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Q8VA42

- RDRP_AQRVA

UniProt

Q8VA42 - RDRP_AQRVA

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Protein

RNA-directed RNA polymerase VP2

Gene
S2
Organism
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands By similarity.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA binding Source: InterPro
  4. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase VP2 (EC:2.7.7.48)
Gene namesi
Name:S2
OrganismiAquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
Taxonomic identifieri928295 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeAquareovirus

Subcellular locationi

Virion Reviewed prediction

GO - Cellular componenti

  1. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12401240RNA-directed RNA polymerase VP2PRO_0000404171Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8VA42.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini516 – 764249RdRp catalyticAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view]
PfamiPF07925. RdRP_5. 1 hit.
[Graphical view]
PROSITEiPS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VA42-1 [UniParc]FASTAAdd to Basket

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MPGTYAPVPN VYHLLDHLTF RSSVVIPNSN FVGRIWSDYW ALQDNIVIRV     50
SPEGAKDADY CHNSNISPIL SPLKTITEYG TLHPTIDKDA SERGYPSARM 100
ASSFFKLASC QARQVKIDPT RFLEFLLVTA SSPRVPSGVD SDQPNPWLPE 150
TSPALQAIWQ IMQRYKLNGN YYAPALVVNT GAVWWIPPPG RTNCVTVQFL 200
ITDLINLAVN AFATRLAPEL EMCAVRVYLA AASTPNYAHA LLDLKSIFPN 250
LSLHSMYREG EFGGKCPRIE WTEPRSSYRF KWIGVTQLYE GLRPLTPSRD 300
SKALLKMRDS GLEDVAKVII TMRRDHPRHT SDSVRFVRGV LSLISGMYLV 350
RPPTMSVLRE YSQTPQIEEP IPPDWWTGAV GNLSYFNDKA KGPLAHLYSV 400
WLEAARQVVM DPSTHDPLTQ AIYKTQFVTP RGGSSAALKQ ALVESKVELP 450
DFSGTGVKRS SKIYQTAQLA HFSFQTLIPT IMGQVTLGIR NQVQRRARSI 500
MPMSNPQQTV SVPHTLVANY INKHMNRSTT SGSAVQDKVI PLLLYASTPP 550
RTVINVDIKA CDASITYAAF LAPICGAMHQ GFDLGDPSLP FMNVPSSTQY 600
DRRNPAAPYN RPVSGLQTMT QHLARLYQAG FSYKVDDPFS SGNSFVFPTT 650
TFPSGSTATS TEHTANNGAM ADFFLREYVP QHAKSSTLKF IVKDMNIQNN 700
YVCQGDDGML IIPDLGTKRI SPEDLAELME LLEKYGRGFG WVYDIDSSDS 750
AEYLKLYALF GARIPNISRH PPVGKEYASP ETGEIWPSLV NIAMGSFYNG 800
VTDCLEWRDW LKFSWAFACF ASRGSFHPKT GPRVDAQYPV WSFIYMGLPP 850
ILLPGQTPFL TSVYMPAGDQ GIFAILHQWR DYLTARATSD YPPLKRRHPV 900
WHLADVPSLL SDLGVYRGYW AAQVSRRPEP SPDDADPASV EAMSAALSTY 950
LLKDPVLRDR VVRGTNAWRR LTDTHPGRLP SRVPSLLDVP TRWIKAGRDA 1000
DKPRPSAVAM MMKDIQRAAS SSRKDFSRLL ELYLHVHVHL GPPVPLAVDP 1050
EVPHVAGADI LNDDHWYKVT SLGPIAQSTK KYFDATLFVG KTVSGLDVEA 1100
VDATLLRMSI LGAEPEEYHA FLAGIGMSDA EAHRIASAIS LADAQIVQLA 1150
RTVNLAVPSS WMSLDFDTLI RSHSYPRQPG ISDSSTLVRE RASWINSVLR 1200
LLCATVAMSR VGPVCQATVS SVDGGVNQIV GCLRAWMRDV 1240
Length:1,240
Mass (Da):137,575
Last modified:March 1, 2002 - v1
Checksum:i7715D9DA5584D08D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF418295 Genomic RNA. Translation: AAL31497.1.
RefSeqiYP_398630.1. NC_007583.1.

Genome annotation databases

GeneIDi3773156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF418295 Genomic RNA. Translation: AAL31497.1 .
RefSeqi YP_398630.1. NC_007583.1.

3D structure databases

ProteinModelPortali Q8VA42.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3773156.

Family and domain databases

InterProi IPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view ]
Pfami PF07925. RdRP_5. 1 hit.
[Graphical view ]
PROSITEi PS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Morphological and biochemical properties of four members of a novel group of reoviruses isolated from aquatic animals."
    Winton J.R., Lannan C.N., Fryer J.L., Hedrick R.P., Meyers T.R., Plumb J.A., Yamamoto T.
    J. Gen. Virol. 68:353-364(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Complete genome sequence of the chum salmon virus."
    Rao S., Carner G.R., Chen W., Winton J.R.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_AQRVA
AccessioniPrimary (citable) accession number: Q8VA42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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