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Protein

Multiple PDZ domain protein

Gene

Mpdz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: MGI
  • myelination Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple PDZ domain protein
Alternative name(s):
Multi-PDZ domain protein 1
Gene namesi
Name:Mpdz
Synonyms:Mupp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1343489. Mpdz.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • apicolateral plasma membrane Source: MGI
  • bicellular tight junction Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic vesicle Source: MGI
  • dendrite Source: UniProtKB-SubCell
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
  • Schmidt-Lanterman incisure Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176783.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20552055Multiple PDZ domain proteinPRO_0000094595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei783 – 7831PhosphoserineBy similarity
Modified residuei1066 – 10661PhosphoserineBy similarity
Modified residuei1803 – 18031PhosphoserineBy similarity
Modified residuei1809 – 18091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VBX6.
MaxQBiQ8VBX6.
PaxDbiQ8VBX6.
PRIDEiQ8VBX6.

PTM databases

iPTMnetiQ8VBX6.
PhosphoSiteiQ8VBX6.

Expressioni

Tissue specificityi

In the brain, it is strongly expressed in the choroid plexus. Within the hippocampal formation, strongest expression was seen in the soma of CA1-4 pyramidal cells. Expressed in most neocortical regions with the strongest expression in piriform cortex and amygdaloid nuclei but also detected in the subiculum and olfactory bulb. In the cerebellum, the highest level of expression was found in Purkinje cells. Moderately expressed in the granular layer and molecular layer. Expressed in the pontine nuclei, parts of spinal trigeminal nuclei, and the principal sensory trigeminal nuclei of the metencephalon. Expressed in all thalamic and hypothalamic nuclei, and the substantia nigra (at protein level). Ubiquitously expressed.2 Publications

Gene expression databases

BgeeiENSMUSG00000028402.
CleanExiMM_MPDZ.
ExpressionAtlasiQ8VBX6. baseline and differential.
GenevisibleiQ8VBX6. MM.

Interactioni

Subunit structurei

Interacts with CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B, HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1 and PLEKHA2/TAPP2 (By similarity). Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and MPP5. Interacts with FAT4 (via cytoplasmic domain). Interacts with the adenovirus type 9 E4-ORF1 oncoprotein. Interacts with DLL1 (PubMed:15509766).By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cldn1O885512EBI-8026435,EBI-7158428
KITP107214EBI-8026435,EBI-1379503From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201476. 7 interactions.
DIPiDIP-41165N.
IntActiQ8VBX6. 4 interactions.
MINTiMINT-146667.
STRINGi10090.ENSMUSP00000099894.

Structurei

Secondary structure

1
2055
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi521 – 53818Combined sources
Beta strandi542 – 5509Combined sources
Beta strandi559 – 5657Combined sources
Beta strandi568 – 5747Combined sources
Helixi579 – 5835Combined sources
Beta strandi591 – 5955Combined sources
Helixi605 – 6139Combined sources
Beta strandi617 – 62610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XH7X-ray1.65A521-665[»]
ProteinModelPortaliQ8VBX6.
SMRiQ8VBX6. Positions 11-63, 120-466, 521-629, 684-776, 1002-1064, 1078-1232, 1270-1557, 1610-2055.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6363L27PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 22588PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini258 – 33881PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 46487PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini546 – 62782PDZ 4PROSITE-ProRule annotationAdd
BLAST
Domaini693 – 77987PDZ 5PROSITE-ProRule annotationAdd
BLAST
Domaini996 – 107782PDZ 6PROSITE-ProRule annotationAdd
BLAST
Domaini1139 – 123193PDZ 7PROSITE-ProRule annotationAdd
BLAST
Domaini1338 – 142184PDZ 8PROSITE-ProRule annotationAdd
BLAST
Domaini1471 – 155282PDZ 9PROSITE-ProRule annotationAdd
BLAST
Domaini1614 – 169784PDZ 10PROSITE-ProRule annotationAdd
BLAST
Domaini1710 – 179283PDZ 11PROSITE-ProRule annotationAdd
BLAST
Domaini1847 – 193387PDZ 12PROSITE-ProRule annotationAdd
BLAST
Domaini1972 – 205584PDZ 13PROSITE-ProRule annotationAdd
BLAST

Domaini

The PDZ domain 2 mainly binds CAMK2A and CAMK2B. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 10 binds the C-terminal PDZ-binding motif of HTR2C. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1 (By similarity). The PDZ domain 1 binds NG2. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT. The PDZ domain 13 binds CXADR.By similarity2 Publications

Sequence similaritiesi

Contains 1 L27 domain.PROSITE-ProRule annotation
Contains 13 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
GeneTreeiENSGT00760000119017.
HOVERGENiHBG080134.
InParanoidiQ8VBX6.
KOiK06095.
TreeFamiTF330709.

