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Protein

RNA-directed RNA polymerase VP2

Gene

S2

Organism
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands (By similarity).PROSITE-ProRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase VP2 (EC:2.7.7.48)
Gene namesi
Name:S2
OrganismiAquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
Taxonomic identifieri928295 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeAquareovirus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004041711 – 1240RNA-directed RNA polymerase VP2Add BLAST1240

Structurei

3D structure databases

ProteinModelPortaliQ8VA42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini516 – 764RdRp catalyticPROSITE-ProRule annotationAdd BLAST249

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
PfamiView protein in Pfam
PF07925. RdRP_5. 1 hit.
PROSITEiView protein in PROSITE
PS50523. RDRP_DSRNA_REO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VA42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGTYAPVPN VYHLLDHLTF RSSVVIPNSN FVGRIWSDYW ALQDNIVIRV
60 70 80 90 100
SPEGAKDADY CHNSNISPIL SPLKTITEYG TLHPTIDKDA SERGYPSARM
110 120 130 140 150
ASSFFKLASC QARQVKIDPT RFLEFLLVTA SSPRVPSGVD SDQPNPWLPE
160 170 180 190 200
TSPALQAIWQ IMQRYKLNGN YYAPALVVNT GAVWWIPPPG RTNCVTVQFL
210 220 230 240 250
ITDLINLAVN AFATRLAPEL EMCAVRVYLA AASTPNYAHA LLDLKSIFPN
260 270 280 290 300
LSLHSMYREG EFGGKCPRIE WTEPRSSYRF KWIGVTQLYE GLRPLTPSRD
310 320 330 340 350
SKALLKMRDS GLEDVAKVII TMRRDHPRHT SDSVRFVRGV LSLISGMYLV
360 370 380 390 400
RPPTMSVLRE YSQTPQIEEP IPPDWWTGAV GNLSYFNDKA KGPLAHLYSV
410 420 430 440 450
WLEAARQVVM DPSTHDPLTQ AIYKTQFVTP RGGSSAALKQ ALVESKVELP
460 470 480 490 500
DFSGTGVKRS SKIYQTAQLA HFSFQTLIPT IMGQVTLGIR NQVQRRARSI
510 520 530 540 550
MPMSNPQQTV SVPHTLVANY INKHMNRSTT SGSAVQDKVI PLLLYASTPP
560 570 580 590 600
RTVINVDIKA CDASITYAAF LAPICGAMHQ GFDLGDPSLP FMNVPSSTQY
610 620 630 640 650
DRRNPAAPYN RPVSGLQTMT QHLARLYQAG FSYKVDDPFS SGNSFVFPTT
660 670 680 690 700
TFPSGSTATS TEHTANNGAM ADFFLREYVP QHAKSSTLKF IVKDMNIQNN
710 720 730 740 750
YVCQGDDGML IIPDLGTKRI SPEDLAELME LLEKYGRGFG WVYDIDSSDS
760 770 780 790 800
AEYLKLYALF GARIPNISRH PPVGKEYASP ETGEIWPSLV NIAMGSFYNG
810 820 830 840 850
VTDCLEWRDW LKFSWAFACF ASRGSFHPKT GPRVDAQYPV WSFIYMGLPP
860 870 880 890 900
ILLPGQTPFL TSVYMPAGDQ GIFAILHQWR DYLTARATSD YPPLKRRHPV
910 920 930 940 950
WHLADVPSLL SDLGVYRGYW AAQVSRRPEP SPDDADPASV EAMSAALSTY
960 970 980 990 1000
LLKDPVLRDR VVRGTNAWRR LTDTHPGRLP SRVPSLLDVP TRWIKAGRDA
1010 1020 1030 1040 1050
DKPRPSAVAM MMKDIQRAAS SSRKDFSRLL ELYLHVHVHL GPPVPLAVDP
1060 1070 1080 1090 1100
EVPHVAGADI LNDDHWYKVT SLGPIAQSTK KYFDATLFVG KTVSGLDVEA
1110 1120 1130 1140 1150
VDATLLRMSI LGAEPEEYHA FLAGIGMSDA EAHRIASAIS LADAQIVQLA
1160 1170 1180 1190 1200
RTVNLAVPSS WMSLDFDTLI RSHSYPRQPG ISDSSTLVRE RASWINSVLR
1210 1220 1230 1240
LLCATVAMSR VGPVCQATVS SVDGGVNQIV GCLRAWMRDV
Length:1,240
Mass (Da):137,575
Last modified:March 1, 2002 - v1
Checksum:i7715D9DA5584D08D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418295 Genomic RNA. Translation: AAL31497.1.
RefSeqiYP_398630.1. NC_007583.1.

Genome annotation databases

GeneIDi3773156.
KEGGivg:3773156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418295 Genomic RNA. Translation: AAL31497.1.
RefSeqiYP_398630.1. NC_007583.1.

3D structure databases

ProteinModelPortaliQ8VA42.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3773156.
KEGGivg:3773156.

Family and domain databases

InterProiView protein in InterPro
IPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
PfamiView protein in Pfam
PF07925. RdRP_5. 1 hit.
PROSITEiView protein in PROSITE
PS50523. RDRP_DSRNA_REO. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRDRP_AQRVA
AccessioniPrimary (citable) accession number: Q8VA42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: March 1, 2002
Last modified: February 15, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.