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Q8VBT0

- TMX1_MOUSE

UniProt

Q8VBT0 - TMX1_MOUSE

Protein

Thioredoxin-related transmembrane protein 1

Gene

Tmx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

    GO - Molecular functioni

    1. disulfide oxidoreductase activity Source: Ensembl
    2. protein disulfide isomerase activity Source: RefGenome

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. protein folding Source: RefGenome
    3. response to endoplasmic reticulum stress Source: RefGenome

    Keywords - Biological processi

    Electron transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin-related transmembrane protein 1
    Alternative name(s):
    Thioredoxin domain-containing protein 1
    Gene namesi
    Name:Tmx1
    Synonyms:Txndc, Txndc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1919986. Tmx1.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated. Endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Predominantly found in the endoplasmic reticulum.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 278252Thioredoxin-related transmembrane protein 1PRO_0000034154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 59Redox-activePROSITE-ProRule annotation
    Modified residuei245 – 2451Phosphoserine3 Publications
    Modified residuei278 – 2781PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiQ8VBT0.
    PaxDbiQ8VBT0.
    PRIDEiQ8VBT0.

    PTM databases

    PhosphoSiteiQ8VBT0.

    Expressioni

    Gene expression databases

    BgeeiQ8VBT0.
    CleanExiMM_TXNDC1.
    GenevestigatoriQ8VBT0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8VBT0. 1 interaction.
    STRINGi10090.ENSMUSP00000021471.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VBT0.
    SMRiQ8VBT0. Positions 23-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 181155ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini203 – 27876CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 132106ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0526.
    GeneTreeiENSGT00390000011580.
    HOGENOMiHOG000045750.
    InParanoidiQ8VBT0.
    OMAiCHNYFIE.
    OrthoDBiEOG7KM5VC.
    PhylomeDBiQ8VBT0.
    TreeFamiTF106376.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VBT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHLGRLMVP LAALVLLLWA VPGAHGRRNN VRVLTDENWT SLLEGEWMIE    50
    FYAPWCPACQ NLQPEWESFA EWGEDLEVKV AKVDVTEQTG LSGRFIITAL 100
    PSIYHCKDGE FRRYVGPRTK KDFINFVSDK EWKNIEPISS WFGPSSVLMT 150
    MMSALFQLSV YIRTSHSYFV HDLGIPAWGS YLVFAFATVL SGLLLGLCMI 200
    FVADCLCPSK RRKPQQQYAK KTSPEFSQPL KKVEEEQEAD EEDVSEEEAE 250
    DREGASKATS QSSIRQRCVG LPSATDTS 278
    Length:278
    Mass (Da):31,396
    Last modified:March 1, 2002 - v1
    Checksum:iEB682243008E3333
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013150 mRNA. Translation: BAB28680.3.
    AK030429 mRNA. Translation: BAC26960.1.
    AK050567 mRNA. Translation: BAC34326.1.
    AK137059 mRNA. Translation: BAE23223.1.
    AK150511 mRNA. Translation: BAE29624.1.
    AK153027 mRNA. Translation: BAE31660.1.
    AK170468 mRNA. Translation: BAE41816.1.
    BC017603 mRNA. Translation: AAH17603.1.
    BC021533 mRNA. Translation: AAH21533.1.
    CCDSiCCDS25958.1.
    RefSeqiNP_082615.1. NM_028339.1.
    UniGeneiMm.204670.

    Genome annotation databases

    EnsembliENSMUST00000021471; ENSMUSP00000021471; ENSMUSG00000021072.
    GeneIDi72736.
    KEGGimmu:72736.
    UCSCiuc007ntu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013150 mRNA. Translation: BAB28680.3 .
    AK030429 mRNA. Translation: BAC26960.1 .
    AK050567 mRNA. Translation: BAC34326.1 .
    AK137059 mRNA. Translation: BAE23223.1 .
    AK150511 mRNA. Translation: BAE29624.1 .
    AK153027 mRNA. Translation: BAE31660.1 .
    AK170468 mRNA. Translation: BAE41816.1 .
    BC017603 mRNA. Translation: AAH17603.1 .
    BC021533 mRNA. Translation: AAH21533.1 .
    CCDSi CCDS25958.1.
    RefSeqi NP_082615.1. NM_028339.1.
    UniGenei Mm.204670.

    3D structure databases

    ProteinModelPortali Q8VBT0.
    SMRi Q8VBT0. Positions 23-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8VBT0. 1 interaction.
    STRINGi 10090.ENSMUSP00000021471.

    PTM databases

    PhosphoSitei Q8VBT0.

    Proteomic databases

    MaxQBi Q8VBT0.
    PaxDbi Q8VBT0.
    PRIDEi Q8VBT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021471 ; ENSMUSP00000021471 ; ENSMUSG00000021072 .
    GeneIDi 72736.
    KEGGi mmu:72736.
    UCSCi uc007ntu.1. mouse.

    Organism-specific databases

    CTDi 81542.
    MGIi MGI:1919986. Tmx1.

    Phylogenomic databases

    eggNOGi COG0526.
    GeneTreei ENSGT00390000011580.
    HOGENOMi HOG000045750.
    InParanoidi Q8VBT0.
    OMAi CHNYFIE.
    OrthoDBi EOG7KM5VC.
    PhylomeDBi Q8VBT0.
    TreeFami TF106376.

    Miscellaneous databases

    ChiTaRSi TMX1. mouse.
    NextBioi 336838.
    PROi Q8VBT0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8VBT0.
    CleanExi MM_TXNDC1.
    Genevestigatori Q8VBT0.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Embryo, Pancreatic islet and Pituitary.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Mammary gland and Retina.
    3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiTMX1_MOUSE
    AccessioniPrimary (citable) accession number: Q8VBT0
    Secondary accession number(s): Q3UCI8, Q9CSD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3