Family and domain databases

Gene3Di2.30.42.10. 13 hits.
InterProiIPR015132. L27_2.
IPR004172. L27_dom.
IPR032078. MPDZ.
IPR001478. PDZ.
[Graphical view]
PfamiPF09045. L27_2. 1 hit.
PF16667. MPDZ_u10. 1 hit.
PF00595. PDZ. 12 hits.
[Graphical view]
SMARTiSM00569. L27. 1 hit.
SM00228. PDZ. 13 hits.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 13 hits.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 13 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VBX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLETIDKNRA LQAAERLQSK LKERGDVANE DKLSLLKSVL QSPLFSQILN
60 70 80 90 100
LQTSLQQLKD QVNIATLATA AADHAHTPQF SSAVISNLQS ESLLLSPNHG
110 120 130 140 150
NLEALPGPGA PAVMDGKPTC DELDQLIKNM AQGRHVEIFE LLKPPCGGLG
160 170 180 190 200
FSVVGLRSEN RGELGIFVQE IQEGSVAHRD GRLKETDQIL AINGQVLDQT
210 220 230 240 250
ITHQQAISIL QKAKDTVQLV IARGSLPPVS SPRISRSPSA ASTISAHSNP
260 270 280 290 300
MHWQHVETIE LVNDGSGLGF GIIGGKATGV IVKTILPGGV ADQHGRLCSG
310 320 330 340 350
DHILKIGDTD LAGMSSEQVA QVLRQCGNRV KLMIARGAVE ETPASSSLGI
360 370 380 390 400
TLSSSTSSTS EMRVDASTQK NDESETFDVE LTKNVQGLGI TIAGYIGDKK
410 420 430 440 450
LEPSGIFVKS ITKSSAVEHD GRIQIGDQII AVDGTNLQGF TNQQAVEVLR
460 470 480 490 500
HTGQTVRLTL MRKGASQEAE LTSRGDTAKD VDLPAENCEK DEESLSLKRN
510 520 530 540 550
TSILPIEEEG FPLLSAELEE AEDVQQEAAL LTKWQRIMGI NYEIVVAHVS
560 570 580 590 600
KFSENSGLGI SLEATVGHHF IRSVLPEGPV GHSGKLFSGD ELLEVNGINL
610 620 630 640 650
LGENHQDVVN ILKELPIDVT MVCCRRTVPP IALSEMDSLD INDLELTEKP
660 670 680 690 700
HIDLGEFIGS SETEDPMLAM SDVDQNAEEI QTPLAMWEAG GQSIELEKGS
710 720 730 740 750
RGLGFSILDY QDPIDPANTV IVIRSLVPGG IAEKDGRLFP GDRLMFVNDI
760 770 780 790 800
NLENSTLEEA VEALKGAPSG MVRIGVAKPL PLSPEEGYVS AKEDAFLCSP
810 820 830 840 850
HACKESGLSD KALFRADLAL IDTPDAESIA ESRFESQFSP DNDSVYSTQA
860 870 880 890 900
SIFSLHDGTC SDGMNYGPSL PSSPPKDVTS SSEVVLGLHL SLEELYTQNL
