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Q8VBV4

- FBXW7_MOUSE

UniProt

Q8VBV4 - FBXW7_MOUSE

Protein

F-box/WD repeat-containing protein 7

Gene

Fbxw7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. lung development Source: MGI
    2. Notch signaling pathway Source: MGI
    3. protein ubiquitination Source: UniProtKB
    4. regulation of transcription, DNA-templated Source: GOC
    5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
    6. vasculogenesis Source: MGI

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196604. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.
    REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/WD repeat-containing protein 7
    Alternative name(s):
    F-box and WD-40 domain-containing protein 7
    F-box protein FBW7
    F-box protein Fbxw6
    F-box-WD40 repeat protein 6
    SEL-10
    Gene namesi
    Name:Fbxw7
    Synonyms:Fbw7, Fbwd6, Fbxw6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1354695. Fbxw7.

    Subcellular locationi

    Nucleusnucleoplasm 1 Publication. Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. endoplasmic reticulum Source: MGI
    3. Golgi apparatus Source: MGI
    4. nucleus Source: BHF-UCL
    5. perinuclear region of cytoplasm Source: BHF-UCL
    6. SCF ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 629629F-box/WD repeat-containing protein 7PRO_0000050995Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei149 – 1491Phosphoserine; by SGK1By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8VBV4.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in brain, heart and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ8VBV4.
    BgeeiQ8VBV4.
    GenevestigatoriQ8VBV4.

    Interactioni

    Subunit structurei

    Component of the SCF(FBXW7) complex consisting of CUL1, RBX1, SKP1 and FBXW7. Interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD and SKP1. Interacts with MYC (when phosphorylated). Interacts with USP28, leading to counteract ubiquitination of MYC By similarity. Forms a trimeric complex with NOTCH1 and SGK1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi206088. 15 interactions.
    IntActiQ8VBV4. 1 interaction.
    MINTiMINT-4609106.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VBV4.
    SMRiQ8VBV4. Positions 185-628.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini200 – 24647F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati300 – 34041WD 1Add
    BLAST
    Repeati342 – 37837WD 2Add
    BLAST
    Repeati381 – 42040WD 3Add
    BLAST
    Repeati422 – 45837WD 4Add
    BLAST
    Repeati461 – 50040WD 5Add
    BLAST
    Repeati502 – 54039WD 6Add
    BLAST
    Repeati544 – 58138WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00710000106459.
    HOGENOMiHOG000236264.
    HOVERGENiHBG051596.
    KOiK10260.
    OMAiMELRNNI.
    OrthoDBiEOG7VX8VF.
    PhylomeDBiQ8VBV4.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR001810. F-box_dom.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00256. FBOX. 1 hit.
    SM00320. WD40. 8 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    PS00678. WD_REPEATS_1. 5 hits.
    PS50082. WD_REPEATS_2. 7 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VBV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVCVPSSVL VLSCVCWCWG VLLPVPLPNL PFLACLSMST LESVTYLPEK    50
    GLYCQRLPSS RTHGGTESLK GKNTENMGFY GTLKMIFYKM KRKLDHGSEV 100
    RSFSLGKKPC KVSDYTSTTG LVPCSATPTT FGDLRAANGQ GQQRRRITSV 150
    QPPTGLQEWL KMFQSWSGPE KLLALDELID SCEPTQVKHM MQVIEPQFQR 200
    DFISLLPKEL ALYVLSFLEP KDLLQAAQTC RYWRILAEDN LLWREKCKEE 250
    GIDEPLHIKR RKIIKPGFIH SPWKSAYIRQ HRIDTNWRRG ELKSPKVLKG 300
    HDDHVITCLQ FCGNRIVSGS DDNTLKVWSA VTGKCLRTLV GHTGGVWSSQ 350
    MRDNIIISGS TDRTLKVWNA ETGECIHTLY GHTSTVRCMH LHEKRVVSGS 400
    RDATLRVWDI ETGQCLHVLM GHVAAVRCVQ YDGRRVVSGA YDFMVKVWDP 450
    ETETCLHTLQ GHTNRVYSLQ FDGIHVVSGS LDTSIRVWDV ETGNCIHTLT 500
    GHQSLTSGME LKDNILVSGN ADSTVKIWDI KTGQCLQTLQ GPSKHQSAVT 550
    CLQFNKNFVI TSSDDGTVKL WDLKTGEFIR NLVTLESGGS GGVVWRIRAS 600
    NTKLVCAVGS RNGTEETKLL VLDFDVDMK 629
    Length:629
    Mass (Da):70,547
    Last modified:March 1, 2002 - v1
    Checksum:i80483A7C2ED61FE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551Q → R in AAL50052. 1 PublicationCurated
    Sequence conflicti540 – 5401Q → E in AAL50052. 1 PublicationCurated
    Sequence conflicti619 – 6191L → F in AAL50052. 1 PublicationCurated
    Sequence conflicti624 – 6241F → V in AAL50052. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF391202
    , AF391193, AF391194, AF391195, AF391196, AF391197, AF391198, AF391199, AF391200, AF391201 Genomic DNA. Translation: AAL40930.1.
    AF391192 mRNA. Translation: AAL40928.1.
    AF427101 mRNA. Translation: AAL50052.1.
    BC131648 mRNA. Translation: AAI31649.1.
    AK032174 mRNA. Translation: BAC27743.1.
    CCDSiCCDS17440.1.
    RefSeqiNP_536353.2. NM_080428.3.
    UniGeneiMm.196475.

    Genome annotation databases

    EnsembliENSMUST00000029727; ENSMUSP00000029727; ENSMUSG00000028086.
    GeneIDi50754.
    KEGGimmu:50754.
    UCSCiuc008pql.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF391202
    , AF391193 , AF391194 , AF391195 , AF391196 , AF391197 , AF391198 , AF391199 , AF391200 , AF391201 Genomic DNA. Translation: AAL40930.1 .
    AF391192 mRNA. Translation: AAL40928.1 .
    AF427101 mRNA. Translation: AAL50052.1 .
    BC131648 mRNA. Translation: AAI31649.1 .
    AK032174 mRNA. Translation: BAC27743.1 .
    CCDSi CCDS17440.1.
    RefSeqi NP_536353.2. NM_080428.3.
    UniGenei Mm.196475.

    3D structure databases

    ProteinModelPortali Q8VBV4.
    SMRi Q8VBV4. Positions 185-628.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206088. 15 interactions.
    IntActi Q8VBV4. 1 interaction.
    MINTi MINT-4609106.

    Proteomic databases

    PRIDEi Q8VBV4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029727 ; ENSMUSP00000029727 ; ENSMUSG00000028086 .
    GeneIDi 50754.
    KEGGi mmu:50754.
    UCSCi uc008pql.2. mouse.

    Organism-specific databases

    CTDi 55294.
    MGIi MGI:1354695. Fbxw7.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00710000106459.
    HOGENOMi HOG000236264.
    HOVERGENi HBG051596.
    KOi K10260.
    OMAi MELRNNI.
    OrthoDBi EOG7VX8VF.
    PhylomeDBi Q8VBV4.

    Enzyme and pathway databases

    Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196604. Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling.
    REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    NextBioi 307631.
    PROi Q8VBV4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VBV4.
    Bgeei Q8VBV4.
    Genevestigatori Q8VBV4.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR001810. F-box_dom.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF00400. WD40. 7 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00256. FBOX. 1 hit.
    SM00320. WD40. 8 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    PS00678. WD_REPEATS_1. 5 hits.
    PS50082. WD_REPEATS_2. 7 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10."
      Maruyama S., Hatakeyama S., Nakayama K., Ishida N., Kawakami K., Nakayama K.
      Genomics 78:214-222(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, INTERACTION WITH SKP1 AND CUL1.
      Strain: 129/Sv.
    2. Ilyin G.P.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 305-629.
      Strain: C57BL/6J.
      Tissue: Olfactory bulb.
    5. "Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor."
      Gupta-Rossi N., Le Bail O., Gonen H., Brou C., Logeat F., Six E., Ciechanover A., Israel A.
      J. Biol. Chem. 276:34371-34378(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NOTCH1 NICD.
    6. "The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog."
      Oeberg C., Li J., Pauley A., Wolf E., Gurney M., Lendahl U.
      J. Biol. Chem. 276:35847-35853(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NOTCH1 NICD.

    Entry informationi

    Entry nameiFBXW7_MOUSE
    AccessioniPrimary (citable) accession number: Q8VBV4
    Secondary accession number(s): A2RRI5, Q8CCS5, Q8VHP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3