SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8VBW1

- SC6A8_MOUSE

UniProt

Q8VBW1 - SC6A8_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Sodium- and chloride-dependent creatine transporter 1
Gene
Slc6a8, Crt
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.

GO - Molecular functioni

  1. choline transmembrane transporter activity Source: Ensembl
  2. creatine:sodium symporter activity Source: Ensembl
  3. neurotransmitter:sodium symporter activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent creatine transporter 1
    Short name:
    CT1
    Short name:
    Creatine transporter 1
    Alternative name(s):
    Solute carrier family 6 member 8
    Gene namesi
    Name:Slc6a8
    Synonyms:Crt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2147834. Slc6a8.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6060Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei61 – 8121Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini82 – 876Extracellular Reviewed prediction
    Transmembranei88 – 10821Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini109 – 13830Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei139 – 15921Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini160 – 23071Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei231 – 25121Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini252 – 26918Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei270 – 29021Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini291 – 30414Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei305 – 32521Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini326 – 34116Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei342 – 36221Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini363 – 39432Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei395 – 41521Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini416 – 44429Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei445 – 47026Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini471 – 48414Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei485 – 50521Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini506 – 52520Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei526 – 54621Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini547 – 56519Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei566 – 58621Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini587 – 64054Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of plasma membrane Source: InterPro
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 640640Sodium- and chloride-dependent creatine transporter 1
    PRO_0000214775Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi197 – 1971N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi553 – 5531N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8VBW1.

    PTM databases

    PhosphoSiteiQ8VBW1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VBW1.
    BgeeiQ8VBW1.
    GenevestigatoriQ8VBW1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VBW1.
    SMRiQ8VBW1. Positions 52-512.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00730000110773.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiQ8VBW1.
    KOiK05039.
    OMAiIVFYCNT.
    OrthoDBiEOG793B71.
    PhylomeDBiQ8VBW1.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002984. Na/ntran_symport_creatine.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01199. CRTTRANSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VBW1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PAKGDGPAGL GAPGGRLAVP    50
    PRETWTRQMD FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV 100
    GGIPIFFLEI SLGQFMKAGS INVWNICPLF KGLGYASMVI VFYCNTYYIM 150
    VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD CVEIFRHEDC ANASLANLTC 200
    DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL ACWVLVYFCV 250
    WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 300
    GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG 350
    TSFFAGFVVF SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP 400
    LWAALFFFML LLLGLDSQFV GVEGFITGLL DLLPASYYFR FQREISVALC 450
    CALCFVIDLS MVTDVSGGKG GMYVFQLFDY YSASGTTLLW QAFWECVVVA 500
    WVYGADRFMD DIACMIGYRP CPWMKWCWSF FTPLVCMGIF IFNIVYYEPL 550
    VYNNTYVYPW WGEAMGWAFA LSSMLCVPLH LLGCLLRAKG TMAERWQHLT 600
    QPIWGLHHLE YRAQDADVRG LTTLTPVSES SKVVVVESVM 640
    Length:640
    Mass (Da):70,999
    Last modified:March 1, 2002 - v1
    Checksum:i67D3AAAC591EEA0B
    GO
    Isoform 2 (identifier: Q8VBW1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         465-469: Missing.

    Show »
    Length:635
    Mass (Da):70,571
    Checksum:iFE76B1A95D2F2149
    GO
    Isoform 3 (identifier: Q8VBW1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         462-469: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:632
    Mass (Da):70,255
    Checksum:i7369D703B507FF24
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei462 – 4698Missing in isoform 3.
    VSP_012132
    Alternative sequencei465 – 4695Missing in isoform 2.
    VSP_012133

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077327 mRNA. Translation: BAC11857.1.
    AF459435 mRNA. Translation: AAL66354.1.
    AF459436 Genomic DNA. Translation: AAL66355.1.
    AL805924 Genomic DNA. Translation: CAM21057.1.
    BC024444 mRNA. Translation: AAH24444.1.
    BC049801 mRNA. Translation: AAH49801.1.
    CCDSiCCDS30208.1. [Q8VBW1-1]
    CCDS53098.1. [Q8VBW1-2]
    RefSeqiNP_001136281.1. NM_001142809.1. [Q8VBW1-2]
    NP_001136282.1. NM_001142810.1. [Q8VBW1-3]
    NP_598748.1. NM_133987.2. [Q8VBW1-1]
    UniGeneiMm.274553.