910 920 930 940 950
LQRQHAGSPP TDMRPAPTSG FPISDYTTTN AVEQKYECAN PVAWPHSQLP
960 970 980 990 1000
SSLSTSELAP ALPAVAQKYL TDQSSLASDA ESVNLQSMSQ EAFERTVTIA
1010 1020 1030 1040 1050
KGSSSLGMTV SANKDGLGVI VRSIIHGGAI SRDGRIAVGD CILSINEEST
1060 1070 1080 1090 1100
ISLTNAQARA MLRRHSLIGP DIKITYVPAE HLEEFRVSFG QQAGGIMALD
1110 1120 1130 1140 1150
IFSSYTGRDI PELPEREEGE GEESELQNAA YSSWSQPRRV ELWREPSKSL
1160 1170 1180 1190 1200
GISIVGGRGM GSRLSNGEVM RGIFIKHVLE DSPAGKNGTL KPGDRIIEVD
1210 1220 1230 1240 1250
GMDLRDASHE QAVEAIRKAG NPVVFMVQSI INRPRKSPLP SLPHSLYPKY
1260 1270 1280 1290 1300
SFSSTNPFAD SLQLTTDQAP SQSESETEKP ALCNVPPSSP SVFSEMGSDC
1310 1320 1330 1340 1350
AQPSATAVSE DEDKEDEFGY SWKNIQERYG SLTGQLHVIE LEKGQSGLGL
1360 1370 1380 1390 1400
SLAGNKDRTR MSVFIVGIDP TGAAGRDGRL QIADELLEIN GQILYGRSHQ
1410 1420 1430 1440 1450
NASSIIKCAP SKVKIIFIRN ADAVNQMAVC PGIAADSPSS TSDSPQNKEV
1460 1470 1480 1490 1500
EPCSTTSASA ADLSSLTDVY QLELPKDQGG LGIAICEEDT INGVMIESLT
1510 1520 1530 1540 1550
EHGGAAKDGR LKPGDHILAV DDEVVAGCPV EKFISLLKTA KATVKLTVRA
1560 1570 1580 1590 1600
ENPACPAVPS SAVTVSGERK DNSQTPAVPA PDLEPIPSTS RSSTPAVFAS
1610 1620 1630 1640 1650
DPATCPIIPG CETTIEISKG QTGLGLSIVG GSDTLLGAII IHEVYEEGAA
1660 1670 1680 1690 1700
CKDGRLWAGD QILEVNGIDL RKATHDEAIN VLRQTPQRVR LTLYRDEAPY
1710 1720 1730 1740 1750
KEEDVCDTFT IELQKRPGKG LGLSIVGKRN DTGVFVSDIV KGGIADADGR
1760 1770 1780 1790 1800
LMQGDQILMV NGEDVRHATQ EAVAALLKCS LGAVTLEVGR VKAAPFHSER
1810 1820 1830 1840 1850
RPSQSSQVSE SSLSSFTPPL SGINTSESLE SNSKKNALAS EIQGLRTVEI
1860 1870 1880 1890 1900
KKGPADSLGL SIAGGVGSPL GDVPIFIAMM HPNGVAAQTQ KLRVGDRIVT
1910 1920 1930 1940 1950
ICGTSTDGMT HTQAVNLMKN ASGSIEVQVV AGGDVSVVTG HQQELANPCL
1960 1970 1980 1990 2000
AFTGLTSSSI FPDDLGPPQS KTITLDRGPD GLGFSIVGGY GSPHGDLPIY
2010 2020 2030 2040 2050
VKTVFAKGAA AEDGRLKRGD QIIAVNGQSL EGVTHEEAVA ILKRTKGTVT

