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Protein

Protein NDRG2

Gene

Ndrg2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor (By similarity). May be involved in dendritic cell and neuron differentiation.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Wnt signaling pathway

Protein family/group databases

ESTHERiratno-NDRG2. Ndr_family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NDRG2
Alternative name(s):
Antidepressant-related protein ADRG123
N-myc downstream-regulated gene 2 protein
NDRG1-related protein
Gene namesi
Name:Ndrg2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621874. Ndrg2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 371370Protein NDRG2PRO_0000238966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei20 – 201PhosphothreonineCombined sources
Modified residuei326 – 3261PhosphoserineCombined sources
Modified residuei328 – 3281PhosphoserineCombined sources
Modified residuei330 – 3301PhosphothreonineCombined sources
Modified residuei332 – 3321PhosphoserineCombined sources1 Publication
Modified residuei334 – 3341PhosphothreonineBy similarity
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei338 – 3381PhosphoserineCombined sources
Modified residuei344 – 3441PhosphoserineBy similarity
Modified residuei348 – 3481PhosphothreonineBy similarity
Modified residuei350 – 3501PhosphoserineBy similarity
Modified residuei352 – 3521PhosphoserineBy similarity
Modified residuei353 – 3531PhosphoserineBy similarity
Modified residuei355 – 3551PhosphoserineBy similarity
Modified residuei357 – 3571PhosphothreonineBy similarity
Modified residuei370 – 3701PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8VBU2.
PRIDEiQ8VBU2.

PTM databases

iPTMnetiQ8VBU2.
PhosphoSiteiQ8VBU2.

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in heart, liver, skeletal muscle and aorta.1 Publication

Inductioni

Up-regulated by aldosterone in kidney and colon, but not in heart. Down-regulated in cortex by antidepressant treatments.2 Publications

Gene expression databases

BgeeiENSRNOG00000010389.

Interactioni

Protein-protein interaction databases

BioGridi251122. 1 interaction.
MINTiMINT-4580246.
STRINGi10116.ENSRNOP00000042949.

Structurei

3D structure databases

ProteinModelPortaliQ8VBU2.
SMRiQ8VBU2. Positions 39-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDRG family.Curated

Phylogenomic databases

eggNOGiKOG2931. Eukaryota.
ENOG410XSPF. LUCA.
HOGENOMiHOG000230891.
HOVERGENiHBG052591.
InParanoidiQ8VBU2.
PhylomeDBiQ8VBU2.
TreeFamiTF313168.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR004142. NDRG.
IPR030690. NDRG2.
[Graphical view]
PANTHERiPTHR11034. PTHR11034. 1 hit.
PTHR11034:SF17. PTHR11034:SF17. 1 hit.
PfamiPF03096. Ndr. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VBU2-1) [UniParc]FASTAAdd to basket
Also known as: Ndrg2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELQEVQIT EEKPLLPGQT PEAAKEAELA ARILLDQGQT HSVETPYGSV
60 70 80 90 100
TFTVYGTPKP KRPAIFTYHD VGLNYKSCFQ PLFQFGDMQE IIQNFVRVHV
110 120 130 140 150
DAPGMEEGAP VFPLGYQYPS QDQLADMIPC ILQYLNFSTI IGVGVGAGAY
160 170 180 190 200
ILSRYALNHP DTVEGLVLIN IDPNAKGWMD WAAHKLTGLT SSIPEMILGH
210 220 230 240 250
LFSQEELSGN SELIQKYRSL ITHAPNLENI ELYWNSYNNR RDLNFERGGE
260 270 280 290 300
MTLKCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP
310 320 330 340 350
GKLTEAFKYF VQGMGYMASS CMTRLSRSRT ASLTSAASID GSRSRSRTLS
360 370
QSSESGTLPS GPPGHTMEVS C
Length:371
Mass (Da):40,779
Last modified:March 1, 2002 - v1
Checksum:iC049A1AAF37D115A
GO
Isoform 2 (identifier: Q8VBU2-2) [UniParc]FASTAAdd to basket
Also known as: Ndrg2S

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.

Show »
Length:357
Mass (Da):39,270
Checksum:i66792DC7A9DD9485
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211Q → L in AAL73186 (PubMed:15769300).Curated
Sequence conflicti121 – 1211Q → L in AAL73187 (PubMed:15769300).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 3914Missing in isoform 2. 2 PublicationsVSP_019032Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ426424 mRNA. Translation: CAD19997.1.
AJ426425 mRNA. Translation: CAD19998.1.
AJ426426 mRNA. Translation: CAD19999.1.
AJ426427 mRNA. Translation: CAD20000.1.
AF334105 mRNA. Translation: AAL73186.1.
AF334106 mRNA. Translation: AAL73187.1.
RefSeqiNP_001257791.1. NM_001270862.1.
NP_001257792.1. NM_001270863.1.
NP_001257793.1. NM_001270864.1.
NP_598267.2. NM_133583.2.
UniGeneiRn.3407.

Genome annotation databases

GeneIDi171114.
KEGGirno:171114.
UCSCiRGD:621874. rat. [Q8VBU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ426424 mRNA. Translation: CAD19997.1.
AJ426425 mRNA. Translation: CAD19998.1.
AJ426426 mRNA. Translation: CAD19999.1.
AJ426427 mRNA. Translation: CAD20000.1.
AF334105 mRNA. Translation: AAL73186.1.
AF334106 mRNA. Translation: AAL73187.1.
RefSeqiNP_001257791.1. NM_001270862.1.
NP_001257792.1. NM_001270863.1.
NP_001257793.1. NM_001270864.1.
NP_598267.2. NM_133583.2.
UniGeneiRn.3407.

3D structure databases

ProteinModelPortaliQ8VBU2.
SMRiQ8VBU2. Positions 39-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251122. 1 interaction.
MINTiMINT-4580246.
STRINGi10116.ENSRNOP00000042949.

Protein family/group databases

ESTHERiratno-NDRG2. Ndr_family.

PTM databases

iPTMnetiQ8VBU2.
PhosphoSiteiQ8VBU2.

Proteomic databases

PaxDbiQ8VBU2.
PRIDEiQ8VBU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171114.
KEGGirno:171114.
UCSCiRGD:621874. rat. [Q8VBU2-1]

Organism-specific databases

CTDi57447.
RGDi621874. Ndrg2.

Phylogenomic databases

eggNOGiKOG2931. Eukaryota.
ENOG410XSPF. LUCA.
HOGENOMiHOG000230891.
HOVERGENiHBG052591.
InParanoidiQ8VBU2.
PhylomeDBiQ8VBU2.
TreeFamiTF313168.

Miscellaneous databases

PROiQ8VBU2.

Gene expression databases

BgeeiENSRNOG00000010389.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR004142. NDRG.
IPR030690. NDRG2.
[Graphical view]
PANTHERiPTHR11034. PTHR11034. 1 hit.
PTHR11034:SF17. PTHR11034:SF17. 1 hit.
PfamiPF03096. Ndr. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDRG2_RAT
AccessioniPrimary (citable) accession number: Q8VBU2
Secondary accession number(s): Q8VBW2, Q8VI00, Q8VI01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.