Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endothelial lipase

Gene

Lipg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin (By similarity).By similarity

Miscellaneous

It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171NucleophileBy similarity1
Active sitei195Charge relay systemPROSITE-ProRule annotation1
Active sitei276Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-8964058 HDL remodeling

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial lipase (EC:3.1.1.3)
Alternative name(s):
Endothelial-derived lipase
Short name:
EDL
Gene namesi
Name:Lipg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1310740 Lipg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3638354

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004340924 – 493Endothelial lipaseAdd BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 79PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 274PROSITE-ProRule annotation
Disulfide bondi299 ↔ 318PROSITE-ProRule annotation
Disulfide bondi310 ↔ 313PROSITE-ProRule annotation
Glycosylationi395N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi465 ↔ 485PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VBX1
PRIDEiQ8VBX1

Expressioni

Gene expression databases

BgeeiENSRNOG00000018694
GenevisibleiQ8VBX1 RN

Interactioni

Subunit structurei

Head to tail Homodimer. Interacts with apolipoprotein C-2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025257

Chemistry databases

BindingDBiQ8VBX1

Structurei

3D structure databases

ProteinModelPortaliQ8VBX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini349 – 484PLATPROSITE-ProRule annotationAdd BLAST136

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni327 – 339Heparin-bindingBy similarityAdd BLAST13

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJUA Eukaryota
ENOG4111GMM LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038553
HOVERGENiHBG002259
InParanoidiQ8VBX1
KOiK22284
OMAiLKIKLTW
OrthoDBiEOG091G052B
PhylomeDBiQ8VBX1
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002330 Lipo_Lipase
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00822 LIPOLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDPVFLLGF WSLYCCFPAG SLTTLRPQGS LRDEHHKPTG VPVTITTKPS
60 70 80 90 100
VTFNIRTSKD PEHEGCNLSL GDSKLLENCG FNMTAKTFFI IHGWTMSGMF
110 120 130 140 150
ESWLHKLVSA LQTREKEANV VVVDWLPLAH QLYIDAVSNT RVVGRRVAGM
160 170 180 190 200
LNWLQEKGEF SLGDVHLIGY SLGAHVAGYA GNFVKGTVGR ITGLDPAGPM
210 220 230 240 250
FEGVDINRRL SPDDADFVDV LHTYTLSFGL SIGIRMPVGH IDIYPNGGDF
260 270 280 290 300
QPGCGFNDVM GSFAYGTISE MVKCEHERAV HLFVDSLVNQ DKPSFAFQCT
310 320 330 340 350
DPNRFKRGIC LSCRKNRCNN IGYNAKKMRK KRNSKMYLKT RAGMPFRVYH
360 370 380 390 400
YQLKVHMFSY KNSGDIQPDL YITLYGSNAD SQNLPLEIVE KIELNATNTF
410 420 430 440 450
LVYTEEYLGD LFKIRLTWEG VSSSWYNLWN EFRSYLSQPS SPSRELHIRR
460 470 480 490
IRVKSGETQR KVAFCVQDPM KNSISPGQEL WFYKCQNDCR VKN
Length:493
Mass (Da):55,924
Last modified:December 6, 2005 - v2
Checksum:i11F8E39B2E2FCBC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti275 – 277EHE → KHK in AAK14774 (PubMed:11924532).Curated3
Sequence conflicti275 – 277EHE → KHK in AAK14775 (PubMed:11924532).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY916123 mRNA Translation: AAX11354.1
AY027561 Genomic DNA Translation: AAK14774.1
AY027562 Genomic DNA Translation: AAK14775.1
RefSeqiNP_001012759.1, NM_001012741.1
UniGeneiRn.199051

Genome annotation databases

EnsembliENSRNOT00000025257; ENSRNOP00000025257; ENSRNOG00000018694
GeneIDi291437
KEGGirno:291437

Similar proteinsi

Entry informationi

Entry nameiLIPE_RAT
AccessioniPrimary (citable) accession number: Q8VBX1
Secondary accession number(s): Q5D216
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health