LMVLS
Length:2,055
Mass (Da):218,711
Last modified:June 21, 2005 - v2
Checksum:i26EA94B814214B69
GO
Isoform 2 (identifier: Q8VBX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1236-1268: Missing.

Note: No experimental confirmation available.
Show »
Length:2,022
Mass (Da):215,061
Checksum:i1B5D7BF3FFA7B4BA
GO
Isoform 3 (identifier: Q8VBX6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2054-2055: LS → SLEVTARVEAAQPLAPLLL

Note: No experimental confirmation available.
Show »
Length:2,072
Mass (Da):220,484
Checksum:iCAA3A0A924541F8D
GO
Isoform 4 (identifier: Q8VBX6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1714-1714: Q → QLQ

Note: No experimental confirmation available.
Show »
Length:2,057
Mass (Da):218,953
Checksum:i7861BBC636A9C862
GO
Isoform 5 (identifier: Q8VBX6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-87: NIATLATAAADHAHTPQFSSAVISN → GWHHPQRPSRCSKDLVRKGSCFSTG
     88-2055: Missing.

Show »
Length:87
Mass (Da):9,845
Checksum:i40BB9E94036D48CB
GO

Sequence cautioni

The sequence BAC27346 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC34766 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti583 – 5831S → N in CAA10523 (PubMed:10395806).Curated
Sequence conflicti588 – 5881S → N in CAA10523 (PubMed:10395806).Curated
Sequence conflicti871 – 8711P → S in CAA10523 (PubMed:10395806).Curated
Sequence conflicti909 – 9102PP → SS in CAA10523 (PubMed:10395806).Curated
Sequence conflicti914 – 9196RPAPTS → KPTPTF in CAA10523 (PubMed:10395806).Curated
Sequence conflicti932 – 9321V → G in CAA10523 (PubMed:10395806).Curated
Sequence conflicti937 – 9382EC → QW in CAA10523 (PubMed:10395806).Curated
Sequence conflicti952 – 9521S → N in CAA10523 (PubMed:10395806).Curated
Sequence conflicti956 – 9561S → F in CAA10523 (PubMed:10395806).Curated
Sequence conflicti960 – 9601P → S in CAA10523 (PubMed:10395806).Curated
Sequence conflicti963 – 9631P → A in CAA10523 (PubMed:10395806).Curated
Sequence conflicti967 – 9671Q → P in CAA10523 (PubMed:10395806).Curated
Sequence conflicti974 – 9752SS → TF in CAA10523 (PubMed:10395806).Curated
Sequence conflicti984 – 9841N → T in CAA10523 (PubMed:10395806).Curated
Sequence conflicti996 – 9961T → P in CAA10523 (PubMed:10395806).Curated
Sequence conflicti1532 – 15321K → N in AAB57835 (PubMed:9192623).Curated
Sequence conflicti1547 – 15471T → I in AAB57835 (PubMed:9192623).Curated
Sequence conflicti1589 – 15891T → P in CAA10523 (PubMed:10395806).Curated
Sequence conflicti1616 – 16172EI → GV in AAB57835 (PubMed:9192623).Curated
Sequence conflicti1691 – 16911L → V in AAB57835 (PubMed:9192623).Curated
Sequence conflicti1844 – 18441G → R in AAB57835 (PubMed:9192623).Curated
Sequence conflicti1914 – 19141A → V in AAH61504 (PubMed:15489334).Curated
Sequence conflicti1968 – 19681P → S in CAA10523 (PubMed:10395806).Curated
Sequence conflicti1983 – 19853GFS → SFN in CAA10523 (PubMed:10395806).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti541 – 5411N → S in strain: DBA/2J and DBA1/J. 1 Publication
Natural varianti691 – 6911G → V in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication
Natural varianti801 – 8011H → R in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication
Natural varianti859 – 8591T → A in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication
Natural varianti880 – 8801S → N in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication
Natural varianti914 – 9141R → S in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication
Natural varianti977 – 9771A → V in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication
Natural varianti1338 – 13381V → M in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication
Natural varianti1433 – 14331I → N in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication
Natural varianti1767 – 17671H → N in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei63 – 8725NIATL…AVISN → GWHHPQRPSRCSKDLVRKGS CFSTG in isoform 5. 1 PublicationVSP_014199Add
BLAST
Alternative sequencei88 – 20551968Missing in isoform 5. 1 PublicationVSP_014200Add
BLAST
Alternative sequencei1236 – 126833Missing in isoform 2. 1 PublicationVSP_014201Add
BLAST
Alternative sequencei1714 – 17141Q → QLQ in isoform 4. 1 PublicationVSP_014202
Alternative sequencei2054 – 20552LS → SLEVTARVEAAQPLAPLLL in isoform 3. 1 PublicationVSP_014203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131869 mRNA. Translation: CAA10523.1.
AF326526 mRNA. Translation: AAL37372.1.
AF326527 mRNA. Translation: AAL37373.1.
AF326528 mRNA. Translation: AAL37374.1.
AF326529 mRNA. Translation: AAL37375.1.
AF326530 mRNA. Translation: AAL37376.1.
AF326531 mRNA. Translation: AAL37377.2.
AF326532 mRNA. Translation: AAL37378.1.
AF326533 mRNA. Translation: AAL37379.1.
AF326534 mRNA. Translation: AAL37380.1.
AF326535 mRNA. Translation: AAL37381.1.
AF326536 mRNA. Translation: AAL37382.1.
AF326537 mRNA. Translation: AAL37383.1.
AF326538 mRNA. Translation: AAL37384.1.
AF326539 mRNA. Translation: AAL37385.1.
AF326540 mRNA. Translation: AAL37386.1.
AF326541 mRNA. Translation: AAL37387.1.
AF326542 mRNA. Translation: AAL37388.1.
AF326543 mRNA. Translation: AAL37389.1.
AF326544 mRNA. Translation: AAL37390.1.
AK031321 mRNA. Translation: BAC27346.1. Different initiation.
AK051782 mRNA. Translation: BAC34766.1. Different initiation.
CR352325, AL670939 Genomic DNA. Translation: CAI25220.1.
AL670939, CR352325 Genomic DNA. Translation: CAI25921.1.
BC061504 mRNA. Translation: AAH61504.1.
BC145117 mRNA. Translation: AAI45118.1.
AF000168 mRNA. Translation: AAB57835.1.
CCDSiCCDS18292.1. [Q8VBX6-1]
PIRiT30259.
RefSeqiNP_001292213.1. NM_001305284.1.
NP_001292215.1. NM_001305286.1. [Q8VBX6-2]
NP_034950.2. NM_010820.3. [Q8VBX6-1]
UniGeneiMm.153039.

