UniProtKB - Q8VBU5 (Q8VBU5_MOUSE)
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Protein
Phosphodiesterase
Gene
Pde4b
Organism
Mus musculus (Mouse)
Status
Functioni
Cofactori
a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation
GO - Molecular functioni
- 3',5'-cyclic-AMP phosphodiesterase activity Source: MGI
- cAMP binding Source: MGI
- gamma-tubulin binding Source: MGI
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cAMP catabolic process Source: MGI
- cellular response to drug Source: MGI
- cellular response to lipopolysaccharide Source: MGI
- leukocyte migration Source: MGI
- neutrophil chemotaxis Source: MGI
- neutrophil homeostasis Source: MGI
- positive regulation of interferon-gamma production Source: MGI
- positive regulation of interleukin-2 production Source: MGI
- T cell receptor signaling pathway Source: MGI
Keywordsi
Molecular function | HydrolaseUniRule annotationSAAS annotation |
Ligand | Metal-bindingUniRule annotationSAAS annotation |
Enzyme and pathway databases
Reactomei | R-MMU-180024. DARPP-32 events. R-MMU-418555. G alpha (s) signalling events. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Pde4bImported ORF Names:mCG_113038Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99557. Pde4b. |
Subcellular locationi
Interactioni
GO - Molecular functioni
- gamma-tubulin binding Source: MGI
Protein-protein interaction databases
IntActi | Q8VBU5. 2 interactors. |
STRINGi | 10090.ENSMUSP00000102521. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 388 – 563 | HDInterPro annotationAdd BLAST | 176 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3689. Eukaryota. ENOG410XRI7. LUCA. |
GeneTreei | ENSGT00760000118889. |
HOGENOMi | HOG000236297. |
HOVERGENi | HBG108239. |
KOi | K13293. |
OMAi | TCFDVEN. |
TreeFami | TF314638. |
Family and domain databases
CDDi | cd00077. HDc. 1 hit. |
Gene3Di | 1.10.1300.10. 1 hit. |
InterProi | View protein in InterPro IPR003607. HD/PDEase_dom. IPR023088. PDEase. IPR002073. PDEase_catalytic_dom. IPR036971. PDEase_catalytic_dom_sf. IPR023174. PDEase_CS. |
Pfami | View protein in Pfam PF00233. PDEase_I. 1 hit. |
PRINTSi | PR00387. PDIESTERASE1. |
SMARTi | View protein in SMART SM00471. HDc. 1 hit. |
PROSITEi | View protein in PROSITE PS00126. PDEASE_I. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8VBU5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAKNSPKEF TASESEVCIK TFKEQMRLEL ELPKLPGNRP TSPKISPRSS
60 70 80 90 100
PRNSPCFFRK LLVNKSIRQR RRFTVAHTCF DVENGPSPGR SPLDPQAGSS
110 120 130 140 150
SGLVLHAAFP GHSQRRESFL YRSDSDYDLS PKAMSRNSSL PSEQHGDDLI
160 170 180 190 200
VTPFAQVLAS LRSVRNNFTL LTNLHGAPNK RSPAASQAPV SRVSLQEESY
210 220 230 240 250
QKLAMETLEE LDWCLDQLET IQTYRSVSEM ASNKFKRMLN RELTHLSEMS
260 270 280 290 300
RSGNQVSEYI SNTFLDKQND VEIPSPTQKD REKKKKQQLM TQISGVKKLM
310 320 330 340 350
HSSSLNNTSI SRFGVNTENE DHLAKELEDL NKWGLNIFNV AGYSHNRPLT
360 370 380 390 400
CIMYAIFQER DLLKTFKISS DTFVTYMMTL EDHYHSDVAY HNSLHAADVA
410 420 430 440 450
QSTHVLLSTP ALDAVFTDLE ILAAIFAAAI HDVDHPGVSN QFLINTNSEL
460 470 480 490 500
ALMYNDESVL ENHHLAVGFK LLQEEHCDIF QNLTKKQRQT LRKMVIDMVL
510 520 530 540 550
ATDMSKHMSL LADLKTMVET KKVTSSGVLL LDNYTDRIQV LRNMVHCADL
560 570 580 590 600
SNPTKSLELY RQWTDRIMEE FFQQGDKERE RGMEISPMCD KHTASVEKSQ
610 620 630 640 650
VGFIDYIVHP LWETWADLVQ PDAQDILDTL EDNRNWYQSM IPQSPSPPLD
660 670 680 690 700
ERSRDCQGLM EKFQFELTLE EEDSEGPEKE GEGHSYFSST KTLCVIDPEN
710 720
RDSLEETDID IATEDKSPID T
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL732551 Genomic DNA. No translation available. AL772293 Genomic DNA. No translation available. AL772358 Genomic DNA. No translation available. AL807794 Genomic DNA. No translation available. AF326555 mRNA. Translation: AAL37401.1. AF326556 mRNA. Translation: AAL37402.1. CH466527 Genomic DNA. Translation: EDL30857.1. |
RefSeqi | NP_001171451.1. NM_001177980.1. NP_062814.2. NM_019840.2. |
UniGenei | Mm.20181. |
Genome annotation databases
Ensembli | ENSMUST00000106908; ENSMUSP00000102521; ENSMUSG00000028525. |
GeneIDi | 18578. |
KEGGi | mmu:18578. |
UCSCi | uc008twj.2. mouse. |
Similar proteinsi
Entry informationi
Entry namei | Q8VBU5_MOUSE | |
Accessioni | Q8VBU5Primary (citable) accession number: Q8VBU5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 28, 2018 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |