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Q8VBW1

- SC6A8_MOUSE

UniProt

Q8VBW1 - SC6A8_MOUSE

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Protein

Sodium- and chloride-dependent creatine transporter 1

Gene

Slc6a8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.

GO - Molecular functioni

  1. choline transmembrane transporter activity Source: Ensembl
  2. creatine:sodium symporter activity Source: Ensembl
  3. neurotransmitter:sodium symporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_239426. Creatine metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent creatine transporter 1
Short name:
CT1
Short name:
Creatine transporter 1
Alternative name(s):
Solute carrier family 6 member 8
Gene namesi
Name:Slc6a8
Synonyms:Crt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2147834. Slc6a8.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6060CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Topological domaini82 – 876ExtracellularSequence Analysis
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Topological domaini109 – 13830CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Topological domaini160 – 23071ExtracellularSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST
Topological domaini252 – 26918CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence AnalysisAdd
BLAST
Topological domaini291 – 30414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Topological domaini326 – 34116CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Topological domaini363 – 39432ExtracellularSequence AnalysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence AnalysisAdd
BLAST
Topological domaini416 – 44429CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei445 – 47026HelicalSequence AnalysisAdd
BLAST
Topological domaini471 – 48414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence AnalysisAdd
BLAST
Topological domaini506 – 52520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei526 – 54621HelicalSequence AnalysisAdd
BLAST
Topological domaini547 – 56519ExtracellularSequence AnalysisAdd
BLAST
Transmembranei566 – 58621HelicalSequence AnalysisAdd
BLAST
Topological domaini587 – 64054CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Sodium- and chloride-dependent creatine transporter 1PRO_0000214775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8VBW1.
PRIDEiQ8VBW1.

PTM databases

PhosphoSiteiQ8VBW1.

Expressioni

Gene expression databases

BgeeiQ8VBW1.
ExpressionAtlasiQ8VBW1. baseline and differential.
GenevestigatoriQ8VBW1.

Structurei

3D structure databases

ProteinModelPortaliQ8VBW1.
SMRiQ8VBW1. Positions 52-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ8VBW1.
KOiK05039.
OMAiIVFYCNT.
OrthoDBiEOG793B71.
PhylomeDBiQ8VBW1.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002984. Na/ntran_symport_creatine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01199. CRTTRANSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VBW1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PAKGDGPAGL GAPGGRLAVP
60 70 80 90 100
PRETWTRQMD FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV
110 120 130 140 150
GGIPIFFLEI SLGQFMKAGS INVWNICPLF KGLGYASMVI VFYCNTYYIM
160 170 180 190 200
VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD CVEIFRHEDC ANASLANLTC
210 220 230 240 250
DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL ACWVLVYFCV
260 270 280 290 300
WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL
310 320 330 340 350
GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG
360 370 380 390 400
TSFFAGFVVF SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP
410 420 430 440 450
LWAALFFFML LLLGLDSQFV GVEGFITGLL DLLPASYYFR FQREISVALC
460 470 480 490 500
CALCFVIDLS MVTDVSGGKG GMYVFQLFDY YSASGTTLLW QAFWECVVVA
510 520 530 540 550
WVYGADRFMD DIACMIGYRP CPWMKWCWSF FTPLVCMGIF IFNIVYYEPL
560 570 580 590 600
VYNNTYVYPW WGEAMGWAFA LSSMLCVPLH LLGCLLRAKG TMAERWQHLT
610 620 630 640
QPIWGLHHLE YRAQDADVRG LTTLTPVSES SKVVVVESVM
Length:640
Mass (Da):70,999
Last modified:March 1, 2002 - v1
Checksum:i67D3AAAC591EEA0B
GO
Isoform 2 (identifier: Q8VBW1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-469: Missing.

Show »
Length:635
Mass (Da):70,571
Checksum:iFE76B1A95D2F2149
GO
Isoform 3 (identifier: Q8VBW1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-469: Missing.

Note: No experimental confirmation available.

Show »
Length:632
Mass (Da):70,255
Checksum:i7369D703B507FF24
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei462 – 4698Missing in isoform 3. 1 PublicationVSP_012132
Alternative sequencei465 – 4695Missing in isoform 2. 2 PublicationsVSP_012133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077327 mRNA. Translation: BAC11857.1.
AF459435 mRNA. Translation: AAL66354.1.
AF459436 Genomic DNA. Translation: AAL66355.1.
AL805924 Genomic DNA. Translation: CAM21057.1.
BC024444 mRNA. Translation: AAH24444.1.
BC049801 mRNA. Translation: AAH49801.1.
CCDSiCCDS30208.1. [Q8VBW1-1]
CCDS53098.1. [Q8VBW1-2]
RefSeqiNP_001136281.1. NM_001142809.1. [Q8VBW1-2]
NP_001136282.1. NM_001142810.1. [Q8VBW1-3]
NP_598748.1. NM_133987.2. [Q8VBW1-1]
UniGeneiMm.274553.

Genome annotation databases

EnsembliENSMUST00000033752; ENSMUSP00000033752; ENSMUSG00000019558. [Q8VBW1-1]
ENSMUST00000114465; ENSMUSP00000110109; ENSMUSG00000019558. [Q8VBW1-2]
ENSMUST00000114467; ENSMUSP00000110111; ENSMUSG00000019558. [Q8VBW1-2]
GeneIDi102857.
KEGGimmu:102857.
UCSCiuc009tmf.2. mouse. [Q8VBW1-1]
uc009tmg.2. mouse. [Q8VBW1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077327 mRNA. Translation: BAC11857.1 .
AF459435 mRNA. Translation: AAL66354.1 .
AF459436 Genomic DNA. Translation: AAL66355.1 .
AL805924 Genomic DNA. Translation: CAM21057.1 .
BC024444 mRNA. Translation: AAH24444.1 .
BC049801 mRNA. Translation: AAH49801.1 .
CCDSi CCDS30208.1. [Q8VBW1-1 ]
CCDS53098.1. [Q8VBW1-2 ]
RefSeqi NP_001136281.1. NM_001142809.1. [Q8VBW1-2 ]
NP_001136282.1. NM_001142810.1. [Q8VBW1-3 ]
NP_598748.1. NM_133987.2. [Q8VBW1-1 ]
UniGenei Mm.274553.

3D structure databases

ProteinModelPortali Q8VBW1.
SMRi Q8VBW1. Positions 52-512.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8VBW1.

Proteomic databases

MaxQBi Q8VBW1.
PRIDEi Q8VBW1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033752 ; ENSMUSP00000033752 ; ENSMUSG00000019558 . [Q8VBW1-1 ]
ENSMUST00000114465 ; ENSMUSP00000110109 ; ENSMUSG00000019558 . [Q8VBW1-2 ]
ENSMUST00000114467 ; ENSMUSP00000110111 ; ENSMUSG00000019558 . [Q8VBW1-2 ]
GeneIDi 102857.
KEGGi mmu:102857.
UCSCi uc009tmf.2. mouse. [Q8VBW1-1 ]
uc009tmg.2. mouse. [Q8VBW1-3 ]

Organism-specific databases

CTDi 6535.
MGIi MGI:2147834. Slc6a8.

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00760000118857.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi Q8VBW1.
KOi K05039.
OMAi IVFYCNT.
OrthoDBi EOG793B71.
PhylomeDBi Q8VBW1.
TreeFami TF343812.

Enzyme and pathway databases

Reactomei REACT_239426. Creatine metabolism.

Miscellaneous databases

ChiTaRSi Slc6a8. mouse.
NextBioi 355683.
PROi Q8VBW1.
SOURCEi Search...

Gene expression databases

Bgeei Q8VBW1.
ExpressionAtlasi Q8VBW1. baseline and differential.
Genevestigatori Q8VBW1.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR002984. Na/ntran_symport_creatine.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR01199. CRTTRANSPORT.
PR00176. NANEUSMPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain."
    Ohtsuki S., Tachikawa M., Takanaga H., Shimizu H., Watanabe M., Hosoya K., Terasaki T.
    J. Cereb. Blood Flow Metab. 22:1327-1335(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Cloning and expression of mouse creatine transporter gene."
    Liu Q.-R., Li Q.-F.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-640 (ISOFORMS 2 AND 3).
    Strain: FVB/N.
    Tissue: Embryo and Kidney.

Entry informationi

Entry nameiSC6A8_MOUSE
AccessioniPrimary (citable) accession number: Q8VBW1
Secondary accession number(s): A2ALM4
, Q80YC9, Q8K4R3, Q8R1L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3