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Q8VBZ0 (DHRSX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dehydrogenase/reductase SDR family member on chromosome X homolog

EC=1.1.-.-
Alternative name(s):
DHRSXY
SCAD family protein
Gene names
Name:Dhrsx
Synonyms:Pscad
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Miscellaneous

Autosomal gene, which is the ortholog of human DHRSX, located at the termini of the long and short arms of the X and Y chromosomes.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   DomainSignal
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 335312Dehydrogenase/reductase SDR family member on chromosome X homolog
PRO_0000031975

Regions

Nucleotide binding47 – 7125NAD or NADP By similarity
Compositional bias157 – 1637Poly-Leu

Sites

Active site2081Proton acceptor By similarity
Binding site1831Substrate By similarity

Experimental info

Sequence conflict1311G → A in CAC82539. Ref.3
Sequence conflict1861H → Q in CAC82539. Ref.3
Sequence conflict2471L → M in CAC82539. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8VBZ0 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: A191AC1BA9065F85

FASTA33535,957
        10         20         30         40         50         60 
MSTLRALRAV LCVYAVGIAV ALAQLLRRLR GDFRPPVLPP QPGRVAIVTG ATAGIGRSTA 

        70         80         90        100        110        120 
RQLARLGMCV VVAGNDEHRG QEVVSSIRAE MGSDRAHFLP LDLASLASVR GFARDFQALG 

       130        140        150        160        170        180 
LPLHLLVNNA GVMLEPRAET EDGFERHLGV NFLGHFLLTL LLLPALRASG AEGRGSRVVT 

       190        200        210        220        230        240 
VGSATHYVGT VDMADLHGRH AYSPYAAYAQ SKLALALFAL QLQRILDARG DPVTSNMADP 

       250        260        270        280        290        300 
GVVDTELYRH AGWVLRTAKR FLGWLVFKSP EEGAWTLVYA AAAPELEGVG GRYLRDEAEA 

       310        320        330 
EPLGTARDQE LQRRLWAEGL RLTGAGGGDS DGVAW 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution."
Gianfrancesco F., Sanges R., Esposito T., Tempesta S., Rao E., Rappold G., Archidiacono N., Graves J.A.M., Forabosco A., D'Urso M.
Genome Res. 11:2095-2100(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-280.
Strain: FVB/N.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK157461 mRNA. Translation: BAE34091.1.
BC138597 mRNA. Translation: AAI38598.1.
BC138599 mRNA. Translation: AAI38600.1.
AJ296079 mRNA. Translation: CAC82539.1.
UniGeneMm.305345.

3D structure databases

ProteinModelPortalQ8VBZ0.
SMRQ8VBZ0. Positions 2-327.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ8VBZ0.
PRIDEQ8VBZ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc009vdc.1. mouse.

Organism-specific databases

MGIMGI:2181510. Dhrsx.

Phylogenomic databases

eggNOGCOG1028.
HOVERGENHBG078800.
InParanoidB2RRV9.
PhylomeDBQ8VBZ0.

Gene expression databases

CleanExMM_DHRSX.
GenevestigatorQ8VBZ0.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8VBZ0.
SOURCESearch...

Entry information

Entry nameDHRSX_MOUSE
AccessionPrimary (citable) accession number: Q8VBZ0
Secondary accession number(s): B2RRV9, Q3TZW6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot