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Q8VBV7 (CSN8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
COP9 signalosome complex subunit 8
Short name=SGN8
Short name=Signalosome subunit 8
Alternative name(s):
COP9 homolog
JAB1-containing signalosome subunit 8
Gene names
Name:Cops8
Synonyms:Csn8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively By similarity.

Subunit structure

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) By similarity. Ref.4

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Widely expressed. Ref.1

Developmental stage

Expressed in embryonic stem (ES) cells and throughout early embryo development from zygote, preimplantation embryos, to post-implantation embryos. Predominantly expressed in the inner cell mass (ICM) of E3.5 blastocyst and widely expressed in E9.5-day embryos. Ref.1

Sequence similarities

Belongs to the CSN8 family.

Contains 1 PCI domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
Signalosome
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcullin deneddylation

Inferred from electronic annotation. Source: Compara

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

signalosome

Inferred from direct assay Ref.4. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 209208COP9 signalosome complex subunit 8
PRO_0000121008

Regions

Domain68 – 15184PCI

Amino acid modifications

Modified residue1751Phosphoserine By similarity

Experimental info

Sequence conflict1931N → M in AAL89689. Ref.1
Sequence conflict1931N → T in AAP13731. Ref.1
Sequence conflict194 – 1952EQ → SR Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8VBV7 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 786226FB7BFAC80E

FASTA20923,256
        10         20         30         40         50         60 
MPVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM NNARYLWKRI 

        70         80         90        100        110        120 
PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL 

       130        140        150        160        170        180 
VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE QGWQADSTTR MVLPRKPASG TLDVSLNRFI 

       190        200 
PLSEPAPVPP IPNEQQLARL TDYVAFLEN

« Hide

References

« Hide 'large scale' references
[1]"Gene structure and embryonic expression of mouse COP9 signalosome subunit 8 (Csn8)."
Lykke-Andersen K., Wei N.
Gene 321:65-72(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: 129/SvJ.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: BALB/c, C57BL/6J and NOD.
Tissue: Embryo, Hypothalamus, Placenta, Thymus and Urinary bladder.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon, Kidney and Mammary tumor.
[4]"The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex."
Wei N., Tsuge T., Serino G., Dohmae N., Takio K., Matsui M., Deng X.-W.
Curr. Biol. 8:919-922(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE CSN COMPLEX.
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF482000 mRNA. Translation: AAL89689.1.
AF502144 Genomic DNA. Translation: AAP13731.1.
AK079111 mRNA. Translation: BAC37543.1.
AK079522 mRNA. Translation: BAC37670.1.
AK088323 mRNA. Translation: BAC40281.1.
AK090013 mRNA. Translation: BAC41045.1.
AK145899 mRNA. Translation: BAE26735.1.
AK162502 mRNA. Translation: BAE36948.1.
BC017690 mRNA. Translation: AAH17690.1.
BC021488 mRNA. Translation: AAH21488.1.
BC024421 mRNA. Translation: AAH24421.1.
IPIIPI00187407.
RefSeqNP_598566.3. NM_133805.3.
UniGeneMm.119177.

3D structure databases

ProteinModelPortalQ8VBV7.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4092211.

2D gel databases

REPRODUCTION-2DPAGEQ8VBV7.

Proteomic databases

PaxDbQ8VBV7.
PRIDEQ8VBV7.

Protocols and materials databases

DNASU108679.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036153; ENSMUSP00000035884; ENSMUSG00000034432.
GeneID108679.
KEGGmmu:108679.
UCSCuc007bzi.1. mouse.

Organism-specific databases

CTD10920.
MGIMGI:1915363. Cops8.

Phylogenomic databases

eggNOGNOG321945.
GeneTreeENSGT00390000000977.
HOGENOMHOG000253954.
HOVERGENHBG051139.
InParanoidQ8VBV7.
KOK12181.
OMAVLEQGWQ.
OrthoDBEOG43XV4D.

Gene expression databases

BgeeQ8VBV7.
GenevestigatorQ8VBV7.
GermOnlineENSMUSG00000034432. Mus musculus.

Family and domain databases

ProtoNetSearch...

Other

NextBio361215.
SOURCESearch...

Entry information

Entry nameCSN8_MOUSE
AccessionPrimary (citable) accession number: Q8VBV7
Secondary accession number(s): Q3TRS9, Q80XF4, Q8R4D2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: May 29, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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