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Q8VBZ0

- DHRSX_MOUSE

UniProt

Q8VBZ0 - DHRSX_MOUSE

Protein

Dehydrogenase/reductase SDR family member on chromosome X homolog

Gene

Dhrsx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei183 – 1831SubstrateBy similarity
    Active sitei208 – 2081Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi47 – 7125NAD or NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dehydrogenase/reductase SDR family member on chromosome X homolog (EC:1.1.-.-)
    Alternative name(s):
    DHRSXY
    SCAD family protein
    Gene namesi
    Name:Dhrsx
    Synonyms:Pscad
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2181510. Dhrsx.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 335312Dehydrogenase/reductase SDR family member on chromosome X homologPRO_0000031975Add
    BLAST

    Proteomic databases

    PaxDbiQ8VBZ0.
    PRIDEiQ8VBZ0.

    Expressioni

    Gene expression databases

    CleanExiMM_DHRSX.
    GenevestigatoriQ8VBZ0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VBZ0.
    SMRiQ8VBZ0. Positions 2-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi157 – 1637Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG078800.
    InParanoidiB2RRV9.
    PhylomeDBiQ8VBZ0.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VBZ0-1 [UniParc]FASTAAdd to Basket

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    MSTLRALRAV LCVYAVGIAV ALAQLLRRLR GDFRPPVLPP QPGRVAIVTG    50
    ATAGIGRSTA RQLARLGMCV VVAGNDEHRG QEVVSSIRAE MGSDRAHFLP 100
    LDLASLASVR GFARDFQALG LPLHLLVNNA GVMLEPRAET EDGFERHLGV 150
    NFLGHFLLTL LLLPALRASG AEGRGSRVVT VGSATHYVGT VDMADLHGRH 200
    AYSPYAAYAQ SKLALALFAL QLQRILDARG DPVTSNMADP GVVDTELYRH 250
    AGWVLRTAKR FLGWLVFKSP EEGAWTLVYA AAAPELEGVG GRYLRDEAEA 300
    EPLGTARDQE LQRRLWAEGL RLTGAGGGDS DGVAW 335
    Length:335
    Mass (Da):35,957
    Last modified:January 9, 2007 - v2
    Checksum:iA191AC1BA9065F85
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti131 – 1311G → A in CAC82539. (PubMed:11731500)Curated
    Sequence conflicti186 – 1861H → Q in CAC82539. (PubMed:11731500)Curated
    Sequence conflicti247 – 2471L → M in CAC82539. (PubMed:11731500)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK157461 mRNA. Translation: BAE34091.1.
    BC138597 mRNA. Translation: AAI38598.1.
    BC138599 mRNA. Translation: AAI38600.1.
    AJ296079 mRNA. Translation: CAC82539.1.
    UniGeneiMm.305345.

    Genome annotation databases

    UCSCiuc009vdc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK157461 mRNA. Translation: BAE34091.1 .
    BC138597 mRNA. Translation: AAI38598.1 .
    BC138599 mRNA. Translation: AAI38600.1 .
    AJ296079 mRNA. Translation: CAC82539.1 .
    UniGenei Mm.305345.

    3D structure databases

    ProteinModelPortali Q8VBZ0.
    SMRi Q8VBZ0. Positions 2-275.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8VBZ0.
    PRIDEi Q8VBZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc009vdc.1. mouse.

    Organism-specific databases

    MGIi MGI:2181510. Dhrsx.

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG078800.
    InParanoidi B2RRV9.
    PhylomeDBi Q8VBZ0.

    Miscellaneous databases

    PROi Q8VBZ0.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_DHRSX.
    Genevestigatori Q8VBZ0.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution."
      Gianfrancesco F., Sanges R., Esposito T., Tempesta S., Rao E., Rappold G., Archidiacono N., Graves J.A.M., Forabosco A., D'Urso M.
      Genome Res. 11:2095-2100(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-280.
      Strain: FVB/N.
      Tissue: Embryo.

    Entry informationi

    Entry nameiDHRSX_MOUSE
    AccessioniPrimary (citable) accession number: Q8VBZ0
    Secondary accession number(s): B2RRV9, Q3TZW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Autosomal gene, which is the ortholog of human DHRSX, located at the termini of the long and short arms of the X and Y chromosomes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3