Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-serine dehydratase/L-threonine deaminase

Gene

Sds

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-serine = pyruvate + NH3.
L-threonine = 2-oxobutanoate + NH3.

Cofactori

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGluconeogenesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-MMU-8849175 Threonine catabolism
UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
L-serine dehydratase/L-threonine deaminase (EC:4.3.1.17)
Short name:
SDH
Alternative name(s):
L-serine deaminase
L-threonine dehydratase (EC:4.3.1.19)
Short name:
TDH
Gene namesi
Name:Sds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:98270 Sds

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001855952 – 327L-serine dehydratase/L-threonine deaminaseAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei41N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8VBT2
PaxDbiQ8VBT2
PRIDEiQ8VBT2

PTM databases

iPTMnetiQ8VBT2
PhosphoSitePlusiQ8VBT2
SwissPalmiQ8VBT2

Expressioni

Gene expression databases

BgeeiENSMUSG00000029597
CleanExiMM_SDS
ExpressionAtlasiQ8VBT2 baseline and differential
GenevisibleiQ8VBT2 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064849

Structurei

3D structure databases

ProteinModelPortaliQ8VBT2
SMRiQ8VBT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1250 Eukaryota
COG1171 LUCA
GeneTreeiENSGT00550000074775
HOGENOMiHOG000046976
HOVERGENiHBG017784
InParanoidiQ8VBT2
KOiK17989
OMAiLCKTWAE
OrthoDBiEOG091G0FCF
PhylomeDBiQ8VBT2
TreeFamiTF329014

Family and domain databases

InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQESLHVK TPLRDSMALS KLAGTSVFLK MDSSQPSGSF KIRGIGHLCK
60 70 80 90 100
MKAKQGCRHF VCSSAGNAGM ATAYAARRLG IPATIVVPNT TPALTIERLK
110 120 130 140 150
NEGATVEVVG EMLDEAIQVA KALEKNNPGW VYISPFDDPL IWEGHTSLVK
160 170 180 190 200
ELKETLSAKP GAIVLSVGGG GLLCGVVQGL REVGWEDVPI IAMETFGAHS
210 220 230 240 250
FHAAIKEGKL VTLPKITSVA KALGVNTVGA QTLKLFYEHP IFSEVISDQE
260 270 280 290 300
AVSALEKFVD DEKILVEPAC GAALAAVYSR VVCRLQDEGR LQTPLASLVV
310 320
IVCGGSNISL AQLQALKVQL GLNGLPE
Length:327
Mass (Da):34,593
Last modified:January 23, 2007 - v3
Checksum:iE4BBA96CE7147237
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021605 mRNA Translation: AAH21605.1
BC021950 mRNA Translation: AAH21950.1
CCDSiCCDS19619.1
RefSeqiNP_663540.1, NM_145565.1
UniGeneiMm.28685

Genome annotation databases

EnsembliENSMUST00000066540; ENSMUSP00000064849; ENSMUSG00000029597
ENSMUST00000201684; ENSMUSP00000143838; ENSMUSG00000029597
GeneIDi231691
KEGGimmu:231691
UCSCiuc008zhg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSDHL_MOUSE
AccessioniPrimary (citable) accession number: Q8VBT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health