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Protein

Guanylyl cyclase-activating protein 2

Gene

Guca1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca2+-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi66 – 77121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi102 – 113122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi155 – 166123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • calcium sensitive guanylate cyclase activator activity Source: MGI
  • guanylate cyclase regulator activity Source: MGI

GO - Biological processi

  • phototransduction Source: MGI
  • regulation of guanylate cyclase activity Source: MGI
  • visual perception Source: MGI
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylyl cyclase-activating protein 2
Short name:
GCAP 2
Alternative name(s):
Guanylate cyclase activator 1B
Gene namesi
Name:Guca1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1194489. Guca1b.

Subcellular locationi

  • Cell membrane By similarity

  • Note: Membranes of outer segment.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 201200Guanylyl cyclase-activating protein 2PRO_0000073809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ8VBV8.
PRIDEiQ8VBV8.

PTM databases

PhosphoSiteiQ8VBV8.

Expressioni

Gene expression databases

BgeeiQ8VBV8.
CleanExiMM_GUCA1B.
ExpressionAtlasiQ8VBV8. baseline and differential.
GenevisibleiQ8VBV8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8VBV8. 1 interaction.
MINTiMINT-4119341.
STRINGi10090.ENSMUSP00000024774.

Structurei

3D structure databases

ProteinModelPortaliQ8VBV8.
SMRiQ8VBV8. Positions 2-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 3130EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini17 – 5236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8836EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini89 – 12436EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini142 – 17736EF-hand 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiQ8VBV8.
KOiK08328.
OMAiQFSWEEA.
OrthoDBiEOG70GMGR.
PhylomeDBiQ8VBV8.
TreeFamiTF333971.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR015756. GCAP-2.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF11. PTHR23055:SF11. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQQLSWEEA EAAGEMDVAE LQEWYKKFVV ECPSGTLFMH EFKRFFKVTG
60 70 80 90 100
NEEASQYVES MFRAFDKNGD NTIDFLEYVA ALNLVLRGSL EHKLKWTFKI
110 120 130 140 150
YDKDRNGCID RLELLDIVEA IYKLKKACRA ELDLEHQGQL LTPEEVVDRI
160 170 180 190 200
FLLVDENGDG QLSLTEFIEG ARRDKWVMKM LQMDINPGCW ITQQRRRSAM

F
Length:201
Mass (Da):23,520
Last modified:January 23, 2007 - v3
Checksum:i75209102B3CDC208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033052 mRNA. Translation: BAC28139.1.
BC018480 mRNA. Translation: AAH18480.1.
BC018258 mRNA. Translation: AAH18258.1.
BC029017 mRNA. Translation: AAH29017.1.
BC029661 mRNA. Translation: AAH29661.1.
BC031367 mRNA. Translation: AAH31367.1.
BC031916 mRNA. Translation: AAH31916.1.
BC033358 mRNA. Translation: AAH33358.1.
BC033380 mRNA. Translation: AAH33380.1.
BC033383 mRNA. Translation: AAH33383.1.
BC034331 mRNA. Translation: AAH34331.1.
BC034595 mRNA. Translation: AAH34595.1.
CCDSiCCDS28847.1.
RefSeqiNP_666191.1. NM_146079.1.
UniGeneiMm.59151.

Genome annotation databases

EnsembliENSMUST00000024774; ENSMUSP00000024774; ENSMUSG00000023979.
GeneIDi107477.
KEGGimmu:107477.
UCSCiuc008cvb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033052 mRNA. Translation: BAC28139.1.
BC018480 mRNA. Translation: AAH18480.1.
BC018258 mRNA. Translation: AAH18258.1.
BC029017 mRNA. Translation: AAH29017.1.
BC029661 mRNA. Translation: AAH29661.1.
BC031367 mRNA. Translation: AAH31367.1.
BC031916 mRNA. Translation: AAH31916.1.
BC033358 mRNA. Translation: AAH33358.1.
BC033380 mRNA. Translation: AAH33380.1.
BC033383 mRNA. Translation: AAH33383.1.
BC034331 mRNA. Translation: AAH34331.1.
BC034595 mRNA. Translation: AAH34595.1.
CCDSiCCDS28847.1.
RefSeqiNP_666191.1. NM_146079.1.
UniGeneiMm.59151.

3D structure databases

ProteinModelPortaliQ8VBV8.
SMRiQ8VBV8. Positions 2-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VBV8. 1 interaction.
MINTiMINT-4119341.
STRINGi10090.ENSMUSP00000024774.

PTM databases

PhosphoSiteiQ8VBV8.

Proteomic databases

PaxDbiQ8VBV8.
PRIDEiQ8VBV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024774; ENSMUSP00000024774; ENSMUSG00000023979.
GeneIDi107477.
KEGGimmu:107477.
UCSCiuc008cvb.1. mouse.

Organism-specific databases

CTDi2979.
MGIiMGI:1194489. Guca1b.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiQ8VBV8.
KOiK08328.
OMAiQFSWEEA.
OrthoDBiEOG70GMGR.
PhylomeDBiQ8VBV8.
TreeFamiTF333971.

Enzyme and pathway databases

ReactomeiR-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

ChiTaRSiGuca1b. mouse.
PROiQ8VBV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VBV8.
CleanExiMM_GUCA1B.
ExpressionAtlasiQ8VBV8. baseline and differential.
GenevisibleiQ8VBV8. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR015756. GCAP-2.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF11. PTHR23055:SF11. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiGUC1B_MOUSE
AccessioniPrimary (citable) accession number: Q8VBV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.