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Protein

Osteoclast-associated immunoglobulin-like receptor

Gene

Oscar

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.1 Publication

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-associated immunoglobulin-like receptor
Short name:
Osteoclast-associated receptor
Short name:
mOSCAR
Alternative name(s):
Ocl178
Gene namesi
Name:Oscar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2179720. Oscar.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 231213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei232 – 24817HelicalSequence AnalysisAdd
BLAST
Topological domaini249 – 26517CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 265247Osteoclast-associated immunoglobulin-like receptorPRO_0000310952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi52 ↔ 99By similarity
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8VBT3.
PRIDEiQ8VBT3.

Expressioni

Tissue specificityi

Specifically expressed in preosteoclasts or mature osteoclasts.1 Publication

Gene expression databases

BgeeiQ8VBT3.
CleanExiMM_OSCAR.
ExpressionAtlasiQ8VBT3. baseline and differential.
GenevisibleiQ8VBT3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041306.

Structurei

3D structure databases

ProteinModelPortaliQ8VBT3.
SMRiQ8VBT3. Positions 27-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11594Ig-like 1Add
BLAST
Domaini125 – 21894Ig-like 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276170.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG108217.
InParanoidiQ8VBT3.
KOiK14377.
OMAiWSHPSDT.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ8VBT3.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VBT3-1) [UniParc]FASTAAdd to basket

Also known as: OSCAR-M2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLSLILQLS TLWPACRADF TPTAPLASYP QPWLGAHPAA VVTPGINVTL
60 70 80 90 100
TCRAPQSAWR FALFKSGLVT PLLLRDVSVE LAEFFLEEVT PAQGGSYHCR
110 120 130 140 150
YRKTDWGPGV WSQPSNVLEL LVTDQLPRPS LVALPGPVVA PGANVSLRCA
160 170 180 190 200
GRIPGMSFAL YRVGVATPLQ YIDSVQPWAD FLLIGTHTPG TYCCYYHTPS
210 220 230 240 250
APYVLSQRSQ PLVISFEGSG SLDYTQGNLI RLGLAGMVLI CLGIIVTCDW
260
HSRSSAFDGL LPQQN
Length:265
Mass (Da):28,726
Last modified:March 1, 2002 - v1
Checksum:iE2E5F1E2CA037DBC
GO
Isoform 2 (identifier: Q8VBT3-2) [UniParc]FASTAAdd to basket

Also known as: OSCAR-M3

The sequence of this isoform differs from the canonical sequence as follows:
     12-12: L → LCELSLP

Show »
Length:271
Mass (Da):29,369
Checksum:iF2E9DD91DF73C7B7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 121L → LCELSLP in isoform 2. 1 PublicationVSP_029356

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391159 mRNA. Translation: AAL68492.1.
AF391160 mRNA. Translation: AAL68493.1.
AF391161 mRNA. Translation: AAL68494.1.
CCDSiCCDS20718.1. [Q8VBT3-2]
CCDS71872.1. [Q8VBT3-1]
RefSeqiNP_001277306.1. NM_001290377.1. [Q8VBT3-1]
NP_783440.1. NM_175632.3. [Q8VBT3-2]
UniGeneiMm.358882.

Genome annotation databases

EnsembliENSMUST00000039507; ENSMUSP00000041306; ENSMUSG00000054594. [Q8VBT3-2]
ENSMUST00000108645; ENSMUSP00000104285; ENSMUSG00000054594. [Q8VBT3-1]
GeneIDi232790.
KEGGimmu:232790.
UCSCiuc009evb.1. mouse. [Q8VBT3-2]
uc009evc.1. mouse. [Q8VBT3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391159 mRNA. Translation: AAL68492.1.
AF391160 mRNA. Translation: AAL68493.1.
AF391161 mRNA. Translation: AAL68494.1.
CCDSiCCDS20718.1. [Q8VBT3-2]
CCDS71872.1. [Q8VBT3-1]
RefSeqiNP_001277306.1. NM_001290377.1. [Q8VBT3-1]
NP_783440.1. NM_175632.3. [Q8VBT3-2]
UniGeneiMm.358882.

3D structure databases

ProteinModelPortaliQ8VBT3.
SMRiQ8VBT3. Positions 27-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041306.

Proteomic databases

PaxDbiQ8VBT3.
PRIDEiQ8VBT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039507; ENSMUSP00000041306; ENSMUSG00000054594. [Q8VBT3-2]
ENSMUST00000108645; ENSMUSP00000104285; ENSMUSG00000054594. [Q8VBT3-1]
GeneIDi232790.
KEGGimmu:232790.
UCSCiuc009evb.1. mouse. [Q8VBT3-2]
uc009evc.1. mouse. [Q8VBT3-1]

Organism-specific databases

CTDi126014.
MGIiMGI:2179720. Oscar.

Phylogenomic databases

eggNOGiNOG276170.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG108217.
InParanoidiQ8VBT3.
KOiK14377.
OMAiWSHPSDT.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ8VBT3.
TreeFamiTF336644.

Miscellaneous databases

NextBioi381226.
PROiQ8VBT3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VBT3.
CleanExiMM_OSCAR.
ExpressionAtlasiQ8VBT3. baseline and differential.
GenevisibleiQ8VBT3. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel member of the leukocyte receptor complex regulates osteoclast differentiation."
    Kim N., Takami M., Rho J., Josien R., Choi Y.
    J. Exp. Med. 195:201-209(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.

Entry informationi

Entry nameiOSCAR_MOUSE
AccessioniPrimary (citable) accession number: Q8VBT3
Secondary accession number(s): Q8VHT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.