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Protein

Dehydrogenase/reductase SDR family member on chromosome X homolog

Gene

Dhrsx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183SubstrateBy similarity1
Active sitei208Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 71NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member on chromosome X homolog (EC:1.1.-.-)
Alternative name(s):
DHRSXY
SCAD family protein
Gene namesi
Name:Dhrsx
Synonyms:Pscad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2181510. Dhrsx.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003197524 – 335Dehydrogenase/reductase SDR family member on chromosome X homologAdd BLAST312

Proteomic databases

MaxQBiQ8VBZ0.
PaxDbiQ8VBZ0.
PeptideAtlasiQ8VBZ0.
PRIDEiQ8VBZ0.

Expressioni

Gene expression databases

CleanExiMM_DHRSX.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076472.

Structurei

3D structure databases

ProteinModelPortaliQ8VBZ0.
SMRiQ8VBZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 163Poly-Leu7

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG078800.
InParanoidiQ8VBZ0.
PhylomeDBiQ8VBZ0.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLRALRAV LCVYAVGIAV ALAQLLRRLR GDFRPPVLPP QPGRVAIVTG
60 70 80 90 100
ATAGIGRSTA RQLARLGMCV VVAGNDEHRG QEVVSSIRAE MGSDRAHFLP
110 120 130 140 150
LDLASLASVR GFARDFQALG LPLHLLVNNA GVMLEPRAET EDGFERHLGV
160 170 180 190 200
NFLGHFLLTL LLLPALRASG AEGRGSRVVT VGSATHYVGT VDMADLHGRH
210 220 230 240 250
AYSPYAAYAQ SKLALALFAL QLQRILDARG DPVTSNMADP GVVDTELYRH
260 270 280 290 300
AGWVLRTAKR FLGWLVFKSP EEGAWTLVYA AAAPELEGVG GRYLRDEAEA
310 320 330
EPLGTARDQE LQRRLWAEGL RLTGAGGGDS DGVAW
Length:335
Mass (Da):35,957
Last modified:January 9, 2007 - v2
Checksum:iA191AC1BA9065F85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131G → A in CAC82539 (PubMed:11731500).Curated1
Sequence conflicti186H → Q in CAC82539 (PubMed:11731500).Curated1
Sequence conflicti247L → M in CAC82539 (PubMed:11731500).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157461 mRNA. Translation: BAE34091.1.
BC138597 mRNA. Translation: AAI38598.1.
BC138599 mRNA. Translation: AAI38600.1.
AJ296079 mRNA. Translation: CAC82539.1.
UniGeneiMm.305345.

Genome annotation databases

UCSCiuc009vdc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157461 mRNA. Translation: BAE34091.1.
BC138597 mRNA. Translation: AAI38598.1.
BC138599 mRNA. Translation: AAI38600.1.
AJ296079 mRNA. Translation: CAC82539.1.
UniGeneiMm.305345.

3D structure databases

ProteinModelPortaliQ8VBZ0.
SMRiQ8VBZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076472.

Proteomic databases

MaxQBiQ8VBZ0.
PaxDbiQ8VBZ0.
PeptideAtlasiQ8VBZ0.
PRIDEiQ8VBZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009vdc.1. mouse.

Organism-specific databases

MGIiMGI:2181510. Dhrsx.

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG078800.
InParanoidiQ8VBZ0.
PhylomeDBiQ8VBZ0.

Miscellaneous databases

PROiQ8VBZ0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_DHRSX.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHRSX_MOUSE
AccessioniPrimary (citable) accession number: Q8VBZ0
Secondary accession number(s): B2RRV9, Q3TZW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Autosomal gene, which is the ortholog of human DHRSX, located at the termini of the long and short arms of the X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.