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Q8VBX4

- CLC4K_MOUSE

UniProt

Q8VBX4 - CLC4K_MOUSE

Protein

C-type lectin domain family 4 member K

Gene

Cd207

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.2 Publications

    GO - Molecular functioni

    1. carbohydrate binding Source: MGI

    GO - Biological processi

    1. defense response to virus Source: Ensembl

    Keywords - Ligandi

    Lectin

    Enzyme and pathway databases

    ReactomeiREACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type lectin domain family 4 member K
    Alternative name(s):
    Langerin
    CD_antigen: CD207
    Gene namesi
    Name:Cd207
    Synonyms:Clec4k
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2180021. Cd207.

    Subcellular locationi

    Membrane; Single-pass type II membrane protein
    Note: Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331C-type lectin domain family 4 member KPRO_0000223694Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi226 ↔ 322PROSITE-ProRule annotation
    Modified residuei240 – 2401PhosphoserineBy similarity
    Modified residuei246 – 2461PhosphotyrosineBy similarity
    Disulfide bondi298 ↔ 314PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ8VBX4.

    PTM databases

    PhosphoSiteiQ8VBX4.

    Expressioni

    Tissue specificityi

    Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.1 Publication

    Gene expression databases

    ArrayExpressiQ8VBX4.
    BgeeiQ8VBX4.
    CleanExiMM_CD207.
    GenevestigatoriQ8VBX4.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000040746.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VBX4.
    SMRiQ8VBX4. Positions 163-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini63 – 331269ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini205 – 323119C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili106 – 19792Sequence AnalysisAdd
    BLAST

    Domaini

    The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.By similarity

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311341.
    GeneTreeiENSGT00750000117265.
    HOGENOMiHOG000064516.
    HOVERGENiHBG073250.
    InParanoidiQ8VBX4.
    KOiK06561.
    OMAiFKGNFYY.
    OrthoDBiEOG7QZGBX.
    PhylomeDBiQ8VBX4.
    TreeFamiTF333341.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VBX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEAEMKEEA PEAHFTVDKQ NISLWPREPP PKQDLSPVLR KPLCICVAFT    50
    CLALVLVTSI VLQAVFYPRL MGKILDVKSD AQMLKGRVDN ISTLGSDLKT 100
    ERGRVDDAEV QMQIVNTTLK RVRSQILSLE TSMKIANDQL QILTMSWGEV 150
    DSLSAKIPEL KRDLDKASAL NTKVQGLQNS LENVNKLLKQ QSDILEMVAR 200
    GWKYFSGNFY YFSRTPKTWY SAEQFCISRK AHLTSVSSES EQKFLYKAAD 250
    GIPHWIGLTK AGSEGDWYWV DQTSFNKEQS RRFWIPGEPN NAGNNEHCAN 300
    IRVSALKCWN DGPCDNTFLF ICKRPYVQTT E 331
    Length:331
    Mass (Da):37,621
    Last modified:March 1, 2002 - v1
    Checksum:i3DFCFDB322CAB7E8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051V → A in AAL83701. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302711 mRNA. Translation: CAC82936.1.
    AY026050 mRNA. Translation: AAK01952.1.
    AY078415 mRNA. Translation: AAL83701.1.
    AK142731 mRNA. Translation: BAE25177.1.
    CCDSiCCDS39534.1.
    RefSeqiNP_659192.2. NM_144943.3.
    UniGeneiMm.136079.

    Genome annotation databases

    EnsembliENSMUST00000037882; ENSMUSP00000040746; ENSMUSG00000034783.
    GeneIDi246278.
    KEGGimmu:246278.
    UCSCiuc009cnw.2. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Langerin

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302711 mRNA. Translation: CAC82936.1 .
    AY026050 mRNA. Translation: AAK01952.1 .
    AY078415 mRNA. Translation: AAL83701.1 .
    AK142731 mRNA. Translation: BAE25177.1 .
    CCDSi CCDS39534.1.
    RefSeqi NP_659192.2. NM_144943.3.
    UniGenei Mm.136079.

    3D structure databases

    ProteinModelPortali Q8VBX4.
    SMRi Q8VBX4. Positions 163-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000040746.

    PTM databases

    PhosphoSitei Q8VBX4.

    Proteomic databases

    PRIDEi Q8VBX4.

    Protocols and materials databases

    DNASUi 246278.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037882 ; ENSMUSP00000040746 ; ENSMUSG00000034783 .
    GeneIDi 246278.
    KEGGi mmu:246278.
    UCSCi uc009cnw.2. mouse.

    Organism-specific databases

    CTDi 50489.
    MGIi MGI:2180021. Cd207.

    Phylogenomic databases

    eggNOGi NOG311341.
    GeneTreei ENSGT00750000117265.
    HOGENOMi HOG000064516.
    HOVERGENi HBG073250.
    InParanoidi Q8VBX4.
    KOi K06561.
    OMAi FKGNFYY.
    OrthoDBi EOG7QZGBX.
    PhylomeDBi Q8VBX4.
    TreeFami TF333341.

    Enzyme and pathway databases

    Reactomei REACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).

    Miscellaneous databases

    NextBioi 387209.
    PROi Q8VBX4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VBX4.
    Bgeei Q8VBX4.
    CleanExi MM_CD207.
    Genevestigatori Q8VBX4.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Lung.
    2. "Mouse langerin homologue: identification, expression pattern, and chromosomal mapping of the cognate mouse and rat gene."
      Takahara K., Omatsu Y., Umemoto E., Yashima Y., Matsubara K., Shimoyama S., Iyoda T., Matsuda Y., Inaba K.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: F1.
    3. "Cloning of mouse Langerin from fetal skin-derived dendritic cells."
      Riedl E., Wilson M., Udey M.C.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart.
    5. "Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo."
      Idoyaga J., Cheong C., Suda K., Suda N., Kim J.Y., Lee H., Park C.G., Steinman R.M.
      J. Immunol. 180:3647-3650(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCLC4K_MOUSE
    AccessioniPrimary (citable) accession number: Q8VBX4
    Secondary accession number(s): Q8R442
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3