Genome annotation databases

EnsembliENSMUST00000102830; ENSMUSP00000099894; ENSMUSG00000028402. [Q8VBX6-1]
GeneIDi17475.
KEGGimmu:17475.
UCSCiuc008tjw.3. mouse. [Q8VBX6-2]
uc008tjx.2. mouse. [Q8VBX6-1]
uc008tjy.2. mouse. [Q8VBX6-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131869 mRNA. Translation: CAA10523.1.
AF326526 mRNA. Translation: AAL37372.1.
AF326527 mRNA. Translation: AAL37373.1.
AF326528 mRNA. Translation: AAL37374.1.
AF326529 mRNA. Translation: AAL37375.1.
AF326530 mRNA. Translation: AAL37376.1.
AF326531 mRNA. Translation: AAL37377.2.
AF326532 mRNA. Translation: AAL37378.1.
AF326533 mRNA. Translation: AAL37379.1.
AF326534 mRNA. Translation: AAL37380.1.
AF326535 mRNA. Translation: AAL37381.1.
AF326536 mRNA. Translation: AAL37382.1.
AF326537 mRNA. Translation: AAL37383.1.
AF326538 mRNA. Translation: AAL37384.1.
AF326539 mRNA. Translation: AAL37385.1.
AF326540 mRNA. Translation: AAL37386.1.
AF326541 mRNA. Translation: AAL37387.1.
AF326542 mRNA. Translation: AAL37388.1.
AF326543 mRNA. Translation: AAL37389.1.
AF326544 mRNA. Translation: AAL37390.1.
AK031321 mRNA. Translation: BAC27346.1. Different initiation.
AK051782 mRNA. Translation: BAC34766.1. Different initiation.
CR352325, AL670939 Genomic DNA. Translation: CAI25220.1.
AL670939, CR352325 Genomic DNA. Translation: CAI25921.1.
BC061504 mRNA. Translation: AAH61504.1.
BC145117 mRNA. Translation: AAI45118.1.
AF000168 mRNA. Translation: AAB57835.1.
CCDSiCCDS18292.1. [Q8VBX6-1]
PIRiT30259.
RefSeqiNP_001292213.1. NM_001305284.1.
NP_001292215.1. NM_001305286.1. [Q8VBX6-2]
NP_034950.2. NM_010820.3. [Q8VBX6-1]
UniGeneiMm.153039.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4XH7X-ray1.65A521-665[»]
ProteinModelPortaliQ8VBX6.
SMRiQ8VBX6. Positions 11-63, 120-466, 521-629, 684-776, 1002-1064, 1078-1232, 1270-1557, 1610-2055.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201476. 7 interactions.
DIPiDIP-41165N.
IntActiQ8VBX6. 4 interactions.
MINTiMINT-146667.
STRINGi10090.ENSMUSP00000099894.

Chemistry

ChEMBLiCHEMBL2176783.

PTM databases

iPTMnetiQ8VBX6.
PhosphoSiteiQ8VBX6.

Proteomic databases

EPDiQ8VBX6.
MaxQBiQ8VBX6.
PaxDbiQ8VBX6.
PRIDEiQ8VBX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102830; ENSMUSP00000099894; ENSMUSG00000028402. [Q8VBX6-1]
GeneIDi17475.
KEGGimmu:17475.
UCSCiuc008tjw.3. mouse. [Q8VBX6-2]
uc008tjx.2. mouse. [Q8VBX6-1]
uc008tjy.2. mouse. [Q8VBX6-5]

Organism-specific databases

CTDi8777.
MGIiMGI:1343489. Mpdz.

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
GeneTreeiENSGT00760000119017.
HOVERGENiHBG080134.
InParanoidiQ8VBX6.
KOiK06095.
TreeFamiTF330709.

Miscellaneous databases

PROiQ8VBX6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028402.
CleanExiMM_MPDZ.
ExpressionAtlasiQ8VBX6. baseline and differential.
GenevisibleiQ8VBX6. MM.

Family and domain databases

Gene3Di2.30.42.10. 13 hits.
InterProiIPR015132. L27_2.
IPR004172. L27_dom.
IPR032078. MPDZ.
IPR001478. PDZ.
[Graphical view]
PfamiPF09045. L27_2. 1 hit.
PF16667. MPDZ_u10. 1 hit.
PF00595. PDZ. 12 hits.
[Graphical view]
SMARTiSM00569. L27. 1 hit.
SM00228. PDZ. 13 hits.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 13 hits.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPDZ_MOUSE
AccessioniPrimary (citable) accession number: Q8VBX6
Secondary accession number(s): B7ZNA1
, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.