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Q8VA42 (RDRP_AQRVA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase VP2

EC=2.7.7.48
Gene names
Name:S2
OrganismAquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
Taxonomic identifier928295 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSpinareovirinaeAquareovirus

Protein attributes

Sequence length1240 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands By similarity.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Subcellular location

Virion Potential.

Sequence similarities

Belongs to the reoviridae RNA-directed RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12401240RNA-directed RNA polymerase VP2
PRO_0000404171

Regions

Domain516 – 764249RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
Q8VA42 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 7715D9DA5584D08D

FASTA1,240137,575
        10         20         30         40         50         60 
MPGTYAPVPN VYHLLDHLTF RSSVVIPNSN FVGRIWSDYW ALQDNIVIRV SPEGAKDADY 

        70         80         90        100        110        120 
CHNSNISPIL SPLKTITEYG TLHPTIDKDA SERGYPSARM ASSFFKLASC QARQVKIDPT 

       130        140        150        160        170        180 
RFLEFLLVTA SSPRVPSGVD SDQPNPWLPE TSPALQAIWQ IMQRYKLNGN YYAPALVVNT 

       190        200        210        220        230        240 
GAVWWIPPPG RTNCVTVQFL ITDLINLAVN AFATRLAPEL EMCAVRVYLA AASTPNYAHA 

       250        260        270        280        290        300 
LLDLKSIFPN LSLHSMYREG EFGGKCPRIE WTEPRSSYRF KWIGVTQLYE GLRPLTPSRD 

       310        320        330        340        350        360 
SKALLKMRDS GLEDVAKVII TMRRDHPRHT SDSVRFVRGV LSLISGMYLV RPPTMSVLRE 

       370        380        390        400        410        420 
YSQTPQIEEP IPPDWWTGAV GNLSYFNDKA KGPLAHLYSV WLEAARQVVM DPSTHDPLTQ 

       430        440        450        460        470        480 
AIYKTQFVTP RGGSSAALKQ ALVESKVELP DFSGTGVKRS SKIYQTAQLA HFSFQTLIPT 

       490        500        510        520        530        540 
IMGQVTLGIR NQVQRRARSI MPMSNPQQTV SVPHTLVANY INKHMNRSTT SGSAVQDKVI 

       550        560        570        580        590        600 
PLLLYASTPP RTVINVDIKA CDASITYAAF LAPICGAMHQ GFDLGDPSLP FMNVPSSTQY 

       610        620        630        640        650        660 
DRRNPAAPYN RPVSGLQTMT QHLARLYQAG FSYKVDDPFS SGNSFVFPTT TFPSGSTATS 

       670        680        690        700        710        720 
TEHTANNGAM ADFFLREYVP QHAKSSTLKF IVKDMNIQNN YVCQGDDGML IIPDLGTKRI 

       730        740        750        760        770        780 
SPEDLAELME LLEKYGRGFG WVYDIDSSDS AEYLKLYALF GARIPNISRH PPVGKEYASP 

       790        800        810        820        830        840 
ETGEIWPSLV NIAMGSFYNG VTDCLEWRDW LKFSWAFACF ASRGSFHPKT GPRVDAQYPV 

       850        860        870        880        890        900 
WSFIYMGLPP ILLPGQTPFL TSVYMPAGDQ GIFAILHQWR DYLTARATSD YPPLKRRHPV 

       910        920        930        940        950        960 
WHLADVPSLL SDLGVYRGYW AAQVSRRPEP SPDDADPASV EAMSAALSTY LLKDPVLRDR 

       970        980        990       1000       1010       1020 
VVRGTNAWRR LTDTHPGRLP SRVPSLLDVP TRWIKAGRDA DKPRPSAVAM MMKDIQRAAS 

      1030       1040       1050       1060       1070       1080 
SSRKDFSRLL ELYLHVHVHL GPPVPLAVDP EVPHVAGADI LNDDHWYKVT SLGPIAQSTK 

      1090       1100       1110       1120       1130       1140 
KYFDATLFVG KTVSGLDVEA VDATLLRMSI LGAEPEEYHA FLAGIGMSDA EAHRIASAIS 

      1150       1160       1170       1180       1190       1200 
LADAQIVQLA RTVNLAVPSS WMSLDFDTLI RSHSYPRQPG ISDSSTLVRE RASWINSVLR 

      1210       1220       1230       1240 
LLCATVAMSR VGPVCQATVS SVDGGVNQIV GCLRAWMRDV 

« Hide

References

[1]"Morphological and biochemical properties of four members of a novel group of reoviruses isolated from aquatic animals."
Winton J.R., Lannan C.N., Fryer J.L., Hedrick R.P., Meyers T.R., Plumb J.A., Yamamoto T.
J. Gen. Virol. 68:353-364(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Complete genome sequence of the chum salmon virus."
Rao S., Carner G.R., Chen W., Winton J.R.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF418295 Genomic RNA. Translation: AAL31497.1.
RefSeqYP_398630.1. NC_007583.1.

3D structure databases

ProteinModelPortalQ8VA42.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3773156.

Family and domain databases

InterProIPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view]
PfamPF07925. RdRP_5. 1 hit.
[Graphical view]
PROSITEPS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_AQRVA
AccessionPrimary (citable) accession number: Q8VA42
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families