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Q8VBV7

- CSN8_MOUSE

UniProt

Q8VBV7 - CSN8_MOUSE

Protein

COP9 signalosome complex subunit 8

Gene

Cops8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cullin deneddylation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COP9 signalosome complex subunit 8
    Short name:
    SGN8
    Short name:
    Signalosome subunit 8
    Alternative name(s):
    COP9 homolog
    JAB1-containing signalosome subunit 8
    Gene namesi
    Name:Cops8
    Synonyms:Csn8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1915363. Cops8.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. COP9 signalosome Source: MGI
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Signalosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 209208COP9 signalosome complex subunit 8PRO_0000121008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei175 – 1751PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8VBV7.
    PRIDEiQ8VBV7.

    2D gel databases

    REPRODUCTION-2DPAGEQ8VBV7.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Developmental stagei

    Expressed in embryonic stem (ES) cells and throughout early embryo development from zygote, preimplantation embryos, to post-implantation embryos. Predominantly expressed in the inner cell mass (ICM) of E3.5 blastocyst and widely expressed in E9.5-day embryos.1 Publication

    Gene expression databases

    BgeeiQ8VBV7.
    GenevestigatoriQ8VBV7.

    Interactioni

    Subunit structurei

    Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) By similarity.By similarity

    Protein-protein interaction databases

    BioGridi224368. 11 interactions.
    IntActiQ8VBV7. 3 interactions.
    MINTiMINT-4092211.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VBV7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 15184PCIAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CSN8 family.Curated
    Contains 1 PCI domain.Curated

    Phylogenomic databases

    eggNOGiNOG321945.
    GeneTreeiENSGT00390000000977.
    HOGENOMiHOG000253954.
    HOVERGENiHBG051139.
    InParanoidiQ8VBV7.
    KOiK12181.
    OMAiISAHQWS.
    OrthoDBiEOG76DTV5.
    PhylomeDBiQ8VBV7.
    TreeFamiTF101150.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VBV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM    50
    NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE 100
    TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE 150
    QGWQADSTTR MVLPRKPASG TLDVSLNRFI PLSEPAPVPP IPNEQQLARL 200
    TDYVAFLEN 209
    Length:209
    Mass (Da):23,256
    Last modified:March 1, 2002 - v1
    Checksum:i786226FB7BFAC80E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti193 – 1931N → M in AAL89689. (PubMed:14636993)Curated
    Sequence conflicti193 – 1931N → T in AAP13731. (PubMed:14636993)Curated
    Sequence conflicti194 – 1952EQ → SR(PubMed:14636993)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF482000 mRNA. Translation: AAL89689.1.
    AF502144 Genomic DNA. Translation: AAP13731.1.
    AK079111 mRNA. Translation: BAC37543.1.
    AK079522 mRNA. Translation: BAC37670.1.
    AK088323 mRNA. Translation: BAC40281.1.
    AK090013 mRNA. Translation: BAC41045.1.
    AK145899 mRNA. Translation: BAE26735.1.
    AK162502 mRNA. Translation: BAE36948.1.
    BC017690 mRNA. Translation: AAH17690.1.
    BC021488 mRNA. Translation: AAH21488.1.
    BC024421 mRNA. Translation: AAH24421.1.
    CCDSiCCDS15153.1.
    RefSeqiNP_598566.3. NM_133805.3.
    UniGeneiMm.119177.

    Genome annotation databases

    EnsembliENSMUST00000036153; ENSMUSP00000035884; ENSMUSG00000034432.
    GeneIDi108679.
    KEGGimmu:108679.
    UCSCiuc007bzi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF482000 mRNA. Translation: AAL89689.1 .
    AF502144 Genomic DNA. Translation: AAP13731.1 .
    AK079111 mRNA. Translation: BAC37543.1 .
    AK079522 mRNA. Translation: BAC37670.1 .
    AK088323 mRNA. Translation: BAC40281.1 .
    AK090013 mRNA. Translation: BAC41045.1 .
    AK145899 mRNA. Translation: BAE26735.1 .
    AK162502 mRNA. Translation: BAE36948.1 .
    BC017690 mRNA. Translation: AAH17690.1 .
    BC021488 mRNA. Translation: AAH21488.1 .
    BC024421 mRNA. Translation: AAH24421.1 .
    CCDSi CCDS15153.1.
    RefSeqi NP_598566.3. NM_133805.3.
    UniGenei Mm.119177.

    3D structure databases

    ProteinModelPortali Q8VBV7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 224368. 11 interactions.
    IntActi Q8VBV7. 3 interactions.
    MINTi MINT-4092211.

    2D gel databases

    REPRODUCTION-2DPAGE Q8VBV7.

    Proteomic databases

    PaxDbi Q8VBV7.
    PRIDEi Q8VBV7.

    Protocols and materials databases

    DNASUi 108679.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036153 ; ENSMUSP00000035884 ; ENSMUSG00000034432 .
    GeneIDi 108679.
    KEGGi mmu:108679.
    UCSCi uc007bzi.1. mouse.

    Organism-specific databases

    CTDi 10920.
    MGIi MGI:1915363. Cops8.

    Phylogenomic databases

    eggNOGi NOG321945.
    GeneTreei ENSGT00390000000977.
    HOGENOMi HOG000253954.
    HOVERGENi HBG051139.
    InParanoidi Q8VBV7.
    KOi K12181.
    OMAi ISAHQWS.
    OrthoDBi EOG76DTV5.
    PhylomeDBi Q8VBV7.
    TreeFami TF101150.

    Miscellaneous databases

    NextBioi 361215.
    PROi Q8VBV7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VBV7.
    Genevestigatori Q8VBV7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Gene structure and embryonic expression of mouse COP9 signalosome subunit 8 (Csn8)."
      Lykke-Andersen K., Wei N.
      Gene 321:65-72(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: 129/SvJ.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: BALB/c, C57BL/6J and NOD.
      Tissue: Embryo, Hypothalamus, Placenta, Thymus and Urinary bladder.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon, Kidney and Mammary tumor.
    4. "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex."
      Wei N., Tsuge T., Serino G., Dohmae N., Takio K., Matsui M., Deng X.-W.
      Curr. Biol. 8:919-922(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CSN COMPLEX.
      Strain: C57BL/6.

    Entry informationi

    Entry nameiCSN8_MOUSE
    AccessioniPrimary (citable) accession number: Q8VBV7
    Secondary accession number(s): Q3TRS9, Q80XF4, Q8R4D2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3