Q8VBT3 (OSCAR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Osteoclast-associated immunoglobulin-like receptor
Short name=Osteoclast-associated receptor
Short name=mOSCAR

Alternative name(s):
Ocl178

Gene names

Name:

Oscar

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Ref.1
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Specifically expressed in preosteoclasts or mature osteoclasts. Ref.1
Sequence similarities	Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. Contains 2 Ig-like (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8VBT3-1)

Also known as: OSCAR-M2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8VBT3-2)

Also known as: OSCAR-M3;

The sequence of this isoform differs from the canonical sequence as follows:
     12-12: L → LCELSLP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 265	247	Osteoclast-associated immunoglobulin-like receptor		PRO_0000310952
Regions
	Topological domain	19 – 231	213	Extracellular Potential
	Transmembrane	232 – 248	17	Helical; Potential
	Topological domain	249 – 265	17	Cytoplasmic Potential
	Domain	22 – 115	94	Ig-like 1
	Domain	125 – 218	94	Ig-like 2
Amino acid modifications
	Glycosylation	47	1	N-linked (GlcNAc...) Potential
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Disulfide bond	52 ↔ 99		By similarity
Natural variations
	Alternative sequence	12	1	L → LCELSLP in isoform 2.		VSP_029356

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (OSCAR-M2) [UniParc]. Last modified March 1, 2002. Version 1. Checksum: E2E5F1E2CA037DBC	FASTA	265	28,726
	10 20 30 40 50 60 MVLSLILQLS TLWPACRADF TPTAPLASYP QPWLGAHPAA VVTPGINVTL TCRAPQSAWR 70 80 90 100 110 120 FALFKSGLVT PLLLRDVSVE LAEFFLEEVT PAQGGSYHCR YRKTDWGPGV WSQPSNVLEL 130 140 150 160 170 180 LVTDQLPRPS LVALPGPVVA PGANVSLRCA GRIPGMSFAL YRVGVATPLQ YIDSVQPWAD 190 200 210 220 230 240 FLLIGTHTPG TYCCYYHTPS APYVLSQRSQ PLVISFEGSG SLDYTQGNLI RLGLAGMVLI 250 260 CLGIIVTCDW HSRSSAFDGL LPQQN
	Isoform 2 (OSCAR-M3) [UniParc]. Checksum: F2E9DD91DF73C7B7	FASTA	271	29,369
	10 20 30 40 50 60 MVLSLILQLS TLCELSLPWP ACRADFTPTA PLASYPQPWL GAHPAAVVTP GINVTLTCRA 70 80 90 100 110 120 PQSAWRFALF KSGLVTPLLL RDVSVELAEF FLEEVTPAQG GSYHCRYRKT DWGPGVWSQP 130 140 150 160 170 180 SNVLELLVTD QLPRPSLVAL PGPVVAPGAN VSLRCAGRIP GMSFALYRVG VATPLQYIDS 190 200 210 220 230 240 VQPWADFLLI GTHTPGTYCC YYHTPSAPYV LSQRSQPLVI SFEGSGSLDY TQGNLIRLGL 250 260 270 AGMVLICLGI IVTCDWHSRS SAFDGLLPQQ N

References

[1]	"A novel member of the leukocyte receptor complex regulates osteoclast differentiation." Kim N., Takami M., Rho J., Josien R., Choi Y. J. Exp. Med. 195:201-209(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF391159 mRNA. Translation: AAL68492.1. AF391160 mRNA. Translation: AAL68493.1. AF391161 mRNA. Translation: AAL68494.1.
IPI	IPI00128709. IPI00831346.
RefSeq	NP_783440.1. NM_175632.2.
UniGene	Mm.358882.
3D structure databases
HSSP	HSSP built from PDB template 1G0X based on UniProtKB Q8NHL6.
ProteinModelPortal	Q8VBT3.
SMR	Q8VBT3. Positions 27-218.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000041306.
Proteomic databases
PaxDb	Q8VBT3.
PRIDE	Q8VBT3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000039507; ENSMUSP00000041306; ENSMUSG00000054594. ENSMUST00000108645; ENSMUSP00000104285; ENSMUSG00000054594.
GeneID	232790.
KEGG	mmu:232790.
UCSC	uc009evb.1. mouse. uc009evc.1. mouse.
Organism-specific databases
CTD	126014.
MGI	MGI:2179720. Oscar.
Phylogenomic databases
eggNOG	NOG276170.
GeneTree	ENSGT00570000078816.
HOGENOM	HOG000234395.
HOVERGEN	HBG108217.
KO	K14377.
OMA	LVISWED.
Gene expression databases
ArrayExpress	Q8VBT3.
Bgee	Q8VBT3.
CleanEx	MM_OSCAR.
Genevestigator	Q8VBT3.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	381226.
SOURCE	Search...

Entry information

Entry name

OSCAR_MOUSE

Accession

Primary (citable) accession number: Q8VBT3
Secondary accession number(s): Q8VHT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program