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Q8VA42

- RDRP_AQRVA

UniProt

Q8VA42 - RDRP_AQRVA

Protein

RNA-directed RNA polymerase VP2

Gene

S2

Organism
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. nucleotide binding Source: UniProtKB-KW
    3. RNA binding Source: InterPro
    4. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral genome replication Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase VP2 (EC:2.7.7.48)
    Gene namesi
    Name:S2
    OrganismiAquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
    Taxonomic identifieri928295 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeAquareovirus

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12401240RNA-directed RNA polymerase VP2PRO_0000404171Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VA42.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini516 – 764249RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR012915. RdRP_5.
    IPR007097. RNA-dir_pol_reovirus.
    [Graphical view]
    PfamiPF07925. RdRP_5. 1 hit.
    [Graphical view]
    PROSITEiPS50523. RDRP_DSRNA_REO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VA42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGTYAPVPN VYHLLDHLTF RSSVVIPNSN FVGRIWSDYW ALQDNIVIRV     50
    SPEGAKDADY CHNSNISPIL SPLKTITEYG TLHPTIDKDA SERGYPSARM 100
    ASSFFKLASC QARQVKIDPT RFLEFLLVTA SSPRVPSGVD SDQPNPWLPE 150
    TSPALQAIWQ IMQRYKLNGN YYAPALVVNT GAVWWIPPPG RTNCVTVQFL 200
    ITDLINLAVN AFATRLAPEL EMCAVRVYLA AASTPNYAHA LLDLKSIFPN 250
    LSLHSMYREG EFGGKCPRIE WTEPRSSYRF KWIGVTQLYE GLRPLTPSRD 300
    SKALLKMRDS GLEDVAKVII TMRRDHPRHT SDSVRFVRGV LSLISGMYLV 350
    RPPTMSVLRE YSQTPQIEEP IPPDWWTGAV GNLSYFNDKA KGPLAHLYSV 400
    WLEAARQVVM DPSTHDPLTQ AIYKTQFVTP RGGSSAALKQ ALVESKVELP 450
    DFSGTGVKRS SKIYQTAQLA HFSFQTLIPT IMGQVTLGIR NQVQRRARSI 500
    MPMSNPQQTV SVPHTLVANY INKHMNRSTT SGSAVQDKVI PLLLYASTPP 550
    RTVINVDIKA CDASITYAAF LAPICGAMHQ GFDLGDPSLP FMNVPSSTQY 600
    DRRNPAAPYN RPVSGLQTMT QHLARLYQAG FSYKVDDPFS SGNSFVFPTT 650
    TFPSGSTATS TEHTANNGAM ADFFLREYVP QHAKSSTLKF IVKDMNIQNN 700
    YVCQGDDGML IIPDLGTKRI SPEDLAELME LLEKYGRGFG WVYDIDSSDS 750
    AEYLKLYALF GARIPNISRH PPVGKEYASP ETGEIWPSLV NIAMGSFYNG 800
    VTDCLEWRDW LKFSWAFACF ASRGSFHPKT GPRVDAQYPV WSFIYMGLPP 850
    ILLPGQTPFL TSVYMPAGDQ GIFAILHQWR DYLTARATSD YPPLKRRHPV 900
    WHLADVPSLL SDLGVYRGYW AAQVSRRPEP SPDDADPASV EAMSAALSTY 950
    LLKDPVLRDR VVRGTNAWRR LTDTHPGRLP SRVPSLLDVP TRWIKAGRDA 1000
    DKPRPSAVAM MMKDIQRAAS SSRKDFSRLL ELYLHVHVHL GPPVPLAVDP 1050
    EVPHVAGADI LNDDHWYKVT SLGPIAQSTK KYFDATLFVG KTVSGLDVEA 1100
    VDATLLRMSI LGAEPEEYHA FLAGIGMSDA EAHRIASAIS LADAQIVQLA 1150
    RTVNLAVPSS WMSLDFDTLI RSHSYPRQPG ISDSSTLVRE RASWINSVLR 1200
    LLCATVAMSR VGPVCQATVS SVDGGVNQIV GCLRAWMRDV 1240
    Length:1,240
    Mass (Da):137,575
    Last modified:March 1, 2002 - v1
    Checksum:i7715D9DA5584D08D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418295 Genomic RNA. Translation: AAL31497.1.
    RefSeqiYP_398630.1. NC_007583.1.

    Genome annotation databases

    GeneIDi3773156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418295 Genomic RNA. Translation: AAL31497.1 .
    RefSeqi YP_398630.1. NC_007583.1.

    3D structure databases

    ProteinModelPortali Q8VA42.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3773156.

    Family and domain databases

    InterProi IPR012915. RdRP_5.
    IPR007097. RNA-dir_pol_reovirus.
    [Graphical view ]
    Pfami PF07925. RdRP_5. 1 hit.
    [Graphical view ]
    PROSITEi PS50523. RDRP_DSRNA_REO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Morphological and biochemical properties of four members of a novel group of reoviruses isolated from aquatic animals."
      Winton J.R., Lannan C.N., Fryer J.L., Hedrick R.P., Meyers T.R., Plumb J.A., Yamamoto T.
      J. Gen. Virol. 68:353-364(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Complete genome sequence of the chum salmon virus."
      Rao S., Carner G.R., Chen W., Winton J.R.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_AQRVA
    AccessioniPrimary (citable) accession number: Q8VA42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3