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Protein

Dehydrogenase/reductase SDR family member on chromosome X homolog

Gene

Dhrsx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the positive regulation of starvation-induced autophagy.By similarity

Miscellaneous

Autosomal gene, which is the ortholog of human DHRSX, located at the termini of the long and short arms of the X and Y chromosomes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183SubstrateBy similarity1
Active sitei208Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 71NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member on chromosome X homolog (EC:1.1.-.-)
Alternative name(s):
DHRSXY
SCAD family protein
Gene namesi
Name:Dhrsx
Synonyms:Pscad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2181510. Dhrsx.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000319751 – 335Dehydrogenase/reductase SDR family member on chromosome X homologAdd BLAST335

Proteomic databases

MaxQBiQ8VBZ0.
PaxDbiQ8VBZ0.
PeptideAtlasiQ8VBZ0.
PRIDEiQ8VBZ0.

PTM databases

iPTMnetiQ8VBZ0.

Expressioni

Gene expression databases

CleanExiMM_DHRSX.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076472.

Structurei

3D structure databases

ProteinModelPortaliQ8VBZ0.
SMRiQ8VBZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 163Poly-Leu7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG078800.
InParanoidiQ8VBZ0.
PhylomeDBiQ8VBZ0.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VBZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLRALRAV LCVYAVGIAV ALAQLLRRLR GDFRPPVLPP QPGRVAIVTG
60 70 80 90 100
ATAGIGRSTA RQLARLGMCV VVAGNDEHRG QEVVSSIRAE MGSDRAHFLP
110 120 130 140 150
LDLASLASVR GFARDFQALG LPLHLLVNNA GVMLEPRAET EDGFERHLGV
160 170 180 190 200
NFLGHFLLTL LLLPALRASG AEGRGSRVVT VGSATHYVGT VDMADLHGRH
210 220 230 240 250
AYSPYAAYAQ SKLALALFAL QLQRILDARG DPVTSNMADP GVVDTELYRH
260 270 280 290 300
AGWVLRTAKR FLGWLVFKSP EEGAWTLVYA AAAPELEGVG GRYLRDEAEA
310 320 330
EPLGTARDQE LQRRLWAEGL RLTGAGGGDS DGVAW
Length:335
Mass (Da):35,957
Last modified:January 9, 2007 - v2
Checksum:iA191AC1BA9065F85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131G → A in CAC82539 (PubMed:11731500).Curated1
Sequence conflicti186H → Q in CAC82539 (PubMed:11731500).Curated1
Sequence conflicti247L → M in CAC82539 (PubMed:11731500).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157461 mRNA. Translation: BAE34091.1.
BC138597 mRNA. Translation: AAI38598.1.
BC138599 mRNA. Translation: AAI38600.1.
AJ296079 mRNA. Translation: CAC82539.1.
UniGeneiMm.305345.

Genome annotation databases

UCSCiuc009vdc.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiDHRSX_MOUSE
AccessioniPrimary (citable) accession number: Q8VBZ0
Secondary accession number(s): B2RRV9, Q3TZW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: January 9, 2007
Last modified: October 25, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families