    Genome annotation databases

    EnsembliENSMUST00000033752; ENSMUSP00000033752; ENSMUSG00000019558. [Q8VBW1-1]
    ENSMUST00000114465; ENSMUSP00000110109; ENSMUSG00000019558. [Q8VBW1-2]
    ENSMUST00000114467; ENSMUSP00000110111; ENSMUSG00000019558. [Q8VBW1-2]
    GeneIDi102857.
    KEGGimmu:102857.
    UCSCiuc009tmf.2. mouse. [Q8VBW1-1]
    uc009tmg.2. mouse. [Q8VBW1-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077327 mRNA. Translation: BAC11857.1 .
    AF459435 mRNA. Translation: AAL66354.1 .
    AF459436 Genomic DNA. Translation: AAL66355.1 .
    AL805924 Genomic DNA. Translation: CAM21057.1 .
    BC024444 mRNA. Translation: AAH24444.1 .
    BC049801 mRNA. Translation: AAH49801.1 .
    CCDSi CCDS30208.1. [Q8VBW1-1 ]
    CCDS53098.1. [Q8VBW1-2 ]
    RefSeqi NP_001136281.1. NM_001142809.1. [Q8VBW1-2 ]
    NP_001136282.1. NM_001142810.1. [Q8VBW1-3 ]
    NP_598748.1. NM_133987.2. [Q8VBW1-1 ]
    UniGenei Mm.274553.

    3D structure databases

    ProteinModelPortali Q8VBW1.
    SMRi Q8VBW1. Positions 52-512.
    ModBasei Search...

    PTM databases

    PhosphoSitei Q8VBW1.

    Proteomic databases

    PRIDEi Q8VBW1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033752 ; ENSMUSP00000033752 ; ENSMUSG00000019558 . [Q8VBW1-1 ]
    ENSMUST00000114465 ; ENSMUSP00000110109 ; ENSMUSG00000019558 . [Q8VBW1-2 ]
    ENSMUST00000114467 ; ENSMUSP00000110111 ; ENSMUSG00000019558 . [Q8VBW1-2 ]
    GeneIDi 102857.
    KEGGi mmu:102857.
    UCSCi uc009tmf.2. mouse. [Q8VBW1-1 ]
    uc009tmg.2. mouse. [Q8VBW1-3 ]

    Organism-specific databases

    CTDi 6535.
    MGIi MGI:2147834. Slc6a8.

    Phylogenomic databases

    eggNOGi COG0733.
    GeneTreei ENSGT00730000110773.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi Q8VBW1.
    KOi K05039.
    OMAi IVFYCNT.
    OrthoDBi EOG793B71.
    PhylomeDBi Q8VBW1.
    TreeFami TF343812.

    Miscellaneous databases

    ChiTaRSi SLC6A8. mouse.
    NextBioi 355683.
    PROi Q8VBW1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VBW1.
    Bgeei Q8VBW1.
    Genevestigatori Q8VBW1.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002984. Na/ntran_symport_creatine.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01199. CRTTRANSPORT.
    PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain."
      Ohtsuki S., Tachikawa M., Takanaga H., Shimizu H., Watanabe M., Hosoya K., Terasaki T.
      J. Cereb. Blood Flow Metab. 22:1327-1335(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Cloning and expression of mouse creatine transporter gene."
      Liu Q.-R., Li Q.-F.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-640 (ISOFORMS 2 AND 3).
      Strain: FVB/N.
      Tissue: Embryo and Kidney.

    Entry informationi

    Entry nameiSC6A8_MOUSE
    AccessioniPrimary (citable) accession number: Q8VBW1
    Secondary accession number(s): A2ALM4
    , Q80YC9, Q8K4R3, Q8R1L0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: March 1, 2002
    Last modified: July 9, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi