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Protein

C-type lectin domain family 4 member K

Gene

Cd207

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.2 Publications

GO - Molecular functioni

  • carbohydrate binding Source: MGI

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member K
Alternative name(s):
Langerin
CD_antigen: CD207
Gene namesi
Name:Cd207
Synonyms:Clec4k
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2180021. Cd207.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini63 – 331ExtracellularSequence analysisAdd BLAST269

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236941 – 331C-type lectin domain family 4 member KAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi226 ↔ 322PROSITE-ProRule annotation
Disulfide bondi298 ↔ 314PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VBX4.
PRIDEiQ8VBX4.

PTM databases

iPTMnetiQ8VBX4.
PhosphoSitePlusiQ8VBX4.

Expressioni

Tissue specificityi

Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000034783.
CleanExiMM_CD207.
GenevisibleiQ8VBX4. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040746.

Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi194 – 198Combined sources5
Turni199 – 201Combined sources3
Beta strandi203 – 205Combined sources3
Beta strandi208 – 212Combined sources5
Helixi219 – 228Combined sources10
Helixi239 – 248Combined sources10
Turni249 – 251Combined sources3
Beta strandi254 – 262Combined sources9
Beta strandi267 – 269Combined sources3
Helixi277 – 280Combined sources4
Turni281 – 283Combined sources3
Helixi292 – 294Combined sources3
Beta strandi298 – 301Combined sources4
Beta strandi303 – 307Combined sources5
Beta strandi309 – 312Combined sources4
Beta strandi318 – 325Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K8YX-ray2.40A/B194-331[»]
5M62X-ray1.70A/B194-331[»]
ProteinModelPortaliQ8VBX4.
SMRiQ8VBX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 323C-type lectinPROSITE-ProRule annotationAdd BLAST119

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili106 – 197Sequence analysisAdd BLAST92

Domaini

The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.By similarity

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00860000133831.
HOGENOMiHOG000064516.
HOVERGENiHBG073250.
InParanoidiQ8VBX4.
KOiK06561.
OMAiTFLFICK.
OrthoDBiEOG091G0GQS.
PhylomeDBiQ8VBX4.
TreeFamiTF333341.

Family and domain databases

CDDicd03590. CLECT_DC-SIGN_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR033989. CD209-like_CTLD.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VBX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAEMKEEA PEAHFTVDKQ NISLWPREPP PKQDLSPVLR KPLCICVAFT
60 70 80 90 100
CLALVLVTSI VLQAVFYPRL MGKILDVKSD AQMLKGRVDN ISTLGSDLKT
110 120 130 140 150
ERGRVDDAEV QMQIVNTTLK RVRSQILSLE TSMKIANDQL QILTMSWGEV
160 170 180 190 200
DSLSAKIPEL KRDLDKASAL NTKVQGLQNS LENVNKLLKQ QSDILEMVAR
210 220 230 240 250
GWKYFSGNFY YFSRTPKTWY SAEQFCISRK AHLTSVSSES EQKFLYKAAD
260 270 280 290 300
GIPHWIGLTK AGSEGDWYWV DQTSFNKEQS RRFWIPGEPN NAGNNEHCAN
310 320 330
IRVSALKCWN DGPCDNTFLF ICKRPYVQTT E
Length:331
Mass (Da):37,621
Last modified:March 1, 2002 - v1
Checksum:i3DFCFDB322CAB7E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105V → A in AAL83701 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302711 mRNA. Translation: CAC82936.1.
AY026050 mRNA. Translation: AAK01952.1.
AY078415 mRNA. Translation: AAL83701.1.
AK142731 mRNA. Translation: BAE25177.1.
CCDSiCCDS39534.1.
RefSeqiNP_659192.2. NM_144943.3.
UniGeneiMm.136079.

Genome annotation databases

EnsembliENSMUST00000037882; ENSMUSP00000040746; ENSMUSG00000034783.
GeneIDi246278.
KEGGimmu:246278.
UCSCiuc009cnw.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Langerin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302711 mRNA. Translation: CAC82936.1.
AY026050 mRNA. Translation: AAK01952.1.
AY078415 mRNA. Translation: AAL83701.1.
AK142731 mRNA. Translation: BAE25177.1.
CCDSiCCDS39534.1.
RefSeqiNP_659192.2. NM_144943.3.
UniGeneiMm.136079.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K8YX-ray2.40A/B194-331[»]
5M62X-ray1.70A/B194-331[»]
ProteinModelPortaliQ8VBX4.
SMRiQ8VBX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040746.

PTM databases

iPTMnetiQ8VBX4.
PhosphoSitePlusiQ8VBX4.

Proteomic databases

PaxDbiQ8VBX4.
PRIDEiQ8VBX4.

Protocols and materials databases

DNASUi246278.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037882; ENSMUSP00000040746; ENSMUSG00000034783.
GeneIDi246278.
KEGGimmu:246278.
UCSCiuc009cnw.2. mouse.

Organism-specific databases

CTDi50489.
MGIiMGI:2180021. Cd207.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00860000133831.
HOGENOMiHOG000064516.
HOVERGENiHBG073250.
InParanoidiQ8VBX4.
KOiK06561.
OMAiTFLFICK.
OrthoDBiEOG091G0GQS.
PhylomeDBiQ8VBX4.
TreeFamiTF333341.

Enzyme and pathway databases

ReactomeiR-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).

Miscellaneous databases

PROiQ8VBX4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034783.
CleanExiMM_CD207.
GenevisibleiQ8VBX4. MM.

Family and domain databases

CDDicd03590. CLECT_DC-SIGN_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR033989. CD209-like_CTLD.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCLC4K_MOUSE
AccessioniPrimary (citable) accession number: Q8VBX4
Secondary accession number(s): Q8R442
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2002
Last modified: March 15, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.