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Protein

L-serine dehydratase/L-threonine deaminase

Gene

Sds

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-serine = pyruvate + NH3.
L-threonine = 2-oxobutanoate + NH3.

Cofactori

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
L-serine dehydratase/L-threonine deaminase (EC:4.3.1.17)
Short name:
SDH
Alternative name(s):
L-serine deaminase
L-threonine dehydratase (EC:4.3.1.19)
Short name:
TDH
Gene namesi
Name:Sds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:98270. Sds.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001855952 – 327L-serine dehydratase/L-threonine deaminaseAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei41N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8VBT2.
PaxDbiQ8VBT2.
PRIDEiQ8VBT2.

PTM databases

iPTMnetiQ8VBT2.
PhosphoSitePlusiQ8VBT2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029597.
CleanExiMM_SDS.
ExpressionAtlasiQ8VBT2. baseline and differential.
GenevisibleiQ8VBT2. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1855643.
STRINGi10090.ENSMUSP00000064849.

Structurei

3D structure databases

ProteinModelPortaliQ8VBT2.
SMRiQ8VBT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1250. Eukaryota.
COG1171. LUCA.
GeneTreeiENSGT00550000074775.
HOGENOMiHOG000046976.
HOVERGENiHBG017784.
InParanoidiQ8VBT2.
KOiK17989.
OMAiSHEIARQ.
OrthoDBiEOG091G0FCF.
PhylomeDBiQ8VBT2.
TreeFamiTF329014.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQESLHVK TPLRDSMALS KLAGTSVFLK MDSSQPSGSF KIRGIGHLCK
60 70 80 90 100
MKAKQGCRHF VCSSAGNAGM ATAYAARRLG IPATIVVPNT TPALTIERLK
110 120 130 140 150
NEGATVEVVG EMLDEAIQVA KALEKNNPGW VYISPFDDPL IWEGHTSLVK
160 170 180 190 200
ELKETLSAKP GAIVLSVGGG GLLCGVVQGL REVGWEDVPI IAMETFGAHS
210 220 230 240 250
FHAAIKEGKL VTLPKITSVA KALGVNTVGA QTLKLFYEHP IFSEVISDQE
260 270 280 290 300
AVSALEKFVD DEKILVEPAC GAALAAVYSR VVCRLQDEGR LQTPLASLVV
310 320
IVCGGSNISL AQLQALKVQL GLNGLPE
Length:327
Mass (Da):34,593
Last modified:January 23, 2007 - v3
Checksum:iE4BBA96CE7147237
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021605 mRNA. Translation: AAH21605.1.
BC021950 mRNA. Translation: AAH21950.1.
CCDSiCCDS19619.1.
RefSeqiNP_663540.1. NM_145565.1.
UniGeneiMm.28685.

Genome annotation databases

EnsembliENSMUST00000066540; ENSMUSP00000064849; ENSMUSG00000029597.
ENSMUST00000201684; ENSMUSP00000143838; ENSMUSG00000029597.
GeneIDi231691.
KEGGimmu:231691.
UCSCiuc008zhg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021605 mRNA. Translation: AAH21605.1.
BC021950 mRNA. Translation: AAH21950.1.
CCDSiCCDS19619.1.
RefSeqiNP_663540.1. NM_145565.1.
UniGeneiMm.28685.

3D structure databases

ProteinModelPortaliQ8VBT2.
SMRiQ8VBT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1855643.
STRINGi10090.ENSMUSP00000064849.

PTM databases

iPTMnetiQ8VBT2.
PhosphoSitePlusiQ8VBT2.

Proteomic databases

MaxQBiQ8VBT2.
PaxDbiQ8VBT2.
PRIDEiQ8VBT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066540; ENSMUSP00000064849; ENSMUSG00000029597.
ENSMUST00000201684; ENSMUSP00000143838; ENSMUSG00000029597.
GeneIDi231691.
KEGGimmu:231691.
UCSCiuc008zhg.1. mouse.

Organism-specific databases

CTDi10993.
MGIiMGI:98270. Sds.

Phylogenomic databases

eggNOGiKOG1250. Eukaryota.
COG1171. LUCA.
GeneTreeiENSGT00550000074775.
HOGENOMiHOG000046976.
HOVERGENiHBG017784.
InParanoidiQ8VBT2.
KOiK17989.
OMAiSHEIARQ.
OrthoDBiEOG091G0FCF.
PhylomeDBiQ8VBT2.
TreeFamiTF329014.

Enzyme and pathway databases

UniPathwayiUPA00138.

Miscellaneous databases

PROiQ8VBT2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029597.
CleanExiMM_SDS.
ExpressionAtlasiQ8VBT2. baseline and differential.
GenevisibleiQ8VBT2. MM.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDHL_MOUSE
AccessioniPrimary (citable) accession number: Q8VBT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.