Q8VBT2 (SDHL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-serine dehydratase/L-threonine deaminase
Short name=SDH
EC=4.3.1.17

Alternative name(s):
L-serine deaminase
L-threonine dehydratase
Short name=TDH
EC=4.3.1.19

Gene names

Name:

Sds

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3. L-threonine = 2-oxobutanoate + NH3.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Lyase
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC L-threonine ammonia-lyase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 327	326	L-serine dehydratase/L-threonine deaminase		PRO_0000185595
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.2
	Modified residue	41	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8VBT2 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: E4BBA96CE7147237	FASTA	327	34,593
	10 20 30 40 50 60 MAAQESLHVK TPLRDSMALS KLAGTSVFLK MDSSQPSGSF KIRGIGHLCK MKAKQGCRHF 70 80 90 100 110 120 VCSSAGNAGM ATAYAARRLG IPATIVVPNT TPALTIERLK NEGATVEVVG EMLDEAIQVA 130 140 150 160 170 180 KALEKNNPGW VYISPFDDPL IWEGHTSLVK ELKETLSAKP GAIVLSVGGG GLLCGVVQGL 190 200 210 220 230 240 REVGWEDVPI IAMETFGAHS FHAAIKEGKL VTLPKITSVA KALGVNTVGA QTLKLFYEHP 250 260 270 280 290 300 IFSEVISDQE AVSALEKFVD DEKILVEPAC GAALAAVYSR VVCRLQDEGR LQTPLASLVV 310 320 IVCGGSNISL AQLQALKVQL GLNGLPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
[2]	Bienvenut W.V. Submitted (JUL-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-10 AND 235-257, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC021605 mRNA. Translation: AAH21605.1. BC021950 mRNA. Translation: AAH21950.1.
IPI	IPI00121348.
RefSeq	NP_663540.1. NM_145565.1.
UniGene	Mm.28685.
3D structure databases
ProteinModelPortal	Q8VBT2.
SMR	Q8VBT2. Positions 1-325.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VBT2.
Proteomic databases
PRIDE	Q8VBT2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000066540; ENSMUSP00000064849; ENSMUSG00000029597.
GeneID	231691.
KEGG	mmu:231691.
Organism-specific databases
CTD	10993.
MGI	MGI:98270. Sds.
Phylogenomic databases
GeneTree	ENSGT00550000074775.
HOGENOM	HBG714501.
HOVERGEN	HBG017784.
InParanoid	Q8VBT2.
OMA	GIGHFCK.
OrthoDB	EOG4PZJ79.
PhylomeDB	Q8VBT2.
Gene expression databases
ArrayExpress	Q8VBT2.
Bgee	Q8VBT2.
CleanEx	MM_SDS.
Genevestigator	Q8VBT2.
GermOnline	ENSMUSG00000029597. Mus musculus.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. [Graphical view]
KO	K01752.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	380707.
SOURCE	Search...

Entry information

Entry name

SDHL_MOUSE

Accession

Primary (citable) accession number: Q8VBT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program