ID   OSCAR_MOUSE             Reviewed;         265 AA.
AC   Q8VBT3; Q8VHT9;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 131.
DE   RecName: Full=Osteoclast-associated immunoglobulin-like receptor;
DE            Short=Osteoclast-associated receptor;
DE            Short=mOSCAR;
DE   AltName: Full=Ocl178;
DE   Flags: Precursor;
GN   Name=Oscar;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=C57BL/6J;
RX   PubMed=11805147; DOI=10.1084/jem.20011681;
RA   Kim N., Takami M., Rho J., Josien R., Choi Y.;
RT   "A novel member of the leukocyte receptor complex regulates osteoclast
RT   differentiation.";
RL   J. Exp. Med. 195:201-209(2002).
CC   -!- FUNCTION: Regulator of osteoclastogenesis which plays an important
CC       bone-specific function in osteoclast differentiation.
CC       {ECO:0000269|PubMed:11805147}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=OSCAR-M2;
CC         IsoId=Q8VBT3-1; Sequence=Displayed;
CC       Name=2; Synonyms=OSCAR-M3;
CC         IsoId=Q8VBT3-2; Sequence=VSP_029356;
CC   -!- TISSUE SPECIFICITY: Specifically expressed in preosteoclasts or mature
CC       osteoclasts. {ECO:0000269|PubMed:11805147}.
CC   -!- SIMILARITY: Belongs to the leukocyte receptor complex/polymeric
CC       immunoglobulin receptor (PIR/LRC) family. {ECO:0000305}.
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DR   EMBL; AF391159; AAL68492.1; -; mRNA.
DR   EMBL; AF391160; AAL68493.1; -; mRNA.
DR   EMBL; AF391161; AAL68494.1; -; mRNA.
DR   CCDS; CCDS20718.1; -. [Q8VBT3-2]
DR   CCDS; CCDS71872.1; -. [Q8VBT3-1]
DR   RefSeq; NP_001277306.1; NM_001290377.1. [Q8VBT3-1]
DR   RefSeq; NP_783440.1; NM_175632.3. [Q8VBT3-2]
DR   AlphaFoldDB; Q8VBT3; -.
DR   SMR; Q8VBT3; -.
DR   STRING; 10090.ENSMUSP00000041306; -.
DR   GlyCosmos; Q8VBT3; 2 sites, No reported glycans.
DR   GlyGen; Q8VBT3; 2 sites.
DR   PaxDb; 10090-ENSMUSP00000041306; -.
DR   Antibodypedia; 32787; 269 antibodies from 27 providers.
DR   DNASU; 232790; -.
DR   Ensembl; ENSMUST00000039507.15; ENSMUSP00000041306.8; ENSMUSG00000054594.14. [Q8VBT3-2]
DR   Ensembl; ENSMUST00000108645.8; ENSMUSP00000104285.2; ENSMUSG00000054594.14. [Q8VBT3-1]
DR   GeneID; 232790; -.
DR   KEGG; mmu:232790; -.
DR   UCSC; uc009evb.2; mouse. [Q8VBT3-2]
DR   UCSC; uc009evc.1; mouse. [Q8VBT3-1]
DR   AGR; MGI:2179720; -.
DR   CTD; 126014; -.
DR   MGI; MGI:2179720; Oscar.
DR   VEuPathDB; HostDB:ENSMUSG00000054594; -.
DR   eggNOG; ENOG502T2B6; Eukaryota.
DR   GeneTree; ENSGT01100000263562; -.
DR   InParanoid; Q8VBT3; -.
DR   OMA; AQRWADF; -.
DR   OrthoDB; 5263922at2759; -.
DR   PhylomeDB; Q8VBT3; -.
DR   TreeFam; TF336644; -.
DR   Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   Reactome; R-MMU-6798695; Neutrophil degranulation.
DR   BioGRID-ORCS; 232790; 3 hits in 79 CRISPR screens.
DR   PRO; PR:Q8VBT3; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8VBT3; Protein.
DR   Bgee; ENSMUSG00000054594; Expressed in blastoderm cell in morula and 31 other cell types or tissues.
DR   ExpressionAtlas; Q8VBT3; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0038064; F:collagen receptor activity; IMP:MGI.
DR   GO; GO:0038094; P:Fc-gamma receptor signaling pathway; IMP:MGI.
DR   GO; GO:0072674; P:multinuclear osteoclast differentiation; IMP:MGI.
DR   GO; GO:0030316; P:osteoclast differentiation; IDA:MGI.
DR   GO; GO:0045780; P:positive regulation of bone resorption; IMP:MGI.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR   PANTHER; PTHR11738:SF189; OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   Genevisible; Q8VBT3; MM.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..265
FT                   /note="Osteoclast-associated immunoglobulin-like receptor"
FT                   /id="PRO_0000310952"
FT   TOPO_DOM        19..231
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..265
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          22..115
FT                   /note="Ig-like 1"
FT   DOMAIN          125..218
FT                   /note="Ig-like 2"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        144
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        52..99
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         12
FT                   /note="L -> LCELSLP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11805147"
FT                   /id="VSP_029356"
SQ   SEQUENCE   265 AA;  28726 MW;  E2E5F1E2CA037DBC CRC64;
     MVLSLILQLS TLWPACRADF TPTAPLASYP QPWLGAHPAA VVTPGINVTL TCRAPQSAWR
     FALFKSGLVT PLLLRDVSVE LAEFFLEEVT PAQGGSYHCR YRKTDWGPGV WSQPSNVLEL
     LVTDQLPRPS LVALPGPVVA PGANVSLRCA GRIPGMSFAL YRVGVATPLQ YIDSVQPWAD
     FLLIGTHTPG TYCCYYHTPS APYVLSQRSQ PLVISFEGSG SLDYTQGNLI RLGLAGMVLI
     CLGIIVTCDW HSRSSAFDGL LPQQN
//