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Q8VBX4

- CLC4K_MOUSE

UniProt

Q8VBX4 - CLC4K_MOUSE

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Protein

C-type lectin domain family 4 member K

Gene

Cd207

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.2 Publications

GO - Molecular functioni

  1. carbohydrate binding Source: MGI

GO - Biological processi

  1. defense response to virus Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member K
Alternative name(s):
Langerin
CD_antigen: CD207
Gene namesi
Name:Cd207
Synonyms:Clec4k
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2180021. Cd207.

Subcellular locationi

Membrane; Single-pass type II membrane protein
Note: Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini63 – 331269ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331C-type lectin domain family 4 member KPRO_0000223694Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi226 ↔ 322PROSITE-ProRule annotation
Modified residuei240 – 2401PhosphoserineBy similarity
Modified residuei246 – 2461PhosphotyrosineBy similarity
Disulfide bondi298 ↔ 314PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ8VBX4.

PTM databases

PhosphoSiteiQ8VBX4.

Expressioni

Tissue specificityi

Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.1 Publication

Gene expression databases

BgeeiQ8VBX4.
CleanExiMM_CD207.
ExpressionAtlasiQ8VBX4. baseline and differential.
GenevestigatoriQ8VBX4.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040746.

Structurei

3D structure databases

ProteinModelPortaliQ8VBX4.
SMRiQ8VBX4. Positions 163-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini205 – 323119C-type lectinPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili106 – 19792Sequence AnalysisAdd
BLAST

Domaini

The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.By similarity

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311341.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000064516.
HOVERGENiHBG073250.
InParanoidiQ8VBX4.
KOiK06561.
OMAiFKGNFYY.
OrthoDBiEOG7QZGBX.
PhylomeDBiQ8VBX4.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VBX4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPEAEMKEEA PEAHFTVDKQ NISLWPREPP PKQDLSPVLR KPLCICVAFT
60 70 80 90 100
CLALVLVTSI VLQAVFYPRL MGKILDVKSD AQMLKGRVDN ISTLGSDLKT
110 120 130 140 150
ERGRVDDAEV QMQIVNTTLK RVRSQILSLE TSMKIANDQL QILTMSWGEV
160 170 180 190 200
DSLSAKIPEL KRDLDKASAL NTKVQGLQNS LENVNKLLKQ QSDILEMVAR
210 220 230 240 250
GWKYFSGNFY YFSRTPKTWY SAEQFCISRK AHLTSVSSES EQKFLYKAAD
260 270 280 290 300
GIPHWIGLTK AGSEGDWYWV DQTSFNKEQS RRFWIPGEPN NAGNNEHCAN
310 320 330
IRVSALKCWN DGPCDNTFLF ICKRPYVQTT E
Length:331
Mass (Da):37,621
Last modified:March 1, 2002 - v1
Checksum:i3DFCFDB322CAB7E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051V → A in AAL83701. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302711 mRNA. Translation: CAC82936.1.
AY026050 mRNA. Translation: AAK01952.1.
AY078415 mRNA. Translation: AAL83701.1.
AK142731 mRNA. Translation: BAE25177.1.
CCDSiCCDS39534.1.
RefSeqiNP_659192.2. NM_144943.3.
UniGeneiMm.136079.

Genome annotation databases

EnsembliENSMUST00000037882; ENSMUSP00000040746; ENSMUSG00000034783.
GeneIDi246278.
KEGGimmu:246278.
UCSCiuc009cnw.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Langerin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302711 mRNA. Translation: CAC82936.1 .
AY026050 mRNA. Translation: AAK01952.1 .
AY078415 mRNA. Translation: AAL83701.1 .
AK142731 mRNA. Translation: BAE25177.1 .
CCDSi CCDS39534.1.
RefSeqi NP_659192.2. NM_144943.3.
UniGenei Mm.136079.

3D structure databases

ProteinModelPortali Q8VBX4.
SMRi Q8VBX4. Positions 163-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000040746.

PTM databases

PhosphoSitei Q8VBX4.

Proteomic databases

PRIDEi Q8VBX4.

Protocols and materials databases

DNASUi 246278.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037882 ; ENSMUSP00000040746 ; ENSMUSG00000034783 .
GeneIDi 246278.
KEGGi mmu:246278.
UCSCi uc009cnw.2. mouse.

Organism-specific databases

CTDi 50489.
MGIi MGI:2180021. Cd207.

Phylogenomic databases

eggNOGi NOG311341.
GeneTreei ENSGT00760000118924.
HOGENOMi HOG000064516.
HOVERGENi HBG073250.
InParanoidi Q8VBX4.
KOi K06561.
OMAi FKGNFYY.
OrthoDBi EOG7QZGBX.
PhylomeDBi Q8VBX4.
TreeFami TF333341.

Enzyme and pathway databases

Reactomei REACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).

Miscellaneous databases

NextBioi 387209.
PROi Q8VBX4.
SOURCEi Search...

Gene expression databases

Bgeei Q8VBX4.
CleanExi MM_CD207.
ExpressionAtlasi Q8VBX4. baseline and differential.
Genevestigatori Q8VBX4.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. "Mouse langerin homologue: identification, expression pattern, and chromosomal mapping of the cognate mouse and rat gene."
    Takahara K., Omatsu Y., Umemoto E., Yashima Y., Matsubara K., Shimoyama S., Iyoda T., Matsuda Y., Inaba K.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: F1.
  3. "Cloning of mouse Langerin from fetal skin-derived dendritic cells."
    Riedl E., Wilson M., Udey M.C.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  5. "Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo."
    Idoyaga J., Cheong C., Suda K., Suda N., Kim J.Y., Lee H., Park C.G., Steinman R.M.
    J. Immunol. 180:3647-3650(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCLC4K_MOUSE
AccessioniPrimary (citable) accession number: Q8VBX4
Secondary accession number(s): Q8R442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3