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Q8V3U0

- HEMA_ISAV8

UniProt

Q8V3U0 - HEMA_ISAV8

Protein

Hemagglutinin-esterase

Gene

HE

Organism
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell.1 Publication

    Catalytic activityi

    N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.

    GO - Molecular functioni

    1. sialate O-acetylesterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-esterase (EC:3.1.1.53)
    Short name:
    HE protein
    Gene namesi
    Name:HE
    OrganismiInfectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV)
    Taxonomic identifieri652965 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeIsavirus
    Virus hostiGadus morhua (Atlantic cod) [TaxID: 8049]
    Oncorhynchus kisutch (Coho salmon) (Salmo kisutch) [TaxID: 8019]
    Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) [TaxID: 8022]
    Pollachius virens (saithe) [TaxID: 8060]
    Salmo salar (Atlantic salmon) [TaxID: 8030]
    Salmo trutta (Brown trout) [TaxID: 8032]
    ProteomesiUP000008772: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 394378Hemagglutinin-esterasePRO_0000403914Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi333 – 3331N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 347331ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini369 – 39426CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei348 – 36821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi119 – 1213Cell attachment siteSequence Analysis

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR010408. Hemagglutn-estrase_ISAV-type.
    [Graphical view]
    PfamiPF06215. ISAV_HA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8V3U0-1 [UniParc]FASTAAdd to Basket

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    MARFIILFLL LAPVYSRLCL RNHPDTTWIG DSRSDQSRVN QQSLDLVTNF    50
    KGILQAKNGN GLMKQMSGRF PSDWYQPTTK YRILYIGTND CTEGPNDVII 100
    PTSMTLDNVA RDLYLGACRG DVRVTPTFVG AAELGLIGRT DALTEFSVKV 150
    LTFNNPTIVV VGLNGMSGIY KVCIAASSGN VGGVNLVNGC GYFSAPLRFD 200
    NFKGQIYVSD TFEVRGTKNK CVILRSSSNA PLCTHIKRNI ELDEYVDTPN 250
    TGGVYPSDGF DSLHGSASIR TFLTEALTCP GVDWDRIDAA SCEYDSCPKL 300
    VKEFDQTGLG NTDTQIMREL EAQKEMIGKL GRNITDVNNR VDAIPPQLSN 350
    IFISMGVAGF GIALFLAGWK ACVWIAAFMY KSRGRNPPAN LSVA 394
    Length:394
    Mass (Da):43,081
    Last modified:March 1, 2002 - v1
    Checksum:i7E169F87E7FAEEA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF404342 Genomic RNA. Translation: AAL67958.1.
    RefSeqiYP_145800.1. NC_006499.1.

    Genome annotation databases

    GeneIDi3170814.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF404342 Genomic RNA. Translation: AAL67958.1 .
    RefSeqi YP_145800.1. NC_006499.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3170814.

    Family and domain databases

    InterProi IPR010408. Hemagglutn-estrase_ISAV-type.
    [Graphical view ]
    Pfami PF06215. ISAV_HA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of infectious salmon anaemia virus."
      Clouthier S.C., Rector T., Brown N.E., Anderson E.D.
      J. Gen. Virol. 83:421-428(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Infectious salmon anemia virus specifically binds to and hydrolyzes 4-O-acetylated sialic acids."
      Hellebo A., Vilas U., Falk K., Vlasak R.
      J. Virol. 78:3055-3062(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiHEMA_ISAV8
    AccessioniPrimary (citable) accession number: Q8V3U0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3