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Protein

Nucleoprotein

Gene

N

Organism
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication.

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NC
Short name:
Protein N
Gene namesi
Name:N
ORF Names:7a
OrganismiBovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
Taxonomic identifieri233264 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000008571 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001059921 – 448NucleoproteinAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167Phosphoserine; by hostBy similarity1
Modified residuei174Phosphothreonine; by hostBy similarity1
Modified residuei390Phosphoserine; by hostBy similarity1
Modified residuei427Phosphothreonine; by hostBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer and oligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with the M protein.

Structurei

3D structure databases

ProteinModelPortaliQ8V432
SMRiQ8V432
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 194RNA-bindingBy similarityAdd BLAST143
Regioni266 – 384DimerizationBy similarityAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 19Ser-richAdd BLAST19
Compositional biasi191 – 219Ser-richAdd BLAST29

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG0900008T

Family and domain databases

InterProiView protein in InterPro
IPR001218 Corona_nucleocap
IPR037179 Nucleocapsid_C
IPR037195 Nucleocapsid_N
PfamiView protein in Pfam
PF00937 Corona_nucleoca, 1 hit
PIRSFiPIRSF003888 Corona_nucleocap, 1 hit
SUPFAMiSSF103068 SSF103068, 1 hit
SSF110304 SSF110304, 1 hit

Sequencei

Sequence statusi: Complete.

Q8V432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFTPGKQSS SRASSGNRSG NGILKWADQS DQSRNVQTRG RRAQSKQTAT
60 70 80 90 100
SQQPSGGNVV PYYSWFSGIT QFQKGKEFEF AEGQGVPIAP GVPATEAKGY
110 120 130 140 150
WYRHNRRSFK TADGNQRQLL PRWYFYYLGT GPHAKDQYGT DIDGVYWVAS
160 170 180 190 200
NQADVNTPAD ILDRDPSSDE AIPTRFPPGT VLPQGYYIEG SGRSAPNSRS
210 220 230 240 250
TSRASSRASS AGSRSRANSG NRTPTSGVTP DMADQIASLV LAKLGKDAAK
260 270 280 290 300
PQQVTKQTAK EIRQKILNKP RQKRSPNKQC TVQQCFGKRG PNQNFGGGEM
310 320 330 340 350
LKLGTSDPQF PILAELAPTA GAFFFGSRLE LAKVQNLSGN LDEPQKDVYE
360 370 380 390 400
LRYNGAIRFD STLSGFETIM KVLNENLNAY QQQDGTMNMS PKPQRQRGQK
410 420 430 440
NGQGENDNIS VAAPKSRVQQ NKIRELTAED ISLLKKMDEP FTEDTSEI
Length:448
Mass (Da):49,285
Last modified:March 1, 2002 - v1
Checksum:iF2B6BB2485D3F8FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391542 Genomic RNA Translation: AAL57313.1

Similar proteinsi

Entry informationi

Entry nameiNCAP_CVBLU
AccessioniPrimary (citable) accession number: Q8V432
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome