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Q8VBV7

- CSN8_MOUSE

UniProt

Q8VBV7 - CSN8_MOUSE

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Protein

COP9 signalosome complex subunit 8

Gene
Cops8, Csn8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. cullin deneddylation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 8
Short name:
SGN8
Short name:
Signalosome subunit 8
Alternative name(s):
COP9 homolog
JAB1-containing signalosome subunit 8
Gene namesi
Name:Cops8
Synonyms:Csn8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1915363. Cops8.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. COP9 signalosome Source: MGI
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 209208COP9 signalosome complex subunit 8PRO_0000121008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VBV7.
PRIDEiQ8VBV7.

2D gel databases

REPRODUCTION-2DPAGEQ8VBV7.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Expressed in embryonic stem (ES) cells and throughout early embryo development from zygote, preimplantation embryos, to post-implantation embryos. Predominantly expressed in the inner cell mass (ICM) of E3.5 blastocyst and widely expressed in E9.5-day embryos.1 Publication

Gene expression databases

BgeeiQ8VBV7.
GenevestigatoriQ8VBV7.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) By similarity.1 Publication

Protein-protein interaction databases

BioGridi224368. 11 interactions.
IntActiQ8VBV7. 3 interactions.
MINTiMINT-4092211.

Structurei

3D structure databases

ProteinModelPortaliQ8VBV7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 15184PCIAdd
BLAST

Sequence similaritiesi

Belongs to the CSN8 family.
Contains 1 PCI domain.

Phylogenomic databases

eggNOGiNOG321945.
GeneTreeiENSGT00390000000977.
HOGENOMiHOG000253954.
HOVERGENiHBG051139.
InParanoidiQ8VBV7.
KOiK12181.
OMAiISAHQWS.
OrthoDBiEOG76DTV5.
PhylomeDBiQ8VBV7.
TreeFamiTF101150.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBV7-1 [UniParc]FASTAAdd to Basket

« Hide

MPVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM    50
NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE 100
TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE 150
QGWQADSTTR MVLPRKPASG TLDVSLNRFI PLSEPAPVPP IPNEQQLARL 200
TDYVAFLEN 209
Length:209
Mass (Da):23,256
Last modified:March 1, 2002 - v1
Checksum:i786226FB7BFAC80E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1931N → M in AAL89689. 1 Publication
Sequence conflicti193 – 1931N → T in AAP13731. 1 Publication
Sequence conflicti194 – 1952EQ → SR1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF482000 mRNA. Translation: AAL89689.1.
AF502144 Genomic DNA. Translation: AAP13731.1.
AK079111 mRNA. Translation: BAC37543.1.
AK079522 mRNA. Translation: BAC37670.1.
AK088323 mRNA. Translation: BAC40281.1.
AK090013 mRNA. Translation: BAC41045.1.
AK145899 mRNA. Translation: BAE26735.1.
AK162502 mRNA. Translation: BAE36948.1.
BC017690 mRNA. Translation: AAH17690.1.
BC021488 mRNA. Translation: AAH21488.1.
BC024421 mRNA. Translation: AAH24421.1.
CCDSiCCDS15153.1.
RefSeqiNP_598566.3. NM_133805.3.
UniGeneiMm.119177.

Genome annotation databases

EnsembliENSMUST00000036153; ENSMUSP00000035884; ENSMUSG00000034432.
GeneIDi108679.
KEGGimmu:108679.
UCSCiuc007bzi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF482000 mRNA. Translation: AAL89689.1 .
AF502144 Genomic DNA. Translation: AAP13731.1 .
AK079111 mRNA. Translation: BAC37543.1 .
AK079522 mRNA. Translation: BAC37670.1 .
AK088323 mRNA. Translation: BAC40281.1 .
AK090013 mRNA. Translation: BAC41045.1 .
AK145899 mRNA. Translation: BAE26735.1 .
AK162502 mRNA. Translation: BAE36948.1 .
BC017690 mRNA. Translation: AAH17690.1 .
BC021488 mRNA. Translation: AAH21488.1 .
BC024421 mRNA. Translation: AAH24421.1 .
CCDSi CCDS15153.1.
RefSeqi NP_598566.3. NM_133805.3.
UniGenei Mm.119177.

3D structure databases

ProteinModelPortali Q8VBV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 224368. 11 interactions.
IntActi Q8VBV7. 3 interactions.
MINTi MINT-4092211.

2D gel databases

REPRODUCTION-2DPAGE Q8VBV7.

Proteomic databases

PaxDbi Q8VBV7.
PRIDEi Q8VBV7.

Protocols and materials databases

DNASUi 108679.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036153 ; ENSMUSP00000035884 ; ENSMUSG00000034432 .
GeneIDi 108679.
KEGGi mmu:108679.
UCSCi uc007bzi.1. mouse.

Organism-specific databases

CTDi 10920.
MGIi MGI:1915363. Cops8.

Phylogenomic databases

eggNOGi NOG321945.
GeneTreei ENSGT00390000000977.
HOGENOMi HOG000253954.
HOVERGENi HBG051139.
InParanoidi Q8VBV7.
KOi K12181.
OMAi ISAHQWS.
OrthoDBi EOG76DTV5.
PhylomeDBi Q8VBV7.
TreeFami TF101150.

Miscellaneous databases

NextBioi 361215.
PROi Q8VBV7.
SOURCEi Search...

Gene expression databases

Bgeei Q8VBV7.
Genevestigatori Q8VBV7.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene structure and embryonic expression of mouse COP9 signalosome subunit 8 (Csn8)."
    Lykke-Andersen K., Wei N.
    Gene 321:65-72(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129/SvJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/c, C57BL/6J and NOD.
    Tissue: Embryo, Hypothalamus, Placenta, Thymus and Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon, Kidney and Mammary tumor.
  4. "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex."
    Wei N., Tsuge T., Serino G., Dohmae N., Takio K., Matsui M., Deng X.-W.
    Curr. Biol. 8:919-922(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CSN COMPLEX.
    Strain: C57BL/6.

Entry informationi

Entry nameiCSN8_MOUSE
AccessioniPrimary (citable) accession number: Q8VBV7
Secondary accession number(s): Q3TRS9, Q80XF4, Q8R4D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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