Q8VBV7Q3TRS9Q80XF4Q8R4D2CSN8_MOUSECOP9 signalosome complex subunit 8SGN8Signalosome subunit 8COP9 homologJAB1-containing signalosome subunit 8Cops8Csn8Mus musculusMouseEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMusGene structure and embryonic expression of mouse COP9 signalosome subunit 8 (Csn8).NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]TISSUE SPECIFICITYDEVELOPMENTAL STAGEThe transcriptional landscape of the mammalian genome.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex.IDENTIFICATION IN THE CSN COMPLEXA tissue-specific atlas of mouse protein phosphorylation and expression.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) (By similarity).CytoplasmNucleusWidely expressed.Expressed in embryonic stem (ES) cells and throughout early embryo development from zygote, preimplantation embryos, to post-implantation embryos. Predominantly expressed in the inner cell mass (ICM) of 3.5 dpc blastocyst and widely expressed in 9.5 dpc embryos.Belongs to the CSN8 family.CytoplasmNucleusPhosphoproteinReference proteomeSignalosomeNMNTEQSRMPVAVMADNAFSFRKLLDQCENQELEAPGGIATPPVYGQLLALYLLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLEQGWQADSTTRMVLPRKPASGTLDVSLNRFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
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