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Protein

COP9 signalosome complex subunit 8

Gene

Cops8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 8
Short name:
SGN8
Short name:
Signalosome subunit 8
Alternative name(s):
COP9 homolog
JAB1-containing signalosome subunit 8
Gene namesi
Name:Cops8
Synonyms:Csn8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915363. Cops8.

Subcellular locationi

GO - Cellular componenti

  • COP9 signalosome Source: MGI
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210082 – 209COP9 signalosome complex subunit 8Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VBV7.
MaxQBiQ8VBV7.
PaxDbiQ8VBV7.
PeptideAtlasiQ8VBV7.
PRIDEiQ8VBV7.
TopDownProteomicsiQ8VBV7.

2D gel databases

REPRODUCTION-2DPAGEQ8VBV7.

PTM databases

iPTMnetiQ8VBV7.
PhosphoSitePlusiQ8VBV7.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Expressed in embryonic stem (ES) cells and throughout early embryo development from zygote, preimplantation embryos, to post-implantation embryos. Predominantly expressed in the inner cell mass (ICM) of E3.5 blastocyst and widely expressed in E9.5-day embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000034432.
ExpressionAtlasiQ8VBV7. baseline and differential.
GenevisibleiQ8VBV7. MM.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi224368. 7 interactors.
IntActiQ8VBV7. 3 interactors.
MINTiMINT-4092211.
STRINGi10090.ENSMUSP00000035884.

Structurei

3D structure databases

ProteinModelPortaliQ8VBV7.
SMRiQ8VBV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 151PCIAdd BLAST84

Sequence similaritiesi

Belongs to the CSN8 family.Curated
Contains 1 PCI domain.Curated

Phylogenomic databases

eggNOGiKOG4414. Eukaryota.
ENOG410XW9N. LUCA.
GeneTreeiENSGT00390000000977.
HOGENOMiHOG000253954.
HOVERGENiHBG051139.
InParanoidiQ8VBV7.
KOiK12181.
OMAiDAKLLWM.
OrthoDBiEOG091G0O7O.
PhylomeDBiQ8VBV7.
TreeFamiTF101150.

Family and domain databases

InterProiIPR033205. COP9_CSN8.
IPR033464. CSN8_PSD8_EIF3K.
[Graphical view]
PANTHERiPTHR13339. PTHR13339. 1 hit.
PfamiPF10075. CSN8_PSD8_EIF3K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM
60 70 80 90 100
NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE
110 120 130 140 150
TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE
160 170 180 190 200
QGWQADSTTR MVLPRKPASG TLDVSLNRFI PLSEPAPVPP IPNEQQLARL

TDYVAFLEN
Length:209
Mass (Da):23,256
Last modified:March 1, 2002 - v1
Checksum:i786226FB7BFAC80E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193N → M in AAL89689 (PubMed:14636993).Curated1
Sequence conflicti193N → T in AAP13731 (PubMed:14636993).Curated1
Sequence conflicti194 – 195EQ → SR (PubMed:14636993).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482000 mRNA. Translation: AAL89689.1.
AF502144 Genomic DNA. Translation: AAP13731.1.
AK079111 mRNA. Translation: BAC37543.1.
AK079522 mRNA. Translation: BAC37670.1.
AK088323 mRNA. Translation: BAC40281.1.
AK090013 mRNA. Translation: BAC41045.1.
AK145899 mRNA. Translation: BAE26735.1.
AK162502 mRNA. Translation: BAE36948.1.
BC017690 mRNA. Translation: AAH17690.1.
BC021488 mRNA. Translation: AAH21488.1.
BC024421 mRNA. Translation: AAH24421.1.
CCDSiCCDS15153.1.
RefSeqiNP_598566.3. NM_133805.3.
UniGeneiMm.119177.

Genome annotation databases

EnsembliENSMUST00000036153; ENSMUSP00000035884; ENSMUSG00000034432.
GeneIDi108679.
KEGGimmu:108679.
UCSCiuc007bzi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482000 mRNA. Translation: AAL89689.1.
AF502144 Genomic DNA. Translation: AAP13731.1.
AK079111 mRNA. Translation: BAC37543.1.
AK079522 mRNA. Translation: BAC37670.1.
AK088323 mRNA. Translation: BAC40281.1.
AK090013 mRNA. Translation: BAC41045.1.
AK145899 mRNA. Translation: BAE26735.1.
AK162502 mRNA. Translation: BAE36948.1.
BC017690 mRNA. Translation: AAH17690.1.
BC021488 mRNA. Translation: AAH21488.1.
BC024421 mRNA. Translation: AAH24421.1.
CCDSiCCDS15153.1.
RefSeqiNP_598566.3. NM_133805.3.
UniGeneiMm.119177.

3D structure databases

ProteinModelPortaliQ8VBV7.
SMRiQ8VBV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224368. 7 interactors.
IntActiQ8VBV7. 3 interactors.
MINTiMINT-4092211.
STRINGi10090.ENSMUSP00000035884.

PTM databases

iPTMnetiQ8VBV7.
PhosphoSitePlusiQ8VBV7.

2D gel databases

REPRODUCTION-2DPAGEQ8VBV7.

Proteomic databases

EPDiQ8VBV7.
MaxQBiQ8VBV7.
PaxDbiQ8VBV7.
PeptideAtlasiQ8VBV7.
PRIDEiQ8VBV7.
TopDownProteomicsiQ8VBV7.

Protocols and materials databases

DNASUi108679.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036153; ENSMUSP00000035884; ENSMUSG00000034432.
GeneIDi108679.
KEGGimmu:108679.
UCSCiuc007bzi.1. mouse.

Organism-specific databases

CTDi10920.
MGIiMGI:1915363. Cops8.

Phylogenomic databases

eggNOGiKOG4414. Eukaryota.
ENOG410XW9N. LUCA.
GeneTreeiENSGT00390000000977.
HOGENOMiHOG000253954.
HOVERGENiHBG051139.
InParanoidiQ8VBV7.
KOiK12181.
OMAiDAKLLWM.
OrthoDBiEOG091G0O7O.
PhylomeDBiQ8VBV7.
TreeFamiTF101150.

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.

Miscellaneous databases

PROiQ8VBV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034432.
ExpressionAtlasiQ8VBV7. baseline and differential.
GenevisibleiQ8VBV7. MM.

Family and domain databases

InterProiIPR033205. COP9_CSN8.
IPR033464. CSN8_PSD8_EIF3K.
[Graphical view]
PANTHERiPTHR13339. PTHR13339. 1 hit.
PfamiPF10075. CSN8_PSD8_EIF3K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSN8_MOUSE
AccessioniPrimary (citable) accession number: Q8VBV7
Secondary accession number(s): Q3TRS9, Q80XF4, Q8R4D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.