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Protein

Membrane protein

Gene

M

Organism
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein
Short name:
M protein
Alternative name(s):
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Gene namesi
Name:M
ORF Names:6
OrganismiBovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
Taxonomic identifieri233264 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000008571 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28Virion surfaceSequence analysisAdd BLAST28
Transmembranei29 – 45HelicalSequence analysisAdd BLAST17
Topological domaini46 – 48IntravirionSequence analysis3
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 80Virion surfaceSequence analysisAdd BLAST11
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 230IntravirionSequence analysisAdd BLAST129

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060271 – 230Membrane proteinAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2O-linked (GalNAc...) serine; by hostBy similarity1
Glycosylationi3O-linked (GalNAc...) serine; by hostBy similarity1
Glycosylationi5O-linked (GalNAc...) threonine; by hostBy similarity1
Glycosylationi6O-linked (GalNAc...) threonine; by hostBy similarity1
Glycosylationi14O-linked (GalNAc...) threonine; by hostBy similarity1
Glycosylationi28O-linked (GalNAc...) serine; by hostBy similarity1

Post-translational modificationi

O-linked glycans consist of Gal-GalNAc disaccharides which are modified with up to 2 sialic acid residues.By similarity

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the coronaviruses M protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000NM.

Family and domain databases

InterProiView protein in InterPro
IPR002574. Corona_M.
PfamiView protein in Pfam
PF01635. Corona_M. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8V433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVTTPAPV YTWTADEAIK FLKEWNFSLG IILLFITVIL QFGYTSRSMF
60 70 80 90 100
VYVIKMIILW LMWPLTIILT IFNCVYALNN VYLGFSIVFT IVAIIMWIVY
110 120 130 140 150
FVNSIRLFIR TGSWWSFNPE TNNLMCIDMK GRMYVRPIIE DYHTLTVTII
160 170 180 190 200
RGHLYMQGIK LGTGYSLSDL PAYVTVAKVS HLLTYKRGFL DKIGDTSGFA
210 220 230
VYVKSKVGNY RLPSTQKGSG LDTALLRNNI
Length:230
Mass (Da):26,340
Last modified:March 1, 2002 - v1
Checksum:iA35E7858BAC18722
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391542 Genomic RNA. Translation: AAL57312.1.

Similar proteinsi

Entry informationi

Entry nameiVME1_CVBLU
AccessioniPrimary (citable) accession number: Q8V433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: May 10, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome