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Protein

Protein BANP

Gene

Banp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest and inhibits tumor growth.7 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • p53 binding Source: MGI

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • chromatin modification Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of protein catabolic process Source: MGI
  • positive regulation of transcription, DNA-templated Source: CACAO
  • protein localization to nucleus Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein, Repressor

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6804759. Regulation of TP53 Activity through Association with Co-factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BANP
Alternative name(s):
Btg3-associated nuclear protein
Scaffold/matrix-associated region-1-binding protein
Gene namesi
Name:Banp
Synonyms:Smar1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1889023. Banp.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi347S → A: Impairs TP53 activation. 1 Publication1
Mutagenesisi348S → A: No effect on TP53 activation. 1 Publication1
Mutagenesisi349S → A: No effect on TP53 activation. 1 Publication1
Mutagenesisi350S → A: No effect on TP53 activation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979111 – 548Protein BANPAdd BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei108PhosphoserineBy similarity1
Modified residuei283N6-acetyllysineCombined sources1
Modified residuei347Phosphoserine1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8VBU8.
PeptideAtlasiQ8VBU8.
PRIDEiQ8VBU8.

PTM databases

iPTMnetiQ8VBU8.
PhosphoSitePlusiQ8VBU8.

Expressioni

Tissue specificityi

Highly expressed in heart, spleen, and thymus. Isoform 1 is highly expressed in kidney, brain and testis. Isoform 3 is highly expressed in kidney and lung.3 Publications

Gene expression databases

BgeeiENSMUSG00000025316.
CleanExiMM_BANP.
ExpressionAtlasiQ8VBU8. baseline and differential.
GenevisibleiQ8VBU8. MM.

Interactioni

Subunit structurei

Interacts with TP53, CUX1/CDP and HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.4 Publications

GO - Molecular functioni

  • p53 binding Source: MGI

Protein-protein interaction databases

BioGridi207288. 1 interactor.
IntActiQ8VBU8. 1 interactor.
MINTiMINT-1686827.
STRINGi10090.ENSMUSP00000132095.

Structurei

3D structure databases

ProteinModelPortaliQ8VBU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 330BENPROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 350Interaction with CUX1 and HDAC12 PublicationsAdd BLAST191
Regioni328 – 357Necessary and sufficient for TP53 activationAdd BLAST30
Regioni350 – 400DNA-bindingAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 98Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi347 – 354Poly-Ser8
Compositional biasi368 – 441Gln-richAdd BLAST74

Sequence similaritiesi

Belongs to the BANP/SMAR1 family.Curated
Contains 1 BEN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGMM. Eukaryota.
ENOG410Z2PJ. LUCA.
GeneTreeiENSGT00390000011116.
HOGENOMiHOG000015355.
HOVERGENiHBG107493.
InParanoidiQ8VBU8.
OMAiIISNAVP.
OrthoDBiEOG091G0JD3.
PhylomeDBiQ8VBU8.
TreeFamiTF331908.

Family and domain databases

InterProiIPR018379. BEN_domain.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
[Graphical view]
PROSITEiPS51457. BEN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VBU8-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSEQDLADV VQIAVEDLSP DHPVVLENHV VTDDDEPALK RQRLEINCQD
60 70 80 90 100
PSIKSFLYSI NQTICLRLDS IEAKLQALEA TCKSLEEKLD LVTNKQHSPI
110 120 130 140 150
QVPMVAGSPL GATQTCNKVR CVVPQTTVIL NNDRQNAIVA KMEDPLSNRA
160 170 180 190 200
PDSLENIISN AVPGRRQNTI VVKVPGQDDS HNEDGESGSE ASDSVSNCGQ
210 220 230 240 250
PGSQNIGSNV TLITLNSEED YPNGTWLGDE NNPEMRVRCA IIPSDMLHIS
260 270 280 290 300
TNCRTAEKMA LTLLDYLFHR EVQAVSNLSG QGKHGKKQLD PLTIYGIRCH
310 320 330 340 350
LFYKFGITES DWYRIKQSID SKCRTAWRRK QRGQSLAVKS FSRRTPSSSS
360 370 380 390 400
YSASETMMGT PPPTSELQQS QPQALHYALA NAQQVQIHQI GEDGQVQVIP
410 420 430 440 450
QGHLHIAQVP QGEQVQITQD SEGNLQIHHV GQDGQSWGLC QNPIPVSGDS
460 470 480 490 500
VAQANPSQLW PLGGDTLDLP AGNEMIQVLQ GAQLIAVASS DPAATGVDGS
510 520 530 540
PLQGSDIQVQ YVQLAPVSDH TAAAQTAEAL QPTLQPDMQL EHGAIQIQ
Length:548
Mass (Da):59,657
Last modified:March 1, 2002 - v1
Checksum:i9C48D5E122ECB2D1
GO
Isoform 2 (identifier: Q8VBU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-160: Missing.

Show »
Length:509
Mass (Da):55,384
Checksum:i5CA169C13D207173
GO
Isoform 3 (identifier: Q8VBU8-3) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     122-160: Missing.
     399-401: Missing.

Show »
Length:506
Mass (Da):55,045
Checksum:iB71B80862BB10443
GO
Isoform 4 (identifier: Q8VBU8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-476: Missing.

Note: No experimental confirmation available.
Show »
Length:506
Mass (Da):55,297
Checksum:i7F6F4CD08FE3F87C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131N → I in AAG16659 (PubMed:10950932).Curated1
Sequence conflicti147S → I in AAG16659 (PubMed:10950932).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027403122 – 160Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST39
Alternative sequenceiVSP_027404399 – 401Missing in isoform 3. 2 Publications3
Alternative sequenceiVSP_027405435 – 476Missing in isoform 4. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091234 mRNA. Translation: AAC36358.1.
AF235503 mRNA. Translation: AAG16659.1.
AK154088 mRNA. Translation: BAE32366.1.
BC013339 mRNA. Translation: AAH13339.1.
BC021650 mRNA. Translation: AAH21650.1.
BC022168 mRNA. Translation: AAH22168.1.
BC062641 mRNA. Translation: AAH62641.1.
CCDSiCCDS40502.1. [Q8VBU8-1]
CCDS72176.1. [Q8VBU8-2]
CCDS72177.1. [Q8VBU8-3]
RefSeqiNP_001103570.1. NM_001110100.2.
NP_001272910.1. NM_001285981.1. [Q8VBU8-2]
NP_001272912.1. NM_001285983.1. [Q8VBU8-3]
NP_058092.2. NM_016812.4. [Q8VBU8-1]
XP_011246744.1. XM_011248442.1. [Q8VBU8-4]
XP_017168388.1. XM_017312899.1. [Q8VBU8-1]
UniGeneiMm.287163.

Genome annotation databases

EnsembliENSMUST00000026354; ENSMUSP00000026354; ENSMUSG00000025316. [Q8VBU8-2]
ENSMUST00000093078; ENSMUSP00000090766; ENSMUSG00000025316. [Q8VBU8-3]
ENSMUST00000170857; ENSMUSP00000132095; ENSMUSG00000025316. [Q8VBU8-1]
ENSMUST00000173254; ENSMUSP00000133783; ENSMUSG00000025316. [Q8VBU8-4]
GeneIDi53325.
KEGGimmu:53325.
UCSCiuc009nsg.3. mouse. [Q8VBU8-1]
uc009nsh.3. mouse. [Q8VBU8-3]
uc033jih.1. mouse. [Q8VBU8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091234 mRNA. Translation: AAC36358.1.
AF235503 mRNA. Translation: AAG16659.1.
AK154088 mRNA. Translation: BAE32366.1.
BC013339 mRNA. Translation: AAH13339.1.
BC021650 mRNA. Translation: AAH21650.1.
BC022168 mRNA. Translation: AAH22168.1.
BC062641 mRNA. Translation: AAH62641.1.
CCDSiCCDS40502.1. [Q8VBU8-1]
CCDS72176.1. [Q8VBU8-2]
CCDS72177.1. [Q8VBU8-3]
RefSeqiNP_001103570.1. NM_001110100.2.
NP_001272910.1. NM_001285981.1. [Q8VBU8-2]
NP_001272912.1. NM_001285983.1. [Q8VBU8-3]
NP_058092.2. NM_016812.4. [Q8VBU8-1]
XP_011246744.1. XM_011248442.1. [Q8VBU8-4]
XP_017168388.1. XM_017312899.1. [Q8VBU8-1]
UniGeneiMm.287163.

3D structure databases

ProteinModelPortaliQ8VBU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207288. 1 interactor.
IntActiQ8VBU8. 1 interactor.
MINTiMINT-1686827.
STRINGi10090.ENSMUSP00000132095.

PTM databases

iPTMnetiQ8VBU8.
PhosphoSitePlusiQ8VBU8.

Proteomic databases

PaxDbiQ8VBU8.
PeptideAtlasiQ8VBU8.
PRIDEiQ8VBU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026354; ENSMUSP00000026354; ENSMUSG00000025316. [Q8VBU8-2]
ENSMUST00000093078; ENSMUSP00000090766; ENSMUSG00000025316. [Q8VBU8-3]
ENSMUST00000170857; ENSMUSP00000132095; ENSMUSG00000025316. [Q8VBU8-1]
ENSMUST00000173254; ENSMUSP00000133783; ENSMUSG00000025316. [Q8VBU8-4]
GeneIDi53325.
KEGGimmu:53325.
UCSCiuc009nsg.3. mouse. [Q8VBU8-1]
uc009nsh.3. mouse. [Q8VBU8-3]
uc033jih.1. mouse. [Q8VBU8-2]

Organism-specific databases

CTDi54971.
MGIiMGI:1889023. Banp.

Phylogenomic databases

eggNOGiENOG410IGMM. Eukaryota.
ENOG410Z2PJ. LUCA.
GeneTreeiENSGT00390000011116.
HOGENOMiHOG000015355.
HOVERGENiHBG107493.
InParanoidiQ8VBU8.
OMAiIISNAVP.
OrthoDBiEOG091G0JD3.
PhylomeDBiQ8VBU8.
TreeFamiTF331908.

Enzyme and pathway databases

ReactomeiR-MMU-6804759. Regulation of TP53 Activity through Association with Co-factors.

Miscellaneous databases

PROiQ8VBU8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025316.
CleanExiMM_BANP.
ExpressionAtlasiQ8VBU8. baseline and differential.
GenevisibleiQ8VBU8. MM.

Family and domain databases

InterProiIPR018379. BEN_domain.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
[Graphical view]
PROSITEiPS51457. BEN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBANP_MOUSE
AccessioniPrimary (citable) accession number: Q8VBU8
Secondary accession number(s): O88973
, Q3U4R5, Q91YZ1, Q9ES51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.