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Q8VBV3

- EXOS2_MOUSE

UniProt

Q8VBV3 - EXOS2_MOUSE

Protein

Exosome complex component RRP4

Gene

Exosc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7 By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of cell growth Source: Ensembl
    2. rRNA processing Source: UniProtKB-KW

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198696. KSRP destabilizes mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exosome complex component RRP4
    Alternative name(s):
    Exosome component 2
    Ribosomal RNA-processing protein 4
    Gene namesi
    Name:Exosc2
    Synonyms:Rrp4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2385133. Exosc2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleusnucleolus By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. exosome (RNase complex) Source: UniProtKB
    3. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Exosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293Exosome complex component RRP4PRO_0000087130Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei124 – 1241PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8VBV3.
    PaxDbiQ8VBV3.
    PRIDEiQ8VBV3.

    PTM databases

    PhosphoSiteiQ8VBV3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VBV3.
    BgeeiQ8VBV3.
    CleanExiMM_EXOSC2.
    GenevestigatoriQ8VBV3.

    Interactioni

    Subunit structurei

    Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with GTPBP1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VBV3.
    SMRiQ8VBV3. Positions 25-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 15981S1 motifAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRP4 family.Curated
    Contains 1 S1 motif domain.Curated

    Phylogenomic databases

    eggNOGiCOG1097.
    GeneTreeiENSGT00440000033656.
    HOGENOMiHOG000193685.
    HOVERGENiHBG051517.
    InParanoidiQ8VBV3.
    KOiK03679.
    OMAiSRLRNCV.
    OrthoDBiEOG7JX34R.
    PhylomeDBiQ8VBV3.
    TreeFamiTF105623.

    Family and domain databases

    InterProiIPR025721. Exosome_cplx_N_dom.
    IPR026699. Exosome_RNA_bind1/RRP40/RRP4.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR21321. PTHR21321. 1 hit.
    PfamiPF14382. ECR1_N. 1 hit.
    [Graphical view]
    SMARTiSM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54791. SSF54791. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8VBV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALEMRLPKA RKPLSESLGR DSKKHLVVPG DTITTDTGFM RGHGTYMGEE    50
    KLIASVAGSV ERVNKLICVK ALKTRYNGEV GDIVVGRITE VQQKRWKVET 100
    NSRLDSVLLL SSMNLPGGEL RRRSAEDELA MRGFLQEGDL ISAEVQAVFS 150
    DGAVSLHTRS LKYGKLGQGV LVQVSPSLVK RQKTHFHDLP CGASVILGNN 200
    GFIWIYPTPE HKDEDAGGFI ANLEPVALSD REVISRLRNC VVLLVTQRMM 250
    LFDTSILYCY EASLAHQIKD ILKPEVMEEI MLETRQRLLD QEG 293
    Length:293
    Mass (Da):32,632
    Last modified:March 1, 2002 - v1
    Checksum:i832C75F57980DDF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC021485 mRNA. Translation: AAH21485.1.
    BC021807 mRNA. Translation: AAH21807.1.
    CCDSiCCDS15900.1.
    RefSeqiNP_659135.1. NM_144886.2.
    UniGeneiMm.150972.

    Genome annotation databases

    EnsembliENSMUST00000038474; ENSMUSP00000043519; ENSMUSG00000039356.
    GeneIDi227715.
    KEGGimmu:227715.
    UCSCiuc008jdy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC021485 mRNA. Translation: AAH21485.1 .
    BC021807 mRNA. Translation: AAH21807.1 .
    CCDSi CCDS15900.1.
    RefSeqi NP_659135.1. NM_144886.2.
    UniGenei Mm.150972.

    3D structure databases

    ProteinModelPortali Q8VBV3.
    SMRi Q8VBV3. Positions 25-293.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8VBV3.

    Proteomic databases

    MaxQBi Q8VBV3.
    PaxDbi Q8VBV3.
    PRIDEi Q8VBV3.

    Protocols and materials databases

    DNASUi 227715.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038474 ; ENSMUSP00000043519 ; ENSMUSG00000039356 .
    GeneIDi 227715.
    KEGGi mmu:227715.
    UCSCi uc008jdy.1. mouse.

    Organism-specific databases

    CTDi 23404.
    MGIi MGI:2385133. Exosc2.

    Phylogenomic databases

    eggNOGi COG1097.
    GeneTreei ENSGT00440000033656.
    HOGENOMi HOG000193685.
    HOVERGENi HBG051517.
    InParanoidi Q8VBV3.
    KOi K03679.
    OMAi SRLRNCV.
    OrthoDBi EOG7JX34R.
    PhylomeDBi Q8VBV3.
    TreeFami TF105623.

    Enzyme and pathway databases

    Reactomei REACT_198696. KSRP destabilizes mRNA.

    Miscellaneous databases

    NextBioi 378776.
    PROi Q8VBV3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VBV3.
    Bgeei Q8VBV3.
    CleanExi MM_EXOSC2.
    Genevestigatori Q8VBV3.

    Family and domain databases

    InterProi IPR025721. Exosome_cplx_N_dom.
    IPR026699. Exosome_RNA_bind1/RRP40/RRP4.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR21321. PTHR21321. 1 hit.
    Pfami PF14382. ECR1_N. 1 hit.
    [Graphical view ]
    SMARTi SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54791. SSF54791. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiEXOS2_MOUSE
    AccessioniPrimary (citable) accession number: Q8VBV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3