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Q8VBT3

- OSCAR_MOUSE

UniProt

Q8VBT3 - OSCAR_MOUSE

Protein

Osteoclast-associated immunoglobulin-like receptor

Gene

Oscar

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.1 Publication

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Osteoclast-associated immunoglobulin-like receptor
    Short name:
    Osteoclast-associated receptor
    Short name:
    mOSCAR
    Alternative name(s):
    Ocl178
    Gene namesi
    Name:Oscar
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2179720. Oscar.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 265247Osteoclast-associated immunoglobulin-like receptorPRO_0000310952Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi52 ↔ 99By similarity
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8VBT3.
    PRIDEiQ8VBT3.

    Expressioni

    Tissue specificityi

    Specifically expressed in preosteoclasts or mature osteoclasts.1 Publication

    Gene expression databases

    BgeeiQ8VBT3.
    CleanExiMM_OSCAR.
    GenevestigatoriQ8VBT3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000041306.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VBT3.
    SMRiQ8VBT3. Positions 27-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 231213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini249 – 26517CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei232 – 24817HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 11594Ig-like 1Add
    BLAST
    Domaini125 – 21894Ig-like 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG276170.
    GeneTreeiENSGT00710000106345.
    HOGENOMiHOG000234395.
    HOVERGENiHBG108217.
    KOiK14377.
    OMAiWSHPSDT.
    OrthoDBiEOG78SQGZ.
    PhylomeDBiQ8VBT3.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8VBT3-1) [UniParc]FASTAAdd to Basket

    Also known as: OSCAR-M2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLSLILQLS TLWPACRADF TPTAPLASYP QPWLGAHPAA VVTPGINVTL    50
    TCRAPQSAWR FALFKSGLVT PLLLRDVSVE LAEFFLEEVT PAQGGSYHCR 100
    YRKTDWGPGV WSQPSNVLEL LVTDQLPRPS LVALPGPVVA PGANVSLRCA 150
    GRIPGMSFAL YRVGVATPLQ YIDSVQPWAD FLLIGTHTPG TYCCYYHTPS 200
    APYVLSQRSQ PLVISFEGSG SLDYTQGNLI RLGLAGMVLI CLGIIVTCDW 250
    HSRSSAFDGL LPQQN 265
    Length:265
    Mass (Da):28,726
    Last modified:March 1, 2002 - v1
    Checksum:iE2E5F1E2CA037DBC
    GO
    Isoform 2 (identifier: Q8VBT3-2) [UniParc]FASTAAdd to Basket

    Also known as: OSCAR-M3

    The sequence of this isoform differs from the canonical sequence as follows:
         12-12: L → LCELSLP

    Show »
    Length:271
    Mass (Da):29,369
    Checksum:iF2E9DD91DF73C7B7
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei12 – 121L → LCELSLP in isoform 2. 1 PublicationVSP_029356

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF391159 mRNA. Translation: AAL68492.1.
    AF391160 mRNA. Translation: AAL68493.1.
    AF391161 mRNA. Translation: AAL68494.1.
    CCDSiCCDS20718.1. [Q8VBT3-2]
    CCDS71872.1. [Q8VBT3-1]
    RefSeqiNP_001277306.1. NM_001290377.1. [Q8VBT3-1]
    NP_783440.1. NM_175632.3. [Q8VBT3-2]
    UniGeneiMm.358882.

    Genome annotation databases

    EnsembliENSMUST00000039507; ENSMUSP00000041306; ENSMUSG00000054594. [Q8VBT3-2]
    ENSMUST00000108645; ENSMUSP00000104285; ENSMUSG00000054594. [Q8VBT3-1]
    GeneIDi232790.
    KEGGimmu:232790.
    UCSCiuc009evb.1. mouse. [Q8VBT3-2]
    uc009evc.1. mouse. [Q8VBT3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF391159 mRNA. Translation: AAL68492.1 .
    AF391160 mRNA. Translation: AAL68493.1 .
    AF391161 mRNA. Translation: AAL68494.1 .
    CCDSi CCDS20718.1. [Q8VBT3-2 ]
    CCDS71872.1. [Q8VBT3-1 ]
    RefSeqi NP_001277306.1. NM_001290377.1. [Q8VBT3-1 ]
    NP_783440.1. NM_175632.3. [Q8VBT3-2 ]
    UniGenei Mm.358882.

    3D structure databases

    ProteinModelPortali Q8VBT3.
    SMRi Q8VBT3. Positions 27-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000041306.

    Proteomic databases

    PaxDbi Q8VBT3.
    PRIDEi Q8VBT3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039507 ; ENSMUSP00000041306 ; ENSMUSG00000054594 . [Q8VBT3-2 ]
    ENSMUST00000108645 ; ENSMUSP00000104285 ; ENSMUSG00000054594 . [Q8VBT3-1 ]
    GeneIDi 232790.
    KEGGi mmu:232790.
    UCSCi uc009evb.1. mouse. [Q8VBT3-2 ]
    uc009evc.1. mouse. [Q8VBT3-1 ]

    Organism-specific databases

    CTDi 126014.
    MGIi MGI:2179720. Oscar.

    Phylogenomic databases

    eggNOGi NOG276170.
    GeneTreei ENSGT00710000106345.
    HOGENOMi HOG000234395.
    HOVERGENi HBG108217.
    KOi K14377.
    OMAi WSHPSDT.
    OrthoDBi EOG78SQGZ.
    PhylomeDBi Q8VBT3.
    TreeFami TF336644.

    Miscellaneous databases

    NextBioi 381226.
    PROi Q8VBT3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VBT3.
    CleanExi MM_OSCAR.
    Genevestigatori Q8VBT3.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel member of the leukocyte receptor complex regulates osteoclast differentiation."
      Kim N., Takami M., Rho J., Josien R., Choi Y.
      J. Exp. Med. 195:201-209(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiOSCAR_MOUSE
    AccessioniPrimary (citable) accession number: Q8VBT3
    Secondary accession number(s): Q8VHT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3