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Q8VBZ0

- DHRSX_MOUSE

UniProt

Q8VBZ0 - DHRSX_MOUSE

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Protein

Dehydrogenase/reductase SDR family member on chromosome X homolog

Gene

Dhrsx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831SubstrateBy similarity
Active sitei208 – 2081Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 7125NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member on chromosome X homolog (EC:1.1.-.-)
Alternative name(s):
DHRSXY
SCAD family protein
Gene namesi
Name:Dhrsx
Synonyms:Pscad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2181510. Dhrsx.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 335312Dehydrogenase/reductase SDR family member on chromosome X homologPRO_0000031975Add
BLAST

Proteomic databases

MaxQBiQ8VBZ0.
PaxDbiQ8VBZ0.
PRIDEiQ8VBZ0.

Expressioni

Gene expression databases

CleanExiMM_DHRSX.
GenevestigatoriQ8VBZ0.

Structurei

3D structure databases

ProteinModelPortaliQ8VBZ0.
SMRiQ8VBZ0. Positions 2-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi157 – 1637Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG078800.
InParanoidiQ8VBZ0.
PhylomeDBiQ8VBZ0.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBZ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTLRALRAV LCVYAVGIAV ALAQLLRRLR GDFRPPVLPP QPGRVAIVTG
60 70 80 90 100
ATAGIGRSTA RQLARLGMCV VVAGNDEHRG QEVVSSIRAE MGSDRAHFLP
110 120 130 140 150
LDLASLASVR GFARDFQALG LPLHLLVNNA GVMLEPRAET EDGFERHLGV
160 170 180 190 200
NFLGHFLLTL LLLPALRASG AEGRGSRVVT VGSATHYVGT VDMADLHGRH
210 220 230 240 250
AYSPYAAYAQ SKLALALFAL QLQRILDARG DPVTSNMADP GVVDTELYRH
260 270 280 290 300
AGWVLRTAKR FLGWLVFKSP EEGAWTLVYA AAAPELEGVG GRYLRDEAEA
310 320 330
EPLGTARDQE LQRRLWAEGL RLTGAGGGDS DGVAW
Length:335
Mass (Da):35,957
Last modified:January 9, 2007 - v2
Checksum:iA191AC1BA9065F85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311G → A in CAC82539. (PubMed:11731500)Curated
Sequence conflicti186 – 1861H → Q in CAC82539. (PubMed:11731500)Curated
Sequence conflicti247 – 2471L → M in CAC82539. (PubMed:11731500)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157461 mRNA. Translation: BAE34091.1.
BC138597 mRNA. Translation: AAI38598.1.
BC138599 mRNA. Translation: AAI38600.1.
AJ296079 mRNA. Translation: CAC82539.1.
UniGeneiMm.305345.

Genome annotation databases

UCSCiuc009vdc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157461 mRNA. Translation: BAE34091.1 .
BC138597 mRNA. Translation: AAI38598.1 .
BC138599 mRNA. Translation: AAI38600.1 .
AJ296079 mRNA. Translation: CAC82539.1 .
UniGenei Mm.305345.

3D structure databases

ProteinModelPortali Q8VBZ0.
SMRi Q8VBZ0. Positions 2-275.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q8VBZ0.
PaxDbi Q8VBZ0.
PRIDEi Q8VBZ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc009vdc.1. mouse.

Organism-specific databases

MGIi MGI:2181510. Dhrsx.

Phylogenomic databases

eggNOGi COG1028.
HOVERGENi HBG078800.
InParanoidi Q8VBZ0.
PhylomeDBi Q8VBZ0.

Miscellaneous databases

PROi Q8VBZ0.
SOURCEi Search...

Gene expression databases

CleanExi MM_DHRSX.
Genevestigatori Q8VBZ0.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution."
    Gianfrancesco F., Sanges R., Esposito T., Tempesta S., Rao E., Rappold G., Archidiacono N., Graves J.A.M., Forabosco A., D'Urso M.
    Genome Res. 11:2095-2100(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-280.
    Strain: FVB/N.
    Tissue: Embryo.

Entry informationi

Entry nameiDHRSX_MOUSE
AccessioniPrimary (citable) accession number: Q8VBZ0
Secondary accession number(s): B2RRV9, Q3TZW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Autosomal gene, which is the ortholog of human DHRSX, located at the termini of the long and short arms of the X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3