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Q8V3U0 (HEMA_ISAV8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Function

Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. Ref.2

Catalytic activity

N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.

Subcellular location

Host membrane; Single-pass type I membrane protein Potential.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 394378Hemagglutinin-esterase
PRO_0000403914

Regions

Topological domain17 – 347331Extracellular Potential
Transmembrane348 – 36821Helical; Potential
Topological domain369 – 39426Cytoplasmic Potential
Motif119 – 1213Cell attachment site Potential

Amino acid modifications

Glycosylation3331N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
Q8V3U0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 7E169F87E7FAEEA4

FASTA39443,081
        10         20         30         40         50         60 
MARFIILFLL LAPVYSRLCL RNHPDTTWIG DSRSDQSRVN QQSLDLVTNF KGILQAKNGN 

        70         80         90        100        110        120 
GLMKQMSGRF PSDWYQPTTK YRILYIGTND CTEGPNDVII PTSMTLDNVA RDLYLGACRG 

       130        140        150        160        170        180 
DVRVTPTFVG AAELGLIGRT DALTEFSVKV LTFNNPTIVV VGLNGMSGIY KVCIAASSGN 

       190        200        210        220        230        240 
VGGVNLVNGC GYFSAPLRFD NFKGQIYVSD TFEVRGTKNK CVILRSSSNA PLCTHIKRNI 

       250        260        270        280        290        300 
ELDEYVDTPN TGGVYPSDGF DSLHGSASIR TFLTEALTCP GVDWDRIDAA SCEYDSCPKL 

       310        320        330        340        350        360 
VKEFDQTGLG NTDTQIMREL EAQKEMIGKL GRNITDVNNR VDAIPPQLSN IFISMGVAGF 

       370        380        390 
GIALFLAGWK ACVWIAAFMY KSRGRNPPAN LSVA 

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References

[1]"Genomic organization of infectious salmon anaemia virus."
Clouthier S.C., Rector T., Brown N.E., Anderson E.D.
J. Gen. Virol. 83:421-428(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Infectious salmon anemia virus specifically binds to and hydrolyzes 4-O-acetylated sialic acids."
Hellebo A., Vilas U., Falk K., Vlasak R.
J. Virol. 78:3055-3062(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF404342 Genomic RNA. Translation: AAL67958.1.
RefSeqYP_145800.1. NC_006499.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3170814.

Family and domain databases

InterProIPR010408. Hemagglutn-estrase_ISAV-type.
[Graphical view]
PfamPF06215. ISAV_HA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMA_ISAV8
AccessionPrimary (citable) accession number: Q8V3U0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program