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Q8VBX4

- CLC4K_MOUSE

UniProt

Q8VBX4 - CLC4K_MOUSE

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Protein
C-type lectin domain family 4 member K
Gene
Cd207, Clec4k
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.2 Publications

GO - Molecular functioni

  1. carbohydrate binding Source: MGI

GO - Biological processi

  1. defense response to virus Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member K
Alternative name(s):
Langerin
CD_antigen: CD207
Gene namesi
Name:Cd207
Synonyms:Clec4k
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2180021. Cd207.

Subcellular locationi

Membrane; Single-pass type II membrane protein
Note: Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei42 – 6221Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini63 – 331269Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331C-type lectin domain family 4 member K
PRO_0000223694Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi226 ↔ 322 By similarity
Modified residuei240 – 2401Phosphoserine By similarity
Modified residuei246 – 2461Phosphotyrosine By similarity
Disulfide bondi298 ↔ 314 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ8VBX4.

PTM databases

PhosphoSiteiQ8VBX4.

Expressioni

Tissue specificityi

Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.1 Publication

Gene expression databases

ArrayExpressiQ8VBX4.
BgeeiQ8VBX4.
CleanExiMM_CD207.
GenevestigatoriQ8VBX4.

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040746.

Structurei

3D structure databases

ProteinModelPortaliQ8VBX4.
SMRiQ8VBX4. Positions 163-329.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini205 – 323119C-type lectin
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili106 – 19792 Reviewed prediction
Add
BLAST

Domaini

The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311341.
GeneTreeiENSGT00750000117265.
HOGENOMiHOG000064516.
HOVERGENiHBG073250.
InParanoidiQ8VBX4.
KOiK06561.
OMAiFKGNFYY.
OrthoDBiEOG7QZGBX.
PhylomeDBiQ8VBX4.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VBX4-1 [UniParc]FASTAAdd to Basket

« Hide

MPEAEMKEEA PEAHFTVDKQ NISLWPREPP PKQDLSPVLR KPLCICVAFT    50
CLALVLVTSI VLQAVFYPRL MGKILDVKSD AQMLKGRVDN ISTLGSDLKT 100
ERGRVDDAEV QMQIVNTTLK RVRSQILSLE TSMKIANDQL QILTMSWGEV 150
DSLSAKIPEL KRDLDKASAL NTKVQGLQNS LENVNKLLKQ QSDILEMVAR 200
GWKYFSGNFY YFSRTPKTWY SAEQFCISRK AHLTSVSSES EQKFLYKAAD 250
GIPHWIGLTK AGSEGDWYWV DQTSFNKEQS RRFWIPGEPN NAGNNEHCAN 300
IRVSALKCWN DGPCDNTFLF ICKRPYVQTT E 331
Length:331
Mass (Da):37,621
Last modified:March 1, 2002 - v1
Checksum:i3DFCFDB322CAB7E8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051V → A in AAL83701. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302711 mRNA. Translation: CAC82936.1.
AY026050 mRNA. Translation: AAK01952.1.
AY078415 mRNA. Translation: AAL83701.1.
AK142731 mRNA. Translation: BAE25177.1.
CCDSiCCDS39534.1.
RefSeqiNP_659192.2. NM_144943.3.
UniGeneiMm.136079.

Genome annotation databases

EnsembliENSMUST00000037882; ENSMUSP00000040746; ENSMUSG00000034783.
GeneIDi246278.
KEGGimmu:246278.
UCSCiuc009cnw.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Langerin

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302711 mRNA. Translation: CAC82936.1 .
AY026050 mRNA. Translation: AAK01952.1 .
AY078415 mRNA. Translation: AAL83701.1 .
AK142731 mRNA. Translation: BAE25177.1 .
CCDSi CCDS39534.1.
RefSeqi NP_659192.2. NM_144943.3.
UniGenei Mm.136079.

3D structure databases

ProteinModelPortali Q8VBX4.
SMRi Q8VBX4. Positions 163-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000040746.

PTM databases

PhosphoSitei Q8VBX4.

Proteomic databases

PRIDEi Q8VBX4.

Protocols and materials databases

DNASUi 246278.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037882 ; ENSMUSP00000040746 ; ENSMUSG00000034783 .
GeneIDi 246278.
KEGGi mmu:246278.
UCSCi uc009cnw.2. mouse.

Organism-specific databases

CTDi 50489.
MGIi MGI:2180021. Cd207.

Phylogenomic databases

eggNOGi NOG311341.
GeneTreei ENSGT00750000117265.
HOGENOMi HOG000064516.
HOVERGENi HBG073250.
InParanoidi Q8VBX4.
KOi K06561.
OMAi FKGNFYY.
OrthoDBi EOG7QZGBX.
PhylomeDBi Q8VBX4.
TreeFami TF333341.

Enzyme and pathway databases

Reactomei REACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).

Miscellaneous databases

NextBioi 387209.
PROi Q8VBX4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VBX4.
Bgeei Q8VBX4.
CleanExi MM_CD207.
Genevestigatori Q8VBX4.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. "Mouse langerin homologue: identification, expression pattern, and chromosomal mapping of the cognate mouse and rat gene."
    Takahara K., Omatsu Y., Umemoto E., Yashima Y., Matsubara K., Shimoyama S., Iyoda T., Matsuda Y., Inaba K.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: F1.
  3. "Cloning of mouse Langerin from fetal skin-derived dendritic cells."
    Riedl E., Wilson M., Udey M.C.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  5. "Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo."
    Idoyaga J., Cheong C., Suda K., Suda N., Kim J.Y., Lee H., Park C.G., Steinman R.M.
    J. Immunol. 180:3647-3650(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCLC4K_MOUSE
AccessioniPrimary (citable) accession number: Q8VBX4
Secondary accession number(s): Q8R442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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