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Protein

Hemagglutinin-esterase

Gene

HE

Organism
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell.1 Publication

Catalytic activityi

N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.

GO - Molecular functioni

  1. sialate O-acetylesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-esterase (EC:3.1.1.53)
Short name:
HE protein
Gene namesi
Name:HE
OrganismiInfectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV)
Taxonomic identifieri652965 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeIsavirus
Virus hostiGadus morhua (Atlantic cod) [TaxID: 8049]
Oncorhynchus kisutch (Coho salmon) (Salmo kisutch) [TaxID: 8019]
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) [TaxID: 8022]
Pollachius virens (Saithe) (Gadus virens) [TaxID: 8060]
Salmo salar (Atlantic salmon) [TaxID: 8030]
Salmo trutta (Brown trout) [TaxID: 8032]
ProteomesiUP000008772: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 347331ExtracellularSequence AnalysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence AnalysisAdd
BLAST
Topological domaini369 – 39426CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 394378Hemagglutinin-esterasePRO_0000403914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi333 – 3331N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi119 – 1213Cell attachment siteSequence Analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR010408. Hemagglutn-estrase_ISAV-type.
[Graphical view]
PfamiPF06215. ISAV_HA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8V3U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFIILFLL LAPVYSRLCL RNHPDTTWIG DSRSDQSRVN QQSLDLVTNF
60 70 80 90 100
KGILQAKNGN GLMKQMSGRF PSDWYQPTTK YRILYIGTND CTEGPNDVII
110 120 130 140 150
PTSMTLDNVA RDLYLGACRG DVRVTPTFVG AAELGLIGRT DALTEFSVKV
160 170 180 190 200
LTFNNPTIVV VGLNGMSGIY KVCIAASSGN VGGVNLVNGC GYFSAPLRFD
210 220 230 240 250
NFKGQIYVSD TFEVRGTKNK CVILRSSSNA PLCTHIKRNI ELDEYVDTPN
260 270 280 290 300
TGGVYPSDGF DSLHGSASIR TFLTEALTCP GVDWDRIDAA SCEYDSCPKL
310 320 330 340 350
VKEFDQTGLG NTDTQIMREL EAQKEMIGKL GRNITDVNNR VDAIPPQLSN
360 370 380 390
IFISMGVAGF GIALFLAGWK ACVWIAAFMY KSRGRNPPAN LSVA
Length:394
Mass (Da):43,081
Last modified:March 1, 2002 - v1
Checksum:i7E169F87E7FAEEA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404342 Genomic RNA. Translation: AAL67958.1.
RefSeqiYP_145800.1. NC_006499.1.

Genome annotation databases

GeneIDi3170814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404342 Genomic RNA. Translation: AAL67958.1.
RefSeqiYP_145800.1. NC_006499.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3170814.

Family and domain databases

InterProiIPR010408. Hemagglutn-estrase_ISAV-type.
[Graphical view]
PfamiPF06215. ISAV_HA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic organization of infectious salmon anaemia virus."
    Clouthier S.C., Rector T., Brown N.E., Anderson E.D.
    J. Gen. Virol. 83:421-428(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Infectious salmon anemia virus specifically binds to and hydrolyzes 4-O-acetylated sialic acids."
    Hellebo A., Vilas U., Falk K., Vlasak R.
    J. Virol. 78:3055-3062(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHEMA_ISAV8
AccessioniPrimary (citable) accession number: Q8V3U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2002
Last modified: March 4, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.