translation: BAE28332.1.
AK152410 mRNA. Translation: BAE31196.1.
AK152809 mRNA. Translation: BAE31514.1.
BC018389 mRNA. Translation: AAH18389.1.
BC022172 mRNA. Translation: AAH22172.1.
RefSeqNP_062623.2. NM_019649.2.
UniGeneMm.290960.

3D structure databases

ProteinModelPortalQ8VBZ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1858736.
STRING10090.ENSMUSP00000051293.

PTM databases

PhosphoSiteQ8VBZ3.

Proteomic databases

PaxDbQ8VBZ3.
PRIDEQ8VBZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055242; ENSMUSP00000051293; ENSMUSG00000002981.
GeneID56457.
KEGGmmu:56457.
UCSCuc009fmq.1. mouse.

Organism-specific databases

CTD1209.
MGIMGI:1927155. Clptm1.

Phylogenomic databases

eggNOGNOG287859.
GeneTreeENSGT00530000063461.
HOGENOMHOG000201405.
HOVERGENHBG057146.
InParanoidQ8VBZ3.
OMAHRVAGIF.
OrthoDBEOG74N5GH.
PhylomeDBQ8VBZ3.
TreeFamTF318501.

Gene expression databases

BgeeQ8VBZ3.
GenevestigatorQ8VBZ3.

Family and domain databases

InterProIPR008429. CLPTM1.
[Graphical view]
PANTHERPTHR21347. PTHR21347. 1 hit.
PfamPF05602. CLPTM1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312694.
PROQ8VBZ3.
SOURCESearch...

Entry information

Entry nameCLPT1_MOUSE
AccessionPrimary (citable) accession number: Q8VBZ3
Secondary accession number(s): O08708 expand/collapse secondary AC list , Q3U758, Q3U823, Q3UG77, Q8VEJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot