Sodium- and chloride-dependent creatine transporter 1

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Q8VBW1 (SC6A8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sodium- and chloride-dependent creatine transporter 1
Short name=CT1
Short name=Creatine transporter 1

Alternative name(s):
Solute carrier family 6 member 8

Gene names

Name:	Slc6a8
Synonyms:	Crt

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	choline transmembrane transporter activity Inferred from electronic annotation. Source: Compara creatine:sodium symporter activity Inferred from electronic annotation. Source: InterPro neurotransmitter:sodium symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8VBW1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8VBW1-2) The sequence of this isoform differs from the canonical sequence as follows: 465-469: Missing.

Isoform 3 (identifier: Q8VBW1-3) The sequence of this isoform differs from the canonical sequence as follows: 462-469: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 640

640

Sodium- and chloride-dependent creatine transporter 1

PRO_0000214775

Regions

Topological domain

1 – 60

Cytoplasmic Potential

Transmembrane

61 – 81

Helical; Potential

Topological domain

82 – 87

Extracellular Potential

Transmembrane

88 – 108

Helical; Potential

Topological domain

109 – 138

Cytoplasmic Potential

Transmembrane

139 – 159

Helical; Potential

Topological domain

160 – 230

Extracellular Potential

Transmembrane

231 – 251

Helical; Potential

Topological domain

252 – 269

Cytoplasmic Potential

Transmembrane

270 – 290

Helical; Potential

Topological domain

291 – 304

Extracellular Potential

Transmembrane

305 – 325

Helical; Potential

Topological domain

326 – 341

Cytoplasmic Potential

Transmembrane

342 – 362

Helical; Potential

Topological domain

363 – 394

Extracellular Potential

Transmembrane

395 – 415

Helical; Potential

Topological domain

416 – 444

Cytoplasmic Potential

Transmembrane

445 – 470

Helical; Potential

Topological domain

471 – 484

Extracellular Potential

Transmembrane

485 – 505

Helical; Potential

Topological domain

506 – 525

Cytoplasmic Potential

Transmembrane

526 – 546

Helical; Potential

Topological domain

547 – 565

Extracellular Potential

Transmembrane

566 – 586

Helical; Potential

Topological domain

587 – 640

Cytoplasmic Potential

Amino acid modifications

Glycosylation

192

N-linked (GlcNAc...) Potential

Glycosylation

197

N-linked (GlcNAc...) Potential

Glycosylation

553

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

462 – 469

Missing in isoform 3.

VSP_012132

Alternative sequence

465 – 469

Missing in isoform 2.

VSP_012133

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 67D3AAAC591EEA0B Show »	FASTA	640	70,999
10 20 30 40 50 60 MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PAKGDGPAGL GAPGGRLAVP PRETWTRQMD 70 80 90 100 110 120 FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 130 140 150 160 170 180 INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 190 200 210 220 230 240 CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL 250 260 270 280 290 300 ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 310 320 330 340 350 360 GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF 370 380 390 400 410 420 SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 430 440 450 460 470 480 GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDVSGGKG GMYVFQLFDY 490 500 510 520 530 540 YSASGTTLLW QAFWECVVVA WVYGADRFMD DIACMIGYRP CPWMKWCWSF FTPLVCMGIF 550 560 570 580 590 600 IFNIVYYEPL VYNNTYVYPW WGEAMGWAFA LSSMLCVPLH LLGCLLRAKG TMAERWQHLT 610 620 630 640 QPIWGLHHLE YRAQDADVRG LTTLTPVSES SKVVVVESVM « Hide
Isoform 2 [UniParc]. Checksum: FE76B1A95D2F2149 Show »	FASTA	635	70,571
10 20 30 40 50 60 MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PAKGDGPAGL GAPGGRLAVP PRETWTRQMD 70 80 90 100 110 120 FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 130 140 150 160 170 180 INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 190 200 210 220 230 240 CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL 250 260 270 280 290 300 ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 310 320 330 340 350 360 GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF 370 380 390 400 410 420 SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 430 440 450 460 470 480 GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG 490 500 510 520 530 540 TTLLWQAFWE CVVVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNIV 550 560 570 580 590 600 YYEPLVYNNT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG 610 620 630 LHHLEYRAQD ADVRGLTTLT PVSESSKVVV VESVM « Hide
Isoform 3 [UniParc]. Checksum: 7369D703B507FF24 Show »	FASTA	632	70,255
10 20 30 40 50 60 MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PAKGDGPAGL GAPGGRLAVP PRETWTRQMD 70 80 90 100 110 120 FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 130 140 150 160 170 180 INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 190 200 210 220 230 240 CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL 250 260 270 280 290 300 ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 310 320 330 340 350 360 GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF 370 380 390 400 410 420 SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 430 440 450 460 470 480 GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MGGMYVFQLF DYYSASGTTL 490 500 510 520 530 540 LWQAFWECVV VAWVYGADRF MDDIACMIGY RPCPWMKWCW SFFTPLVCMG IFIFNIVYYE 550 560 570 580 590 600 PLVYNNTYVY PWWGEAMGWA FALSSMLCVP LHLLGCLLRA KGTMAERWQH LTQPIWGLHH 610 620 630 LEYRAQDADV RGLTTLTPVS ESSKVVVVES VM « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain." Ohtsuki S., Tachikawa M., Takanaga H., Shimizu H., Watanabe M., Hosoya K., Terasaki T. J. Cereb. Blood Flow Metab. 22:1327-1335(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Cloning and expression of mouse creatine transporter gene." Liu Q.-R., Li Q.-F. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-640 (ISOFORMS 2 AND 3). Strain: FVB/N. Tissue: Embryo and Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB077327 mRNA. Translation: BAC11857.1. AF459435 mRNA. Translation: AAL66354.1. AF459436 Genomic DNA. Translation: AAL66355.1. AL805924 Genomic DNA. Translation: CAM21057.1. BC024444 mRNA. Translation: AAH24444.1. BC049801 mRNA. Translation: AAH49801.1.
IPI	IPI00121477. IPI00480326. IPI00480478.
RefSeq	NP_001136281.1. NM_001142809.1. NP_001136282.1. NM_001142810.1.
UniGene	Mm.274553.
3D structure databases
ProteinModelPortal	Q8VBW1.
SMR	Q8VBW1. Positions 52-390.
ModBase	Search...
PTM databases
PhosphoSite	Q8VBW1.
Proteomic databases
PRIDE	Q8VBW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033752; ENSMUSP00000033752; ENSMUSG00000019558. ENSMUST00000114465; ENSMUSP00000110109; ENSMUSG00000019558. ENSMUST00000114467; ENSMUSP00000110111; ENSMUSG00000019558.
GeneID	102857.
KEGG	mmu:102857.
UCSC	uc009tmg.2. mouse.
Organism-specific databases
CTD	6535.
MGI	MGI:2147834. Slc6a8.
Phylogenomic databases
eggNOG	COG0733.
GeneTree	ENSGT00640000091023.
HOGENOM	HOG000116406.
HOVERGEN	HBG071421.
InParanoid	Q8VBW1.
KO	K05039.
OrthoDB	EOG4M3984.
Gene expression databases
ArrayExpress	Q8VBW1.
Bgee	Q8VBW1.
Genevestigator	Q8VBW1.
GermOnline	ENSMUSG00000019558. Mus musculus.
Family and domain databases
InterPro	IPR000175. Na/ntran_symport. IPR002984. Na/ntran_symport_creatine. [Graphical view]
PANTHER	PTHR11616. PTHR11616. 1 hit.
Pfam	PF00209. SNF. 1 hit. [Graphical view]
PRINTS	PR01199. CRTTRANSPORT. PR00176. NANEUSMPORT.
PROSITE	PS00610. NA_NEUROTRAN_SYMP_1. 1 hit. PS00754. NA_NEUROTRAN_SYMP_2. 1 hit. PS50267. NA_NEUROTRAN_SYMP_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC6A8. mouse.
NextBio	355683.
SOURCE	Search...

Entry information

Entry name

SC6A8_MOUSE

Accession

Primary (citable) accession number: Q8VBW1
Secondary accession number(s): A2ALM4

Q8R1L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents