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Q8VBT3

- OSCAR_MOUSE

UniProt

Q8VBT3 - OSCAR_MOUSE

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Protein
Osteoclast-associated immunoglobulin-like receptor
Gene
Oscar
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.1 Publication

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-associated immunoglobulin-like receptor
Short name:
Osteoclast-associated receptor
Short name:
mOSCAR
Alternative name(s):
Ocl178
Gene namesi
Name:Oscar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2179720. Oscar.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 231213Extracellular Reviewed prediction
Add
BLAST
Transmembranei232 – 24817Helical; Reviewed prediction
Add
BLAST
Topological domaini249 – 26517Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 265247Osteoclast-associated immunoglobulin-like receptor
PRO_0000310952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi52 ↔ 99 By similarity
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VBT3.
PRIDEiQ8VBT3.

Expressioni

Tissue specificityi

Specifically expressed in preosteoclasts or mature osteoclasts.1 Publication

Gene expression databases

BgeeiQ8VBT3.
CleanExiMM_OSCAR.
GenevestigatoriQ8VBT3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041306.

Structurei

3D structure databases

ProteinModelPortaliQ8VBT3.
SMRiQ8VBT3. Positions 27-218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11594Ig-like 1
Add
BLAST
Domaini125 – 21894Ig-like 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276170.
GeneTreeiENSGT00710000106345.
HOGENOMiHOG000234395.
HOVERGENiHBG108217.
KOiK14377.
OMAiWSHPSDT.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ8VBT3.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VBT3-1) [UniParc]FASTAAdd to Basket

Also known as: OSCAR-M2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVLSLILQLS TLWPACRADF TPTAPLASYP QPWLGAHPAA VVTPGINVTL    50
TCRAPQSAWR FALFKSGLVT PLLLRDVSVE LAEFFLEEVT PAQGGSYHCR 100
YRKTDWGPGV WSQPSNVLEL LVTDQLPRPS LVALPGPVVA PGANVSLRCA 150
GRIPGMSFAL YRVGVATPLQ YIDSVQPWAD FLLIGTHTPG TYCCYYHTPS 200
APYVLSQRSQ PLVISFEGSG SLDYTQGNLI RLGLAGMVLI CLGIIVTCDW 250
HSRSSAFDGL LPQQN 265
Length:265
Mass (Da):28,726
Last modified:March 1, 2002 - v1
Checksum:iE2E5F1E2CA037DBC
GO
Isoform 2 (identifier: Q8VBT3-2) [UniParc]FASTAAdd to Basket

Also known as: OSCAR-M3

The sequence of this isoform differs from the canonical sequence as follows:
     12-12: L → LCELSLP

Show »
Length:271
Mass (Da):29,369
Checksum:iF2E9DD91DF73C7B7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 121L → LCELSLP in isoform 2.
VSP_029356

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF391159 mRNA. Translation: AAL68492.1.
AF391160 mRNA. Translation: AAL68493.1.
AF391161 mRNA. Translation: AAL68494.1.
CCDSiCCDS20718.1. [Q8VBT3-2]
CCDS71872.1. [Q8VBT3-1]
RefSeqiNP_001277306.1. NM_001290377.1. [Q8VBT3-1]
NP_783440.1. NM_175632.3. [Q8VBT3-2]
UniGeneiMm.358882.

Genome annotation databases

EnsembliENSMUST00000039507; ENSMUSP00000041306; ENSMUSG00000054594. [Q8VBT3-2]
ENSMUST00000108645; ENSMUSP00000104285; ENSMUSG00000054594. [Q8VBT3-1]
GeneIDi232790.
KEGGimmu:232790.
UCSCiuc009evb.1. mouse. [Q8VBT3-2]
uc009evc.1. mouse. [Q8VBT3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF391159 mRNA. Translation: AAL68492.1 .
AF391160 mRNA. Translation: AAL68493.1 .
AF391161 mRNA. Translation: AAL68494.1 .
CCDSi CCDS20718.1. [Q8VBT3-2 ]
CCDS71872.1. [Q8VBT3-1 ]
RefSeqi NP_001277306.1. NM_001290377.1. [Q8VBT3-1 ]
NP_783440.1. NM_175632.3. [Q8VBT3-2 ]
UniGenei Mm.358882.

3D structure databases

ProteinModelPortali Q8VBT3.
SMRi Q8VBT3. Positions 27-218.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000041306.

Proteomic databases

PaxDbi Q8VBT3.
PRIDEi Q8VBT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039507 ; ENSMUSP00000041306 ; ENSMUSG00000054594 . [Q8VBT3-2 ]
ENSMUST00000108645 ; ENSMUSP00000104285 ; ENSMUSG00000054594 . [Q8VBT3-1 ]
GeneIDi 232790.
KEGGi mmu:232790.
UCSCi uc009evb.1. mouse. [Q8VBT3-2 ]
uc009evc.1. mouse. [Q8VBT3-1 ]

Organism-specific databases

CTDi 126014.
MGIi MGI:2179720. Oscar.

Phylogenomic databases

eggNOGi NOG276170.
GeneTreei ENSGT00710000106345.
HOGENOMi HOG000234395.
HOVERGENi HBG108217.
KOi K14377.
OMAi WSHPSDT.
OrthoDBi EOG78SQGZ.
PhylomeDBi Q8VBT3.
TreeFami TF336644.

Miscellaneous databases

NextBioi 381226.
PROi Q8VBT3.
SOURCEi Search...

Gene expression databases

Bgeei Q8VBT3.
CleanExi MM_OSCAR.
Genevestigatori Q8VBT3.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel member of the leukocyte receptor complex regulates osteoclast differentiation."
    Kim N., Takami M., Rho J., Josien R., Choi Y.
    J. Exp. Med. 195:201-209(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.

Entry informationi

Entry nameiOSCAR_MOUSE
AccessioniPrimary (citable) accession number: Q8VBT3
Secondary accession number(s): Q8VHT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi