ID   DHRSX_MOUSE             Reviewed;         335 AA.
AC   Q8VBZ0; B2RRV9; Q3TZW6;
DT   03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   27-MAR-2024, entry version 116.
DE   RecName: Full=Dehydrogenase/reductase SDR family member on chromosome X homolog;
DE            EC=1.1.-.-;
DE   AltName: Full=DHRSXY;
DE   AltName: Full=SCAD family protein;
GN   Name=Dhrsx; Synonyms=Pscad;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=NOD; TISSUE=Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-280.
RC   STRAIN=FVB/N; TISSUE=Embryo;
RX   PubMed=11731500; DOI=10.1101/gr.197001;
RA   Gianfrancesco F., Sanges R., Esposito T., Tempesta S., Rao E., Rappold G.,
RA   Archidiacono N., Graves J.A.M., Forabosco A., D'Urso M.;
RT   "Differential divergence of three human pseudoautosomal genes and their
RT   mouse homologs: implications for sex chromosome evolution.";
RL   Genome Res. 11:2095-2100(2001).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Liver, Lung, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Involved in the positive regulation of starvation-induced
CC       autophagy. {ECO:0000250|UniProtKB:Q8N5I4}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8N5I4}.
CC       Note=Secreted in a non-classical form. A signal peptide sequence at
CC       position 1-23 is predicted. {ECO:0000250|UniProtKB:Q8N5I4}.
CC   -!- MISCELLANEOUS: Autosomal gene, which is the ortholog of human DHRSX,
CC       located at the termini of the long and short arms of the X and Y
CC       chromosomes.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AK157461; BAE34091.1; -; mRNA.
DR   EMBL; BC138597; AAI38598.1; -; mRNA.
DR   EMBL; BC138599; AAI38600.1; -; mRNA.
DR   EMBL; AJ296079; CAC82539.1; -; mRNA.
DR   AlphaFoldDB; Q8VBZ0; -.
DR   SMR; Q8VBZ0; -.
DR   STRING; 10090.ENSMUSP00000076472; -.
DR   iPTMnet; Q8VBZ0; -.
DR   PhosphoSitePlus; Q8VBZ0; -.
DR   EPD; Q8VBZ0; -.
DR   MaxQB; Q8VBZ0; -.
DR   PaxDb; 10090-ENSMUSP00000076472; -.
DR   PeptideAtlas; Q8VBZ0; -.
DR   ProteomicsDB; 279529; -.
DR   Pumba; Q8VBZ0; -.
DR   UCSC; uc009vdc.1; mouse.
DR   AGR; MGI:2181510; -.
DR   MGI; MGI:2181510; Dhrsx.
DR   eggNOG; KOG1208; Eukaryota.
DR   InParanoid; Q8VBZ0; -.
DR   PhylomeDB; Q8VBZ0; -.
DR   PRO; PR:Q8VBZ0; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q8VBZ0; Protein.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
DR   CDD; cd05327; retinol-DH_like_SDR_c_like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR24320:SF251; DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER ON CHROMOSOME X; 1.
DR   PANTHER; PTHR24320; RETINOL DEHYDROGENASE; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Reference proteome; Secreted.
FT   CHAIN           1..335
FT                   /note="Dehydrogenase/reductase SDR family member on
FT                   chromosome X homolog"
FT                   /id="PRO_0000031975"
FT   ACT_SITE        208
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         47..71
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         183
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        131
FT                   /note="G -> A (in Ref. 3; CAC82539)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        186
FT                   /note="H -> Q (in Ref. 3; CAC82539)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        247
FT                   /note="L -> M (in Ref. 3; CAC82539)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   335 AA;  35957 MW;  A191AC1BA9065F85 CRC64;
     MSTLRALRAV LCVYAVGIAV ALAQLLRRLR GDFRPPVLPP QPGRVAIVTG ATAGIGRSTA
     RQLARLGMCV VVAGNDEHRG QEVVSSIRAE MGSDRAHFLP LDLASLASVR GFARDFQALG
     LPLHLLVNNA GVMLEPRAET EDGFERHLGV NFLGHFLLTL LLLPALRASG AEGRGSRVVT
     VGSATHYVGT VDMADLHGRH AYSPYAAYAQ SKLALALFAL QLQRILDARG DPVTSNMADP
     GVVDTELYRH AGWVLRTAKR FLGWLVFKSP EEGAWTLVYA AAAPELEGVG GRYLRDEAEA
     EPLGTARDQE LQRRLWAEGL RLTGAGGGDS DGVAW
//