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Protein

Thioredoxin-related transmembrane protein 1

Gene

Tmx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-related transmembrane protein 1
Alternative name(s):
Thioredoxin domain-containing protein 1
Gene namesi
Name:Tmx1
Synonyms:Txndc, Txndc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919986. Tmx1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 181ExtracellularSequence analysisAdd BLAST155
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 278CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003415427 – 278Thioredoxin-related transmembrane protein 1Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 59Redox-activePROSITE-ProRule annotation
Modified residuei245PhosphoserineCombined sources1
Modified residuei278PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ8VBT0.
MaxQBiQ8VBT0.
PaxDbiQ8VBT0.
PeptideAtlasiQ8VBT0.
PRIDEiQ8VBT0.

PTM databases

iPTMnetiQ8VBT0.
PhosphoSitePlusiQ8VBT0.
SwissPalmiQ8VBT0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021072.
CleanExiMM_TXNDC1.
ExpressionAtlasiQ8VBT0. baseline and differential.
GenevisibleiQ8VBT0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8VBT0. 1 interactor.
STRINGi10090.ENSMUSP00000021471.

Structurei

3D structure databases

ProteinModelPortaliQ8VBT0.
SMRiQ8VBT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 132ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0913. Eukaryota.
ENOG4111H66. LUCA.
GeneTreeiENSGT00390000011580.
HOGENOMiHOG000045750.
InParanoidiQ8VBT0.
OMAiTWGSYAL.
OrthoDBiEOG091G0MRE.
PhylomeDBiQ8VBT0.
TreeFamiTF106376.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VBT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLGRLMVP LAALVLLLWA VPGAHGRRNN VRVLTDENWT SLLEGEWMIE
60 70 80 90 100
FYAPWCPACQ NLQPEWESFA EWGEDLEVKV AKVDVTEQTG LSGRFIITAL
110 120 130 140 150
PSIYHCKDGE FRRYVGPRTK KDFINFVSDK EWKNIEPISS WFGPSSVLMT
160 170 180 190 200
MMSALFQLSV YIRTSHSYFV HDLGIPAWGS YLVFAFATVL SGLLLGLCMI
210 220 230 240 250
FVADCLCPSK RRKPQQQYAK KTSPEFSQPL KKVEEEQEAD EEDVSEEEAE
260 270
DREGASKATS QSSIRQRCVG LPSATDTS
Length:278
Mass (Da):31,396
Last modified:March 1, 2002 - v1
Checksum:iEB682243008E3333
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013150 mRNA. Translation: BAB28680.3.
AK030429 mRNA. Translation: BAC26960.1.
AK050567 mRNA. Translation: BAC34326.1.
AK137059 mRNA. Translation: BAE23223.1.
AK150511 mRNA. Translation: BAE29624.1.
AK153027 mRNA. Translation: BAE31660.1.
AK170468 mRNA. Translation: BAE41816.1.
BC017603 mRNA. Translation: AAH17603.1.
BC021533 mRNA. Translation: AAH21533.1.
CCDSiCCDS25958.1.
RefSeqiNP_082615.1. NM_028339.1.
UniGeneiMm.204670.

Genome annotation databases

EnsembliENSMUST00000021471; ENSMUSP00000021471; ENSMUSG00000021072.
GeneIDi72736.
KEGGimmu:72736.
UCSCiuc007ntu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013150 mRNA. Translation: BAB28680.3.
AK030429 mRNA. Translation: BAC26960.1.
AK050567 mRNA. Translation: BAC34326.1.
AK137059 mRNA. Translation: BAE23223.1.
AK150511 mRNA. Translation: BAE29624.1.
AK153027 mRNA. Translation: BAE31660.1.
AK170468 mRNA. Translation: BAE41816.1.
BC017603 mRNA. Translation: AAH17603.1.
BC021533 mRNA. Translation: AAH21533.1.
CCDSiCCDS25958.1.
RefSeqiNP_082615.1. NM_028339.1.
UniGeneiMm.204670.

3D structure databases

ProteinModelPortaliQ8VBT0.
SMRiQ8VBT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VBT0. 1 interactor.
STRINGi10090.ENSMUSP00000021471.

PTM databases

iPTMnetiQ8VBT0.
PhosphoSitePlusiQ8VBT0.
SwissPalmiQ8VBT0.

Proteomic databases

EPDiQ8VBT0.
MaxQBiQ8VBT0.
PaxDbiQ8VBT0.
PeptideAtlasiQ8VBT0.
PRIDEiQ8VBT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021471; ENSMUSP00000021471; ENSMUSG00000021072.
GeneIDi72736.
KEGGimmu:72736.
UCSCiuc007ntu.1. mouse.

Organism-specific databases

CTDi81542.
MGIiMGI:1919986. Tmx1.

Phylogenomic databases

eggNOGiKOG0913. Eukaryota.
ENOG4111H66. LUCA.
GeneTreeiENSGT00390000011580.
HOGENOMiHOG000045750.
InParanoidiQ8VBT0.
OMAiTWGSYAL.
OrthoDBiEOG091G0MRE.
PhylomeDBiQ8VBT0.
TreeFamiTF106376.

Miscellaneous databases

ChiTaRSiTmx1. mouse.
PROiQ8VBT0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021072.
CleanExiMM_TXNDC1.
ExpressionAtlasiQ8VBT0. baseline and differential.
GenevisibleiQ8VBT0. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMX1_MOUSE
AccessioniPrimary (citable) accession number: Q8VBT0
Secondary accession number(s): Q3UCI8, Q9CSD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.