Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8VBT3 (OSCAR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Osteoclast-associated immunoglobulin-like receptor

Short name=Osteoclast-associated receptor
Short name=mOSCAR
Alternative name(s):
Ocl178
Gene names
Name:Oscar
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Ref.1

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Specifically expressed in preosteoclasts or mature osteoclasts. Ref.1

Sequence similarities

Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.

Contains 2 Ig-like (immunoglobulin-like) domains.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8VBT3-1)

Also known as: OSCAR-M2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8VBT3-2)

Also known as: OSCAR-M3;

The sequence of this isoform differs from the canonical sequence as follows:
     12-12: L → LCELSLP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 265247Osteoclast-associated immunoglobulin-like receptor
PRO_0000310952

Regions

Topological domain19 – 231213Extracellular Potential
Transmembrane232 – 24817Helical; Potential
Topological domain249 – 26517Cytoplasmic Potential
Domain22 – 11594Ig-like 1
Domain125 – 21894Ig-like 2

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Disulfide bond52 ↔ 99 By similarity

Natural variations

Alternative sequence121L → LCELSLP in isoform 2.
VSP_029356

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (OSCAR-M2) [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: E2E5F1E2CA037DBC

FASTA26528,726
        10         20         30         40         50         60 
MVLSLILQLS TLWPACRADF TPTAPLASYP QPWLGAHPAA VVTPGINVTL TCRAPQSAWR 

        70         80         90        100        110        120 
FALFKSGLVT PLLLRDVSVE LAEFFLEEVT PAQGGSYHCR YRKTDWGPGV WSQPSNVLEL 

       130        140        150        160        170        180 
LVTDQLPRPS LVALPGPVVA PGANVSLRCA GRIPGMSFAL YRVGVATPLQ YIDSVQPWAD 

       190        200        210        220        230        240 
FLLIGTHTPG TYCCYYHTPS APYVLSQRSQ PLVISFEGSG SLDYTQGNLI RLGLAGMVLI 

       250        260 
CLGIIVTCDW HSRSSAFDGL LPQQN 

« Hide

Isoform 2 (OSCAR-M3) [UniParc].

Checksum: F2E9DD91DF73C7B7
Show »

FASTA27129,369

References

[1]"A novel member of the leukocyte receptor complex regulates osteoclast differentiation."
Kim N., Takami M., Rho J., Josien R., Choi Y.
J. Exp. Med. 195:201-209(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF391159 mRNA. Translation: AAL68492.1.
AF391160 mRNA. Translation: AAL68493.1.
AF391161 mRNA. Translation: AAL68494.1.
RefSeqNP_783440.1. NM_175632.2.
XP_006539812.1. XM_006539749.1.
UniGeneMm.358882.

3D structure databases

ProteinModelPortalQ8VBT3.
SMRQ8VBT3. Positions 11-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000041306.

Proteomic databases

PaxDbQ8VBT3.
PRIDEQ8VBT3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039507; ENSMUSP00000041306; ENSMUSG00000054594. [Q8VBT3-2]
ENSMUST00000108645; ENSMUSP00000104285; ENSMUSG00000054594. [Q8VBT3-1]
GeneID232790.
KEGGmmu:232790.
UCSCuc009evb.1. mouse. [Q8VBT3-2]
uc009evc.1. mouse. [Q8VBT3-1]

Organism-specific databases

CTD126014.
MGIMGI:2179720. Oscar.

Phylogenomic databases

eggNOGNOG276170.
GeneTreeENSGT00710000106345.
HOGENOMHOG000234395.
HOVERGENHBG108217.
KOK14377.
OMAWSHPSDT.
OrthoDBEOG78SQGZ.
PhylomeDBQ8VBT3.
TreeFamTF336644.

Gene expression databases

BgeeQ8VBT3.
CleanExMM_OSCAR.
GenevestigatorQ8VBT3.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio381226.
PROQ8VBT3.
SOURCESearch...

Entry information

Entry nameOSCAR_MOUSE
AccessionPrimary (citable) accession number: Q8VBT3
Secondary accession number(s): Q8VHT9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot