ID   PAP1_SWPV1              Reviewed;         470 AA.
AC   Q8V3R4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   08-NOV-2023, entry version 71.
DE   RecName: Full=Poly(A) polymerase catalytic subunit;
DE            EC=2.7.7.19;
DE   AltName: Full=Poly(A) polymerase large subunit;
DE            Short=PAP-L;
GN   Name=PAPL; OrderedLocusNames=SPV030;
OS   Swinepox virus (strain Swine/Nebraska/17077-99/1999) (SWPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Suipoxvirus; Swinepox virus.
OX   NCBI_TaxID=300880;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11752168; DOI=10.1128/jvi.76.2.783-790.2002;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Osorio F.A., Balinsky C.,
RA   Kutish G.F., Rock D.L.;
RT   "The genome of swinepox virus.";
RL   J. Virol. 76:783-790(2002).
CC   -!- FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC   -!- SUBUNIT: Heterodimer of a large (catalytic) subunit and a small
CC       (regulatory) subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae poly(A) polymerase catalytic
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AF410153; AAL69769.1; -; Genomic_DNA.
DR   RefSeq; NP_570190.1; NC_003389.1.
DR   SMR; Q8V3R4; -.
DR   GeneID; 932422; -.
DR   KEGG; vg:932422; -.
DR   Proteomes; UP000000871; Segment.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd20919; polyA_pol_Pox; 1.
DR   Gene3D; 1.20.1270.320; Poxvirus poly(A) polymerase, N domain; 1.
DR   Gene3D; 3.30.460.60; Poxvirus poly(A) polymerase, nucleotidyltransferase domain; 1.
DR   InterPro; IPR004976; PolyA_pol_cat_Poxvir.
DR   InterPro; IPR037265; PolyA_pol_cat_sf.
DR   InterPro; IPR024231; PolyA_pol_nucTrfase_Poxvir.
DR   InterPro; IPR038419; PolyA_pol_nucTrfase_sf_Poxvir.
DR   InterPro; IPR024397; Poxvirus_polyA_pol_cat_C.
DR   InterPro; IPR024398; Poxvirus_polyA_pol_cat_N.
DR   InterPro; IPR038337; Poxvirus_polyA_pol_cat_N_sf.
DR   Pfam; PF03296; Pox_polyA_pol; 1.
DR   Pfam; PF12629; Pox_polyA_pol_C; 1.
DR   Pfam; PF12630; Pox_polyA_pol_N; 1.
DR   PIRSF; PIRSF015693; VAC-48L_nuct; 1.
DR   SUPFAM; SSF160957; Poly(A) polymerase catalytic subunit-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..470
FT                   /note="Poly(A) polymerase catalytic subunit"
FT                   /id="PRO_0000308940"
FT   ACT_SITE        192
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        194
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   470 AA;  54520 MW;  A4E8243F7690846F CRC64;
     MNRQIANILE NYLGRYPSLN EYHTLKSQYR NIQKVNIFNK DIFISLLRKN KKKFFSDLVC
     TQSDIKHSVL SYFSKQENTY SIGKLYTIIE LQTILVTTYT DVLGVLTTKG PDIFSSTIYY
     NISSIKKLAT DIVHAMMITT VSDKIMGRHN VSSLVGNVNT LMEEYLRRHN KNCICYGSYS
     LHLLNPDVRY GDIDILQTNS RTFLIDLAFL IKFITGYNVV LLKVPYLKNY MVLKDHNDNH
     IIDSFNIRQD TMETIPKILI DNIYIVDPVL QLMSMLKMFS QIDRLEDIVK NPDKVIIRLA
     TLLEYVRINY GIILNGDHGN MPMLSTFNHD QRIITVQTNM YNFPFKKCFI YLDENTLSRD
     ILHLNADDAV DFENVSNSAY LIHNDTMYTY FSNTILLRSE NEIHEISTRA ISAHILLYQI
     LTKGDIIQPL SDIINSLISI EKCTIYKVIQ RDKKTGKHGI IDIEKDIITH
//