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Protein

Phosphodiesterase

Gene

Pde4b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cAMP catabolic process Source: MGI
  • cellular response to drug Source: MGI
  • cellular response to lipopolysaccharide Source: MGI
  • leukocyte migration Source: MGI
  • neutrophil chemotaxis Source: MGI
  • neutrophil homeostasis Source: MGI
  • positive regulation of interferon-gamma production Source: MGI
  • positive regulation of interleukin-2 production Source: MGI
  • T cell receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-180024. DARPP-32 events.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:Pde4bImported
ORF Names:mCG_113038Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99557. Pde4b.

Subcellular locationi

GO - Cellular componenti

  • cell periphery Source: MGI
  • centrosome Source: MGI
  • cytosol Source: MGI
  • dendritic spine Source: MGI
  • excitatory synapse Source: MGI
  • gamma-tubulin complex Source: MGI
  • membrane Source: MGI
  • postsynaptic density Source: MGI
  • synaptic vesicle Source: MGI
Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2111373.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ8VBU5.

Interactioni

GO - Molecular functioni

  • gamma-tubulin binding Source: MGI

Protein-protein interaction databases

MINTiMINT-4119314.
STRINGi10090.ENSMUSP00000102521.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini388 – 563176HDcInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3689. Eukaryota.
ENOG410XRI7. LUCA.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000236297.
HOVERGENiHBG108239.
KOiK13293.
OMAiHTCFDVE.
TreeFamiTF314638.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VBU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAKNSPKEF TASESEVCIK TFKEQMRLEL ELPKLPGNRP TSPKISPRSS
60 70 80 90 100
PRNSPCFFRK LLVNKSIRQR RRFTVAHTCF DVENGPSPGR SPLDPQAGSS
110 120 130 140 150
SGLVLHAAFP GHSQRRESFL YRSDSDYDLS PKAMSRNSSL PSEQHGDDLI
160 170 180 190 200
VTPFAQVLAS LRSVRNNFTL LTNLHGAPNK RSPAASQAPV SRVSLQEESY
210 220 230 240 250
QKLAMETLEE LDWCLDQLET IQTYRSVSEM ASNKFKRMLN RELTHLSEMS
260 270 280 290 300
RSGNQVSEYI SNTFLDKQND VEIPSPTQKD REKKKKQQLM TQISGVKKLM
310 320 330 340 350
HSSSLNNTSI SRFGVNTENE DHLAKELEDL NKWGLNIFNV AGYSHNRPLT
360 370 380 390 400
CIMYAIFQER DLLKTFKISS DTFVTYMMTL EDHYHSDVAY HNSLHAADVA
410 420 430 440 450
QSTHVLLSTP ALDAVFTDLE ILAAIFAAAI HDVDHPGVSN QFLINTNSEL
460 470 480 490 500
ALMYNDESVL ENHHLAVGFK LLQEEHCDIF QNLTKKQRQT LRKMVIDMVL
510 520 530 540 550
ATDMSKHMSL LADLKTMVET KKVTSSGVLL LDNYTDRIQV LRNMVHCADL
560 570 580 590 600
SNPTKSLELY RQWTDRIMEE FFQQGDKERE RGMEISPMCD KHTASVEKSQ
610 620 630 640 650
VGFIDYIVHP LWETWADLVQ PDAQDILDTL EDNRNWYQSM IPQSPSPPLD
660 670 680 690 700
ERSRDCQGLM EKFQFELTLE EEDSEGPEKE GEGHSYFSST KTLCVIDPEN
710 720
RDSLEETDID IATEDKSPID T
Length:721
Mass (Da):82,075
Last modified:March 1, 2002 - v1
Checksum:iB3725A478A7612FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732551 Genomic DNA. No translation available.
AL772293 Genomic DNA. No translation available.
AL772358 Genomic DNA. No translation available.
AL807794 Genomic DNA. No translation available.
AF326555 mRNA. Translation: AAL37401.1.
AF326556 mRNA. Translation: AAL37402.1.
CH466527 Genomic DNA. Translation: EDL30857.1.
RefSeqiNP_001171451.1. NM_001177980.1.
NP_062814.2. NM_019840.2.
UniGeneiMm.20181.

Genome annotation databases

EnsembliENSMUST00000106908; ENSMUSP00000102521; ENSMUSG00000028525.
GeneIDi18578.
KEGGimmu:18578.
UCSCiuc008twj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732551 Genomic DNA. No translation available.
AL772293 Genomic DNA. No translation available.
AL772358 Genomic DNA. No translation available.
AL807794 Genomic DNA. No translation available.
AF326555 mRNA. Translation: AAL37401.1.
AF326556 mRNA. Translation: AAL37402.1.
CH466527 Genomic DNA. Translation: EDL30857.1.
RefSeqiNP_001171451.1. NM_001177980.1.
NP_062814.2. NM_019840.2.
UniGeneiMm.20181.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4119314.
STRINGi10090.ENSMUSP00000102521.

Chemistry

ChEMBLiCHEMBL2111373.

Proteomic databases

PeptideAtlasiQ8VBU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106908; ENSMUSP00000102521; ENSMUSG00000028525.
GeneIDi18578.
KEGGimmu:18578.
UCSCiuc008twj.2. mouse.

Organism-specific databases

CTDi5142.
MGIiMGI:99557. Pde4b.

Phylogenomic databases

eggNOGiKOG3689. Eukaryota.
ENOG410XRI7. LUCA.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000236297.
HOVERGENiHBG108239.
KOiK13293.
OMAiHTCFDVE.
TreeFamiTF314638.

Enzyme and pathway databases

ReactomeiR-MMU-180024. DARPP-32 events.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

ChiTaRSiPde4b. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
    Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
    J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2JImported.
    Tissue: Whole brainImported.
  2. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8VBU5_MOUSE
AccessioniPrimary (citable) accession number: Q8VBU5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.