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Q8VA42

- RDRP_AQRVA

UniProt

Q8VA42 - RDRP_AQRVA

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Protein

RNA-directed RNA polymerase VP2

Gene

S2

Organism
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands (By similarity).PROSITE-ProRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA binding Source: InterPro
  4. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase VP2 (EC:2.7.7.48)
Gene namesi
Name:S2
OrganismiAquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
Taxonomic identifieri928295 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeAquareovirus

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12401240RNA-directed RNA polymerase VP2PRO_0000404171Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8VA42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini516 – 764249RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view]
PfamiPF07925. RdRP_5. 1 hit.
[Graphical view]
PROSITEiPS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VA42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGTYAPVPN VYHLLDHLTF RSSVVIPNSN FVGRIWSDYW ALQDNIVIRV
60 70 80 90 100
SPEGAKDADY CHNSNISPIL SPLKTITEYG TLHPTIDKDA SERGYPSARM
110 120 130 140 150
ASSFFKLASC QARQVKIDPT RFLEFLLVTA SSPRVPSGVD SDQPNPWLPE
160 170 180 190 200
TSPALQAIWQ IMQRYKLNGN YYAPALVVNT GAVWWIPPPG RTNCVTVQFL
210 220 230 240 250
ITDLINLAVN AFATRLAPEL EMCAVRVYLA AASTPNYAHA LLDLKSIFPN
260 270 280 290 300
LSLHSMYREG EFGGKCPRIE WTEPRSSYRF KWIGVTQLYE GLRPLTPSRD
310 320 330 340 350
SKALLKMRDS GLEDVAKVII TMRRDHPRHT SDSVRFVRGV LSLISGMYLV
360 370 380 390 400
RPPTMSVLRE YSQTPQIEEP IPPDWWTGAV GNLSYFNDKA KGPLAHLYSV
410 420 430 440 450
WLEAARQVVM DPSTHDPLTQ AIYKTQFVTP RGGSSAALKQ ALVESKVELP
460 470 480 490 500
DFSGTGVKRS SKIYQTAQLA HFSFQTLIPT IMGQVTLGIR NQVQRRARSI
510 520 530 540 550
MPMSNPQQTV SVPHTLVANY INKHMNRSTT SGSAVQDKVI PLLLYASTPP
560 570 580 590 600
RTVINVDIKA CDASITYAAF LAPICGAMHQ GFDLGDPSLP FMNVPSSTQY
610 620 630 640 650
DRRNPAAPYN RPVSGLQTMT QHLARLYQAG FSYKVDDPFS SGNSFVFPTT
660 670 680 690 700
TFPSGSTATS TEHTANNGAM ADFFLREYVP QHAKSSTLKF IVKDMNIQNN
710 720 730 740 750
YVCQGDDGML IIPDLGTKRI SPEDLAELME LLEKYGRGFG WVYDIDSSDS
760 770 780 790 800
AEYLKLYALF GARIPNISRH PPVGKEYASP ETGEIWPSLV NIAMGSFYNG
810 820 830 840 850
VTDCLEWRDW LKFSWAFACF ASRGSFHPKT GPRVDAQYPV WSFIYMGLPP
860 870 880 890 900
ILLPGQTPFL TSVYMPAGDQ GIFAILHQWR DYLTARATSD YPPLKRRHPV
910 920 930 940 950
WHLADVPSLL SDLGVYRGYW AAQVSRRPEP SPDDADPASV EAMSAALSTY
960 970 980 990 1000
LLKDPVLRDR VVRGTNAWRR LTDTHPGRLP SRVPSLLDVP TRWIKAGRDA
1010 1020 1030 1040 1050
DKPRPSAVAM MMKDIQRAAS SSRKDFSRLL ELYLHVHVHL GPPVPLAVDP
1060 1070 1080 1090 1100
EVPHVAGADI LNDDHWYKVT SLGPIAQSTK KYFDATLFVG KTVSGLDVEA
1110 1120 1130 1140 1150
VDATLLRMSI LGAEPEEYHA FLAGIGMSDA EAHRIASAIS LADAQIVQLA
1160 1170 1180 1190 1200
RTVNLAVPSS WMSLDFDTLI RSHSYPRQPG ISDSSTLVRE RASWINSVLR
1210 1220 1230 1240
LLCATVAMSR VGPVCQATVS SVDGGVNQIV GCLRAWMRDV
Length:1,240
Mass (Da):137,575
Last modified:March 1, 2002 - v1
Checksum:i7715D9DA5584D08D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418295 Genomic RNA. Translation: AAL31497.1.
RefSeqiYP_398630.1. NC_007583.1.

Genome annotation databases

GeneIDi3773156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418295 Genomic RNA. Translation: AAL31497.1 .
RefSeqi YP_398630.1. NC_007583.1.

3D structure databases

ProteinModelPortali Q8VA42.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3773156.

Family and domain databases

InterProi IPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view ]
Pfami PF07925. RdRP_5. 1 hit.
[Graphical view ]
PROSITEi PS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Morphological and biochemical properties of four members of a novel group of reoviruses isolated from aquatic animals."
    Winton J.R., Lannan C.N., Fryer J.L., Hedrick R.P., Meyers T.R., Plumb J.A., Yamamoto T.
    J. Gen. Virol. 68:353-364(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Complete genome sequence of the chum salmon virus."
    Rao S., Carner G.R., Chen W., Winton J.R.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_AQRVA
AccessioniPrimary (citable) accession number: Q8VA42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3